From 63a69f1e0d1966d48cd028977f28480543907ee9 Mon Sep 17 00:00:00 2001
From: Viktoria Petrova <vipet103@hhu.de>
Date: Wed, 14 Feb 2024 16:18:17 +0100
Subject: [PATCH] add high-level metadata to assays and studies

---
 .../isa.assay.xlsx                            | Bin 10307 -> 10308 bytes
 assays/DCWMeasurement/isa.assay.xlsx          | Bin 9885 -> 9910 bytes
 .../protocols/DCWMeasurement.md               |   1 +
 .../isa.assay.xlsx                            | Bin 12988 -> 13093 bytes
 ...surementsForTheQuantificationOfSqualene.md |   1 +
 assays/MetabolicModeling/isa.assay.xlsx       | Bin 6898 -> 6930 bytes
 ...TheIdentificationOfAmplificationTargets.md |   1 +
 assays/PigmentQuantification/isa.assay.xlsx   | Bin 6900 -> 6917 bytes
 .../protocols/PigmentQuantification.md        |   1 +
 assays/cPCR/isa.assay.xlsx                    | Bin 9592 -> 9601 bytes
 assays/qPCR/isa.assay.xlsx                    | Bin 10421 -> 11256 bytes
 assays/qPCR/protocols/qRT-PCR.md              |   1 +
 isa.investigation.xlsx                        | Bin 8570 -> 8571 bytes
 studies/Englund-2014/isa.study.xlsx           | Bin 11311 -> 11312 bytes
 studies/KnoopAndSteuer-2015/isa.study.xlsx    | Bin 8476 -> 8477 bytes
 .../isa.study.xlsx                            | Bin 7545 -> 7702 bytes
 .../isa.study.xlsx                            | Bin 20205 -> 20212 bytes
 studies/Synechocystis/isa.study.xlsx          | Bin 12921 -> 13129 bytes
 18 files changed, 5 insertions(+)

diff --git a/assays/AbsorptionSpectraAndODMeasurements/isa.assay.xlsx b/assays/AbsorptionSpectraAndODMeasurements/isa.assay.xlsx
index c7447e4a0df9b94b75fd07f2a82cc3d85b64d4d2..dfa20d8968ca0b72391682d571b53b7c6a3576c1 100644
GIT binary patch
delta 780
zcmX>ca3p{?z?+$ci-CcGgTb`QZzJyvMrI&Ac?F{)h~9jLksl&(k4X+J@t;WrETP7%
z29fY*(F6-rvutMqGfdfEv4WK<@#=%=5Z?D-2{%4<X0Skkpek5khTvbYmdP_jAcpQ2
z*~JEysga%sk&%^y$hgRDWvmA}D8lN;U-NiI28PE>3=D!mXQ$*R2NdNO6zeDF7p3Y|
z<mSu`I-PgOKw!^zZKeCo!VCCa6+Lo~uJoA7m34J?w*G@jH>T}1dGh|X4TsCqE4R;`
zds89r_x!jLf87DAl~;R?Ebd@gutO{;H$7!<R13dK!HFpeJHrf=MJ<fZ=hX-039ZxJ
z6P0^l5sP?*@>8L_w3PM?AurkcjtB3Y(4L}heoKtUc1v`Y#Qn{>7Yar0USyiU+17Kd
zZQ)B<&vea-{7gQxd>)qN6Py{jWP9BWZL<Y)9<CEJIn%mnLWJZFE!&BEf4xZ2*EwAj
z;wQE8z5O!z)6=)7T?trK6)NK~jcZ<g0XNUqv)8iLm#hq`nz*`h$_(dgOLkvyfA`@l
zugvWd{u-SFh1$HothYW<czAwe`>HEp7U%f_YBk$7T-}zn()g1?I^XnvcceKVZM6FS
zYr5C&yW5N#IR5xeDr;7MR{QD8o~Q{qGQG<aP52(a)Y|9!=y!_M&o$L@SLX9}znfTZ
zJ&#9Z*H5<pM!#86Qq1N~#p#fQpsZ{Mj@=YxLohu<*$hlyRMrF2-s;kmWmP1>Y)cha
zFx{wP38wd|ID=_sRS4~=Y7gdjtNMZIJ5auynkkqcrUsD*nYmdFV&-`@i2VZU7GO2r
k>Ly^iN!^+go^mE1Q-`?fzq&MI?PO^UB{orIU@~F=0C(OdCjbBd

delta 778
zcmX>Sa5#WBz?+$ci-CcGgTc4McO&l%MrI&Ac?F{)h~9jLksl&(k4X+J@t;WrETP7%
z29fY*(F6-rvutMqGfdfEv4WK<@#=%=5Z?D-2{%4<X0Skkpek5khTvbYmdP_jAcpQ2
z*~JEysga%sk&%^y$hgRDWvmA}C}Q82oloKz85kZjF)#=Mot=`O98i>BP^_PvUzDm>
zk()C&=(OKq1A#rCMJK*rIawr7Wa&zl73x}wfh>>G-sEP_x-o69>e>5`ZDws*q@HJO
zz4>viMYPOmr5}v1mxL7y`6~%EJc{zzI(PE+uSR>+8=aT2Xm4q<TzPP!YhC^1!pTLs
z507Rsi>dB7AgwvQ$XMOlWpdD~AADZV)Z!M}?7X-w<;B9gL5F|L%WYH(EOGaCP?Ipa
zCDE2vpt5)AgXX1{Hx`)+%yD8=)hIEUcckQs(v3^8x*0Q#Q#Ci56@*qPv46dI(lH|R
z>XKR8g6`M**oU28|8~W~kh7~SCfEqu)ISxI$eO)><=#tEPrZm-_b@Ptv2yl1XZf9n
zubUUVxy1ZoBg65vCNJJ!nJCU#-)DPe>b66b-<V9NCvimQzV4Hn$j(~4<J0qd9s>Md
zZ@iAzdR>0|EQ8VqYtP-h^JaX1`S@~`=O-1fyu%utk6&8NTN*e?ZS(nM&%1wJ-0(*J
z=k~`Z7YNUP|0w?1ev|~Wxl3_6Bps+I+kqoDRoM_s&r~)8)0dR>z_gFL^kg{|Nif?=
z#T869saS&PeJajinne{td#T!k`8}$BVEQhUFRx|_=7+06<UwX`QG=LyK@DQRpt=QE
ljgPtsm~K|L=7cAl$;Z{fu9~DF%~&&8Mnj2BL>ZWf7yug#G|K=0

diff --git a/assays/DCWMeasurement/isa.assay.xlsx b/assays/DCWMeasurement/isa.assay.xlsx
index d9e740f8d0e487b4df70fa2761ae7809d87f3041..7714e81c20dcfafff88e6ed39b5e09d3a782afad 100644
GIT binary patch
delta 3153
zcmZ8jc{~)_7oTC$*cD+IX0iP&W6v)85VD8tLbC70#G9J2Bqqy{k!P|+B+*3HqIywz
zmYzgoiL4Lt5ZQk-qx|0IcmKHOoO`~X?>(P;&pr1Po@+SAX=A|*VgmpGV8CgNRUIb@
z$V`*O2S5Z}Qo4cMhYMp&q726YlQ_d6$t-#3um(wU(U8uUO|Zkam;iurR-*oK2=N{W
zhK(uQSQO%|W<oa*8+N|8Xjn`&6n*5*iahf}V{xZ;?cr<<VZ%_kavRq!hsc_1s`7n-
z>Uz9GO*@sE?w9a~%f~caE7+*!o%I&+Lq_?DmuT?ZIRl}flo+V+*v;Gd`9j7S`7ZOf
zFK~QUQ^WIDN2<q!SQ33tT(#VoGIL(YP{ca8Tga>3TGr~PiW#Tfxga;L8mTDd(y51A
zApJJNDc}~vj1={iT}s1eKlr-vnCcO*(Ki{S_v-h5c&W#hR|=<GAm^!&$^BE?`-K#Z
zv@D02+}G+F-Iy{H_sk&YaT|C<eoI=IdzN0bL+afnmunT|=isIgxf)w@WIg54;vZP`
zIssHUTXw7HPPL2rjEuXJg0QznkCVZN_1&ACl<Mw!%&qVlpi`VzN=)ME^pU*o%ePF{
zUe$k!1#&^sH~q3Zca$?U_jzJwY%@#`I!i^ldvx+z{)vj-y^x2f_r$cmj~LTQRNstU
zi|`P7X`$<()#IAD!Y>-8)Z?1Gaz_*!rrG0~wBjflcDm=iAx3&FcDTS}HA=C+F%y)Z
z`NNE)pZs>3dW;vvtqR^UuT8B<ffL#{!IDBSoF$W|1Zge-oXr|v;8n7R=#pAV!m%>L
z&7@ZfajdNHE}4~jTrgAqF+{?(xdDH@F44cKMpBE#1{*fxqT7SyA?gp72JETv{IPdq
z#*ZF|fCUU;>K8W0t2*{x$zyB=tG@A_ZmeKWxM_oTk-o+@DYjWr+k&ujxp?E-WxGs+
zfQR`{V^wY+*pe=*<6n;^Us?;UD}zM-1HB{xJ1Yp~OUdBvaYik*ZKGtVjUm*eSxQGS
z?nk_u>;coi(iu$4%Bv>AJ)bDr$8&-5QtV#?>J^`iho37tJE41nKS`J=giViE<9?q+
zIJ(%h$Y{byzzWT`4N_)fX6hvFgJq7l^eu)gB)1b4SfN<`wdUEk@LpnQ=h)RyT?4XI
z*BU4e-DlEQ0PlV9!BkOS@pqb{Y^aD<MD#uXHVmB_Uc9onmt1phYS@^3ZVF-`V9;w!
zw!NR>b=~VS@)tDx$|&V@7v<y9kbP4_rayZeZ34N2blKz3xo2=dTyc_4={s<TAhx57
z{ZW5R?*_d0$}^wkr9rjTV6k4c)%2pYB7d=;5j@TEcYq)S#YjA|Ul+&~cpd8&k)5>-
zzBn?n*PanU*e#t>b65wUBb=ttc{>uFo0L-iWQilkXm8BcLRNK*$o^d_IC<O{$IlQZ
z=nD1(P6@|a7wN+l#S(X=S!5@QgxAsTqTqGJ=8$umT`E=UCpdUGM5Z9;(cm{=$=B})
zn(2h(V-lsIz5C+mxuift1vmT8d7PE(m8JpX>eb&7oN!L*wk}JX5KsU|fZ>A#A9){U
z<|m>2KATc1h6-&ebA<-WH=8ptIUcd5_1H6Iz%s;rfic@dxX38!uc6xZ^cV_c2MI~a
zg5dKZ_+m(ze3>Y|33A8|>F)75LQ{uo0fZQeP>WuZl3=kCsaQ#{#Ncnkzm-U(9WJmB
zfDf4+a-4(c%r}{m1N{We+nnqJ&gw07J47fxO9-Ej6~Y$_9kL7kVjnzWzq^opEV#O0
zdPpEjBz;J*dq|LD7#@T8F4#Tn^@uwF5YXi{$Py%G=3~ZdSh3gCGxz%q(Z6&vK49)S
z5gb?CWnK509((q<Qa{;2sZLe1rI~g)j~_ByKWjbnc%b*a6?m%|tLU-4|7v>vL8_LM
zXURqmrV?g?T2Rfaa&|wE;QNnSXMAOWPiOSv{E%(Jy;#)RBHQHwli&8mO5O~*%fCoH
zSbe1PRH|`lb&2$27ql9W**pEnuhehSp*~OBsUAZP%fl>%QCkR`)Q^)(iP-OYzupmm
z{w+8I07PRBImQPN#j(suU#ds1RHxGF{T4Bd6NP=qQ&xfs=trksuew_m5Lsw{@oj_~
zb^eR)hTFCB;bH;RI+ZUaCua}zcJwyR&dpscP+4cQ>&Io_Jt~CZU&_p+$J6mUF}qtj
z`sP05i;m%f$F*%bOxC^2a?mW(flyzUG;cwfY=hh9D|p%ot8QJ;ptbX%h7#gm9Q*)U
z{@&OZR9*Hc%ed=iwvoDA+sqV;xAPXPPCM^DdGHYU2xzUl)s941sf}rAAOF}b^9hl=
z%#QaHp^fN;!s~b6vp{8Tq`nO~`Jc?kJjRtH2&VMnaeeiCbSH{12#-=lfO2$YqMc@}
z;nv<xCeo}$)2dhOgWwPa=epr0Ohkdz*=ek?H8@wXdg*>MLCNp>xA3tp!lUY!3lCH9
zKCG253(e<)^FOQIdFpgKdtTW?ZuYO~cWr(b%LmtYMG9=Amv(zj*~g`aSlO$7b+GSt
zco-4LLaNuw?$%LU$`7Zk86{+wUkao~S(5KbmpT_v!@i@~S(aqa-?nF|db?E-@W!MP
z+yAwo!{b$NvqV;syjh1^EbhL6s@b};Zu84s;HdND*oa%3BYW~0d3pa=9-rd3@zz#R
zZ97+{;6l@7@l`cU0iPH9_Ozbl3ojR;=N6_SZB6D1v6^ZzvQa#)M)LX>L&$&fA`kSU
zlrJbGZwz4Y6d#pm%4v4X72sK1T>0EG7M7dkS?1eN*xdN!g?<~R-cv!9V-z!8Z9BXi
zG!_{%;k{(x!<V8rDg*P9IBt;JxPi!>xm1qo9(eT{Wx41b>OvCcj-tLCX(nATPq>*2
zO~m{|rsP6FS)Z?6%AN62b6!udyss%(M;wo*OH}Kg>%7Q`y9c8sSbC<i(mNPNsuH<*
zBp3~fI!_}LBVkuh9(F7c-ewktXAnX@^jw7=ddSdvAS*qmwSMfWdlKD5Vc5`@iaf2G
zvdD2fZxOc%!Yt&EO0!(Hz>ft%3SY8^?zE{+EidSRji(2wJw1!DFss>4B=>LaT9qHu
zUzgql6*cnPh4}lnxg>Inhj-<8H90DZozhV54YdnBS%YeI3283@3B-y`pA5a^n{xT2
zxyZOd$4HlKj+FXmeh%HIu7Oy=aSEz0f^W2+DU&rheK5IrUgWI5bZl4vms%JHs3Ow{
z$R<KCRniSQ5j;`DuiBmTB-0tvD5IOzwms*oAoo7f!AhudS+5-SKJVG30h=n!d8pYP
zHgY&SNBy6Jfsdmr?J!vn<8nwwgJms!rr%b+b3&=n-0^bl5we`y+V$8e_(X4AO4Wd)
zMlY95f^>52$A-X4l~uSuSKj`JFzaNU*5-DedCO>n%60IrRrVFU)J($adaFxjFqBZ?
zt;+RvUgr6^$sJ#<t?Fx{1NS)7zGY#x$sEmFEC<Rv$9@$TM$hTIJ|UVB1Oxz{(5eYH
z?G|H$6)2l9{9${UfH=dr#pej6!`notF{CU~o*~_kstid)nlL04smUl$N9`yPA*KnV
zUoN8+0096JZ~#D%o-Id1o){-4#lRdb(G<QTgNLSR6M^CavNje#CO*JXyX+i*A-%4n
zdBthriyh(VN(c?F%-}pKl&t^eq+>jZcH&~%hxL_iACALRrt9>5g=iD)K%%`b2Kz-R
z{NMh>T5(~ZA+cLr?B`hs1NVqr5`qj%T0$5oPBf7~GOR!eVfX}u!4(x9N8^%@4GI1q
z-QnADLka_N#Ezc?BQ%0a;tvVfzupF1@)XdUs3r+#kY11!1}+n0B#|sB2ztQ(1wYtQ
Awg3PC

