diff --git a/runs/.gitkeep b/runs/.gitkeep
deleted file mode 100644
index e69de29bb2d1d6434b8b29ae775ad8c2e48c5391..0000000000000000000000000000000000000000
diff --git a/runs/deseq2-run/README.md b/runs/deseq2-run/README.md
deleted file mode 100644
index f416fa74b81c27b40e1ede6cbaf308d5ba2e9287..0000000000000000000000000000000000000000
--- a/runs/deseq2-run/README.md
+++ /dev/null
@@ -1,10 +0,0 @@
-
-
-
-```bash
-cd runs/deseq2-run
-```
-
-```bash
-cwltool ../../workflows/deseq2/deseq2.cwl job.yml
-```
diff --git a/runs/deseq2/results_ma-plot.svg b/runs/deseq2/results_ma-plot.svg
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diff --git a/runs/deseq2/results_stats.csv b/runs/deseq2/results_stats.csv
new file mode 100644
index 0000000000000000000000000000000000000000..b190038e4ba21a6ab6ff0deb95cb333159dbe061
--- /dev/null
+++ b/runs/deseq2/results_stats.csv
@@ -0,0 +1,31435 @@
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+"Tfru15316_t",31.3698192384791,0.0858504817728482,1.54286565079505,0.055643523937816,0.955625791105956,0.974784630386101
+"Tfru15317_t",0,NA,NA,NA,NA,NA
+"Tfru22034_t",679.668183861666,-5.17808911039113,0.307615811869497,-16.8329744785287,1.39894205028978e-63,6.02083136259332e-61
+"Tfru22035_t",0,NA,NA,NA,NA,NA
+"Tfru22036_t",0,NA,NA,NA,NA,NA
+"Tfru13283_t",0,NA,NA,NA,NA,NA
+"Tfru13284_t",48.3236584689852,0.847639474435859,0.440675624966762,1.92349979534219,0.0544173121738966,0.116552727194163
+"Tfru13285_t",30.6825804269464,0.337403316853574,0.972332721209812,0.347003972502092,0.728588334368714,0.824408502641243
+"Tfru13286_t",0,NA,NA,NA,NA,NA
+"Tfru06160_t",0,NA,NA,NA,NA,NA
+"Tfru06161_t",0,NA,NA,NA,NA,NA
+"Tfru08181_t",0.154850615209362,-1.02608130630382,4.0804728567969,-0.251461372814834,0.801457422905763,NA
+"Tfru08182_t",42.3205255307188,-1.42989640947962,0.369562916059168,-3.86915555469503,0.000109212950544067,0.000540151565342809
+"Tfru08183_t",0,NA,NA,NA,NA,NA
+"Tfru08184_t",0,NA,NA,NA,NA,NA
+"Tfru30209_t",22.8351836386159,-0.813539885367203,0.457363079553658,-1.77876160480889,0.0752788544353602,0.151792122016701
+"Tfru30210_t",193.730681281368,-0.118839671898435,0.223553445339181,-0.53159400750066,0.595007216072026,0.721396689728151
+"Tfru20410_t",21.7620872267647,-0.0975972470122713,0.430323726839502,-0.226799595107318,0.820579578557779,0.886487829920886
+"Tfru20411_t",71.7606202647373,-0.512167752162269,0.329383418556625,-1.55492876480126,0.119963035789502,0.219883107368473
+"Tfru17325_t",41.4704428308916,3.92034681425892,0.771823345571444,5.0793317366636,3.78764821887552e-07,3.04809662489874e-06
+"Tfru18037_t",0,NA,NA,NA,NA,NA
+"Tfru13253_t",0.331952291441413,-1.88946190119366,4.04108740625553,-0.46756274023393,0.64009731538694,NA
+"Tfru13254_t",0.162767189711808,0.897472045338672,4.0804728567969,0.219943147972113,0.825915431767156,NA
+"Tfru13255_t",0,NA,NA,NA,NA,NA
+"Tfru28728_t",40.5923154805746,3.48924695651772,0.677264635345577,5.15196981271186,2.57764534888314e-07,2.13026967902528e-06
+"Tfru23072_t",144.000214259146,0.575668275893094,0.245191257686099,2.34783361089522,0.0188829545449383,0.0487391739670561
diff --git a/runs/deseq2/run.cwl b/runs/deseq2/run.cwl
new file mode 100644
index 0000000000000000000000000000000000000000..849cd989221e74fb6874efe6cc412166927a1847
--- /dev/null
+++ b/runs/deseq2/run.cwl
@@ -0,0 +1,24 @@
+#!/usr/bin/env cwl-runner
+cwlVersion: v1.2
+class: Workflow
+
+inputs:
+  inKallistoResults: Directory
+  inMetadataFile: File
+  inMetadataSample: string
+  inMetadataFactorList: string[]
+
+steps:
+  deseq2:
+    run: ../../workflows/deseq2/workflow.cwl
+    in:
+      inKallistoResults: inKallistoResults
+      inMetadataFile: inMetadataFile
+      inMetadataSample: inMetadataSample
+      inMetadataFactorList: inMetadataFactorList
+    out: [output]
+
+outputs:
+  output: 
+    type: File[]
+    outputSource: deseq2/output
diff --git a/runs/deseq2-run/job.yml b/runs/deseq2/run.yml
similarity index 50%
rename from runs/deseq2-run/job.yml
rename to runs/deseq2/run.yml
index 25f66f6d26c6cdd6179212db52d906332973f912..b8e9909794f2554784021064e4914996f866bcc2 100644
--- a/runs/deseq2-run/job.yml
+++ b/runs/deseq2/run.yml
@@ -3,7 +3,7 @@ inKallistoResults:
     path: ../../runs/kallisto/kallisto_results
 inMetadataFile:
     class: File
-    path: ../../runs/merged_isa_metadata/out/merged_isa.tsv
-inMetadataSample: "Source.Name"
+    path: ../../runs/isaSampleToRawDataSeq/rnaseq-samples.csv
+inMetadataSample: "Input [Source Name]"
 inMetadataFactorList:
-  - "Factor..Photosynthesis.mode."
\ No newline at end of file
+  - "Factor [Photosynthesis mode]"
\ No newline at end of file
diff --git a/runs/isaSampleToRawDataSeq-run/README.md b/runs/isaSampleToRawDataSeq-run/README.md
deleted file mode 100644
index 6c83a17dc1ab439d90ae08c2749a9047ac74ba3f..0000000000000000000000000000000000000000
--- a/runs/isaSampleToRawDataSeq-run/README.md
+++ /dev/null
@@ -1,10 +0,0 @@
-
-
-
-```bash
-cd runs/isaSampleToRawDataSeq-run
-```
-
-```bash
-cwltool ../../workflows/isaSampleToRawDataSeq/isaSampleToRawDataSeq.cwl job.yml
-```
diff --git a/runs/isaSampleToRawDataSeq-run/rnaseq-samples.xlsx b/runs/isaSampleToRawDataSeq-run/rnaseq-samples.xlsx
deleted file mode 100644
index 759961513f5d109aacc26dcc233d07e5c0e1325f..0000000000000000000000000000000000000000
Binary files a/runs/isaSampleToRawDataSeq-run/rnaseq-samples.xlsx and /dev/null differ
diff --git a/runs/isaSampleToRawDataSeq-run/rnaseq-samples.csv b/runs/isaSampleToRawDataSeq/rnaseq-samples.csv
similarity index 58%
rename from runs/isaSampleToRawDataSeq-run/rnaseq-samples.csv
rename to runs/isaSampleToRawDataSeq/rnaseq-samples.csv
index d9aed97c919b39486aa0d1ccea4319a46a00dd5e..e1628284e772d2df90fbd91be2d47449ad23c0ee 100644
--- a/runs/isaSampleToRawDataSeq-run/rnaseq-samples.csv
+++ b/runs/isaSampleToRawDataSeq/rnaseq-samples.csv
@@ -1,7 +1,7 @@
-Input [Sample Name],Characteristic [organism],Term Source REF (OBI:0100026),Term Accession Number (OBI:0100026),Characteristic [organism part],Term Source REF (EFO:0000635),Term Accession Number (EFO:0000635),Characteristic [plant age],Term Source REF (DPBO:0000033),Term Accession Number (DPBO:0000033),Parameter [growth day length],Term Source REF (DPBO:0000041),Term Accession Number (DPBO:0000041),Parameter [light intensity exposure],Unit,Term Source REF (PECO:0007224),Term Accession Number (PECO:0007224),Parameter [humidity day],Unit ,Term Source REF (DPBO:0000005),Term Accession Number (DPBO:0000005),Parameter [temperature day],Unit  ,Term Source REF (DPBO:0000007),Term Accession Number (DPBO:0000007),Parameter [temperature night],Unit   ,Term Source REF (DPBO:0000008),Term Accession Number (DPBO:0000008),Factor [watering exposure],Term Source REF (PECO:0007383),Term Accession Number (PECO:0007383),Factor [Timepoint],Term Source REF (NCIT:C68568),Term Accession Number (NCIT:C68568),Factor [timepoint-ZT],Term Source REF (),Term Accession Number (),Factor [Photosynthesis mode],Term Source REF () ,Term Accession Number () ,Parameter [biosource amount],Unit    ,Term Source REF (DPBO:0000013),Term Accession Number (DPBO:0000013),Parameter [extraction method],Term Source REF (DPBO:0000054),Term Accession Number (DPBO:0000054),Parameter [extraction buffer],Term Source REF (DPBO:0000050),Term Accession Number (DPBO:0000050),Parameter [extraction buffer volume],Unit     ,Term Source REF (DPBO:0000051),Term Accession Number (DPBO:0000051),Parameter [RNA quality check],Term Source REF (DPBO:0000062),Term Accession Number (DPBO:0000062),Parameter [library strategy],Term Source REF (DPBO:0000035),Term Accession Number (DPBO:0000035),Parameter [library selection],Term Source REF (DPBO:0000036),Term Accession Number (DPBO:0000036),Parameter [library layout],Term Source REF (DPBO:0000015),Term Accession Number (DPBO:0000015),Parameter [library preparation kit],Term Source REF (GENEPIO:0000085),Term Accession Number (GENEPIO:0000085),Parameter [library preparation kit version],Term Source REF (GENEPIO:0000149),Term Accession Number (GENEPIO:0000149),Parameter [adapter sequence],Term Source REF (GENEPIO:0000083),Term Accession Number (GENEPIO:0000083),Parameter [next generation sequencing instrument model],Term Source REF (DPBO:0000040),Term Accession Number (DPBO:0000040),Parameter [base-calling software],Term Source REF (DPBO:0000017),Term Accession Number (DPBO:0000017),Parameter [base-calling software version],Term Source REF (DPBO:0000018),Term Accession Number (DPBO:0000018),Parameter [Raw data file format],Term Source REF (DPBO:0000021),Term Accession Number (DPBO:0000021),Output [Data]
