diff --git a/_isa-md/README.md b/_isa-md/README.md
deleted file mode 100644
index 5b042ab2590eb927eb07a2de284e30489e1ea5fa..0000000000000000000000000000000000000000
--- a/_isa-md/README.md
+++ /dev/null
@@ -1,14 +0,0 @@
-# ISA Metadata as markdown tables
-
-:warning: This is just for convenience since .xlsx files are not shown in GitLab. Check the original `isa.*.xlsx` for latest metadata.
-
-
-## Convert xlsx to md
-
-For convenience (i.e. since `.xlsx` are not shown in GitLab), I wrote a [little helper tool](https://github.com/nfdi4plants/xlsx2markdownTable) that converts all xlsx into markdown tables.
-
-```bash
-xlsx2md -e "isa" -o _isa-md -d -di
-```
-
-:bulb: This collects all "isa" metadata it will find in a separate folder (in root).
\ No newline at end of file
diff --git a/_isa-md/assays/GCqTOF_targets/isa.assay/02_metabolites_extr.md b/_isa-md/assays/GCqTOF_targets/isa.assay/02_metabolites_extr.md
deleted file mode 100644
index 8ab7dca78dcbbb5529d1d13bd01db4decdb1de22..0000000000000000000000000000000000000000
--- a/_isa-md/assays/GCqTOF_targets/isa.assay/02_metabolites_extr.md
+++ /dev/null
@@ -1,9 +0,0 @@
-| Source Name   | Parameter [Bio entity]   |   Parameter [Biosource amount] | Unit (#2)   | Parameter [Biosource material state]   | Parameter [Extraction buffer]             |   Parameter [Extraction buffer volume] | Parameter [Internal standard]   |   Parameter [Sample volume] | Unit       | Parameter [MS sample post-extraction]   | Parameter [MS sample resuspension]   | Parameter [MS derivatization]                                                                                                                  | Sample Name   |
-|:--------------|:-------------------------|-------------------------------:|:------------|:---------------------------------------|:------------------------------------------|---------------------------------------:|:--------------------------------|----------------------------:|:-----------|:----------------------------------------|:-------------------------------------|:-----------------------------------------------------------------------------------------------------------------------------------------------|:--------------|
-| CAM_01        | metabolites              |                            6.1 | milligram   | Dry material                           | water:methanol:chloroform 1:2.5:1 (v:v:v) |                                   1500 | ribitol                         |                          50 | microliter | dried in vacuum concentrator            | -                                    | (1) with 10 μl methoxyamine hydrochloride (Acros organics; freshly prepared at 20 mg/ml in pure pyridine (Sigma-Aldrich)) and shaking at 37 ◦C | DB23          |
-|               |                          |                                |             |                                        |                                           |                                        |                                 |                             |            |                                         |                                      | for 90 min, (2) adding 90 μl N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA; Macherey-Nagel) and shaking at 37 ◦C for 30 min.            |               |
-| CAM_02        | metabolites              |                            5.2 | milligram   | Dry material                           | water:methanol:chloroform 1:2.5:1 (v:v:v) |                                   1500 | ribitol                         |                          50 | microliter | dried in vacuum concentrator            | -                                    | 10 μl methoxyamine hydrochloride and 90 μl N-Methyl-N-(trimethylsilyl)trifluoroacetamide MSTFA                                                 | DB24          |
-| CAM_03        | metabolites              |                            8.2 | milligram   | Dry material                           | water:methanol:chloroform 1:2.5:1 (v:v:v) |                                   1500 | ribitol                         |                          50 | microliter | dried in vacuum concentrator            | -                                    | MaHCl and MSTFA                                                                                                                                | DB26          |
-| reC3_01       | metabolites              |                            4.9 | milligram   | Dry material                           | water:methanol:chloroform 1:2.5:1 (v:v:v) |                                   1500 | ribitol                         |                          50 | microliter | dried in vacuum concentrator            | -                                    | methoxyamination + trimethylsylilation (TMS)                                                                                                   | DB39          |
-| reC3_02       | metabolites              |                            6   | milligram   | Dry material                           | water:methanol:chloroform 1:2.5:1 (v:v:v) |                                   1500 | ribitol                         |                          50 | microliter | dried in vacuum concentrator            | -                                    | methoxyamination + trimethylsylilation (TMS)                                                                                                   | DB40          |
-| reC3_03       | metabolites              |                            6.2 | milligram   | Dry material                           | water:methanol:chloroform 1:2.5:1 (v:v:v) |                                   1500 | ribitol                         |                          50 | microliter | dried in vacuum concentrator            | -                                    | methoxyamination + trimethylsylilation (TMS)                                                                                                   | DB41          |
\ No newline at end of file