delta 3215
zcmZ8jc|6oz7oQmuLn9-D$;dDmTXsUWEXhN%JSikiS+iu{X|hBLGfehfXso5NZxym-
zY}q0tvM&#zqVkUMsrTvm{d3N}=bZ1o=XcM&=UZivVZdypPX}fK000nx!F_{r=42op
zRT4=+z5_|_2C^JZOoDi5hJBC#&48i992yM4BFCwoX4Maj>%u_*Kr<r%fB+B;__>IA
zU@n|X#?A_Ytpub~MXcJ}u2<BbEz2HaiBm+X9ouV4|C}~o7IRD!S-2be@)Td(LT!=F
z3$c#g$h~6rsA${Z*A_z$LmMDkx4T%r5eM)Etj#)*1p^H(r$}#Z<mCO>loT#)ylmyb
zNit&Tnlrt)*(aW*v1CjqdM$aSGwRv!`VAbZF458%KINNREp(qloSfWrYZlv65&ME+
zMEXY!s;p*-UfbDLZ1rJSJZWaRx8CYjmCFV>>qgJll+{p$uNOT^ql;Fd?l`vKJ&Jky
zYhBULdLKEtuc!{>N_2>qtP2xrx+f@KBsyKs6lqg-N`I7Psxj6&omw;2LswRpuDr%^
zy2HdTvJ3dD?ig3z?zXKfvpU`EX8ANUZ}Ag5(#|}^X&XM>MYp#3GIkH*gz%S0>4y{N
z+5=rT=(%MOs4f9Ki!G1mcfO_O$9yVF8`yN;lg;%zeqQMcEYlR#$!$eR=IMMMSGAt2
z;s0>(NS>S**YeZHS0m<2HT}f!)!evwTORyRe3E~|(7pM&wePjg->(tC?13Mz%xl+b
zC95}`l``Id<-r;}9C8=<I?(^fhep*!^2WVXV8rO5LM=hpG0CJmkO9V^EUYE~BEuAv
zk8K7*;+cYqvGO6^p@b$CsT(ZJ&m(tt`U>q>ZCJKfbN0vB0vlbh${Pub8MqaL!3Sd@
zZv0z?_&TRzdf$7d6{f>QYuxgqRrl0%NE)S&R2ep+_OwQSz(mBQHGFr4JF+W=E?5L1
z+Hqp(4hmtdc3NcrDzgD-t>57Dc>DzfH@sb4$g<pGjA2{<a+Q0=yL(AHxNhDi?iXF^
ze-yJB*VAH9#xPlfApt1SestzmrPT8&H-iu1&4C~TCIzqs{0^qCpij_EFX#M+=w=4c
zNv0nX>CwVahz$|UD2iiTaak@nN|~&>qtkb;kN=s_EYNfpLJx@m@2EcRg1kb!3V+$@
z-AmNS6q<-_Tz?-Bs$xi(XWWd=eweMGk!hTd$KJ&%QWe{9Y&2Fg+k1kn)Iol?I=aVv
zEv<tbrIOYm8!8c+8Kv@A5A_Q0s!#iu>xZp6dnX*hzIeR+iH8ecFUO`cUoWH%62P$;
zEgB4_18W`i*GXUvl@4VL>GAH};qCQ#@^~n)zA{E-yn`I0!oPrCc-J9Yw8aXAL0x7~
znCd{<AedIB`ZfPE9iJ=4%hg>C<K{&+RnBFyda-U5{BnIlRia_htQYPlAU$!T&V+gM
zYHQrFG`?QhS^o$cEQMfyX^|hni|C;$C-@Nj$uKd6IVpRB{Szu|BsIY>73IUc!hYrT
z`xlhFPi`4?Ff)=_+F3EY8E!=?s8~<!JNk}LM+kVd6Wn5f8UPFs1|D{Uhja+IHUeg_
zKc+UC8QM{29zBuO4Qbr!$@Zmh<X_TUG7gwNIkZclCqz85@;hJ2nkSvd=<Q{F(YggB
zJ4~@#d1wRIv4h&#K_l!A(4lj7&xRxA?#kInDTn>`zD@O(8>Tp}{G4sWhPPoO+OYTO
z3y&7IV`J%^aKXBCx?1#PIWwdNmsYCLd4)N})2EEACsx|l3_YMaj!-*CXoTY-y5leO
ztH05m%8(q-%5NuHU+?yox@j$CZ7pRJHh6E)TFO4GQY{ad#}{UfEQ#Tb;WHpT{%L9N
z)pHiVn0fwIV{fsJ*w?ZIT<OpEBa-u_t4<=Zt71c+jdex3MutM3T(!!&vNUfi6drU9
zAsM_sz3DZmolz`l9H`egh|f**PSrOpDce8J1W&VW8l;q4pV{$RAvGB`B>MXtky}Em
z@3R_PFH0m%wc@^A<{4vq@AJ*)LeL$MzgpwZ)Zyp-GVVoVZ!(H4R8hUv`i(o)s}pT|
ztBxB!%`bLQzpfYHpjQxep^~(g5CC0gKIi}&5AvS+Q9D2@(T7<aR|+%gPpoioiMm^q
zT6D`JgU-xjWza{|53f3sdCO<)XzHkhTS)7-{oZf*U@2%%wUX9TUUv2%gtx^i1So`l
z9Hbh}li2x%3=xU(k4X6-744Iq`?)_U#Dwd_qv9JC{dEiN<!EF_xnmTl#`v=4oLL&)
z<7BZWsArJ=?EI-UT-CUcd#nf^#ws|{LK;_&G3s2@XH0TUc<Up_C47c!q2I3@vCq{S
zAa~zox{(B*%u#+>^oT$=;!rF0L5kBNw7WkUW>n?mb$zav7k`5@_Yt@+D88mpkig7&
zp~N@DO#ZEOVfq4Vj!8tNDymvK2im9FgRCu2Fb(qlR#PpGlQyj}6)6?}d%P`vXUphJ
ziV*qRgiVv1x{N%XLqOAOyCO@&pC9x{Dy=@}W#v9y`n&s5pQ1FmBQ(~_+D<*4Q9*fX
zq}?1tc@?2r%x(*J^4!&!vXp{6y`&U-f`pmRDiD#>i^-g1-a*_M5if*Wz+PGUJ;>LP
z)7{d(D}5<h0oNBJ$kW|9<Wz}WSYEj~wq8Lg9^adj8>wgE59}8f`sC>i*L`ajxwEuf
z3}W--Ppvly3A#t>idJI|PO$1Of@F|Ukp;(O0?XxRkLZ?Ad_Ujs$g;oK{>FT2&Eko#
zhr=ANtl0KAe7XUfDYE<Jic1H|L}vWrHOo;H@nYjxDUOpX!l%(=fYhKm^4`OH+I>;q
z8Xl=WE{ehmGH95(f6@}AP%ePFTU!Kxm<_2B;M`ctdvG$6Q<g$vDUS~`lAH{#iVx#8
z3H(wrz}?Noc@6dVtz!kFompxH1KiOP4L`0f(y^w!xbb-ZkE%4IQkjE~C<!}BBPxcl
z8W62anb;1Qi!@suJ<YOqBJ<FK=RUMlaaRIy2bJ8kRXb}11OR5J)yzr-vvIXH@^E$Y
zl(csBu$Az0an3M#bFoDV*6^7<ZoQBQH-_gIf=NQ6e8%99b}KGUsiTRFf|RKlmDGw{
zq1(#J<e6Z_tK4tUUxCYcmpzXgqL1JGXrWt~L9E`EX%Gt0DgcXBgen!jiaU1)M|3B8
zxJ<uxq~j2*d5IKB@{ko$)+U-PeLbc(hq200sqL?_S;(0%Y5AJz5`r=II<J2ggOC|R
zMA*3rH0FN@%U2rBm4~Hk0tJP=<T6{m2GOGf*TfxCWNk&tPrI20pc%INJ2lKqhw@UZ
zOr~%b)GzlwT_xpQq7*3-RM=E-pEwYXX)g*J2NJp#%*&>YZvy?(*0fNyEh7qUD+6@@
zlmpsJ<rdZl<2V^{v8sa!Rn7i8Ao--5kgG1sv0QNsM?7mb=O=YxEZd{Y*F~3o$0-2x
zKgxgAGiN4$S)6$r@Ykk*-t87)#+k)4nfb=?7;<mH{KMV;XDg_0)ia&hY+36cug|^s
zb*3~{O8$;YIwYHkd}_3_9O09u$)o7gG^vf2pvfjdB$0qVLDNgn=V)>ZtwejCeiKyU
z8Ga?+gJY)hgN$J?03gVFKw1C&2{RD&7`TX~{7@Q113wZdM;ztnr;UD6M|MOm0U6XE
zuO5~6!vBo{Fe5q%97e<mAb}uaslegJIt7p*Q5ew*#zFipaJT?<-%6j30|0)`l3otB
zF1C_J`alpI@SB&L#rMbyMblH?R_a#S{#XUdMm)>LF81GmBg%KJe5mD1M-5{BBcPL*
zCCE)ngu1GtBlo|``@bM}r@TiVQ15{T9RL9P10;^fib2ux|L<M-zuR9#Lkus?XKR`V
a??lCUPTdg8{~f5>FfkT`roYX1F!?`+6MAz1