-CAM_01,Talinum fruticosum,NCBITaxon,http://purl.obolibrary.org/obo/NCBITaxon_110664,leaf,PO,https://www.ebi.ac.uk/ols4/ontologies/po/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FPO_0025034,28 days after germination,user-specific,,12 hr light / 12 hr dark,user-specific,,425,microeinstein per square meter per second,UO,https://bioregistry.io/UO:0000160,37,percent,UO,https://bioregistry.io/UO:0000187,30,degree celsius,UO,https://bioregistry.io/UO:0000027,22,degree celsius,UO,https://bioregistry.io/UO:0000027,12 days drought,user-specific,,MD,user-specific,,6,user-specific,,CAM,user-specific,,80,milligram,UO,https://bioregistry.io/UO:0000022,Roboklon EURx GeneMATRIX Universal RNA Purification version 2.3 September 2011,user-specific,,Roboklon commercial buffers,user-specific,,300,microliter,UO,https://bioregistry.io/UO:0000101,RIN 7.6 (Agilent Bioanalyzer 2100 expert_Plant RNA Nano),user-specific,,RNA-seq,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000003,cDNA method,user-specific,,single-end,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_0000086,Illumina TruSeq RNA Sample Prep Kit,,,version 2,,,CAGATC,,,Illumina HiSeq 2000,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000041,Illumina Cassava,user-specific,,v1.8.2,,,*.fastq.gz,,,DB_097_CAMMD_CAGATC_L001_R1_001.fastq.gz
-CAM_02,Talinum fruticosum,NCBITaxon,http://purl.obolibrary.org/obo/NCBITaxon_110664,leaf,PO,https://www.ebi.ac.uk/ols4/ontologies/po/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FPO_0025034,28 days after germination,user-specific,,12 hr light / 12 hr dark,user-specific,,425,microeinstein per square meter per second,UO,https://bioregistry.io/UO:0000160,37,percent,UO,https://bioregistry.io/UO:0000187,30,degree celsius,UO,https://bioregistry.io/UO:0000027,22,degree celsius,UO,https://bioregistry.io/UO:0000027,12 days drought,user-specific,,MD,user-specific,,6,user-specific,,CAM,user-specific,,78,milligram,UO,https://bioregistry.io/UO:0000022,Roboklon EURx GeneMATRIX Universal RNA Purification version 2.3 September 2011,user-specific,,Roboklon commercial buffers,user-specific,,300,microliter,UO,https://bioregistry.io/UO:0000101,RIN 7.7 (Agilent Bioanalyzer 2100 expert_Plant RNA Nano),user-specific,,RNA-seq,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000003,cDNA method,user-specific,,single-end,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_0000086,Illumina TruSeq RNA Sample Prep Kit,,,version 2,,,CTTGTA,,,Illumina HiSeq 2000,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000041,Illumina Cassava,user-specific,,v1.8.2,,,*.fastq.gz,,,DB_099_CAMMD_CTTGTA_L001_R1_001.fastq.gz
-CAM_03,Talinum fruticosum,NCBITaxon,http://purl.obolibrary.org/obo/NCBITaxon_110664,leaf,PO,https://www.ebi.ac.uk/ols4/ontologies/po/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FPO_0025034,28 days after germination,user-specific,,12 hr light / 12 hr dark,user-specific,,425,microeinstein per square meter per second,UO,https://bioregistry.io/UO:0000160,37,percent,UO,https://bioregistry.io/UO:0000187,30,degree celsius,UO,https://bioregistry.io/UO:0000027,22,degree celsius,UO,https://bioregistry.io/UO:0000027,12 days drought,user-specific,,MD,user-specific,,6,user-specific,,CAM,user-specific,,93,milligram,UO,https://bioregistry.io/UO:0000022,Roboklon EURx GeneMATRIX Universal RNA Purification version 2.3 September 2011,user-specific,,Roboklon commercial buffers,user-specific,,300,microliter,UO,https://bioregistry.io/UO:0000101,RIN 6.5 (Agilent Bioanalyzer 2100 expert_Plant RNA Nano),user-specific,,RNA-seq,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000003,cDNA method,user-specific,,single-end,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_0000086,Illumina TruSeq RNA Sample Prep Kit,,,version 2,,,AGTCAA,,,Illumina HiSeq 2000,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000041,Illumina Cassava,user-specific,,v1.8.2,,,*.fastq.gz,,,DB_103_CAMMD_AGTCAA_L001_R1_001.fastq.gz
-reC3_01,Talinum fruticosum,NCBITaxon,http://purl.obolibrary.org/obo/NCBITaxon_110664,leaf,PO,https://www.ebi.ac.uk/ols4/ontologies/po/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FPO_0025034,28 days after germination,user-specific,,12 hr light / 12 hr dark,user-specific,,425,microeinstein per square meter per second,UO,https://bioregistry.io/UO:0000160,37,percent,UO,https://bioregistry.io/UO:0000187,30,degree celsius,UO,https://bioregistry.io/UO:0000027,22,degree celsius,UO,https://bioregistry.io/UO:0000027,12 days drought + 2 days rewatered,user-specific,,MD,user-specific,,6,user-specific,,reC3,user-specific,,82,milligram,UO,https://bioregistry.io/UO:0000022,Roboklon EURx GeneMATRIX Universal RNA Purification version 2.3 September 2011,user-specific,,Roboklon commercial buffers,user-specific,,300,microliter,UO,https://bioregistry.io/UO:0000101,RIN 7.8 (Agilent Bioanalyzer 2100 expert_Plant RNA Nano),user-specific,,RNA-seq,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000003,cDNA method,user-specific,,single-end,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_0000086,Illumina TruSeq RNA Sample Prep Kit,,,version 2,,,GTCCGC,,,Illumina HiSeq 2000,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000041,Illumina Cassava,user-specific,,v1.8.2,,,*.fastq.gz,,,DB_161_reC3MD_GTCCGC_L001_R1_001.fastq.gz
-reC3_02,Talinum fruticosum,NCBITaxon,http://purl.obolibrary.org/obo/NCBITaxon_110664,leaf,PO,https://www.ebi.ac.uk/ols4/ontologies/po/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FPO_0025034,28 days after germination,user-specific,,12 hr light / 12 hr dark,user-specific,,425,microeinstein per square meter per second,UO,https://bioregistry.io/UO:0000160,37,percent,UO,https://bioregistry.io/UO:0000187,30,degree celsius,UO,https://bioregistry.io/UO:0000027,22,degree celsius,UO,https://bioregistry.io/UO:0000027,12 days drought + 2 days rewatered,user-specific,,MD,user-specific,,6,user-specific,,reC3,user-specific,,96,milligram,UO,https://bioregistry.io/UO:0000022,Roboklon EURx GeneMATRIX Universal RNA Purification version 2.3 September 2011,user-specific,,Roboklon commercial buffers,user-specific,,300,microliter,UO,https://bioregistry.io/UO:0000101,RIN 7.6 (Agilent Bioanalyzer 2100 expert_Plant RNA Nano),user-specific,,RNA-seq,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000003,cDNA method,user-specific,,single-end,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_0000086,Illumina TruSeq RNA Sample Prep Kit,,,version 2,,,GTGAAA,,,Illumina HiSeq 2000,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000041,Illumina Cassava,user-specific,,v1.8.2,,,*.fastq.gz,,,DB_163_reC3MD_GTGAAA_L001_R1_001.fastq.gz