diff --git a/_isa-md/assays/GCqTOF_targets/isa.assay/03_metabolites_chromatography.md b/_isa-md/assays/GCqTOF_targets/isa.assay/03_metabolites_chromatography.md
deleted file mode 100644
index 76ee838bd465c67b472ba1d7475ff7de745af2b8..0000000000000000000000000000000000000000
--- a/_isa-md/assays/GCqTOF_targets/isa.assay/03_metabolites_chromatography.md
+++ /dev/null
@@ -1,22 +0,0 @@
-| Source Name   | Parameter [MS sample type]   | Parameter [Chromatography instrument model]   | Parameter [Chromatography autosampler model]   | Parameter [Chromatography column type]   | Parameter [Chromatography column model]   | Parameter [mobile phase]   |   Parameter [Chromatography injection volume] | Unit       | Parameter [Chromatography injection mode]   | Parameter [Chromatography gradient]   |   Sample Name |
-|:--------------|:-----------------------------|:----------------------------------------------|:-----------------------------------------------|:-----------------------------------------|:------------------------------------------|:---------------------------|----------------------------------------------:|:-----------|:--------------------------------------------|:--------------------------------------|--------------:|
-| Std. Mix 5µM  |                              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-433                        | helium(0)                  |                                             1 | microliter | splitless                                   | gradient elution                      |     150112_03 |
-| Std. Mix 5µM  |                              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-434                        | helium(0)                  |                                             1 | microliter | split                                       | gradient elution                      |     150112_04 |
-| blank 1       |                              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-435                        | helium(0)                  |                                             1 | microliter | splitless                                   | gradient elution                      |     150112_15 |
-| blank 1       |                              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-436                        | helium(0)                  |                                             1 | microliter | split                                       | gradient elution                      |     150112_16 |
-| DB23          | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-437                        | helium(0)                  |                                             1 | microliter | splitless                                   | gradient elution                      |     150112_55 |
-| DB23          | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-438                        | helium(0)                  |                                             1 | microliter | split                                       | gradient elution                      |     150112_56 |
-| DB24          | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-439                        | helium(0)                  |                                             1 | microliter | splitless                                   | gradient elution                      |     150112_61 |
-| DB24          | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-440                        | helium(0)                  |                                             1 | microliter | split                                       | gradient elution                      |     150112_62 |
-| DB26          | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-441                        | helium(0)                  |                                             1 | microliter | splitless                                   | gradient elution                      |     150112_65 |
-| DB26          | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-442                        | helium(0)                  |                                             1 | microliter | split                                       | gradient elution                      |     150112_66 |
-| Std. Mix 5µM  |                              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-443                        | helium(0)                  |                                             1 | microliter | splitless                                   | gradient elution                      |     150115_03 |
-| Std. Mix 5µM  |                              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-444                        | helium(0)                  |                                             1 | microliter | split                                       | gradient elution                      |     150115_04 |
-| DB39          | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-445                        | helium(0)                  |                                             1 | microliter | splitless                                   | gradient elution                      |     150115_11 |
-| DB39          | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-446                        | helium(0)                  |                                             1 | microliter | split                                       | gradient elution                      |     150115_12 |
-| DB40          | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-447                        | helium(0)                  |                                             1 | microliter | splitless                                   | gradient elution                      |     150115_13 |
-| DB40          | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-448                        | helium(0)                  |                                             1 | microliter | split                                       | gradient elution                      |     150115_14 |