diff --git a/assays/DCWMeasurement/protocols/DCWMeasurement.md b/assays/DCWMeasurement/protocols/DCWMeasurement.md
index 6bf234d..177118a 100644
--- a/assays/DCWMeasurement/protocols/DCWMeasurement.md
+++ b/assays/DCWMeasurement/protocols/DCWMeasurement.md
@@ -1,2 +1,3 @@
 ## DCW measurement
+
 Cell dry weight measurements were carried out by transferring the cell pellet of 2 ml of cyanobacterial culture to a pre-weighed PCR tube, which was incubated at 60°C for 20 h. The tube was weighed and the difference noted as the cell dry weight, with measurements carried out in triplicates.
\ No newline at end of file
diff --git a/assays/GC-MSMeasurementsForTheQuantificationOfSqualene/isa.assay.xlsx b/assays/GC-MSMeasurementsForTheQuantificationOfSqualene/isa.assay.xlsx
index 6bb65d8f2ea30e85eb06bc8e73341555ad6867d5..700f7d74c699e6cd8092353906e7cdc34ff00351 100644
GIT binary patch
delta 6342
zcmb_g2RNM1)?Y2^>b-9ydfgx!vT6hoB@(iF7bUu|2ye6vvFd8ki9|#Xi5_h&DMAok
zlvP8B5Q5+?x&M0a^F8<bzPr!!?wmPi<~?VA^P8D>PLso9N3eko2`Lo_1fl@R1?p9S
z(}_q3CFUs+<hZPUM@08a@rjuC#K6GE%w*;5aN9@fFCD7|Nd$j2)F&08CG<pOTNa~>
zh(RDU6-I@e1CvWi4t#LWlx9Y)?=W}ofJZ{<Pv^O?8D-XJ4-7dE)23UqNI%am935E4
znw-8LW@^Rnb$5E7?j_*Uzd!tPWBaP8WCP8N$-Rq1ECq9u^6D+QxofH2*E9Uix?Spm
z`r1=XF6Q=!CrCYWycz^rx`A>j+fP|9DR7i9I`^TP7MhYE@e!bZQ&ti9+R53{g)5h|
zt=&Upz3*XV5}!@fvsp5;7~A3JdbyA!xf|-c&lZ{+`o?Aj>QdjNSpYYqUXo)`=gs-R
z%mHpydktSA3NueB?X%pksjJledTQ#M8r4}*ILXA3+Ej?otdLT|x0<=HWJM-BXG)-3
z_io0M3MlLMbm%_;y7~IWOf>vs4@GFL*r$d#hlJH~MwU_jt6byNrwlo$+`E)waOj6u
zZq9r4+#uRa$ro<8Qd;~ZK(w<h{9#w+8#ug7z;Y&WCyXOHZ)tXGmE<BwooY6ixA0I&
z|A1Ih#UcPZo4A9-&d!MS&hdWX<`~Xsbn21#bT`jovE8c-=+h9ZL4Htq`(6U~;xt=X
z_iQJLgkmlCuxXu>gt#TN@3{}s)(0zTTLtD`i~Dh4V%`uX;U)v6Z`6L@^^uY71@;t*
z<VB{vY&nWVX#AACw{1h^xVAMP87xPIQE0BmS-Q$%V}jC|i%W>9yN}X&Kke$O5BCL#
zTPEYhP;(dra66wAjc4l8(;D}-Zzn@8N7Te>2+~?+!60rs36wkZLOb;1aQk*R_B9;q
zN5|37ReRVEpM1W4!#$v=31xJOlp4~@6Iwr9aNfT%MqbVJgJl6HC%vFP!$=;ZnicWU
zyMxZH@|}n|gS_QO&_U|rv-6ymsErn4#-4`7uloY3+Uer9Ng%e2%RMoP5n-x+3R%`T
z(em6*KFiNzTkL{O^3WoxpRNKAk4XN)ZG?g6JML^65D14+CKmt-hFLYHdMomf`YT1=
zA6#_HI(6xpRp-84W;Xl$6rtjuw7Ej3TV%E{ww(Bbm3!M;X0&58C84Lw>IfO~CitPm
z&CSlY&Pw~0xxGD>Ypgq)Y5GOGZMp|(-b%Hm`c`X2`Y~yv&WF9DqDL#EfYRYB#G(Ip
zSZ0||CXrOhz)w67co6u!wzeTC3$A~YkF}yY4IF?F&n;T%>6kBS{<z{T-#m4gzgW~9
zesD1RY18*G=}3OYe%HfMoR@dOzxwm++UDk}!+~43_qMEs$B-5Lz17XBBKXunrdRL4
zJfPfi=v|8pnMD6^JCwCLs^`h*g->P6DmRO#4ov09>+b{ct4@JC!Q0!a(8GX`TJus?
zx)r)iFF+zgX%XLyZ|*6qj^EkrIrk$Y(EUOXtjEl6mTmM}$oeXNyK!Y)qVes-!K%&P
zuJfeX&k&_dAkf^yvQSN__D54lM$5agYN_fXutLxJ%CKlm(U;+uB{>sECfQ|c@}b!a
z)RBD31qy(Ley@@wTg#&Shg+FxyLa}!N50d0a39zt-%;jfmUo>BK5!hryR)EE(u0?}
zMLr)NWc6NYZSsK3V!EpRjpW6Nn+TS4ky6Tw1_(Cf(@Mx!t(p4Pu=Xdd1?{P=N$u33
zko=de2?n>=cq1bu$xspHq^O7nVs*7)!UHE5fmf{weX)c`#ae60*jme}j+z>hpGZ(3
z2$j>)XY9S_s3E5@=d36=9&+!gQM{fTWK+8$*!7Cu7J6YPG6D0tO$wEFRWC&5jDz=9
z3`7)DZG|>@JtKuHo!erwGxq)&BO`X<s53o<!T@a&O+*lc4IY?8lRQpO(K2`dm_(Bi
zB&TB)IYEdz7AOhA(_?}9aY9NA_56SOhwz_OyWn_MlDoy>MeXt=-+a*5@^A2wZ1znS
z_SrHDnq^}$l&34P`pY|^kTFzi!fJghK!5wXb@z)G)YS)`r=*fm=&`NqilkDMmJF+m
zO@bo>i;R~2N}WOKKIEhxl(dv_zLTEaxGNnZnZmIxYgfH~1}`#48aX+aoGycu3Aiow
zdzJZ^H$*=&(~?RkAVD#*n_52&%_m2lM$kF)i9EAj3d^TK$&XMhvoA+H<ucTK06<}H
zrsd#$48zMRK_r@XJcO!n_<c2`7*p{~hyTZ~Gi%-AhZ0U{f^c!^?aJ1X4q`hxYBc;V
zMaA1)NW}1<5a*j34Ie2d_e|^i(`Vbn!YsmuNrRHq3_FtB!96_mO=n?eVEuROz+$m-
zrLx5~o!a2*%*OeT%O2FAYT{~ud>tV<w9a`iUuqFi>!o}7q$pN)7we_ae2O9UG0g{}
z><!k!;rU>BHHFIxkk6>W!~&W)C{mZs*RaDkuQ~J)VRv=#Om5Rai3jbU6_vZYRnDoD
zl(=EVvD#mVBExaAvb!RzOKn1{Q1R1uE+~h6&DgutaakfGNY!VYRFM?;9cm1766X_U
zcc-;`(-Livw#0HSSA=t^&0}q_n4U{|K_!)hn^B=$;hjRTg+j5-FOaVhsgu*3m9A+u
zAW^5I(WvC@S2DcO)<>q!LE~1*&@a<ZdF^~*9P@F2u7P<N&L<>az}&HJ1cV>aNJ8yL
z$2|bn;+ghFmpXm{e2di-!5KALPF#AZvK2u98q7urSxN<|8(dI@a$Y0rabsGgZ#sk2
zsMPtIVXbed<&th#mtRj3R!e%HRI|aI5N#DIMNqC3R&4X2U9_ggC~+uZC{f;bxe(>G
zEEwkw(IBJYkxp*yBUT5~z@?en0s*akt!rfJY%~tiHEox*y0nBYO(rN9CbwNXRk0jO
z7&vXsc~9Awp^pft*L5d2c(`hV*`|y-G&nebSxH@&e`5O!=sE%^0vOs|KQqP3UH#8E
z0sK2s{P#Gq{~F+uY%W3RGz!qo0$iW|4saT9jIb(FH=sZpJTO6>F)la)L27?}V4XHC
z*OpV5Fev@l^G}Np(Q$>qWWun$3_Je1@U+4BeqHWKwFgw}3f97*`D7?g_CRalu<r@m
zi3L<BN%l9^PT{c$afy0S4Ujv9#|*F>Ajt*>rFon@rk!q+XmSvUoCr}w24yA=dhS}t
znWrXh^ei+I)(nBXzcYCT+9bK?Kv5y0PcZz(;{Q8|0m4@C|70<_M@vc}DxN@!E-3U6
zF#DH??T{Al;~`B?E`BKd7ZwBm9UA}dSj_WtPQrBbaNqsQ2#}V)p=%n35j5s3K{&74
zKCVKi;N*=tR|plm;C5{Yeu<iU^75E!VDuK1GuyIUe-18D_8iVD{1Lg9M<Q)vTzh|2
zE=e32k7s{hs1Qr+Lj>8)T2VYFUIBj@0T*$xY<@jphBl$KQ$&B4-tIuq+o_{js(A5A
zcB$AAMms<k4X<Lr%it+(&*R>w%Xtl9U1#!y$l}N+xh`gNVNIBB>6**ErVaVVTCtj)
z=HUR9Jv3-@j-}RhF?TY=t6@0VG6s>Sr26ao3vu(5MRIzNq&$7OoXMBZ_KOu-6b@?z
zacY|4nY+Moy!_1?3YQe92peuWtk|p5IaW;H707~CQI)$J;pA|4aIuwvrue!*Oi?X+
zH8;+WeZ^+=eic6s#V%$G#|7iWqpQy1GT4J`1#osaCagO;TgG*^G<vvQRo^v>w&6Td
z;e1rJ;QNd^m!xBaZAbUZH{Q(YB_Y|KQ0uvJS9~+f7=&3aJeDo?YI-mBNC%Oz7Xb`#
z7JXoYHN@70Z!s>j^h@@;7Q$l%%DkFJsWs^mKAq+{%@g?;!@0QMOswbnlh6G}`_<C0
z60;PqSg&j^fzq5InAKM2|Ag?r1-MA=J=?tvUw3-omTs1u*T*x8KVO@@d%j~qlKMJZ
zaKqMxEo%t&iS)^FsMJ@T4e>}W#O1U)+3y5|<JiJxmgM_s`*jL$YBg$AByP*b)!;T9
zrMclMfib>OzRan5E?Mj3)UdJ*pbkQF?r#9!y~eKZA>()f{Y84H0~n#RQ$>SijIn{}
zeY6Rqoeo+~W*d7M-Gvs4nq*hB8zNAkA~O7Vocy?fdR0QSLs%os>Q^C;Yi~dK$07v%
z3$Xgpo&-+db#1R;IJ+9L$%1lmwb2f~lvl6kdYa;q`RsA-0$=!>F9k-{#B6ao>*KXt
zxjk4rK9CdwwOaSJG;Nj(al0W^_XaqR?sMU!nM$TV8#|cWncteAC^?2Ic4LdxF12HX
z)((z7kY>e>(A#O0cGdN!pOtxuMKIav-^L=}A;U&utIjzR@Z2zkEjh<-lG*>6!FaQY
zZ9k<)pYQBB4?UDr?y)kiFB<ItUN-9NPJA0*v~fEMXhu#RUWerFyH#0A<+LaVX6dfq
zdRq}M50E1f;zLt>tHGJ$xn;^N3#@N<7uHF~;~5ltS|n3f=6zp%`Z?1xd{jGfujup2
zPg%g%^RBPCI1jhSLdZjj;myVtqLLoATUJw<wJo~=o8NnEVJ%k5?#ec<%KKltx{$$>
z)(7A5oecx?fhmn<cSA-)0v1c^=U@Lklx?~F$)hD`{mb}yx{$l1<D*AJzujg)$5(s|
zDYMkcO<taP9XP(IPnzkT`$!4`C9#4)%!EV$^0t(Zla057{dHe&XZKq^l1R7PWr%h6
zSs49Mh`!DIKz5BR5tRf5;)Qt4N6ARCX9L9wWfNF>ow)2VJ?h}Npd`#1*&5OILw81m
zNG8lVEKW)|XSe6)#dEwz9Cs(kXqxGZpH8cn1S}wcD9@Y7WRLqp9f4zYH3|LcLFtrw
zsG%I;75q|Ks39j&a!LNYE6=u@S-lcvr2-RVhJTcT!y26H?OI~MxGIuM&m-M953^8g
zO*ZRhVHj2~8NO{QJiB$_G`>Ttdh*3(5)Dlfc!OzK`62sApll^R6rX2^jCUk0(Mr1K
z89M~*C)mFrF4(|W-(X_CQk75hB+`?n%#p4vnx-#hg^`7vVp6k>DbZwA24r()^kLK_
zTw8qS^}CsY9IL5dpXuQ>zZIlKv{nPDgwTLE6-@@XEPBPK4eRHD#<7ac?HQ_AVvT3}
zrUbOo)kM#fqihNsRL!BNqn1h)3E7}#PCX#zQ4)y+`;ZrlBa2k4$le&Dw`j?6BE78d
zV=6SNd32iDeu<a7-bv7*a20z=G~7jWZcNBZ;GNv00h?=7-`(oKIB6I}-sp#TXwH}P
zvH82W7jdi@0=cquQ^n2|k(J)0*k_}O>AUnrs7xfqXwY#`-9O9a!9!7_tk!;q$D9B)
zpQ*+Lp{(2h(~$W9Mwb%vTTB&;XPO=d>a=OqKfd(HRF`e$!P{?f_Y*J2YevGrfTIyB
zqP<d(5w0dD${k_goo~>f>St<uKF5}J3snCm&f#gEm9j+n;z8XGZ1Kw!dTf-kC0xcZ
z@`gsAdL48_9Pb-KTyzoFt*zemwDU3GL!5ST;g%$C;ue|c7MSZgLak`vnSR$j?GH9T
zqAPbq&>lj={s(?V^IOlL!r^EQdbM-+V!y~#ZyJ=>pp)QI^p-3x#jXDOTE@KBuhMFo
za#LyNw64vP`UPAS_2=*_x4zcunuc7AV6|>-dRr3GDydI_Ahf*AWwV^ESMd$FBHUTH
zL^dm;WE7!f%mRhI%H}EE4ou0sAtKlrQTf!=HEh6i%2}~2=lVl+jx!pn_30h%U6qA_
zM@osK&!(=X`Z(~OjS`Q&`3Ao6ARQSAxlHm*jOjD1CnMr&6tUVh_8gV&VqM{Qt?%7?
zJo`?=&conX%0wzKe_W7Dr{Iqcp!9nEKr(+n^@UeTHgTheU?o?t3l$-!#Z(LHkY5*F
zu3=CE&zjOw`LD`W?sH$$z=(H#Hw-tN2iK6w#Ba?^2gB$%={`*z8NS-@iA_hnH8ZYD
zoQ?I2kaICtFv-_^nM6Ow_{1r>(c<De*H4jr3$Lk(-U*PPrx1IhSV<032#{4BeHSuB
z!7949lPg7UTVUfAqEbeCx3_Png^S*^4n{9Ba-YxCHax@W6a#xTVpDnv!?Qr@5O8@q
zpP_{udvmx{djAVmdD}HVB(zL1SOvT3k>j74vH&zyK8ksp<CC2k9;5!oTJd$W!$oub
z)Xn{dVr>=5=1&e{{(Kjq^?-$}LiL1O_B90Yr=WGZg=ex4Laf+slw8oux}C4{N+p{Y
znnKMoa&B+K?^&wA^YDXcoEgb`#pqa$W&@TGQPbe)QVKZ{Rb8rU1B`<;^mnd@HHciA
zOwDued8!!C8fu%!@F*wdTXGaSU4qt3Bkz*qrO2S&dWw{8v@j3rdl6P<2kDoFfm?ik
z-5}RE&Yt8xSvh}@{xj!!=0pMGYdCcxd_S8*d}2uz{$*(venCWeyqPNeI5=;G2@>T4
z+}ow;n|8!bPlYq((P==m+&YW3Qm9-$X1YpECyk^w%g(K@T%@=(KREvW{VI}AZ?Wq%
zT}Z1!@kccFQ50!j9jl?+E&FEE2)Z+#-O1MV#?k^TFlev4p*v%_M3bpoYXK=6Qed9Z
z-O>KO6XO-0Db==#Zn0#c^JA<u@ES80fPJc3qR)$Y@&j=KB?>)+%3tQuz9oY6aHf^_
zpdl?vP$#0|iPe;WyE5FKDQA^^7x_E^!BHm)Pi)>>vX>Hn>wQCyvv^(k3E$haTE{_y
zXMslCTB%eyp42oidWKvoe2WbO6H5Y;)76Ix8~ZfZzJ3RDkNeWy6>s$t1Mexm0Ot5-
zdaLd~8#IRX(i#MdpejGUbSXafjsF&H+TjEj<!qJ0&R*J;#>toG?os^IOY#dBS_uBO
z)nuA*n>)71MwS-8Ec!}!cHdrMw={@%Fc%!NmIx^3&@}9xI)d(#{WfDKS!=}B3~#(E
z5eW30kZ-2@b%a&3iiiJ7NM}hXoy^swgv?3FASr)RUXhgiRhQwyq)Kv}$j>D;PRc#W
z3x7{yt4hK6j%WDyWS|=e#7^+_$4>{7E+ur*<`3PkBlTCEo>1^&_@&vz40MQynL)p2
z-4V`#>DVfQ^$cMQ0)OrdG9a{vp1kw#$Mhe~)G%Js0*c46{h<S$y!}`G*snI{$-(Yx
zV|&}-ICcLQ|CnBBE+Q|?inPFQfDqlrNXW3C_)U5*Cxku)0%7?<Af`V%0AVopGN(^^
zM9XmT8wmdTbnp!zcsTxM_`}Js?+ykTE}{+0v<&-6mwg#7Vs;S>JCyfN>qZ&MLez&b
ag7WhpkLK^Q`iFB%aZCyna%x-RSoII7jxLA*