-reC3_03,Talinum fruticosum,NCBITaxon,http://purl.obolibrary.org/obo/NCBITaxon_110664,leaf,PO,https://www.ebi.ac.uk/ols4/ontologies/po/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FPO_0025034,28 days after germination,user-specific,,12 hr light / 12 hr dark,user-specific,,425,microeinstein per square meter per second,UO,https://bioregistry.io/UO:0000160,37,percent,UO,https://bioregistry.io/UO:0000187,30,degree celsius,UO,https://bioregistry.io/UO:0000027,22,degree celsius,UO,https://bioregistry.io/UO:0000027,12 days drought + 2 days rewatered,user-specific,,MD,user-specific,,6,user-specific,,reC3,user-specific,,78,milligram,UO,https://bioregistry.io/UO:0000022,Roboklon EURx GeneMATRIX Universal RNA Purification version 2.3 September 2011,user-specific,,Roboklon commercial buffers,user-specific,,300,microliter,UO,https://bioregistry.io/UO:0000101,RIN 7.6 (Agilent Bioanalyzer 2100 expert_Plant RNA Nano),user-specific,,RNA-seq,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000003,cDNA method,user-specific,,single-end,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_0000086,Illumina TruSeq RNA Sample Prep Kit,,,version 2,,,GTGAAA,,,Illumina HiSeq 2000,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000041,Illumina Cassava,user-specific,,v1.8.2,,,*.fastq.gz,,,DB_165_re-C3MD_GTGAAA_L002_R1_001.fastq.gz
\ No newline at end of file
+Input [Source Name],Characteristic [organism],Term Source REF (OBI:0100026),Term Accession Number (OBI:0100026),Characteristic [organism part],Term Source REF (EFO:0000635),Term Accession Number (EFO:0000635),Characteristic [plant age],Term Source REF (DPBO:0000033),Term Accession Number (DPBO:0000033),Parameter [growth day length],Term Source REF (DPBO:0000041),Term Accession Number (DPBO:0000041),Parameter [light intensity exposure],Unit,Term Source REF (PECO:0007224),Term Accession Number (PECO:0007224),Parameter [humidity day],Unit ,Term Source REF (DPBO:0000005),Term Accession Number (DPBO:0000005),Parameter [temperature day],Unit  ,Term Source REF (DPBO:0000007),Term Accession Number (DPBO:0000007),Parameter [temperature night],Unit   ,Term Source REF (DPBO:0000008),Term Accession Number (DPBO:0000008),Factor [watering exposure],Term Source REF (PECO:0007383),Term Accession Number (PECO:0007383),Factor [Timepoint],Term Source REF (NCIT:C68568),Term Accession Number (NCIT:C68568),Factor [timepoint-ZT],Term Source REF (),Term Accession Number (),Factor [Photosynthesis mode],Term Source REF () ,Term Accession Number () ,Parameter [biosource amount],Unit    ,Term Source REF (DPBO:0000013),Term Accession Number (DPBO:0000013),Parameter [extraction method],Term Source REF (DPBO:0000054),Term Accession Number (DPBO:0000054),Parameter [extraction buffer],Term Source REF (DPBO:0000050),Term Accession Number (DPBO:0000050),Parameter [extraction buffer volume],Unit     ,Term Source REF (DPBO:0000051),Term Accession Number (DPBO:0000051),Parameter [RNA quality check],Term Source REF (DPBO:0000062),Term Accession Number (DPBO:0000062),Parameter [library strategy],Term Source REF (DPBO:0000035),Term Accession Number (DPBO:0000035),Parameter [library selection],Term Source REF (DPBO:0000036),Term Accession Number (DPBO:0000036),Parameter [library layout],Term Source REF (DPBO:0000015),Term Accession Number (DPBO:0000015),Parameter [library preparation kit],Term Source REF (GENEPIO:0000085),Term Accession Number (GENEPIO:0000085),Parameter [library preparation kit version],Term Source REF (GENEPIO:0000149),Term Accession Number (GENEPIO:0000149),Parameter [adapter sequence],Term Source REF (GENEPIO:0000083),Term Accession Number (GENEPIO:0000083),Parameter [next generation sequencing instrument model],Term Source REF (DPBO:0000040),Term Accession Number (DPBO:0000040),Parameter [base-calling software],Term Source REF (DPBO:0000017),Term Accession Number (DPBO:0000017),Parameter [base-calling software version],Term Source REF (DPBO:0000018),Term Accession Number (DPBO:0000018),Parameter [Raw data file format],Term Source REF (DPBO:0000021),Term Accession Number (DPBO:0000021),Output [Data],Data Format,Data Selector Format
+DB_097,Talinum fruticosum,NCBITaxon,http://purl.obolibrary.org/obo/NCBITaxon_110664,leaf,PO,https://www.ebi.ac.uk/ols4/ontologies/po/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FPO_0025034,28 days after germination,user-specific,,12 hr light / 12 hr dark,user-specific,,425,microeinstein per square meter per second,UO,https://bioregistry.io/UO:0000160,37,percent,UO,https://bioregistry.io/UO:0000187,30,degree celsius,UO,https://bioregistry.io/UO:0000027,22,degree celsius,UO,https://bioregistry.io/UO:0000027,12 days drought,user-specific,,MD,user-specific,,6,user-specific,,CAM,user-specific,,80,milligram,UO,https://bioregistry.io/UO:0000022,Roboklon EURx GeneMATRIX Universal RNA Purification version 2.3 September 2011,user-specific,,Roboklon commercial buffers,user-specific,,300,microliter,UO,https://bioregistry.io/UO:0000101,RIN 7.6 (Agilent Bioanalyzer 2100 expert_Plant RNA Nano),user-specific,,RNA-seq,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000003,cDNA method,user-specific,,single-end,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_0000086,Illumina TruSeq RNA Sample Prep Kit,,,version 2,,,CAGATC,,,Illumina HiSeq 2000,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000041,Illumina Cassava,user-specific,,v1.8.2,,,*.fastq.gz,,,DB_097_CAMMD_CAGATC_L001_R1_001.fastq.gz,,
+DB_099,Talinum fruticosum,NCBITaxon,http://purl.obolibrary.org/obo/NCBITaxon_110664,leaf,PO,https://www.ebi.ac.uk/ols4/ontologies/po/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FPO_0025034,28 days after germination,user-specific,,12 hr light / 12 hr dark,user-specific,,425,microeinstein per square meter per second,UO,https://bioregistry.io/UO:0000160,37,percent,UO,https://bioregistry.io/UO:0000187,30,degree celsius,UO,https://bioregistry.io/UO:0000027,22,degree celsius,UO,https://bioregistry.io/UO:0000027,12 days drought,user-specific,,MD,user-specific,,6,user-specific,,CAM,user-specific,,78,milligram,UO,https://bioregistry.io/UO:0000022,Roboklon EURx GeneMATRIX Universal RNA Purification version 2.3 September 2011,user-specific,,Roboklon commercial buffers,user-specific,,300,microliter,UO,https://bioregistry.io/UO:0000101,RIN 7.7 (Agilent Bioanalyzer 2100 expert_Plant RNA Nano),user-specific,,RNA-seq,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000003,cDNA method,user-specific,,single-end,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_0000086,Illumina TruSeq RNA Sample Prep Kit,,,version 2,,,CTTGTA,,,Illumina HiSeq 2000,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000041,Illumina Cassava,user-specific,,v1.8.2,,,*.fastq.gz,,,DB_099_CAMMD_CTTGTA_L001_R1_001.fastq.gz,,
+DB_103,Talinum fruticosum,NCBITaxon,http://purl.obolibrary.org/obo/NCBITaxon_110664,leaf,PO,https://www.ebi.ac.uk/ols4/ontologies/po/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FPO_0025034,28 days after germination,user-specific,,12 hr light / 12 hr dark,user-specific,,425,microeinstein per square meter per second,UO,https://bioregistry.io/UO:0000160,37,percent,UO,https://bioregistry.io/UO:0000187,30,degree celsius,UO,https://bioregistry.io/UO:0000027,22,degree celsius,UO,https://bioregistry.io/UO:0000027,12 days drought,user-specific,,MD,user-specific,,6,user-specific,,CAM,user-specific,,93,milligram,UO,https://bioregistry.io/UO:0000022,Roboklon EURx GeneMATRIX Universal RNA Purification version 2.3 September 2011,user-specific,,Roboklon commercial buffers,user-specific,,300,microliter,UO,https://bioregistry.io/UO:0000101,RIN 6.5 (Agilent Bioanalyzer 2100 expert_Plant RNA Nano),user-specific,,RNA-seq,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000003,cDNA method,user-specific,,single-end,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_0000086,Illumina TruSeq RNA Sample Prep Kit,,,version 2,,,AGTCAA,,,Illumina HiSeq 2000,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000041,Illumina Cassava,user-specific,,v1.8.2,,,*.fastq.gz,,,DB_103_CAMMD_AGTCAA_L001_R1_001.fastq.gz,,