-| DB41          | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-449                        | helium(0)                  |                                             1 | microliter | splitless                                   | gradient elution                      |     150115_15 |
-| DB41          | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-450                        | helium(0)                  |                                             1 | microliter | split                                       | gradient elution                      |     150115_16 |
-| blank 2       |                              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-451                        | helium(0)                  |                                             1 | microliter | splitless                                   | gradient elution                      |     150115_25 |
-| blank 2       |                              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-452                        | helium(0)                  |                                             1 | microliter | split                                       | gradient elution                      |     150115_26 |
\ No newline at end of file
diff --git a/_isa-md/assays/GCqTOF_targets/isa.assay/04_metabolites_massspec.md b/_isa-md/assays/GCqTOF_targets/isa.assay/04_metabolites_massspec.md
deleted file mode 100644
index b8fbf5b50434a294cb6887f0bb564c7900d877ce..0000000000000000000000000000000000000000
--- a/_isa-md/assays/GCqTOF_targets/isa.assay/04_metabolites_massspec.md
+++ /dev/null
@@ -1,22 +0,0 @@
-|   Source Name | Parameter [scan polarity]   |   Parameter [scan window lower limit] |   Parameter [scan window upper limit] |   Parameter [scan rate] | Unit   | Parameter [instrument model]        | Parameter [ionization type]   | Parameter [mass analyzer type]   | Parameter [detector type]   | Data File Name   |
-|--------------:|:----------------------------|--------------------------------------:|--------------------------------------:|------------------------:|:-------|:------------------------------------|:------------------------------|:---------------------------------|:----------------------------|:-----------------|
-|     150112_03 | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150112_03.D      |
-|     150112_04 | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150112_04.D      |
-|     150112_15 | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150112_15.D      |
-|     150112_16 | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150112_16.D      |
-|     150112_55 | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150112_55.D      |
-|     150112_56 | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150112_56.D      |
-|     150112_61 | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150112_61.D      |
-|     150112_62 | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150112_62.D      |
-|     150112_65 | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150112_65.D      |
-|     150112_66 | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150112_66.D      |
-|     150115_03 | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150115_03.D      |
-|     150115_04 | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150115_04.D      |
-|     150115_11 | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150115_11.D      |
-|     150115_12 | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150115_12.D      |
-|     150115_13 | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150115_13.D      |
-|     150115_14 | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150115_14.D      |
-|     150115_15 | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150115_15.D      |
-|     150115_16 | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150115_16.D      |
-|     150115_25 | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150115_25.D      |
-|     150115_26 | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150115_26.D      |
\ No newline at end of file
diff --git a/_isa-md/assays/GCqTOF_targets/isa.assay/gas_chromatography.md b/_isa-md/assays/GCqTOF_targets/isa.assay/gas_chromatography.md
new file mode 100644
index 0000000000000000000000000000000000000000..5e7bcfc8e62eac80d11771b1ad315e0c7510b5ef
--- /dev/null
+++ b/_isa-md/assays/GCqTOF_targets/isa.assay/gas_chromatography.md
@@ -0,0 +1,22 @@
+| Source Name   | Protocol REF          | Protocol Type   | Parameter [MS sample type]   | Parameter [Chromatography instrument model]   | Parameter [Chromatography autosampler model]   | Parameter [Chromatography column type]   | Parameter [Chromatography column model]   | Parameter [mobile phase]   |   Parameter [Chromatography injection volume] | Unit       | Parameter [Chromatography injection mode]   | Parameter [Chromatography gradient]   |   Sample Name |
+|:--------------|:----------------------|:----------------|:-----------------------------|:----------------------------------------------|:-----------------------------------------------|:-----------------------------------------|:------------------------------------------|:---------------------------|----------------------------------------------:|:-----------|:--------------------------------------------|:--------------------------------------|--------------:|
+| Std. Mix 5µM  | gas_chromatography.md | assay protocol  |                              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-433                        | helium(0)                  |                                             1 | microliter | splitless                                   | gradient elution                      |     150112_03 |
+| Std. Mix 5µM  | gas_chromatography.md | assay protocol  |                              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-434                        | helium(0)                  |                                             1 | microliter | split                                       | gradient elution                      |     150112_04 |