delta 6196
zcmcgw2Q-{rw;l{ekkL(agF!|aLWq_`iy9^g8PN$Lh?*!NZ;al{L~kitlpwljLy)LJ
zgb*#FM~kSV+~NEG`+whe*S%}qyZ&`&t-bb~ckgq~KF@jfIqU2k+j<*XeQh%E84w5r
z0qKV7meD4YkP$U5pM>{Bmv@su|M)OL%5`cuCgndhAjlAZ81%rx3`9>%bvU{%kQ4-J
zp#p(mAY8pT8<3EQc1}alJ)PV^#!j-!%JB1&7Cb^%YNkm!Wo-Y1F&2@kSK+D%TkmAG
zf4q4<1dWqrS2{~*Oy5kKe-m|9nf>)XwpoNXZlSi|ZWHoDUkIU)IV{q~ukFrI1hyWc
z@}LvChZ~5=rEgJ(Ea+Zka|n6J!9Echosz<)8grp?0N^Z#Etxt}h+<~BmPV5iAK|OX
zKR<?*ep$23uS+y>WSaDRSuGgKB3ho@X#c~aw<5ZUa#-T9hWky;5{0Ux4RR$SAU=O)
zx$m8seU;Njd6s4GZpsQ)X7{>Vab&>?jVr+DN9Zw1Z__xxsr8+e<F?|!OR*24MQcK_
zHQnPqJAl|nXSo8^p6%kpH<?OQwGJYyXf1eUb@9(OR#!UF>&*P#ireVQ2i-PxZ_F;X
zxR{h+vlnNX*=>zd9JZLIJIPjmHAfR54lr-Alzt}MT*qVQ4GIoP7<VUs4Ah3p{eX9=
z<rS~O(uPI4CuhsMZ7+{>8R&G6;>4D$IPG)}7vQYaYaF=F!X?f*FRJ3D9a9aPFIM(K
z##D36+i=Ak#Uy#x4+YK7tsc}m9+<|0nIC_@J+E4;l6<-G3JSeJmrYmiX7_S|_XB)g
z8XHy@!V}jlLxs@d#+s0tBa-u<KnAFMvn-TB5Xm#XITkG>koYscg%;BO-PqVh1(YQe
zpnV&%zy0a8E&W~S*2;_HQO3s&P8RYT35yv&bw7uX`n&M`ejQWiP)Ok!WKd!7rC^mq
zdZa2yNj?8+@iRrrjWB}B$RVAusKiyzeW4G}D~5FL_`*5>WV)S9z<XPja_=h408Ope
z=eO}OIxr5Vj?023Wp_p?x3mqbTr<7~CGl(n-8_vPO`Vtj!f}kQjmAz24G0vAv!dh!
zQWqK2*LF&t*JLf+1AiXSdFURG;|b+hg|!8ao@a^e?mpT|i`D$G==s*Ro?66df4L+n
zCLuOy)BM=Wr`s>3<V(ctrkc`Y&*Z+IthL0Qi1`@Sy=mQ*B%JSqh7`rgKCYy`&4`1n
z&4)+B(Bn(Tezp5+`-8rXADyTbO2mI<0T<Jf$^!zn#`E?D9S<MuNdgn`A+t;NRbQ1%
z{1h-vMRVnZaT!HLE)GsE7HFnz#QZ_^nR|u6P3yh&(wel}iJn<mbA4&fYKEH~Uv0;Z
z_6NV)95##&jyDPKNEsjQY<7uzcI72Gg-x==MD%36d%5>*aNKBSX46fYu;TjoD*)W>
zD1WzB=?RVhr5EvT$gRP5q<$=sP}u)FRS$X{T9u%bJ}F*xd;Q^3?a;wA-1%!t_1l>P
ze8}eb?cqnJ+lIA-z1E+bGr3I%hi;9#yY}S`nnAt~_PjT1yfUlj&F5l_J>o8Zp6~4H
z7<YeX*tdFI)IIDu=5P9gI*3~wodP)7a`)cunsguQzc)5^AW87yD=+^}XxeLU^}H73
zH0EjEG*V^W;CH{l?_jpIzkd&(1f8e!1g^5~npql6m9>O7V_OQEU$&$+$G6lqGX^D*
z>M>v3o+hXS>H4R%BsQa7R1qbbC`f-xWmBRk5@ndQHE^FO6aZmeR%b!oBKea(QHqIf
zaYQL2N*GaIH=}rQ3760ENq*g%LGj^o!~=O#9Q}B8KHgoSw$wp9Hix)N8XYLZo_(BS
zZOPU#Y@$=Qc}obAMH(F`rzbc9yuDgqnqc<?2<DOH3?$*MhE`W3dbOB@+Ks}<+GLS&
z&jF&5g=wZpHNYx8!Aqa$MXyElQWoyjx+T<R6h@tcLb9@ISsIFoJ!>g4F%b$fs;$vK
zQ|{*ag2{IFyRvY1XIl{N#OL~nSvJg7P%QmDv7cZ`x!lOyYRtN#&&^$~mD`b<%&>N2
z7Fez^JuKLm8D?ud7LsRK0X+1#e49ktYQaw0YLZ6UdZr2-OjWrkEe|e%Jfhl$m@)pO
zrrB}7Qr__5tqQgpd=1<|+KSZ$2a~6riM+gUcecEB7uRcl)-X4^7+Vou5nS;`x1&m|
zY>^`I0o;kV?NElP`4dQmoQ4zita)F9Qlp<tg`P$ibqn9FA*hk33XI3f-FSvaQ<N+z
zUo&|Xv@Ms|&f{|O!P$PWL;_B7aHLCeV5ZeR32fWPH<MbEQb$sWpb+ayIt;st-;%m^
zQ1!uPc8~$YkP~|RBK|BMi8aM4Vu!&5Qfu%a-Gls}u~VXWdVE<k3{U(*tpmq+@`hQY
z1|+<;F61c&;KjVf4uhIt>p@zPan<l;=bGbSQW%>>{?iv^!3-GgMUb$Mg%I`yRq*){
z*dloGSw8!XYvGczol^#;3;bC77Y)%l5>y;E#F&joe=qClhfU4MsI8Yhiv-Z6dN>FR
zj1OZGY2hz{-LYiAcet2~#aMdLHhlVo#w}IlKLFA!LZ+DUVt6jR1J;k|We<_L^+;nq
zaVm7`AN|M?^hNJtRZ%_o&d+5Av4(M9V!u=_@?-zNxNS@38=yi$LyNlA{E0+`swl?e
zDU%|K3I7SK!t5C7f%VY(O#7No?Hq^AdV!b+1HR&uS;s&!IQnD>qE5j6mSBXc%d{@N
z$%uGLTN8RRPZLZXNiTv@FC`*IK!r__5>Y0lDdA;JRYm>ZK>i;v2L87os|AZZcG8B|
z?B+tmv_9^J6QsgUz$I@#LE4KOL2nXBa5D;=mj0oPgXGqU7K|ZAc)iq0wM(z9r&^d3
zw}P#OHi46&UO*Nu%K`)b*d0yqvKT+Tj(e%(Lr3OpgKX*ShfZ=~7LIlPIcXZMhqODB
z`XCiD8fKJ7vp(rEA199*ltv9Dh1Vx%=gZ*9V0fsqq=BZmcCNmFIztsDS}|NEh46nx
z6D?WuA=c*dUiH*K8oY*IV5W(DZIJ&T!4kK3$`43Zb)j1AvY`qdj-}RxC!cWQ|C18H
zf8hjNC9$C~M+3h5LzmtcE-+)<xns|8nmVVfASNDs7rfdvOZ9J|1n_UjyAw(rrts7I
z?&m_365=-i+m*k9oUFPoOeFD5n3;+gkuC*eFYBDJoY>pocVOT#xP)q($evu@Z~9+(
z@y1v_to1+ml&o61s?30wqD0>8FuZz4?T*Tw;anV~J(nF*7sfO^>2gd<j*@EDCsCoK
z5hzs}Ai43oSs$#zNMlecF+epSjF!ocW;!_-3hO>;f(Ml!b81^N5VKAwAcDqd8&_>@
z6XFcW<7Ql%7SO&biBtSR3GFaLHg}9YjnxZH24obvNXoX%%!Q#HQx}vorXjCU68k7_
zJJyVE1sU}^a<B&9sghl-aZRH`%laZRYPv{DbH0>QQ(@*xQKX-7kZXc#l&fMzW}sB{
z#MF{*yGU@^x%T_8ca|a{Wt{Ckn5>Pb66}CgQD_-od;Cc9M&Jfh8N2np?o?Ta??a^v
znqD(6A7>Q0`w*K&VTFjV{dyC<2@M;VVx91IR_1i|nos;KK?r&xqU(OC>RuEwi#O~U
zrrq%Nfj1Xf5+Crb@H8los*S4nL{*eXg}J1*(;9NY8`R{K<qT6*Pdn$*zX8VL)MaVk
zcaBsWz;2%#h7GGM+Xq@N)4rLw+ie9)vn&cOV{dnZjae3jY@LI`%6Z$vVe(cYVNvJw
zV0!fLBp$UFg_R@BXd^P!Wku_TYvuAn$`QS(HTUB=4}Yv!d>uPG-}$3H&Z{Md`Z^y6
zbm2y-sw`K(fK-%=LN@XhnIXXD^WO!mP)3b}#!bLEc{!1~aE`u}8>#BMm(#xmk(Ehq
zJ2AH#v`e>deez+O_I=8F+gZ|9BC-c%*g8UMeJOGU^`&(`k}~ouowZsdr$plW_DI3V
zywGu&y!Ds&MvNuFYI=O>(CzO_=>S*n3El;okACB-aW>BK6G$BKHGv)!lO={YtxZJK
zt3BzHRLjP*lE|}m_6y{B^wE@lmWvk$&JG~6O|uoVhcyUVI7kO$Q|T|dMbQEJfwBSq
zmW^-XIrf3atsl*0>5$fwhL$EaCe|j<;yn6Z%BQYd2y2$s5gKdhNMIb5*gA67TCu3l
zt2vog!tnhFy|t!ew^xf-_()XQ1zX*8>5coC-%>4m7N|G9i_<4?ze&A&?XtK0o$aa_
zyyT@d{wH$*C+O-yZW7VWq(_{fD<JZU%<L50nX8tVx~PhP-)HPu?V*d(1C1x~y+;)(
zsQN?z9)TW3M0P01=-9JOAG^50&i;)In<Q2y4Ih)+P#0S<wAM0_v#6?840QPd7s^&8
zl3C)>dkh2ng-lc?{E_v~NF&C3y7g=<icu~~n8-hI7ws!QhM&mOZRl3&l`kLaXxo(A
zkp)I(9|6Ky#(spmh2vQ=T}k6vXZF51clFrr{XXo^+xz*Xaev<~?HJlMJ4XlzaDGU+
z*)yN?&8>3eNU4-?r8MH8%dOI=hb3)A#yRVF(v6x6DIO7Vu+hJ`VPEFqQCCc`X&e<<
zJ)$V8*6VF*gs!;|d?I>!+$w4&eMkKazpPHjK;?hzkK*T+DTB6b3wz`|s}Bz9AN#C*
z{kG)j3dEU9uX>vMt?$o{QC?QkS!q2c`R7Xpbn;rqA(_NaALXV@YiCd1;CZf$$IrkZ
zP!Kcj4l^5&kv#t3yDU@3+KzCM$%>W=qn*7rdE_06+@Z5UBn3kSccQ+%r_+wk7`;yI
z7ws3HuuZ;AGMBQ=kGg?y{RV!Z@7p_hw3j{;lYQ*UF7aDA`z02dz8yBt)8a?3-*`?I
zTBx}^a8=8i%K{;LPFDV9dQ7YNzLq`s#v6+3`44?(fx1qpX5dg*C>3SboevNPuV?JH
z+v2CL1O+aH)^hgAd-Cbj2KdIgD7yGeqy#Wr&tjAut*+2hyf<>&V`R8>dG^<SUt?j2
zpNx~N)cGJ!JFQYJ{xHa}U1fx(qId;dQhB&h@0OgCN0zFd>cxIBHMk#^WhTt168_`^
zIb&J|IZ!zDIj~d62_$_FlSd^fe_e=gf$N&UgY?t{g7@cCF?WA7BkyhAy;O@gi>dn<
zvSY^v-|Hy8^qO1KI31t2HusI$F6fG<#<1ePTFIG-^ys(?p&^~DG!O476Fxd9+i+G3
z(|+R2OSQ@^inh)-wB1S$DV6)FQ=_n1e<%mxzY9#PmYdyFFJHfN$bzMRte0{P7mi#m
z=vs;H2vd)t43VM*m`&#}%H;?K#p_8L(?Y@V5kUi@Z-*ENi%i-tDL)vL6+gv3Ih1Nj
zG4)<t`}teum8WaVnq6dmY=J6XJx?e7Vs1HKawi)fE;!>kz4i_y@$KBb#HSkjq|E!l
zQNlpQl!tteD@`iL*;c*4h8R>G=j1ojj7RcjC1U=%k_>2?G?H}Im?uKy99SzpSB_P>
zS*<R9c`Z2o=c`@hM+c#I6QqY+Wc#hmHGV<rBKQ_MQ%zRScr;pQzGqMJ+6fhHe(s%A
z=-n(91Hl;Gq^;5{rHSq+Y+xu#<uK#V954pdIIIl#0$z<RHV&JWY$I%jerQ0nmz;Dj
zV7^bh9$xgWJm(nCf&C>BG8k>CxwYySyZEahLv((WgGG&gCgInWdN{)DMOc66(&!b_
zl5x5Z+4&%?@4FD55(#~yxG}!8wULk~4THHaB!t~wkhD$f6xUK6Eqp0#7{oB`1<}X=
z-hr2F-^qA6zIQV`R<}j}z>w~4R@#M5KfIrn!xBVAM(Cq5km|Z|N1QhHKKFB$Hj#cp
z#LkhDUA-4@Y#ekXbJ>#3Y$Ck9lF2!cuL!+7fMg?k8yCovg;K)}jJ35EjkxWK&<Vz8
zgbLypaPQrc{Gd;-?O1O2jP<?Z(YcHSOkTqXcc<RF^dWu)$*N%T7n*>kE1_Y*ZF?jS
z>(&+2CXel}Hcz+tYv7d*))^c=tKST54$a9Vw8uJ12<CrCX@-c_bP*N{9r`i8+vLM2
z{W5O_dpSS->`mvajB1CTV;`~(K}QwVB*nE{DN62+XL#4Q$edZ*`s8sLU0npwx$cvc
zF+iB||M6&I>AJS_a%2kwB)piFQ=@zM%l(U2zjlzh8?fmDMdu5KI0Ua>EY)tjlCgTh
z;0*KcdmMrz1?psRqUm~4ifk_4u@x6)gl@HE6&RY^7T$;wEpW}bZ-v%9Z;&Ng(3enP
z9I^DJsE*n$K}h<X^iu74y_ApnU(Zj~+!W|^R5z%{HQjzKnTF1p>AaMai)}a1f*w=;
z^&~T76F4m^K4IGhpB`!6+<(*=pL5qyoLWo~nWU$dBcVSm0>YIfz{#oC_`CLp83_n9
zL##g16Dyf_ovroVoL$_-t)1O$#JrpwGj4QUZ$;77Z!*WNy~Z)2nQ~r(^99fIqQT#7
ze>yp&jwCh+^i0kuq*lBXd>}7hKI12A%+UqkC0WikbZ5|mGd%r%N24+WSG^@!FX*q5
z3r1F8FTKXcsXYO3t~fWR>9+f1ECMyn?7~TI7X;;1aW|HB&uYyP$*WM?Uv+ok#rTcZ
z-ApHc1lr@8_7wz7augP9>%!lVGZm0?Y2>9eUAi)ffRKk&=6jFN@R0#iQM;52Ho|2W
zT?~BSlw18DuVM^_vQw*WOaeNW4f{$~@?YHQDUgj-U{nBRSz!0mnqD^yBy=tqy_rT^
zk$9)As&Ln~4$HXw93WdS19cQjEv$WxW2FM36+b6bwRmrnN+(%CjGdOF+2Sb4-D`f$
zPiW9Vw?>xD&o6t9^?=~(@|y2xGn01~X9j&VfAMQQXceNGS(MAnLB}J?`*P<a_WMhJ
za_?2oe0<KBwf5b7uIZn9d0Im*cMwVXqclt|rgXYv>S7Y7+DGi-sV)~2JJq6+?6_mG
zbEp5=#nn!=wfLpetL$IpWL$x`EceMi|7YFK>7>H^=bsRc1SNRd9f@Km-C@LOpx~!X
zCt_2W3FpWpfGa`K@ci|T1c8|TJP3%L8E3}K0@c?hA!P!cl*CUj*?0+d(&=+JP6^m)
z5F~_yrjNuc))D^q?o_y25`3q#64%86<_3Yh9K}8CY@BSw|25<(Lbx*Gm`HA12{*II
z-%J>C`KM-&h(so%0D)-#65fIU4l2q1&j~Jt3H^!be;?)P<ip``VoF>k1A*xNGD@is
m&R>%2bSZz&n}7M);Tk1*PG_2yWGCH1;*KPFDWXJA9R35hA}v+`