+DB_161,Talinum fruticosum,NCBITaxon,http://purl.obolibrary.org/obo/NCBITaxon_110664,leaf,PO,https://www.ebi.ac.uk/ols4/ontologies/po/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FPO_0025034,28 days after germination,user-specific,,12 hr light / 12 hr dark,user-specific,,425,microeinstein per square meter per second,UO,https://bioregistry.io/UO:0000160,37,percent,UO,https://bioregistry.io/UO:0000187,30,degree celsius,UO,https://bioregistry.io/UO:0000027,22,degree celsius,UO,https://bioregistry.io/UO:0000027,12 days drought + 2 days rewatered,user-specific,,MD,user-specific,,6,user-specific,,reC3,user-specific,,82,milligram,UO,https://bioregistry.io/UO:0000022,Roboklon EURx GeneMATRIX Universal RNA Purification version 2.3 September 2011,user-specific,,Roboklon commercial buffers,user-specific,,300,microliter,UO,https://bioregistry.io/UO:0000101,RIN 7.8 (Agilent Bioanalyzer 2100 expert_Plant RNA Nano),user-specific,,RNA-seq,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000003,cDNA method,user-specific,,single-end,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_0000086,Illumina TruSeq RNA Sample Prep Kit,,,version 2,,,GTCCGC,,,Illumina HiSeq 2000,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000041,Illumina Cassava,user-specific,,v1.8.2,,,*.fastq.gz,,,DB_161_reC3MD_GTCCGC_L001_R1_001.fastq.gz,,
+DB_163,Talinum fruticosum,NCBITaxon,http://purl.obolibrary.org/obo/NCBITaxon_110664,leaf,PO,https://www.ebi.ac.uk/ols4/ontologies/po/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FPO_0025034,28 days after germination,user-specific,,12 hr light / 12 hr dark,user-specific,,425,microeinstein per square meter per second,UO,https://bioregistry.io/UO:0000160,37,percent,UO,https://bioregistry.io/UO:0000187,30,degree celsius,UO,https://bioregistry.io/UO:0000027,22,degree celsius,UO,https://bioregistry.io/UO:0000027,12 days drought + 2 days rewatered,user-specific,,MD,user-specific,,6,user-specific,,reC3,user-specific,,96,milligram,UO,https://bioregistry.io/UO:0000022,Roboklon EURx GeneMATRIX Universal RNA Purification version 2.3 September 2011,user-specific,,Roboklon commercial buffers,user-specific,,300,microliter,UO,https://bioregistry.io/UO:0000101,RIN 7.6 (Agilent Bioanalyzer 2100 expert_Plant RNA Nano),user-specific,,RNA-seq,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000003,cDNA method,user-specific,,single-end,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_0000086,Illumina TruSeq RNA Sample Prep Kit,,,version 2,,,GTGAAA,,,Illumina HiSeq 2000,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000041,Illumina Cassava,user-specific,,v1.8.2,,,*.fastq.gz,,,DB_163_reC3MD_GTGAAA_L001_R1_001.fastq.gz,,
+DB_165,Talinum fruticosum,NCBITaxon,http://purl.obolibrary.org/obo/NCBITaxon_110664,leaf,PO,https://www.ebi.ac.uk/ols4/ontologies/po/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FPO_0025034,28 days after germination,user-specific,,12 hr light / 12 hr dark,user-specific,,425,microeinstein per square meter per second,UO,https://bioregistry.io/UO:0000160,37,percent,UO,https://bioregistry.io/UO:0000187,30,degree celsius,UO,https://bioregistry.io/UO:0000027,22,degree celsius,UO,https://bioregistry.io/UO:0000027,12 days drought + 2 days rewatered,user-specific,,MD,user-specific,,6,user-specific,,reC3,user-specific,,78,milligram,UO,https://bioregistry.io/UO:0000022,Roboklon EURx GeneMATRIX Universal RNA Purification version 2.3 September 2011,user-specific,,Roboklon commercial buffers,user-specific,,300,microliter,UO,https://bioregistry.io/UO:0000101,RIN 7.6 (Agilent Bioanalyzer 2100 expert_Plant RNA Nano),user-specific,,RNA-seq,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000003,cDNA method,user-specific,,single-end,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_0000086,Illumina TruSeq RNA Sample Prep Kit,,,version 2,,,GTGAAA,,,Illumina HiSeq 2000,DPBO,http://purl.org/nfdi4plants/ontology/dpbo/DPBO_1000041,Illumina Cassava,user-specific,,v1.8.2,,,*.fastq.gz,,,DB_165_re-C3MD_GTGAAA_L002_R1_001.fastq.gz,,
\ No newline at end of file
diff --git a/runs/isaSampleToRawDataSeq/rnaseq-samples.xlsx b/runs/isaSampleToRawDataSeq/rnaseq-samples.xlsx
new file mode 100644
index 0000000000000000000000000000000000000000..1c05d363efc105474dc4887ac57f94beba0ac181
Binary files /dev/null and b/runs/isaSampleToRawDataSeq/rnaseq-samples.xlsx differ
diff --git a/runs/isaSampleToRawDataSeq/run.cwl b/runs/isaSampleToRawDataSeq/run.cwl
new file mode 100644
index 0000000000000000000000000000000000000000..8f00f6abfd1d3f757b20fdf253fbbcd0b0003aa5
--- /dev/null
+++ b/runs/isaSampleToRawDataSeq/run.cwl
@@ -0,0 +1,24 @@
+cwlVersion: v1.2
+class: Workflow
+
+inputs:
+  arcPath: Directory 
+  assayName: string
+  startingNodeNum: int
+  outName: string
+
+steps:
+  isaSampleToRawDataSeq:
+    run: ../../workflows/isaSampleToRawDataSeq/workflow.cwl
+    in:
+      arcPath: arcPath
+      assayName: assayName
+      startingNodeNum: startingNodeNum
+      outName: outName
+    out: [output]
+
+outputs:
+  output: 
+    type: File[]
+    outputSource: isaSampleToRawDataSeq/output
+
diff --git a/runs/isaSampleToRawDataSeq-run/job.yml b/runs/isaSampleToRawDataSeq/run.yml
similarity index 100%
rename from runs/isaSampleToRawDataSeq-run/job.yml
rename to runs/isaSampleToRawDataSeq/run.yml
diff --git a/runs/kallisto/README.md b/runs/kallisto/README.md
deleted file mode 100644
index e3c73f34783ecbe96fe58e4044df92be08372cf9..0000000000000000000000000000000000000000
--- a/runs/kallisto/README.md
+++ /dev/null
@@ -1,8 +0,0 @@
-# Kallisto Workflow
-
-## Executing the multi-step workflow
-
-```bash
-cd runs/kallisto/
-cwltool --cachedir cache2 ../../workflows/kallisto/kallisto-workflow.cwl workflow.yml > $(date +"%Y-%m-%d_%H-%M").log 2>&1 &
-```
diff --git a/runs/kallisto/run.cwl b/runs/kallisto/run.cwl
new file mode 100644
index 0000000000000000000000000000000000000000..7ab4d83630e9cacda2b7da8c7a9b3ac804c5f12e
--- /dev/null
+++ b/runs/kallisto/run.cwl
@@ -0,0 +1,40 @@
+#!/usr/bin/env cwl-runner
+cwlVersion: v1.2
+class: Workflow
+
+requirements:
+  SubworkflowFeatureRequirement: {}
+
+inputs:
+  IndexInput: File[]
+  InputReadsMultipleSamples:
+    type: 
+      type: array
+      items: 
+        type: array
+        items: File
+  numUnderscoresFileName: int
+  isSingle: boolean
+  FragmentLength: double?  
+  StandardDeviation: double?
+  BootstrapSamples: int?
+  resultsFolder: string
+
+steps:
+  kallisto:
+    run:  ../../workflows/kallisto/workflow.cwl
+    in:
+      IndexInput: IndexInput
+      InputReadsMultipleSamples: InputReadsMultipleSamples
+      numUnderscoresFileName: numUnderscoresFileName
+      isSingle: isSingle
+      FragmentLength: FragmentLength
+      StandardDeviation: StandardDeviation
+      BootstrapSamples: BootstrapSamples
+      resultsFolder: resultsFolder
+    out: [finalOut]
+
+outputs:
+  finalOut:
+    type: Directory[]
+    outputSource: kallisto/finalOut
diff --git a/runs/kallisto/workflow.yml b/runs/kallisto/run.yml
similarity index 56%
rename from runs/kallisto/workflow.yml
rename to runs/kallisto/run.yml