+| blank 1       | gas_chromatography.md | assay protocol  |                              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-435                        | helium(0)                  |                                             1 | microliter | splitless                                   | gradient elution                      |     150112_15 |
+| blank 1       | gas_chromatography.md | assay protocol  |                              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-436                        | helium(0)                  |                                             1 | microliter | split                                       | gradient elution                      |     150112_16 |
+| DB23          | gas_chromatography.md | assay protocol  | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-437                        | helium(0)                  |                                             1 | microliter | splitless                                   | gradient elution                      |     150112_55 |
+| DB23          | gas_chromatography.md | assay protocol  | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-438                        | helium(0)                  |                                             1 | microliter | split                                       | gradient elution                      |     150112_56 |
+| DB24          | gas_chromatography.md | assay protocol  | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-439                        | helium(0)                  |                                             1 | microliter | splitless                                   | gradient elution                      |     150112_61 |
+| DB24          | gas_chromatography.md | assay protocol  | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-440                        | helium(0)                  |                                             1 | microliter | split                                       | gradient elution                      |     150112_62 |
+| DB26          | gas_chromatography.md | assay protocol  | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-441                        | helium(0)                  |                                             1 | microliter | splitless                                   | gradient elution                      |     150112_65 |
+| DB26          | gas_chromatography.md | assay protocol  | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-442                        | helium(0)                  |                                             1 | microliter | split                                       | gradient elution                      |     150112_66 |
+| Std. Mix 5µM  | gas_chromatography.md | assay protocol  |                              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-443                        | helium(0)                  |                                             1 | microliter | splitless                                   | gradient elution                      |     150115_03 |
+| Std. Mix 5µM  | gas_chromatography.md | assay protocol  |                              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-444                        | helium(0)                  |                                             1 | microliter | split                                       | gradient elution                      |     150115_04 |
+| DB39          | gas_chromatography.md | assay protocol  | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-445                        | helium(0)                  |                                             1 | microliter | splitless                                   | gradient elution                      |     150115_11 |
+| DB39          | gas_chromatography.md | assay protocol  | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-446                        | helium(0)                  |                                             1 | microliter | split                                       | gradient elution                      |     150115_12 |
+| DB40          | gas_chromatography.md | assay protocol  | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-447                        | helium(0)                  |                                             1 | microliter | splitless                                   | gradient elution                      |     150115_13 |
+| DB40          | gas_chromatography.md | assay protocol  | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-448                        | helium(0)                  |                                             1 | microliter | split                                       | gradient elution                      |     150115_14 |
+| DB41          | gas_chromatography.md | assay protocol  | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-449                        | helium(0)                  |                                             1 | microliter | splitless                                   | gradient elution                      |     150115_15 |
+| DB41          | gas_chromatography.md | assay protocol  | material sample              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-450                        | helium(0)                  |                                             1 | microliter | split                                       | gradient elution                      |     150115_16 |
+| blank 2       | gas_chromatography.md | assay protocol  |                              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-451                        | helium(0)                  |                                             1 | microliter | splitless                                   | gradient elution                      |     150115_25 |