diff --git a/assays/GC-MSMeasurementsForTheQuantificationOfSqualene/protocols/GC-MSMeasurementsForTheQuantificationOfSqualene.md b/assays/GC-MSMeasurementsForTheQuantificationOfSqualene/protocols/GC-MSMeasurementsForTheQuantificationOfSqualene.md
index 115d371..27b0f7c 100644
--- a/assays/GC-MSMeasurementsForTheQuantificationOfSqualene/protocols/GC-MSMeasurementsForTheQuantificationOfSqualene.md
+++ b/assays/GC-MSMeasurementsForTheQuantificationOfSqualene/protocols/GC-MSMeasurementsForTheQuantificationOfSqualene.md
@@ -1,4 +1,5 @@
 ## GC-MS measurements for the quantification of squalene
+
 Each culture (1.5 ml) was sampled after 72 hours at the end of the growth experiment. The sample was centrifuged at 14,000 g, for five minutes and 4°C. The supernatant was discarded and the pellet was frozen at -80°C until further processing. The pellet was extracted with 500 µL acetone, containing 25 µM β-sitosterol as internal standard, under agitation at 1000 rpm and 50°C for 10 min. 500 µL of 1 M NaCl was added and mixed by vortexing. After adding 250 µL hexane, the sample was vigorously mixed for 1 min and centrifuged for phase separation (1 min at 1,780 g and 4°C). The upper hexane phase was transferred into GC-MS vials and stored at -20°C until the analysis.
 