index 0f8f15d1452b75328f81888b196b8fd19ac97a11..1d147f9882253552f871d417b493cb2cf9ca5c17 100644
--- a/runs/kallisto/workflow.yml
+++ b/runs/kallisto/run.yml
@@ -17,22 +17,22 @@ InputReadsMultipleSamples:
     - class: File
       path: ../../assays/Talinum_RNASeq_minimal/dataset/DB_099_CAMMD_CTTGTA_L001_R1_001.fastq.gz
       format: edam:format_1930 # FASTQ
-  - 
-    - class: File
-      path: ../../assays/Talinum_RNASeq_minimal/dataset/DB_103_CAMMD_AGTCAA_L001_R1_001.fastq.gz
-      format: edam:format_1930 # FASTQ
-  - 
-    - class: File
-      path: ../../assays/Talinum_RNASeq_minimal/dataset/DB_161_reC3MD_GTCCGC_L001_R1_001.fastq.gz
-      format: edam:format_1930 # FASTQ
-  - 
-    - class: File
-      path: ../../assays/Talinum_RNASeq_minimal/dataset/DB_163_reC3MD_GTGAAA_L001_R1_001.fastq.gz
-      format: edam:format_1930 # FASTQ
-  - 
-    - class: File
-      path: ../../assays/Talinum_RNASeq_minimal/dataset/DB_165_re-C3MD_GTGAAA_L002_R1_001.fastq.gz
-      format: edam:format_1930 # FASTQ
+  # - 
+  #   - class: File
+  #     path: ../../assays/Talinum_RNASeq_minimal/dataset/DB_103_CAMMD_AGTCAA_L001_R1_001.fastq.gz
+  #     format: edam:format_1930 # FASTQ
+  # - 
+  #   - class: File
+  #     path: ../../assays/Talinum_RNASeq_minimal/dataset/DB_161_reC3MD_GTCCGC_L001_R1_001.fastq.gz
+  #     format: edam:format_1930 # FASTQ
+  # - 
+  #   - class: File
+  #     path: ../../assays/Talinum_RNASeq_minimal/dataset/DB_163_reC3MD_GTGAAA_L001_R1_001.fastq.gz
+  #     format: edam:format_1930 # FASTQ
+  # - 
+  #   - class: File
+  #     path: ../../assays/Talinum_RNASeq_minimal/dataset/DB_165_re-C3MD_GTGAAA_L002_R1_001.fastq.gz
+  #     format: edam:format_1930 # FASTQ
 
 numUnderscoresFileName: 2
 
@@ -42,7 +42,7 @@ FragmentLength: 200
 StandardDeviation: 20
 BootstrapSamples: 30
 
-resultsFolder: kallisto_results
+resultsFolder: test
 
 $namespaces:
   edam: https://edamontology.org/
\ No newline at end of file
diff --git a/runs/kallisto_collect/README.md b/runs/kallisto_collect/README.md
deleted file mode 100644
index a680462d2b59efc28e5f8ca5373093ba2b984b2c..0000000000000000000000000000000000000000
--- a/runs/kallisto_collect/README.md
+++ /dev/null
@@ -1,6 +0,0 @@
-
-
-```bash
-cd runs/kallisto_collect/
-cwltool ../../workflows/kallisto_collect/kallisto_collect.cwl run.yml > $(date +"%Y-%m-%d_%H-%M").log 2>&1 &
-```
diff --git a/runs/kallisto_collect/out/isa.dataset.xlsx b/runs/kallisto_collect/out/isa.dataset.xlsx
deleted file mode 100644
index f590d99f95e7568392f316133577e385bd72228b..0000000000000000000000000000000000000000
Binary files a/runs/kallisto_collect/out/isa.dataset.xlsx and /dev/null differ
diff --git a/runs/kallisto_collect/out/kallisto_mappingStats.csv b/runs/kallisto_collect/out/kallisto_mappingStats.csv
deleted file mode 100644
index 21b8d2b5c3158bf2102012cb0216197f58087c98..0000000000000000000000000000000000000000
--- a/runs/kallisto_collect/out/kallisto_mappingStats.csv
+++ /dev/null
@@ -1,7 +0,0 @@
-"ID","n_targets","n_bootstraps","n_processed","n_pseudoaligned","n_unique","p_pseudoaligned","p_unique","kallisto_version","index_version","start_time","call"
-"DB_097",31434,100,11071656,7663654,7522185,69.2,67.9,"0.44.0",10,"Fri Aug  6 15:48:13 2021","kallisto quant --single -b 100 -t 30 -l 200 -s 20 -i /Users/dominikbrilhaus/sciebo/CEPLAS_DM/CEPLAS_ARCs/ARC0005//runs/01_kallisto_index -o /Users/dominikbrilhaus/sciebo/CEPLAS_DM/CEPLAS_ARCs/ARC0005//runs/01_kallisto_results/DB_097 /Users/dominikbrilhaus/sciebo/CEPLAS_DM/CEPLAS_ARCs/ARC0005/assays/Talinum_RNASeq_minimal/dataset/DB_097_CAMMD_CAGATC_L001_R1_001.fastq.gz"
-"DB_099",31434,100,14332278,10066506,9848811,70.2,68.7,"0.44.0",10,"Fri Aug  6 15:49:19 2021","kallisto quant --single -b 100 -t 30 -l 200 -s 20 -i /Users/dominikbrilhaus/sciebo/CEPLAS_DM/CEPLAS_ARCs/ARC0005//runs/01_kallisto_index -o /Users/dominikbrilhaus/sciebo/CEPLAS_DM/CEPLAS_ARCs/ARC0005//runs/01_kallisto_results/DB_099 /Users/dominikbrilhaus/sciebo/CEPLAS_DM/CEPLAS_ARCs/ARC0005/assays/Talinum_RNASeq_minimal/dataset/DB_099_CAMMD_CTTGTA_L001_R1_001.fastq.gz"
-"DB_103",31434,100,13083957,9007720,8828236,68.8,67.5,"0.44.0",10,"Fri Aug  6 15:50:41 2021","kallisto quant --single -b 100 -t 30 -l 200 -s 20 -i /Users/dominikbrilhaus/sciebo/CEPLAS_DM/CEPLAS_ARCs/ARC0005//runs/01_kallisto_index -o /Users/dominikbrilhaus/sciebo/CEPLAS_DM/CEPLAS_ARCs/ARC0005//runs/01_kallisto_results/DB_103 /Users/dominikbrilhaus/sciebo/CEPLAS_DM/CEPLAS_ARCs/ARC0005/assays/Talinum_RNASeq_minimal/dataset/DB_103_CAMMD_AGTCAA_L001_R1_001.fastq.gz"
-"DB_161",31434,100,12785081,9058396,8740183,70.9,68.4,"0.44.0",10,"Fri Aug  6 15:51:58 2021","kallisto quant --single -b 100 -t 30 -l 200 -s 20 -i /Users/dominikbrilhaus/sciebo/CEPLAS_DM/CEPLAS_ARCs/ARC0005//runs/01_kallisto_index -o /Users/dominikbrilhaus/sciebo/CEPLAS_DM/CEPLAS_ARCs/ARC0005//runs/01_kallisto_results/DB_161 /Users/dominikbrilhaus/sciebo/CEPLAS_DM/CEPLAS_ARCs/ARC0005/assays/Talinum_RNASeq_minimal/dataset/DB_161_reC3MD_GTCCGC_L001_R1_001.fastq.gz"
-"DB_163",31434,100,14312514,10054493,9707941,70.2,67.8,"0.44.0",10,"Fri Aug  6 15:53:12 2021","kallisto quant --single -b 100 -t 30 -l 200 -s 20 -i /Users/dominikbrilhaus/sciebo/CEPLAS_DM/CEPLAS_ARCs/ARC0005//runs/01_kallisto_index -o /Users/dominikbrilhaus/sciebo/CEPLAS_DM/CEPLAS_ARCs/ARC0005//runs/01_kallisto_results/DB_163 /Users/dominikbrilhaus/sciebo/CEPLAS_DM/CEPLAS_ARCs/ARC0005/assays/Talinum_RNASeq_minimal/dataset/DB_163_reC3MD_GTGAAA_L001_R1_001.fastq.gz"
-"DB_165",31434,100,13679479,9552504,9264346,69.8,67.7,"0.44.0",10,"Fri Aug  6 15:54:35 2021","kallisto quant --single -b 100 -t 30 -l 200 -s 20 -i /Users/dominikbrilhaus/sciebo/CEPLAS_DM/CEPLAS_ARCs/ARC0005//runs/01_kallisto_index -o /Users/dominikbrilhaus/sciebo/CEPLAS_DM/CEPLAS_ARCs/ARC0005//runs/01_kallisto_results/DB_165 /Users/dominikbrilhaus/sciebo/CEPLAS_DM/CEPLAS_ARCs/ARC0005/assays/Talinum_RNASeq_minimal/dataset/DB_165_re-C3MD_GTGAAA_L002_R1_001.fastq.gz"
diff --git a/runs/kallisto_collect/out/kallisto_sleuthObject.RData b/runs/kallisto_collect/out/kallisto_sleuthObject.RData
deleted file mode 100644
index 01ae821be97add02315b15830f0c4bb54587c8ca..0000000000000000000000000000000000000000
--- a/runs/kallisto_collect/out/kallisto_sleuthObject.RData
+++ /dev/null
@@ -1,3 +0,0 @@
-version https://git-lfs.github.com/spec/v1
-oid sha256:b06f8ec26e9941ac83ba9e3324d172fba6c2c5b09f51b1d99e66549c7f7f00fa
-size 9478478
diff --git a/runs/kallisto_collect/out/kallisto_tpmMatrix.csv b/runs/kallisto_collect/out/kallisto_tpmMatrix.csv
deleted file mode 100644
index b36c4780c19ab8ac4aedb712754668b9c6451371..0000000000000000000000000000000000000000
--- a/runs/kallisto_collect/out/kallisto_tpmMatrix.csv
+++ /dev/null
@@ -1,31435 +0,0 @@
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-"Tfru31364_t",45.5537602925727,44.5140622508975,54.8633523839479,41.9982624391199,47.8568523509566,57.4800952403847
-"Tfru31365_t",0,0,0,0,0,0
-"Tfru31366_t",18.9481082936108,16.0979122468321,15.4738429489392,16.7807701460697,14.6312195612634,15.9815386167926
-"Tfru31367_t",0,0,0,0,0,0
-"Tfru31368_t",0,0,0,0,0,0
-"Tfru31369_t",0,0,0,0,0,0
-"Tfru31370_t",18.5743023693464,18.8075191477391,16.2887920332356,2.73211375116209,4.64601642196156,8.10391255317353
-"Tfru31371_t",0,0,0,0,0,0
-"Tfru31372_t",0,0,0,0,0,0
-"Tfru31373_t",0,0,0,0,0,0
-"Tfru31374_t",0,0,0,0,0,0
-"Tfru31375_t",1.80279778479501,3.47297021546702,1.24198654021346,2.2377384676554,0.93622975517149,0.791395620082117
-"Tfru31376_t",2.12615489557849,2.49429577285407,2.8168351447411,2.98873375914736,2.64242393369621,2.55273447689044
-"Tfru31377_t",0,0,0,0,0,0
