From 9146ed6013d2fb39b9f43d4d30bf351c3db0e1ae Mon Sep 17 00:00:00 2001
From: Dominik Brilhaus <brilhaus@nfdi4plants.org>
Date: Fri, 14 Mar 2025 14:51:33 +0100
Subject: [PATCH] deseq: use csv as input, return svg figures

---
 runs/deseq2/results_ma-plot.svg  | 25033 +++++++++++++++++++++++
 runs/deseq2/results_pca-plot.svg |   305 +
 runs/deseq2/results_stats.csv    | 31435 +++++++++++++++++++++++++++++
 runs/deseq2/run.yml              |     6 +-
 workflows/deseq2/deseq2.R        |    24 +-
 workflows/deseq2/workflow.cwl    |     2 +-
 6 files changed, 56792 insertions(+), 13 deletions(-)
 create mode 100644 runs/deseq2/results_ma-plot.svg
 create mode 100644 runs/deseq2/results_pca-plot.svg
 create mode 100644 runs/deseq2/results_stats.csv

diff --git a/runs/deseq2/results_ma-plot.svg b/runs/deseq2/results_ma-plot.svg
new file mode 100644
index 0000000..f2f6b21
--- /dev/null
+++ b/runs/deseq2/results_ma-plot.svg
@@ -0,0 +1,25033 @@
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diff --git a/runs/deseq2/results_stats.csv b/runs/deseq2/results_stats.csv
new file mode 100644
index 0000000..b190038
--- /dev/null
+++ b/runs/deseq2/results_stats.csv
@@ -0,0 +1,31435 @@
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+"Tfru15316_t",31.3698192384791,0.0858504817728482,1.54286565079505,0.055643523937816,0.955625791105956,0.974784630386101
+"Tfru15317_t",0,NA,NA,NA,NA,NA
+"Tfru22034_t",679.668183861666,-5.17808911039113,0.307615811869497,-16.8329744785287,1.39894205028978e-63,6.02083136259332e-61
+"Tfru22035_t",0,NA,NA,NA,NA,NA
+"Tfru22036_t",0,NA,NA,NA,NA,NA
+"Tfru13283_t",0,NA,NA,NA,NA,NA
+"Tfru13284_t",48.3236584689852,0.847639474435859,0.440675624966762,1.92349979534219,0.0544173121738966,0.116552727194163
+"Tfru13285_t",30.6825804269464,0.337403316853574,0.972332721209812,0.347003972502092,0.728588334368714,0.824408502641243
+"Tfru13286_t",0,NA,NA,NA,NA,NA
+"Tfru06160_t",0,NA,NA,NA,NA,NA
+"Tfru06161_t",0,NA,NA,NA,NA,NA
+"Tfru08181_t",0.154850615209362,-1.02608130630382,4.0804728567969,-0.251461372814834,0.801457422905763,NA
+"Tfru08182_t",42.3205255307188,-1.42989640947962,0.369562916059168,-3.86915555469503,0.000109212950544067,0.000540151565342809
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+"Tfru08184_t",0,NA,NA,NA,NA,NA
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+"Tfru13253_t",0.331952291441413,-1.88946190119366,4.04108740625553,-0.46756274023393,0.64009731538694,NA
+"Tfru13254_t",0.162767189711808,0.897472045338672,4.0804728567969,0.219943147972113,0.825915431767156,NA
+"Tfru13255_t",0,NA,NA,NA,NA,NA
+"Tfru28728_t",40.5923154805746,3.48924695651772,0.677264635345577,5.15196981271186,2.57764534888314e-07,2.13026967902528e-06
+"Tfru23072_t",144.000214259146,0.575668275893094,0.245191257686099,2.34783361089522,0.0188829545449383,0.0487391739670561
diff --git a/runs/deseq2/run.yml b/runs/deseq2/run.yml
index 25f66f6..b8e9909 100644
--- a/runs/deseq2/run.yml
+++ b/runs/deseq2/run.yml
@@ -3,7 +3,7 @@ inKallistoResults:
     path: ../../runs/kallisto/kallisto_results
 inMetadataFile:
     class: File
-    path: ../../runs/merged_isa_metadata/out/merged_isa.tsv
-inMetadataSample: "Source.Name"
+    path: ../../runs/isaSampleToRawDataSeq/rnaseq-samples.csv
+inMetadataSample: "Input [Source Name]"
 inMetadataFactorList:
-  - "Factor..Photosynthesis.mode."
\ No newline at end of file
+  - "Factor [Photosynthesis mode]"
\ No newline at end of file
diff --git a/workflows/deseq2/deseq2.R b/workflows/deseq2/deseq2.R
index 0d5f022..dcad6b6 100644
--- a/workflows/deseq2/deseq2.R
+++ b/workflows/deseq2/deseq2.R
@@ -6,13 +6,12 @@ library("DESeq2")
 library("tximport")
 library("rhdf5")
 library("ggplot2")
-library("readxl")
 