 GC-MS analysis was carried out using a Gerstel automatic liner exchange system with multipurpose sample MPS2 dual rail and two derivatization stations, used in conjunction with a Gerstel CIS cold injection system (Gerstel, Muehlheim, Germany). For every 10-12 samples, a fresh multibaffled liner was inserted. Chromatography was performed using the Agilent 7890B GC. Metabolites were separated on an Agilent HP-5MS column (30ml x 0.25mm), the oven temperature was ramped with 12.5 °C/min from 70 °C (initial temp for 2 min) to 320 °C (final temp hold 5 min). Metabolites were ionized and fragmented in an EI source (70V, 200 °C source temp) and detected using 7200 accurate mass Q-TOF GC-MS from Agilent Technologies. Data analysis was performed using Agilent MassHunter Quantitative Analysis B.09.00. Peaks were identified using already available EI-MS fragmentation data. Peaks were identified using characteristic fragment ions (Bhatia et al., 2013) and retention times of standards (Squalene: mass/charge (m/z) = 81.07, retention time (RT) = 9.5 min; β-sitosterol: m/z = 107.09, RT = 13.6 min). Squalene concentrations in the measured samples were calculated using a calibration curve with a squalene standard (Figure S2 (SI)).
\ No newline at end of file
diff --git a/assays/MetabolicModeling/isa.assay.xlsx b/assays/MetabolicModeling/isa.assay.xlsx
index 878b6335f73c3984cb7f53951bc9f3d46b0f25a4..75fbcc60b0016062149f32a10567453391ebe5c7 100644
GIT binary patch
delta 1911
zcmZ8ic{tly7fwPoNE$n_2W3==T5B6qOQlt*q8`KdSt^JiAygw;X-P4bY51x5R2AJO
zwKcWXmQk&xw6%O_RVB5n7G-S3n2DIqGt>Led+&YExzBx`_nh}En`WEAU7dx5#Xuks
z6l6-pvf(LUAwB|3Flra88o`LYi<b~p0kHtl5)iUNs(XZ)ur8b*=|#`27s-ZzK-)mL
zur{rOx30_JDMb@8cETR>B?Q1Mbk1^qc%O6`<ajMmyS37I)OoVDXb^!Z=-FQQ)My(U
zyZWxC&lj(G_Lg*Bo0ili)}dii^zz4@wR4UdfpLCIo~s%<=vGGQxcl0jmD{28hmsH~
z0JOgiaAD~x^+g%GC(ZV`>y1XG-{ZO&)9_F9*3Z0llj{(F8#N4Q29(>jx}Mi}W}lg=
zkZ!iItH#&2t+;6Jk1jbs<rJy%`dZ^yiO1;W)cwOJx5kUK=DJp2M^u{7@KM7(hBH$?
z&1YQLz~*`*&yFC+cMfhQywr8k%}y)Jew_HU!pVEUqCR;QE@YSf!i97G#7^&-g9I8U
zZ2l&7Q)9B0?RA^(KnU>}PA8p1d&f*^CD^R}SVMdf)KKAT)|&I!&*DUObSk{Ask54z
z7C8ehwf=0c5&+lawHfF7_fG{Zm||N{No$-`;|8>m_juAT#@FJk*KAdPqeM<y@G=(z
zC)ft|<X=}P%!#HrC~0A7dZI~-PGeG<a0PYHF@0<9xq>>_n7$2{Tu>**`n_wSoIAi>
zzdOP1XLzxAAxk&>D+>%&;p6K6d-grKBo1{dj<e!lLc6jL<;NnGTt#65->1X08x#_8
zBAi$LC0Qs;=zC|lHWiupOoa2+-}DNsUuh#TNmRDw5cI>xG?(ob6x@!sITs*37jSGY
zfJ1#lr+P7{d6lYbo;Cwkvimu*yn1dI*P;9u6{vXeHJyj?b%aRL8%IQ!_u$Pk5yZt}
zgj`pVXICMNI=LegYwmE;`Bd+y583Fu2veq<ZTpg~n96)GgCfI@DKyAE>}cTIUv}6@
zS!93P*bLpu(>cB}p_|raws7jg^q29-&dY^pVw>N;s@y9EoH0lSgFs=zAdn2d_9@}$
zXnX)U2<IL{4kd;}8&D#`ujja&ergCyUffRm?n3Sn6y0?s)UKTF&@u3{kW=OA5ax?Q
zR9Y?Vbec$FxyJ~5?KjKV?R$MO_hq+!aO$V!=kYSy3yN9c`Y*MoE4x2!78)=66I_S<
zU#w#;=Ksghp>Q9oIM19*Qll3=I0iR)<YR)Ws>LQDZV@%{A0-F`iDu7pMyfnfcz>kl
z@X$uyX`)3~=0(!dk`BW`3+U9TdQ{Nt*s7B?3rSIz{Pg3`Ka|^NwpUFhq<7>TN9fT?
zac$M*XRc<wDt($eYjWePtlI_saPFLJgLC!Wi2q(K!&D^<N|m;I1(|Pg+vAI!8|JS2
z_72!xS(Kx|f`c}fuUP_O!^$hq4SVmNnB;YLA{r&K{a3Cl&&$kXAH>Foq*r(PrdjKE
z?YPT7sUI^aM7?1zezx_{9<}f?2wTHB++h~sB~B&%G^ozTx86oBh+=jAxOr=^MqFGi
zcqojeweddfSj9uJ6unE5Ooe%m*E2?vJ95u;zRCpJH6x%By5}`R&;}8K=>UjAh`@zR
zr1lsesY)<y*L^HEemD2yD>}h<AW6QWI8vZ1nG_j~4kVF-cICY3)=g|RlxSMl)8HjZ
z7a<%`n20tO=DHYR@J1N=efFE&W|PUqkJeC!sezGKuRc-KurnPRh=dkP)?mi7+o{4u
zkLBDVLU7IAbc9x9XO4fpr=h0oQKKFr&5bBkq2J^k(NZETPtlx`A_n79@KPsLc*mZ+
z>(tB9F@Gxuv#ItWDDbNEd!uAV`ydR_<cy)@;twh(LUbvl&;w>9nDBjuJy=X7)9Hv!
zm}K}^g`CNYtB)97$j66lvYIz%ap=R{WDl$&Yti<eS~s&Uc);}m^{g@`SFDg0DGsZ7
zIYg+8VYyMWO5<|!?1%0&_Bt(mUWF@<#2_vnZi&)^Z(7w%s*m-sQyvU>9_=~cdPz6=
z;b1L+WxT8&a)7z>PDyl}ZMnY5JlQx}YkV2Hjm?ft(wV-rywc>&2v^R$A7FA|;=>`1
z%lH<~@=IB~>cA~{`a%}Xst_jA@I~Ygqpf{kwG#}Is(jhhz4>rZ{(FIB!SY80m@jW8
z!2in|2yhdr1gI$>1$!$6M*$`&SbQ^6o-0_W?dtq(=klfgYpDPzq~_Nbm7hQbT^)lD
ziU>lxI)foHpudM4kbqPI&jR^K4MF&?{L@`v1gZRY@^Ptu6wtTHM--L75rB)Ln&3a*
e*4@|NfIw<Mx}v(^$qIf(Inbr3Az~)K%l`?4&q99y