-"Tfru31378_t",1.16329841405376,1.50213105697076,1.65510969702739,1.30792961811085,1.00687442463657,1.44318924336468
-"Tfru31379_t",669.925389329916,831.386666216333,535.086964858195,39.4994744669476,55.1949360459478,71.9138694258883
-"Tfru31380_t",2.99259761815389,2.00902929454747,2.48336978385622,1.68844903809491,2.40181739652479,2.94586426629012
-"Tfru31381_t",17.5297242869556,18.3185505754801,18.228841818566,13.8690765284612,14.9743834453231,15.878163546911
-"Tfru31382_t",0,0.0890799273672187,0.0955689774999127,0.172190575615491,0.288165829530987,0.162391175234816
-"Tfru31383_t",6.63029597974339,5.87772230734414,5.93899855326953,7.79472989005437,7.67471003423146,7.77323577519008
-"Tfru31384_t",112.922269482637,222.41643368437,110.457316692168,128.080806487324,142.145822602525,112.136889824287
-"Tfru31385_t",0.847273000798151,0.470831299575532,0.561254584696927,1.14606698608521,0.733343658757291,0.762948764330522
-"Tfru31386_t",1.46982134317112,1.96632861970624,1.63801621058341,1.93771006818988,1.57151704701684,1.41274751573492
-"Tfru31387_t",10.7156092820724,11.3536003344923,10.8887684746903,13.5225241670009,9.645714042226,6.11514625823656
-"Tfru31388_t",2.44550754300446,2.74237284957771,3.12796117838648,4.57558124604281,3.57966271258848,3.9994388243191
-"Tfru31389_t",10.1447302049769,10.5359471714053,8.53298973116019,7.34325180159081,6.51584359349757,8.94436663289132
-"Tfru31390_t",0.332275715641849,0.222259410075757,0.143069972249375,0.286416756187491,0.143797978216847,0.607762621882443
-"Tfru31391_t",0,0,0,0,0,0
-"Tfru31392_t",0,0,0,0,0,0
-"Tfru31393_t",6.47419417321246,6.9289473044975,6.7699660813562,6.69679163439625,6.27073519809357,6.87957550350283
-"Tfru31394_t",4.86755401894653,6.94594043093403,4.26932873198376,11.002214132639,6.86568487125759,6.5949635006843
-"Tfru31395_t",0.728413671428735,1.46170892377857,1.15000415555169,1.50691636694713,3.36248991067371,2.22055851973908
-"Tfru31396_t",1.2188033935754,1.74698199525867,2.62393788482921,5.31298630653865,7.08300659681035,8.78982202698458
-"Tfru31397_t",0,0,0.196591619476723,1.88910530059314,1.18555180953781,0.835123095467089
-"Tfru31398_t",13.0699596955579,10.1271540807882,17.4358380209283,26.022765282811,20.2055556603962,12.0498048940201
-"Tfru31399_t",7.53939278718118,9.50985327162603,6.64714911666594,5.57043870687722,4.19502947990302,6.56677989598052
-"Tfru31400_t",11.1926050557571,8.24422161649655,10.0921139829179,4.76717795290746,6.49637794066487,7.80355775225172
-"Tfru31401_t",2.70355205343156,5.70653022193791,5.60485284610632,5.38586397976019,10.9200767391039,15.0182804104975
-"Tfru31402_t",36.1104150151614,42.9216327945531,38.3920517250493,122.751280927805,116.31984604909,87.7668262244749
-"Tfru31403_t",0.152468923360159,0,0.131298940049789,0.315422300643501,0.263934099159053,0
-"Tfru31404_t",0.286724835397432,0,0.493827412746989,0,0,0
-"Tfru31405_t",0,0,0,0,0,0.0274642805301062
-"Tfru31406_t",0.507104889968496,1.22112986952286,1.31008338774025,1.39877414611323,2.04827730474138,1.97875444109063
-"Tfru31407_t",14.3357156692562,2.84581764291862,21.5045981407785,212.224515842414,102.199641739142,53.4576850600056
-"Tfru31408_t",0,0,0,0,0,0
-"Tfru31409_t",18.7865724433788,18.6902313117942,19.2542141708604,9.44255153398841,11.909039069457,15.2936684292404
-"Tfru31410_t",12.8337459992563,13.1478391691407,11.6334819646125,6.72483515045318,7.89255797625976,13.2813948368555
-"Tfru31411_t",9.95867688172173,9.01846267704353,4.3979158642817,3.96195336598562,5.08333866055118,12.1435528532357
-"Tfru31412_t",0.655599519470326,0.265623826844945,0,0.68587261500485,0,0.709212228765897
-"Tfru31413_t",5.26828790504038,4.2287528342118,3.07854110499719,2.9193340591473,1.9542354576032,3.44149271144332
-"Tfru31414_t",4.4765742506988,4.91078810958502,4.62601380964053,4.78483864768352,4.26209034192634,5.78623120923271
-"Tfru31415_t",0,0.315109836527965,0,1.6242774547156,1.35913727697793,1.00526967005758
-"Tfru31416_t",3.08609547323685,1.10095518395077,4.72461818562834,1.41875663391485,0.593582402598523,2.25790015688735
-"Tfru31417_t",0,0,0,0,0,0
-"Tfru31418_t",0,0,0,0,0,0
-"Tfru31419_t",0.0182829982092377,0,0,0,0,0.0267530184227977
-"Tfru31420_t",2.42337625302252,1.78309748842988,2.60861956613343,1.46224016055527,0.873964474979796,0.886515285957371
-"Tfru31421_t",2.0834573439319,1.56445731639404,1.73629718321841,0.486633525432794,0.465368603637242,0.68840867005543
-"Tfru31422_t",5.77760288072329,5.12289722240187,7.60772622928233,4.69066130215251,7.41384658183581,5.92286262221392
-"Tfru31423_t",5.88399526025702,2.62387179054415,3.37801008408252,2.02876678195995,0.848799739124347,4.78327313823951
-"Tfru31424_t",3.33686075961357,2.99354344701567,4.39483321297496,3.2485549094312,3.90751967131154,4.16468863309569
-"Tfru31425_t",115.851568824009,122.737642964533,135.551395013929,40.193041256303,21.3314703888859,18.6895899257937
-"Tfru31426_t",5.90513426228543,5.43512786453671,6.23786866823235,14.6595987712383,15.810320414105,12.0971532929141
-"Tfru31427_t",0,0,0,0,0,0
-"Tfru31428_t",0,0,0,0,0,0
-"Tfru31429_t",0.115082707906092,0.0461873322034141,0.0991037205033341,0.0595197560460854,0,0.0420993560454642
-"Tfru31430_t",0.913156269254864,0,0,0.708414487722429,0.395183936512604,0
-"Tfru31431_t",382.216970919618,419.256022769115,412.739212689341,571.943963453987,445.607405679208,352.183127864385
-"Tfru31432_t",74.8409327628316,79.0232842657612,90.2251949593327,67.8012500484394,108.281613298853,135.168477188002
-"Tfru31433_t",22.3954100105926,24.1137401238341,21.4889051609584,21.5363464109528,16.3638531191259,20.0445353403519
-"Tfru31434_t",9.41495598052051,12.7891129702441,6.23669962787562,6.74215164978073,6.26843483041352,5.82858323651105
diff --git a/runs/kallisto_collect/run.cwl b/runs/kallisto_collect/run.cwl
new file mode 100644
index 0000000000000000000000000000000000000000..1d3f6bbe6142584c5754ea2248333fd7bacb75a1
--- /dev/null
+++ b/runs/kallisto_collect/run.cwl
@@ -0,0 +1,27 @@
+#!/usr/bin/env cwl-runner
+
+cwlVersion: v1.2
+class: Workflow
+
+inputs:
+  in_kallisto_results:  Directory
+  in_metadata_file: File
+  in_metadata_sample:  string
+  in_metadata_factor:  string
+  out_folder: string
+
+steps: 
+  collectResults:
+    run: ../../workflows/kallisto_collect/workflow.cwl
+    in:
+      in_kallisto_results: in_kallisto_results
+      in_metadata_file: in_metadata_file
+      in_metadata_sample: in_metadata_sample
+      in_metadata_factor: in_metadata_factor
+      out_folder: out_folder
+    out: [outdir]
+
+outputs:
+ outdir:
+    type: Directory[]
+    outputSource: collectResults/outdir
diff --git a/runs/kallisto_collect/run.yml b/runs/kallisto_collect/run.yml
index ba0dd1857cb36cc3dcaa5bafdd83b4ad55c0b3fb..d39e600f703d3012ffc8888b5aac722a33c960c3 100644
--- a/runs/kallisto_collect/run.yml
+++ b/runs/kallisto_collect/run.yml
@@ -6,4 +6,4 @@ in_metadata_file:
   path: ../merged_isa_metadata/out/merged_isa.tsv
 in_metadata_sample: "Sample.Name.2"
 in_metadata_factor: "Factor..Photosynthesis.mode."
-out_folder: out
+out_folder: results
diff --git a/workflows/.gitkeep b/workflows/.gitkeep
deleted file mode 100644
index e69de29bb2d1d6434b8b29ae775ad8c2e48c5391..0000000000000000000000000000000000000000
diff --git a/workflows/_aux-tools/collectFilesInDir.cwl b/workflows/_aux-tools/collectFilesInDir.cwl
deleted file mode 100644
index f8d411fe571e1a22a08e23a6dc472cd5ac1c25d1..0000000000000000000000000000000000000000
--- a/workflows/_aux-tools/collectFilesInDir.cwl
+++ /dev/null
@@ -1,19 +0,0 @@
-cwlVersion: v1.2
-class: ExpressionTool
-doc: |
-  Takes Files (e.g. from a workflow step) and yields them in a desired directory.