+| blank 2       | gas_chromatography.md | assay protocol  |                              | Agilent 7890B GC                              | GERSTEL MultiPurpose Sampler (MPS) Dual Head   | low polarity                             | Agilent 19091S-452                        | helium(0)                  |                                             1 | microliter | split                                       | gradient elution                      |     150115_26 |
\ No newline at end of file
diff --git a/_isa-md/assays/GCqTOF_targets/isa.assay/mass_spec.md b/_isa-md/assays/GCqTOF_targets/isa.assay/mass_spec.md
new file mode 100644
index 0000000000000000000000000000000000000000..9ec4346a00050d18196888294bc8650805cd4298
--- /dev/null
+++ b/_isa-md/assays/GCqTOF_targets/isa.assay/mass_spec.md
@@ -0,0 +1,22 @@
+|   Source Name | Protocol Type   | Protocol REF   | Parameter [scan polarity]   |   Parameter [scan window lower limit] |   Parameter [scan window upper limit] |   Parameter [scan rate] | Unit   | Parameter [instrument model]        | Parameter [ionization type]   | Parameter [mass analyzer type]   | Parameter [detector type]   | Data File Name   |
+|--------------:|:----------------|:---------------|:----------------------------|--------------------------------------:|--------------------------------------:|------------------------:|:-------|:------------------------------------|:------------------------------|:---------------------------------|:----------------------------|:-----------------|
+|     150112_03 | assay protocol  | mass_spec.md   | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150112_03.D      |
+|     150112_04 | assay protocol  | mass_spec.md   | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150112_04.D      |
+|     150112_15 | assay protocol  | mass_spec.md   | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150112_15.D      |
+|     150112_16 | assay protocol  | mass_spec.md   | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150112_16.D      |
+|     150112_55 | assay protocol  | mass_spec.md   | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150112_55.D      |
+|     150112_56 | assay protocol  | mass_spec.md   | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150112_56.D      |
+|     150112_61 | assay protocol  | mass_spec.md   | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150112_61.D      |
+|     150112_62 | assay protocol  | mass_spec.md   | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150112_62.D      |
+|     150112_65 | assay protocol  | mass_spec.md   | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150112_65.D      |
+|     150112_66 | assay protocol  | mass_spec.md   | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150112_66.D      |
+|     150115_03 | assay protocol  | mass_spec.md   | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150115_03.D      |
+|     150115_04 | assay protocol  | mass_spec.md   | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150115_04.D      |
+|     150115_11 | assay protocol  | mass_spec.md   | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150115_11.D      |
+|     150115_12 | assay protocol  | mass_spec.md   | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150115_12.D      |
+|     150115_13 | assay protocol  | mass_spec.md   | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150115_13.D      |
+|     150115_14 | assay protocol  | mass_spec.md   | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150115_14.D      |
+|     150115_15 | assay protocol  | mass_spec.md   | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150115_15.D      |
+|     150115_16 | assay protocol  | mass_spec.md   | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150115_16.D      |
+|     150115_25 | assay protocol  | mass_spec.md   | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150115_25.D      |
+|     150115_26 | assay protocol  | mass_spec.md   | positive                    |                                    60 |                                   800 |                      20 | hertz  | 7200 GC-QTOF (Agilent Technologies) | electron ionization           | quadrupole                       | electron multiplier         | 150115_26.D      |
\ No newline at end of file
diff --git a/_isa-md/assays/GCqTOF_targets/isa.assay/metabolite_extraction.md b/_isa-md/assays/GCqTOF_targets/isa.assay/metabolite_extraction.md
new file mode 100644
index 0000000000000000000000000000000000000000..2f8c22da2b5aa5207a1c31eefe3423c7e9faf899
--- /dev/null
+++ b/_isa-md/assays/GCqTOF_targets/isa.assay/metabolite_extraction.md
@@ -0,0 +1,9 @@
+| Source Name   | Protocol Type       | Protocol REF             | Parameter [Bio entity]   |   Parameter [Biosource amount] | Unit (#2)   | Parameter [Biosource material state]   | Parameter [Extraction buffer]             |   Parameter [Extraction buffer volume] | Parameter [Internal standard]   |   Parameter [Sample volume] | Unit       | Parameter [MS sample post-extraction]   | Parameter [MS sample resuspension]   | Parameter [MS derivatization]                                                                                                                  | Sample Name   |
+|:--------------|:--------------------|:-------------------------|:-------------------------|-------------------------------:|:------------|:---------------------------------------|:------------------------------------------|---------------------------------------:|:--------------------------------|----------------------------:|:-----------|:----------------------------------------|:-------------------------------------|:-----------------------------------------------------------------------------------------------------------------------------------------------|:--------------|
+| CAM_01        | extraction protocol | metabolite_extraction.md | metabolites              |                            6.1 | milligram   | Dry material                           | water:methanol:chloroform 1:2.5:1 (v:v:v) |                                   1500 | ribitol                         |                          50 | microliter | dried in vacuum concentrator            | -                                    | (1) with 10 μl methoxyamine hydrochloride (Acros organics; freshly prepared at 20 mg/ml in pure pyridine (Sigma-Aldrich)) and shaking at 37 ◦C | DB23          |