delta 1879
zcmZ8idpy)xAD&^BVVg$GFlHv2iJ>$ow~>2j$EEDlOOlE*a+z@%HbiDANtVHH<t{9}
zC|V7}jO()2r6{+OKAUBValbV#p?$}A+t2%U{&~(h&-tFu`Fx(|Jl{0KWdqpv4w4XA
z5C{YXow|Ff3KkER6d{lS#_b@x9t_{z=#fwn6Y~;kVgf0tvP&334#7kxU2E@Ac()}$
zpjLneAuxX&UDHY##gL5Da1!O$DK&OE`t-cjS(L(KiIW_Fvni}6IlQkd7=ovgFy?zV
zn{rojCM%Qnp1_oSifuW9OBHa-y_&T;U&L=dLMHq~z1i+Ilo;CpwGQZpZvg$Qhx=Mj
zLItO+(Ejm1U@`CRCTC@#ZCH9W{rlOd>5DWeCeihS%JfJkp$k8sIop-+>#GINQr>-c
z8e%l8s8-{yB9Wch<on*Ew>r65`t{N6I@QX$X(<~TRckKsR$3{4=0*J_Uk-hV{lK$#
zJ!>x3X#F&!;-~VtJ;6+co0~o7bKA*>SM0}?u;<MBi?ln5j~6sk>Yo4Ev!>k@c)Z-E
zhq+p@U72q#!}UKhPqD|>)K<*4D+S9DPb1YL%vLEi0ne$t%1ef=LGDjti>E#yG2Z91
z{Dp|IZpr!OmgG&SKPo~ys}BK8bVLR&NnwwnRJ+w!aH>kk7H+!r7o6$zl1FaX{?_`{
z@X%Z%_*jqGJ0VF2Hddk%Xx@9__M#$FMQ8sc(K_6LRg0ReI1#SJs>M!HRal={84(Rb
zag!7CTU^@K#S{oKa{Sz+4c9u;qRCR1vLsh5*TC>865u-Viw3a?y!ZpDEk-f~d(~KX
ziOYn{(r9SEOw<F96Cmg@*{BkaRxmV8HtLawLCo{mlqOSMPdMyp{HN8IWlZmVUU1=D
z;ol<)k&Sc@lcn^jyxCKO_eNrZ4t^|S@%$f2g~d5nJHINQ#~KWC;>=H$T2=gPCcTuf
zX+69xcZhh@D(sVHXF>IlqgxcJgQ=D4V|43xZ)<i0$F+YCH+=AE8p{!dMRZtbxL3K2
zNDCcYIKg>u;xbm5&kr<Vo0;7f|L1Gh+09l*PcR6i4*`J?BDaUrbV7VQ8C0*cp$y-E
zYa!a<bXq##<j`g**S-*akGgQ(AC6BeM)+Fl8mKM(6`bvu6SsXf%&<Qy(#Y0^4xJ0W
z79F?-TQPJ~sk!n%Kz37DsehBJr(Z)ae$%m4!L$!lB^`u61XE#uG<-My>^%X$e1r^Z
zZxDW7)PxKX{R*<o3S{!~en3Z&c#Q?OtbIytKe{EfM@8%CliSYIP54)vT!UUIZ}g1~
zIN=h=gj6RND)$EKwiEs+qAAhlC3{cI@pyF7HD_kaGfkJm0h;q`a@$MVz!Z_^UtKcC
zbWeKh`fq-@?93}y>e}}03g%0L%9ADMGP{xMo@RWH!^o#Ff!?TYwVjv1(?9*O-rE9M
z<9%r!*Zq2v?<HTW-TSTA29JC>k#_NC{*wt@tmmu}l#7nsf~VVu$=vU{V}_Yh*UW~z
z#wGcsb-qpc?CTU{zOnGR+}C}0PM`hOPF?-Cc#tC_&Y5&`Afb+Mc9K_RnXotq=zLKH
zw39YKFLXCdgixN8I8~m)^CiSFb5?$rxgq}q%-o5WrjOkBmqY^cMG>=4B%oK|)$bXB
zK_NO<0~ypE_43X<JKd%$*RX<2T_^((6huiGq*UWDjsh9?o~8R|58rQ8?-}KrW>*(!
z1elnx`8P=yu+Q-8;F)5V5P2uO{Ey>q<eEI7R(PyIBgXn6M5{X1xa_x7+h`^b3^3?p
z?S7Jq>UAxcLm3P`4HFyS%=G$R`w7COLQ`%Z$4gN7=b5(ke0mIl68fEkB>{D81a-$d
zNUgEtuUjR?!$k&ixhKHtnxXpnzlRRuhx;!QeX{hZhpG&NoNwTzg?(LCuFgZn*_<<@
zOh*fs7f<F&3;)$qPD(LVFlByFMET`3mo@gMcMHx}j!~|FBXZ`gRk>}ije=(TB^Rqe
z9Tob5g~3!M8D_HCU^=HYVpYN*;|lZweI^;5D*a7J-SXr+vK(AEJahT*OxW8V5Ps3b
zt{#@3xi-ZgxM8=fW*^X|DZ`&So?k*qBd}jQoJ{=G_v@_cMlHXqK;gl{_~nV_FVcw{
z1)GPwyPN;EO6Fq4?kF7<BTvatj4MjoVnm}cfCWlfJimal72_``<F9(g6v|k2N9M2p
zsYvPn4me<?eDKSS*dnO-4~P0t=~R)az!C`1KTQnCSH^(50G={le0)^2x&v$~WB)1E
ukpCb5d|gaIW5A~YI$Blyp0929<uxJ%9-$A2uk007BmvWCyp*ES4*wr(ls6gx

diff --git a/assays/MetabolicModeling/protocols/MetabolicModelingForTheIdentificationOfAmplificationTargets.md b/assays/MetabolicModeling/protocols/MetabolicModelingForTheIdentificationOfAmplificationTargets.md
index 7532025..ba46f91 100644
--- a/assays/MetabolicModeling/protocols/MetabolicModelingForTheIdentificationOfAmplificationTargets.md
+++ b/assays/MetabolicModeling/protocols/MetabolicModelingForTheIdentificationOfAmplificationTargets.md
@@ -1,4 +1,5 @@
 ## Metabolic modeling for the identification of amplification targets
+
 All simulations are based on a genome-scale stoichiometric network model of *Synechocystis* published by Knoop and colleagues (Knoop and Steuer, 2015). A modified, extended version was used, kindly provided by Ralf Steuer. All flux distributions have been calculated with constraint-based flux analysis using COBRApy (v.0.25.0) (Ebrahim et al., 2013). To simulate phototrophic growth, different constraints were applied to the model of Synechocystis (see Table S5 (SI)).
 
 FSEOF (Choi et al., 2010) was used to find amplification targets by simulating the transition from a wildtype to a production phenotype. All isoreactions were excluded for the transition experiments (Knoop and Steuer, 2015). The initial fluxes of all reactions were calculated by using the objective function to maximize the growth rate. Then, the theoretical maximum squalene production rate was calculated by setting the objective function as maximizing squalene flux. Subsequently, under constant light flux, the product formation flux rate was stepwise increased from 0% to 67% of the maximum achievable rate, while the growth rate was maximized. Only targets for which the overall mean flux rate from maximum biomass synthesis to maximum product synthesis increases were chosen. Additionally, only reactions that did not change flux direction during transition were considered. To confirm the results, flux variability analysis was performed for the selected targets, by stepwise increasing squalene flux from 0% to 67% of the maximum rate and subsequently maximizing biomass synthesis. For each simulation step, the variability of all selected targets was determined. To visualize the flux distributions a simplified network was implemented with d3flux (v.0.2.7) (St. John, 2016), a d3.js based visualization tool for COBRApy models.
\ No newline at end of file
diff --git a/assays/PigmentQuantification/isa.assay.xlsx b/assays/PigmentQuantification/isa.assay.xlsx
index 16531865e2bbb4211ee35dc94773ceca3c1a3ab6..205414e723dc21370243df04c056da4612ade4ad 100644
GIT binary patch
delta 1888
zcmZ8idpwi-AKzv)!ZMfHXs*r6Wl^z>NN%S^Im=OLLQcbEa~aOrS+v{>i<#R_5!EZ#
zTz<n*=y2pjv~mtkozYH69AaAT;mjPr*Q@jV^Zq{1_x<^Pp6B^|KJWJ@n-r`H(L)Zb
z1ONaa02`)fy-FHTPKw+DpuraMTY%8*2hTw$*+xA?Lp^{VM2)umB9N~shuS7$!KNzG
zNFRzD>vcK^01$DhU|T|L(c%nJy&CjY6Srw?p#|?T-c&LO<<O5T<7d|DBvtQg*o)3O
z6|0Hu76zQjhn3`?G2OLm!VJypnL+Vgq`{2DR)|Z@v#+@yz(^L4G<D;g@&Xo{q*YDF
z#nMi2$!g!9SR5z#OlMhn`+4lgrq9{+3yoYe^3Pd_tm#%Jq^FLF(}h=tRp94i<qT0|
z^A8zGIpt&1wL<^U#h0UDj-9vW)rInN;-Ya9;<OMkx}mwcQN+h*aJ(n-p5X9(%zJKr
z*<n5+qJ9*Q)shk6$8n7DzW(C}(&e(^$B>6Ki<(pJhK>9OGhMiPIOe`mPAh7ynuMD$
z^E+#)6Nnd_b^7ho=W8nb>b^#1dgKJ~><<^xVv}t$hYR{B>28wF#y=Q9RYc}eP|nk}
zgITs4dtxU}WgXjmdKU#1*cY_SN5_0VS76W>z-;Y}V!g3X#w{@<QU1tZJRJP(1ir~)
zEmXt-fp4lf9~EIM@J$h)K}FaIdYzf362|MB{vV^Q`kS-CyzFH{;nCEdcS3n}4AdI3
z;$C;XCQYB+z63!d^%75j0`?V7#zS%x<8EHKvu@CBB2GzEl+!1eii;8z74^H##Epqm
z5RWBq5Px}cAjGj7^|#Q)WTw<<ktjl~4i&!=E-N%?ig<6Hy>Wd|z83;_*2A4!5><Ar
zckX8rhbm_^Y?{k<$6q5RkxVZujT$YL)wLLSk-klsrFdmKg;wzz7>90bo+_l^lAesD
z21}^*_Ym}X-QazC$F+4e(z4VAK9~<}t1OJUu$d-IdC%`CO<az{ns0)>=tUpXV4e*P
z2mttl0RRnYYcr^p(Ud@X5c!)JdT4k^^nM17nwNXhqx0yV)VYoHpt<kD<kgOQrCaO2
zLjKMa<I%qd2Ri;%#BSJpb5gS&oxE7c3qjBIwH~(~3F|u2&*C(oCvbNUgiw@x-TCYl
zp<UbK_nG#Euv{B$i5%=U`m7o!q;!DTXFfN*%b>iRD95I<(PZpUsQ7I^O@2_d^qx|G
z*go{we9=pNm5>x#X4cAhKL6Klzoe|66O0Xcu19ze&hVEA%f>L;UnT_buBM|Uzm|SA
z_Ii~##;VL`2``5Kadn<<v|AkbOv0?Uv3nlumM~D0iqTn5n9cb!k9I!6;&$2k=`ahk
zi+Lj`X4jH)LHXa9wxizn+kZMXv+J9RY>d<QF)laJocOto1@eM3Eb~S?rIsR^8ZQ1Z
zNMaw~1DC`NZcbPf+GK7hcO=AvJj=ZwMc1WRyykNJof7XjMWW)W6s}h*iF)eLlb#zm
zM{^JO?BPBt)~g5TxEcBIG=6xBaDKEZ-0yaU>#~z^z)pn#TQb9~hZxJ`<rU<Sf^3lo
zEe6T-1q<8W@q^U@6}NQ6Zh0LSz}3{yV}<`>wWoE-+)$LHUIKM9Akexh2zg4E25*L0
z{+078zs-7lZrUE=`ffld5X><2Jl{VxgkEX4s~F6Da`zgzq*=?07D8?#B}0uPyK^r*
zJY!{~i9h%v+$$VbgJ~tv+V6nj45N3j@L+Np1?Ik2<kT_TZJuj_`%_EVp~3eOOIyUp
zyo}Nq=?7&ire+SMmQL+G9%9Of2vx;KD1*zgU4Tk^*~bnzgsD;A)@WJxrTj132hnWi
zz-e2ZBwJea(!D*A6?2aF^?D0_3LYR<GEeIg@|B7scPlqOAG%Z<Q{lzrRQ-@!=rVM#
z<>j$i@q&u3Fa{cD(H>>4vU<3YHLm~mMSWW3z#04tRbsqpYTaPdrHVrz^+Qw(HimT+
zN9*mDRtwx)Mw$*?g?#qR`7X(1BL3s2R#G-qmt7WUtvWVk_W0!J8rg28`Z8+Zwo1k<
zhjqAE`O%8P=D{`jodU^xz$X~va^<{qgkq!$4&5Fhew}8_w#1vjkH~68fgh0JEjU(&
zgYf+_{EX1y8fYVAYX@yN8K!94{>K)2wQcpb3jE(`m1g_*(&QQ;jCM}cZGgxoIffEM
z3zC`-5TpV4zi)A`B6NU4?k$9&jNT!=E98zKba#UBwlDyI9C49IkBHoIt}lXpdfs&g
zB}+dREe8PX*-0+L3*4`fda}2awV{+VCjB95UvOYtHd0@fs1B(EEaCPc4HZn`Ta<qQ
DM~)yW