-requirements:
-  - class: InlineJavascriptRequirement
-inputs:
-  files: File[]
-  destination: string
-expression: |
-  ${
-    return {"outDir": {
-      "class": "Directory", 
-      "basename": inputs.destination,
-      "listing": inputs.files
-    } };
-  }
-outputs:
-  outDir: Directory
\ No newline at end of file
diff --git a/workflows/deseq2/README.md b/workflows/deseq2/README.md
index 39cf2dcfacc76eeaee434d0f5d1abc07809fbe5d..4a64681c020e2dd6d7da19503fc7c82f39896bce 100644
--- a/workflows/deseq2/README.md
+++ b/workflows/deseq2/README.md
@@ -35,11 +35,6 @@ RScript deseq2.R "../../runs/kallisto/kallisto_results" "../../runs/merged_isa_m
 ```
 
 
-## Run CWL-wrapped script
-
-see [runs/deseq2-run](../../runs/deseq2-run)
-
-
 ## Multi-package containers
 
 - R and combinations of library dependencies are available as multi-package containers from [BioContainers](https://github.com/BioContainers/multi-package-containers)
diff --git a/workflows/deseq2/deseq2.R b/workflows/deseq2/deseq2.R
index 88ec8ee0f98fcd29d3bffd4ee3772dfacbc2f4d5..dcad6b63d978ab9e6b6f144549f9095f59d8eaa8 100644
--- a/workflows/deseq2/deseq2.R
+++ b/workflows/deseq2/deseq2.R
@@ -6,14 +6,13 @@ library("DESeq2")
 library("tximport")
 library("rhdf5")
 library("ggplot2")
-library("readxl")
 
-## In-and-out
+# ## Tests 
 
-inKallistoResults <- "../../runs/kallisto/kallisto_results"
-inMetadataFile <- "../../runs/isaSampleToRawDataSeq-run/rnaseq-samples.xlsx"
-inMetadataSample <- "Input [Source Name]"
-inMetadataFactorList <- list("Factor [Photosynthesis mode]")
+# inKallistoResults <- "../../runs/kallisto/kallisto_results"
+# inMetadataFile <- "../../runs/isaSampleToRawDataSeq/rnaseq-samples.csv"
+# inMetadataSample <- "Input [Source Name]"
+# inMetadataFactorList <- list("Factor [Photosynthesis mode]")
 
 ### Read arguments from CLI
 
@@ -35,7 +34,7 @@ head(txi$counts)
 
 ## Read sample metadata
 
-samples_metadata <- as.data.frame(read_xlsx(path = inMetadataFile))
+samples_metadata <- as.data.frame(read.csv(inMetadataFile, check.names=FALSE))
 samples <- samples_metadata[order(samples_metadata[[inMetadataSample]]), c(inMetadataSample, unlist(inMetadataFactorList))]
 
 rownames(samples) <- samples[,inMetadataSample]
@@ -63,20 +62,27 @@ write.csv(res, file = "results_stats.csv", quote = TRUE)
 
 ### Generate and save default plots
 
-png("results_ma-plot.png")
-  plotMA(res, ylim=c(-2,2))
+#### MA Plot
+
+svg("results_ma-plot.svg")
+  p1 <- plotMA(res, ylim=c(-2,2))
 dev.off()
 
+#### PCA
+
 vsd <- vst(dds, blind=FALSE)
 pcaData <- plotPCA(vsd, intgroup=factors, returnData=TRUE)
 percentVar <- round(100 * attr(pcaData, "percentVar"))
 
-p2 <- ggplot(pcaData, aes(PC1, PC2, color=factors[[1]])) +
+p2 <- ggplot(pcaData, aes(PC1, PC2, color=.data[[factors[[1]]]])) +
   geom_point(size=3) +
   xlab(paste0("PC1: ",percentVar[1],"% variance")) +
-  ylab(paste0("PC2: ",percentVar[2],"% variance")) + 
+  ylab(paste0("PC2: ",percentVar[2],"% variance")) +
+  theme(aspect.ratio = 1) +
+  theme(panel.background = element_blank()) +  #background of the plotting area
+  theme(panel.grid.major = element_blank(), panel.grid.minor = element_blank()) +
   coord_fixed()
 
-png("results_pca-plot.png")
+svg("results_pca-plot.svg", width = 8, height = 8)
   print(p2)
 dev.off()
diff --git a/workflows/deseq2/deseq2.cwl b/workflows/deseq2/workflow.cwl
similarity index 71%
rename from workflows/deseq2/deseq2.cwl
rename to workflows/deseq2/workflow.cwl
index c3dd72790b6493ced407c5525754856d7ab4b441..993371903c5258fdc98b03740978714854530c22 100644
--- a/workflows/deseq2/deseq2.cwl
+++ b/workflows/deseq2/workflow.cwl
@@ -1,5 +1,14 @@
 #!/usr/bin/env cwl-runner
 
+doc: |
+  DESeq2 example workflow
+  This workflow runs DESeq2 on the output of the kallisto workflow
+  and the metadata file.
+  It runs an R script, deseq2.R, which ideally should be split into three sub scripts and accordingly three workflow steps
+    1. Read kallsito data
+    2. Prep / run deseq2
+    3. Plot results
+
 cwlVersion: v1.2
 class: CommandLineTool
 hints:
@@ -37,5 +46,5 @@ outputs:
     type: File[]
     outputBinding:
       glob:
-        - "*.png"
+        - "*.svg"
         - "*.csv"
diff --git a/workflows/isaSampleToRawDataSeq/README.md b/workflows/isaSampleToRawDataSeq/README.md
deleted file mode 100644
index 8ecbd0b4085a745e8261cee82c4a8116ed624667..0000000000000000000000000000000000000000
--- a/workflows/isaSampleToRawDataSeq/README.md
+++ /dev/null
@@ -1,7 +0,0 @@
-
-
-```bash
-
-dotnet fsi isaSampleToRawDataSeq.fsx ../../ Talinum_RNASeq_minimal 1 rnaseq-samples
-
-```
diff --git a/workflows/isaSampleToRawDataSeq/isaSampleToRawDataSeq.fsx b/workflows/isaSampleToRawDataSeq/isaSampleToRawDataSeq.fsx
index 5ac29ad4f621be4d6914973b674c266ef4037851..c73f8d1634a81d2888baf39f021ca985d2c0951e 100644
--- a/workflows/isaSampleToRawDataSeq/isaSampleToRawDataSeq.fsx
+++ b/workflows/isaSampleToRawDataSeq/isaSampleToRawDataSeq.fsx
@@ -2,17 +2,25 @@
 
 // Dependencies
 
-#r "nuget: ARCtrl.NET"
+#r "nuget: ARCtrl"
 #r "nuget: ARCtrl.QueryModel"
 #r "nuget: FsSpreadsheet.CsvIO"
 
-open ARCtrl.NET
 open ARCtrl
 open ARCtrl.QueryModel
 open ARCtrl.Helper
 open FsSpreadsheet.Net
 open FsSpreadsheet.CsvIO
 
+
+// test parameters
+// let source = __SOURCE_DIRECTORY__
+// let arcPath = System.IO.Path.Combine(source, "../../")
+// let assayName = "Talinum_RNASeq_minimal"
+// let startingNodeNum = 0
+// let outName = "rnaseq-samples"
+
+
 // input parameters
 
 let args : string array = fsi.CommandLineArgs |> Array.tail
@@ -31,13 +39,6 @@ type ArcTables with
         )
         |> ArcTables
 
-// // test parameters
-// let source = __SOURCE_DIRECTORY__
-// let arcPath = Path.Combine(source, "../../")
-// let assayName = "Talinum_RNASeq_minimal"
-// let startingNodeNum = 0
-// let outName = "rnaseq-samples"
-
 // Load ARC
 
 // Remove all tables with either an input or output column missing
@@ -97,8 +98,6 @@ let shittify (a : ARC) =
 let arc = ARC.load(arcPath) |> clean |> shittify
 
 
-
-
 let inv = arc.ISA.Value 
 
 // Load first data node
@@ -108,7 +107,11 @@ let firstData = inv.GetAssay(assayName).FirstData
 
 // Create headers for output table
 let headers = [
-    CompositeHeader.Input IOType.Sample
+    
+    CompositeHeader.Input IOType.Source
+    
+    // CompositeHeader.Input IOType.Sample
+
     for v in inv.ArcTables.IgnoreShitty().ValuesOf firstData.[0].Name do
         if v.IsCharacteristicValue then
             CompositeHeader.Characteristic v.Category
@@ -128,7 +131,7 @@ let headers = [
 
 let getRow (d: QNode) = 
     [|
-    CompositeCell.createFreeText (inv.ArcTables.SamplesOf d).[startingNodeNum].Name
+    CompositeCell.createFreeText (inv.ArcTables.SourcesOf d).[startingNodeNum].Name
 
     for v in inv.ArcTables.ValuesOf d do
         if v.HasUnit then
@@ -165,4 +168,4 @@ wb.AddWorksheet ws
 wb.ToXlsxFile ($"{outName}.xlsx")
 
 // Write to csv
-wb.ToCsvFile ($"{outName}.csv")
\ No newline at end of file
+wb.ToCsvFile ($"{outName}.csv")
diff --git a/workflows/isaSampleToRawDataSeq/isaSampleToRawDataSeq.cwl b/workflows/isaSampleToRawDataSeq/workflow.cwl
similarity index 88%
rename from workflows/isaSampleToRawDataSeq/isaSampleToRawDataSeq.cwl
rename to workflows/isaSampleToRawDataSeq/workflow.cwl
index e743f327893969785482e36b2ba868dde93de35a..c2ef89de0657e40149af4c0419e5e21076c92cc6 100644
--- a/workflows/isaSampleToRawDataSeq/isaSampleToRawDataSeq.cwl
+++ b/workflows/isaSampleToRawDataSeq/workflow.cwl
@@ -1,5 +1,9 @@
 cwlVersion: v1.2
 class: CommandLineTool
+
+doc: |
+  Run script with `dotnet fsi isaSampleToRawDataSeq.fsx ../../ Talinum_RNASeq_minimal 1 rnaseq-samples`
+
 hints:
   DockerRequirement:
     dockerPull: mcr.microsoft.com/dotnet/sdk:8.0
diff --git a/workflows/kallisto/kallisto-index.cwl b/workflows/kallisto/kallisto-index.cwl
index 3d29b9edba1ec8b2f5e1033659ecd36f394dba56..d35f52022fabbb4028a84fe2866fbf3343122947 100644
--- a/workflows/kallisto/kallisto-index.cwl
+++ b/workflows/kallisto/kallisto-index.cwl
@@ -4,7 +4,7 @@ class: CommandLineTool
 
 hints:
   DockerRequirement:
-    dockerPull: quay.io/biocontainers/kallisto:0.50.1--h6de1650_2
+    dockerPull: quay.io/biocontainers/kallisto:0.51.1--ha4fb952_1
   SoftwareRequirement:
     packages:
       kallisto:
diff --git a/workflows/kallisto/kallisto-quant.cwl b/workflows/kallisto/kallisto-quant.cwl
index 6d3e3578d1e8a43199e2aa18afe8d22888c2f551..026f7e1bc37dba078b750b3f7ecb70019c4bc753 100755