+|               |                     |                          |                          |                                |             |                                        |                                           |                                        |                                 |                             |            |                                         |                                      | for 90 min, (2) adding 90 μl N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA; Macherey-Nagel) and shaking at 37 ◦C for 30 min.            |               |
+| CAM_02        | extraction protocol | metabolite_extraction.md | metabolites              |                            5.2 | milligram   | Dry material                           | water:methanol:chloroform 1:2.5:1 (v:v:v) |                                   1500 | ribitol                         |                          50 | microliter | dried in vacuum concentrator            | -                                    | 10 μl methoxyamine hydrochloride and 90 μl N-Methyl-N-(trimethylsilyl)trifluoroacetamide MSTFA                                                 | DB24          |
+| CAM_03        | extraction protocol | metabolite_extraction.md | metabolites              |                            8.2 | milligram   | Dry material                           | water:methanol:chloroform 1:2.5:1 (v:v:v) |                                   1500 | ribitol                         |                          50 | microliter | dried in vacuum concentrator            | -                                    | MaHCl and MSTFA                                                                                                                                | DB26          |
+| reC3_01       | extraction protocol | metabolite_extraction.md | metabolites              |                            4.9 | milligram   | Dry material                           | water:methanol:chloroform 1:2.5:1 (v:v:v) |                                   1500 | ribitol                         |                          50 | microliter | dried in vacuum concentrator            | -                                    | methoxyamination + trimethylsylilation (TMS)                                                                                                   | DB39          |
+| reC3_02       | extraction protocol | metabolite_extraction.md | metabolites              |                            6   | milligram   | Dry material                           | water:methanol:chloroform 1:2.5:1 (v:v:v) |                                   1500 | ribitol                         |                          50 | microliter | dried in vacuum concentrator            | -                                    | methoxyamination + trimethylsylilation (TMS)                                                                                                   | DB40          |
+| reC3_03       | extraction protocol | metabolite_extraction.md | metabolites              |                            6.2 | milligram   | Dry material                           | water:methanol:chloroform 1:2.5:1 (v:v:v) |                                   1500 | ribitol                         |                          50 | microliter | dried in vacuum concentrator            | -                                    | methoxyamination + trimethylsylilation (TMS)                                                                                                   | DB41          |
\ No newline at end of file
diff --git a/assays/GCqTOF_targets/isa.assay.xlsx b/assays/GCqTOF_targets/isa.assay.xlsx
index b96d001c466170d5d527a042fb4b22a398a4bea0..9a899eecad80a561b3e5a8c2497dea8ea2317895 100644
Binary files a/assays/GCqTOF_targets/isa.assay.xlsx and b/assays/GCqTOF_targets/isa.assay.xlsx differ
diff --git a/assays/GCqTOF_targets/protocols/ProtRef03_chromatography.md b/assays/GCqTOF_targets/protocols/gas_chromatography.md
similarity index 79%
rename from assays/GCqTOF_targets/protocols/ProtRef03_chromatography.md
rename to assays/GCqTOF_targets/protocols/gas_chromatography.md
index fb4c79d5f7238e04eefe3221cae0e0220e9c067b..9682e590b13ae94c4e6268dcc25631bfa8fc178c 100644
--- a/assays/GCqTOF_targets/protocols/ProtRef03_chromatography.md
+++ b/assays/GCqTOF_targets/protocols/gas_chromatography.md
@@ -1,7 +1,3 @@
-> ARC Note:
-> - This is a somewhat polished protocol as found in a publication's "materials and methods" section. 
-> - This is not an example for a typical lab protocol or method. 
-
 # Metabolite Profiling - Chromatography
 
 After incubation for 2 hours at room temperature, 1 μl of derivatized compounds were injected at a flow of 1 ml/min with an automatic liner exchange system in conjunction with a cold injection system (Gerstel) in splitless mode (ramping from 50 ◦C to 250 ◦C at 12 ◦C/s) into the GC. Chromatography was performed using a 7890B GC system (Agilent Technologies) with a 30 m long, 0.25 mm internal diameter, HP-5MS column with 5% phenyl methyl siloxane film (Agilent 19091S-433). The oven temperature was held constant at 70◦C for 2 min and then ramped at 12.5◦C/min to 320◦C at which it was held constant for 5 min; resulting in a total run time of 27 minutes.
diff --git a/assays/GCqTOF_targets/protocols/ProtRef04_MassSpec.md b/assays/GCqTOF_targets/protocols/mass_spec.md
similarity index 58%
rename from assays/GCqTOF_targets/protocols/ProtRef04_MassSpec.md
rename to assays/GCqTOF_targets/protocols/mass_spec.md
index 5c9922882c6ecf642e615a3e842ae4b6af3ef2ee..26364270bd076a836b78d4d5f52688dfa7ab81e9 100644
--- a/assays/GCqTOF_targets/protocols/ProtRef04_MassSpec.md
+++ b/assays/GCqTOF_targets/protocols/mass_spec.md
@@ -1,7 +1,3 @@
-> ARC Note:
-> - This is a somewhat polished protocol as found in a publication's "materials and methods" section. 