 # ## Tests 
 
 # inKallistoResults <- "../../runs/kallisto/kallisto_results"
-# inMetadataFile <- "../../runs/isaSampleToRawDataSeq/rnaseq-samples.xlsx"
-# inMetadataSample <- "Input [Sample Name]"
+# inMetadataFile <- "../../runs/isaSampleToRawDataSeq/rnaseq-samples.csv"
+# inMetadataSample <- "Input [Source Name]"
 # inMetadataFactorList <- list("Factor [Photosynthesis mode]")
 
 ### Read arguments from CLI
@@ -35,7 +34,7 @@ head(txi$counts)
 
 ## Read sample metadata
 
-samples_metadata <- as.data.frame(read_xlsx(path = inMetadataFile))
+samples_metadata <- as.data.frame(read.csv(inMetadataFile, check.names=FALSE))
 samples <- samples_metadata[order(samples_metadata[[inMetadataSample]]), c(inMetadataSample, unlist(inMetadataFactorList))]
 
 rownames(samples) <- samples[,inMetadataSample]
@@ -63,20 +62,27 @@ write.csv(res, file = "results_stats.csv", quote = TRUE)
 
 ### Generate and save default plots
 
-png("results_ma-plot.png")
-  plotMA(res, ylim=c(-2,2))
+#### MA Plot
+
+svg("results_ma-plot.svg")
+  p1 <- plotMA(res, ylim=c(-2,2))
 dev.off()
 
+#### PCA
+
 vsd <- vst(dds, blind=FALSE)
 pcaData <- plotPCA(vsd, intgroup=factors, returnData=TRUE)
 percentVar <- round(100 * attr(pcaData, "percentVar"))
 
-p2 <- ggplot(pcaData, aes(PC1, PC2, color=factors[[1]])) +
+p2 <- ggplot(pcaData, aes(PC1, PC2, color=.data[[factors[[1]]]])) +
   geom_point(size=3) +
   xlab(paste0("PC1: ",percentVar[1],"% variance")) +
-  ylab(paste0("PC2: ",percentVar[2],"% variance")) + 
+  ylab(paste0("PC2: ",percentVar[2],"% variance")) +
+  theme(aspect.ratio = 1) +
+  theme(panel.background = element_blank()) +  #background of the plotting area
+  theme(panel.grid.major = element_blank(), panel.grid.minor = element_blank()) +
   coord_fixed()
 
-png("results_pca-plot.png")
+svg("results_pca-plot.svg", width = 8, height = 8)
   print(p2)
 dev.off()
diff --git a/workflows/deseq2/workflow.cwl b/workflows/deseq2/workflow.cwl
index c3dd727..84cb882 100644
--- a/workflows/deseq2/workflow.cwl
+++ b/workflows/deseq2/workflow.cwl
@@ -37,5 +37,5 @@ outputs:
     type: File[]
     outputBinding:
       glob:
-        - "*.png"
+        - "*.svg"
         - "*.csv"
-- 
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