--- a/workflows/kallisto/kallisto-quant.cwl
+++ b/workflows/kallisto/kallisto-quant.cwl
@@ -4,7 +4,7 @@ class: CommandLineTool
 
 hints:
   DockerRequirement:
-    dockerPull: quay.io/biocontainers/kallisto:0.50.1--h6de1650_2
+    dockerPull: quay.io/biocontainers/kallisto:0.51.1--ha4fb952_1
   SoftwareRequirement:
     packages:
       kallisto:
diff --git a/workflows/kallisto/kallisto-workflow.cwl b/workflows/kallisto/workflow.cwl
similarity index 97%
rename from workflows/kallisto/kallisto-workflow.cwl
rename to workflows/kallisto/workflow.cwl
index e7f0350801fb853d1dc23a029c2d2f161e00b1c1..1d020e1110afc46d500e96eef07a1f7282164219 100644
--- a/workflows/kallisto/kallisto-workflow.cwl
+++ b/workflows/kallisto/workflow.cwl
@@ -57,7 +57,7 @@ steps:
       BootstrapSamples: BootstrapSamples
     out: [outFolder]
   collectResults:
-    run: ../_aux-tools/yield-dirInDestination.cwl
+    run: ./yield-dirInDestination.cwl
     scatter: inDir
     in:
       inDir: quant/outFolder
diff --git a/workflows/_aux-tools/yield-dirInDestination.cwl b/workflows/kallisto/yield-dirInDestination.cwl
similarity index 100%
rename from workflows/_aux-tools/yield-dirInDestination.cwl
rename to workflows/kallisto/yield-dirInDestination.cwl
diff --git a/workflows/kallisto_collect/Dockerfile b/workflows/kallisto_collect/Dockerfile
new file mode 100644
index 0000000000000000000000000000000000000000..39a6609301f9954da43bf426be379cfda98e5f85
--- /dev/null
+++ b/workflows/kallisto_collect/Dockerfile
@@ -0,0 +1,29 @@
+# Use an official R base image
+FROM rocker/r-ver:4.1.3
+
+# Install system dependencies for R packages and other utilities
+RUN apt-get update && apt-get install -y \
+    libcurl4-openssl-dev \
+    libssl-dev \
+    libxml2-dev \
+    git \
+    build-essential \
+    && rm -rf /var/lib/apt/lists/*
+
+# Install BiocManager
+RUN R -e "install.packages('BiocManager')"
+
+# Install Bioconductor version 3.14
+RUN R -e "BiocManager::install(version = '3.11')"
+
+# Install sleuth from Bioconductor
+RUN R -e "BiocManager::install('sleuth')"
+
+# Install other necessary CRAN packages
+RUN R -e "install.packages('jsonlite', repos='https://cran.r-project.org')"
+
+# Set the working directory to /app
+WORKDIR /app
+
+# Default command to run when the container starts
+CMD ["R"]
diff --git a/workflows/kallisto_collect/kallisto_collect.R b/workflows/kallisto_collect/kallisto_collect.R
index b2023ffd7fdc45584c9dc8ae05b80466da3dbe53..1386c9f0d795bd872a01d9063c190662fbaa8b30 100644
--- a/workflows/kallisto_collect/kallisto_collect.R
+++ b/workflows/kallisto_collect/kallisto_collect.R
@@ -4,14 +4,8 @@
 #### Load required library
 ################################################
 
-if(!"BiocManager" %in% row.names(installed.packages())){install.packages('BiocManager')}
-
-if(!"sleuth" %in% row.names(installed.packages())){
-  BiocManager::install('pachterlab/sleuth')
-}
-if(!"tidyverse" %in% row.names(installed.packages())){install.packages("tidyverse")}
-if(!"openxlsx" %in% row.names(installed.packages())){install.packages("openxlsx")}
-if(!"jsonlite" %in% row.names(installed.packages())){install.packages("jsonlite")}
+library('sleuth')
+library("jsonlite")
 
 ################################################
 #### Read arguments from CLI
@@ -25,7 +19,6 @@ in_metadata_sample <- args[3]
 in_metadata_factor <- args[4]
 out_folder <- args[5]
 
-
 ################################################
 #### If it does not exist, create out dir
 ################################################
@@ -36,7 +29,7 @@ dir.create(out_folder, recursive = T, showWarnings = F)
 #### Read ISA sample metadata
 ################################################
 
-samples <- read.table(file = in_metadata_file, sep = "\t")
+samples <- read.table(file = in_metadata_file, sep = "\t", header = TRUE)
 
 ################################################
 #### Read Kallisto results
@@ -57,12 +50,10 @@ path_df <- data.frame(path = kal_dirs, out_name = gsub(".+/", "", kal_dirs))
 s2c <- merge(s2c, path_df, by = "out_name")
 
 # Build a sleuth object
-
 so <- sleuth_prep(s2c, full_model = ~condition, num_cores = 1)
 
 save(so, file = paste(out_folder, "kallisto_sleuthObject.RData", sep = "/"))
 
-
 ################################################
 #### Extract expression tables
 ################################################
@@ -74,21 +65,20 @@ expression_data <- kallisto_table(so)
 write.csv(expression_data, paste(out_folder, "/kallisto_df.csv", sep = "/"), row.names = F)
 
 ## as tpm matrix (gene x sample)
-tpm_table <- pivot_wider(expression_data, id_cols = target_id, names_from = sample, values_from = tpm)
+# Replacing pivot_wider() with base R operations
+tpm_table <- reshape(expression_data, idvar = "target_id", timevar = "sample", direction = "wide", v.names = "tpm")
 
-## write to file
+# Write to file
 write.csv(tpm_table, paste(out_folder, "/kallisto_tpmMatrix.csv", sep = "/"), row.names = F)
 
 ################################################
 #### Summarize mapping stats
 ################################################
 
-mapping_stats <- c()
-for (i in dir(kal_dirs, pattern = ".json", full.names = T))
-{
+mapping_stats <- list()
+for (i in dir(kal_dirs, pattern = ".json", full.names = T)) {
   id <- unlist(strsplit(i, split = "/"))
-
-  z <- data.frame(ID = id[length(id) - 1], read_json(i, simplifyVector = T))
+  z <- data.frame(ID = id[length(id) - 1], fromJSON(i, simplifyVector = T))
   mapping_stats <- rbind(mapping_stats, z)
 }
 
diff --git a/workflows/kallisto_collect/kallisto_collect.cwl b/workflows/kallisto_collect/kallisto_collect.cwl
deleted file mode 100644
index 64283103d8bd3474c239a41643bef2242d73c245..0000000000000000000000000000000000000000
--- a/workflows/kallisto_collect/kallisto_collect.cwl
+++ /dev/null
@@ -1,46 +0,0 @@
-#!/usr/bin/env cwl-runner
-
-cwlVersion: v1.2
-class: CommandLineTool
-
-requirements:
-  - class: InitialWorkDirRequirement
-    listing:
-      - entryname: kallisto_collect.R
-        entry:
-          $include: kallisto_collect.R
-  - class: NetworkAccess
-    networkAccess: true
-
-baseCommand: [Rscript, kallisto_collect.R]
-
-inputs:
-
-- id: in_kallisto_results
-  type: Directory
-  inputBinding:
-    position: 1
-- id: in_metadata_file
-  type: File
-  inputBinding:
-    position: 2
-- id: in_metadata_sample
-  type: string
-  inputBinding:
-    position: 3
-- id: in_metadata_factor
-  type: string
-  inputBinding:
-    position: 4
-- id: out_folder
-  type: string
-  inputBinding:
-    position: 5
-
-outputs:
-- id: outdir
-  type:
-    type: array
-    items: Directory
-  outputBinding:
-    glob: $(runtime.outdir)/$(inputs.out_folder)
diff --git a/workflows/kallisto_collect/workflow.cwl b/workflows/kallisto_collect/workflow.cwl
new file mode 100644
index 0000000000000000000000000000000000000000..28a198f142412696588b0f9a6d8734ae0212fe8e
--- /dev/null
+++ b/workflows/kallisto_collect/workflow.cwl
@@ -0,0 +1,52 @@
+#!/usr/bin/env cwl-runner
+
+cwlVersion: v1.2
+class: CommandLineTool
+
+hints:
+  # DockerRequirement:
+  #   dockerImageId: "sleuth"
+  #   dockerFile: {$include: "Dockerfile"}
+  DockerRequirement: 
+    dockerPull: quay.io/biocontainers/mulled-v2-fdd016122f200fdc6dc30f6ea2fd0000e8067dff:f9531f6ac1f44332eff70b5912d7d5f3ebe8df38-0
+
+requirements:
+  - class: InitialWorkDirRequirement
+    listing:
+      - entryname: kallisto_collect.R
+        entry:
+          $include: kallisto_collect.R
+  - class: NetworkAccess
+    networkAccess: true
+
+baseCommand: [Rscript, kallisto_collect.R]
+
+inputs:
+  - id: in_kallisto_results
+    type: Directory
+    inputBinding:
+      position: 1
+  - id: in_metadata_file
+    type: File
+    inputBinding:
+      position: 2
+  - id: in_metadata_sample
+    type: string
+    inputBinding:
+      position: 3
+  - id: in_metadata_factor
+    type: string
+    inputBinding:
+      position: 4
+  - id: out_folder
+    type: string
+    inputBinding:
+      position: 5
+
+outputs:
+- id: outdir
+  type:
+    type: array
+    items: Directory
+  outputBinding:
+    glob: $(runtime.outdir)/$(inputs.out_folder)
diff --git a/workflows/merge_isa_metadata/placeholder.cwl b/workflows/merge_isa_metadata/placeholder.cwl
deleted file mode 100644
index 30d74d258442c7c65512eafab474568dd706c430..0000000000000000000000000000000000000000
--- a/workflows/merge_isa_metadata/placeholder.cwl
+++ /dev/null
@@ -1 +0,0 @@
-test
\ No newline at end of file