-> - This is not an example for a typical lab protocol or method. 
-
 # Metabolite Profiling - Mass Spectrometry
 
 Metabolites were ionized with an electron impact source at 70V and 200 â—¦C source temperature and recorded in a mass range of m/z 60 to m/z 800 at 20 scans per second with a 7200 GC-QTOF (Agilent Technologies).
\ No newline at end of file
diff --git a/assays/GCqTOF_targets/protocols/ProtRef02_extraction.md b/assays/GCqTOF_targets/protocols/metabolite_extraction.md
similarity index 85%
rename from assays/GCqTOF_targets/protocols/ProtRef02_extraction.md
rename to assays/GCqTOF_targets/protocols/metabolite_extraction.md
index 6874abf8813b451185def032b1cc2ed935af0ff5..dbe7005e0ed856eb50b48e89a53cc46152ab0028 100644
--- a/assays/GCqTOF_targets/protocols/ProtRef02_extraction.md
+++ b/assays/GCqTOF_targets/protocols/metabolite_extraction.md
@@ -1,8 +1,3 @@
-> ARC Note:
-> - This is a somewhat polished protocol as found in a publication's "materials and methods" section. 
-> - This is not an example for a typical lab protocol or method. 
-
-
 # Metabolite Profiling - Extraction
 
 Each of the samples was analyzed one time via gas chromatography-mass spectrometry (GC-MS) using an adapted protocol from Lisec et al. (2006). Metabolites were extracted from
diff --git a/assays/MassHunter_targets/protocols/DataTransformation.md b/assays/MassHunter_targets/protocols/DataTransformation.md
new file mode 100644
index 0000000000000000000000000000000000000000..b3032d443eb0210d451cf0a89b26d30d48f8afc8
--- /dev/null
+++ b/assays/MassHunter_targets/protocols/DataTransformation.md
@@ -0,0 +1,3 @@
+# Metabolite Profiling - Data transformation
+
+Raw data files exported from MassHunter Qualitative (v b07, Agilent Technologies) in the Agilent data file format (*.D/) 
\ No newline at end of file
diff --git a/assays/MassHunter_targets/protocols/MetaboliteIdentification.md b/assays/MassHunter_targets/protocols/MetaboliteIdentification.md
new file mode 100644
index 0000000000000000000000000000000000000000..2844e93978f26def42afafaf27dea9a9f91421cd
--- /dev/null
+++ b/assays/MassHunter_targets/protocols/MetaboliteIdentification.md
@@ -0,0 +1 @@
+# Metabolite Profiling - Identification
diff --git a/assays/MassHunter_targets/protocols/ProtRef05_DataTransformation.md b/assays/MassHunter_targets/protocols/ProtRef05_DataTransformation.md
deleted file mode 100644
index eb22b35fc69bedbcaa7fb19a77ed2bfe48648f3e..0000000000000000000000000000000000000000
--- a/assays/MassHunter_targets/protocols/ProtRef05_DataTransformation.md
+++ /dev/null
@@ -1,7 +0,0 @@
-> ARC Note:
-> - This is a somewhat polished protocol as found in a publication's "materials and methods" section. 
-> - This is not an example for a typical lab protocol or method. 
-
-# Metabolite Profiling - Data transformation
-
-Raw data files exported from MassHunter Qualitative (v b07, Agilent Technologies) in the Agilent data file format (*.D/) 
\ No newline at end of file
diff --git a/assays/MassHunter_targets/protocols/ProtRef06_MetaboliteIdentification.md b/assays/MassHunter_targets/protocols/ProtRef06_MetaboliteIdentification.md
deleted file mode 100644
index e9dcfed0e36a7e0d04cff92d4d3b7aa3fcb49ce7..0000000000000000000000000000000000000000
--- a/assays/MassHunter_targets/protocols/ProtRef06_MetaboliteIdentification.md
+++ /dev/null
@@ -1,5 +0,0 @@
-> ARC Note:
-> - This is a somewhat polished protocol as found in a publication's "materials and methods" section. 
-> - This is not an example for a typical lab protocol or method. 
-
-# Metabolite Profiling - Identification