delta 1868
zcmZ8ido<hG7XF1ygw===5~M;(ys91@L_Jz!+LBhKYjhMPoe@h(1a%wfL)u`}n2Pw-
zqZO24E@|l_8t+G=s*Kd-G9De%qQomSZ5bEsT+-F9WzIj}Ui<9*?X}L{=i8}H?;R2T
zWL2mJ003~{*tKI15NQzAO$75GCR-?KgdjgTq$)<ri^p)3PFOsRe$IAVqDWWO=u@B*
z)Dp3o8Cd%hr6ENH03;wC>T-lpxUzuJxvO$W42sv68;RuC)wc(ce4?R;=6Z|ZU4g9n
zx~7+5<r=qbj|qRKUKrkL{j4`_{f=(>&$P=OL4z6GCO9dk8wtvx2AqA5`ge&ibEoMr
zo4_ffxzT(=7k)8+p)39V?@MPY8gfJEsF$qLTJvjqHlqBNv#+VoYcgBahU`Do;i~KA
zVBU0^wLBv^yJB*_w=wjrn4u6ApLxD|Q_gi>^^33iSt#ET$I-dGE<GjaIAZnAcLI(5
z&b_~M?=zdbOBPvmJ)AM=UwgZl`-R@pm8uWbMIP$)(R&stzW7JARSO;HI4v7LT~oIE
z3guBu53Qj()JYN>a*ta!JEdzFaq4FDGHSeAb@6Rm<~lqY!`^$d4+TzlUSuj@SO*NQ
z+mwf-8J*iOnUnlt;x?zC3Rt@&jVp->0%zp7)cwz8qAh|mUT(zncpjYcM$gE0m&}Hg
zNaodIWK~{?*1TG*jAq39$jf6l4W`Pb7dPtZ8>h3Nx)&$DlX=&Z@(;8ew4*4r%Cwr|
zBTHvYp5fm(a?=~qjQMTO>I7dLH$)|jkYAAm?^nN6O!Wfb4jPxrsS*f0TjSCls^irj
zZdQvM$L<Ug@i1*|<v*1XJHwI7@{+$tbuKnDsIH2f*}{cm13!&kjotmelGhM@2gXVb
zs0sL8xQKNe7N>d~s_?A3;jX4gUndQJ(6Y3#_hhYEJiA>pcr@q|rjuhWh;&YV5<wEN
z#ew}h>JtYZX7i3>u&B-h<{=M)M%9+dC&h7vyGK&<RyaMzE!fuX1KXxB(5pE-_Xh|7
z5WziaSPm%lYq!%%S#nFAa*dmXnA|86`tLUB)9#OdRY!dBG@HX6@|3@r{1y(mUb>P$
z#uS`dA{NT8M-<QaxD+S~!X^4avr#mbK4%Oy#1c?|;N<gq`;rb$h&HUuH1_z~(3;ds
zn$g_wWSB*q&FJvRex~u0<E=Ua7gBB+JfYTb^8E<4k}D4dK0_l}irE{Y=R%$)E=hy!
zYjvFD5q3|;tc0_z)+8)GT$7%Du<&rQ(|u`4$2$wLCv!N&w=5}AJlEs8My`n-VyE8?
zLbVGK-B0(+&!_DS{`)pL1mSCI7Z3&iaN)<tUT4Ft?aW(Bn4raAbt^AVlkOjEX2S7q
z_1bBA*mxv*v{>+mEk7qim{^^g5#_!ib9ic(`4MU#OoDy%Pkk$+k^@AC?{HO){qhP=
zIKk7V>4de_nG*{)Se(!yk42VXBqrx%CwbSD)xYC5%67;3RQvslRHChzm4$tNe_%^K
z0ylN!%TWh=;d)9DnSnRJltwwSNJXh4hqO(V4u<wUi27Dy%lrD*p`aNG$JuIG(>q=M
zQYDC@pvo(u73NkZ6zD|60wem?aBj1i^yQ@6t(sEv7*|)(<Yi(o_BZ@0WWMa=Iql<k
z?JE;OM;;Y|waX4o=2uC-Lal4KE|rh@-z0%?U_4{IBT7}ztgg+_GB19gxvMvLVs2H_
zcbX7d;#S`$4xcF*JHcsREn-|HP!bN44-zmAqnIBfVojUNUnQ5j43|1;3A`X?771S$
zJxLhA5BHz8iM+XwX8FJ=HsAtYZMm<@GcaJV?3Vb%OU}^)CwuS7D@wkV3W-^6I&M>X
zn5cr*%I5x@?wM27<CO0q?1DuSuD*T9Id-96_00pIv+C=arGY3uTAh>WK9D1puvb(Z
z^S*}%Gv+f5_-bFBt9vW^^N1F5d3Zj|YM%8%3gF+k`ZOYn^8cEh{O<*yx2C=^?H1~j
zv-^w6DcJ;3@2|3qwZ8icxc}8ocHJ&snh2Y2{oF03*o&%kuYJ;NBHBaQ7B<>miB)JP
zB~GLFDiL8|2s&W&m9`(|8ztsqT>hc+e_&jUw|e>I6G8z1^<^Bk45S)pucil*^>=)x
z#g@SVAdzmH5J_XuHdhKn1qFQBMj&6`5b_&XrH{vL@qXocCG`B}Mp1<U0Ad^OHE>ZM
z`<aqxsSN<(%pd&YnXy}2Y8z!>*Hk+#Wm6#tssNz1jl>_M8sL<Ll*70gGr3u8=e8IX
Yu*kqzS?IBWA%q8x8Q@_U^j66K0c8;ueE<Le

diff --git a/assays/PigmentQuantification/protocols/PigmentQuantification.md b/assays/PigmentQuantification/protocols/PigmentQuantification.md
index 685f426..251dc24 100644
--- a/assays/PigmentQuantification/protocols/PigmentQuantification.md
+++ b/assays/PigmentQuantification/protocols/PigmentQuantification.md
@@ -1,4 +1,5 @@
 ## Pigment quantification
+
 Each culture (300 µL) was sampled after 72 hours at the end of the growth experiment. The sample was centrifuged at 14,000 g for 5 minutes and 4°C. The supernatant was discarded and the pellet was resuspended in 100 μl water. The samples were frozen at -80°C until further processing. 900 μl of 100% methanol were added to the sample and the sample was mixed by vortexing. After incubation in the dark under gentle agitation for 1 h at 4°C the sample was centrifuged at 14,000 g for 5 minutes. The supernatant was transferred into a cuvette and an absorbance spectrum was measured from 400 nm to 750 nm. The absorbance spectra were divided by the OD750 or CDW and the amount of chlorophyll a in the sample was quantified by the absorbance maximum of chlorophyll a at 665 nm (A665nm) using following equation (Lichtenthaler and Buschmann 2001):
 
 *Chlorophyll content[μg/ml]=12.66 μg/ml * A665 nm*
diff --git a/assays/cPCR/isa.assay.xlsx b/assays/cPCR/isa.assay.xlsx
index 9d0a7030aa4654ffb5318498cc846aa807de695f..600018ee5c5f5b57233bff264af43dbac67f5528 100644
GIT binary patch
delta 3313
zcmZWrc_5Ts7k@@ImM|g97>1d#WLI{QH`_~=P|3cO-7ttqX)0S9%kX5$u7xmJqb5tD
zMbua#G)fpt$x<lB_Koqr@7Mc%_m6Y#J?A{<ocr8!@A<79yK2T|WwvWK2LJ$UfLf$w
zHCGm77lVWMA*gL$`vwBr5qx4nG8J1a5=@2EE~y>G@!c}q3`;v#eP!hvEC4XV4*tOk
z2MczK;luKNeiP;+u^88b^=r!wnr5{6!hTq4$dMJzZ);VH<x>?&KlKr%^lL5hsMKk4
zna5Lw_R2LXfj=S9GwOvyKjB&<n?Xg#@l~)lrI@GHm~GnPsIY&0m<Zz2_2gT(gbh<}
zIebaB=Ui4-j}{<>XoLlrgC0EL=09mBb~7o;_><0Nit0D!wR@--LqdkV{D^9Zvb4i1
zy=yaBmxs9oox*mZksflhgy^*U<1>|17vG=VWBz(=x!?Jyd*&DNXb$jGRQT8?KYcT=
zR+Er=ax(q7hUS~dyGG7Lf4dPY@!(qx1e|lKUg*h$>{*A4CHc*4<N)~!>tpD;+6UiW
z;5DiR6^c318j))x2aQQt=hI3EcTLLaqrFS(*STs*Z|Wj%1WiItUvP^Li&0A)&V1u@
z!)URsZXg1}4Nv^#nf7Y!P>R;(zOc!jeaPhqWl96*sB`3DZAwo3!X$D&BsVkiFkR2(
z>-S0T{LYUn<j{3{0`Y?&5_gc|7`Kpt#N)Imj<E~2NSqp_Q-4x@F=8l(ynIf%=P_~j
zE#gXh!lzhe@}&m1+fk@?r3lGELskRgna?`VMRpIO=VyN?UlYuCU+*J!sSje;F0r^C
z$WjKb-DDY&$sz*RNGz^$?NUU0hCbdh>Sy$~qGsLDR-~{8Y<ac_H=EFugmc3?e$V^z
z;G0F?jSp9YP)osJ*wzE#VZCp+Sv?<owX}}D_@q0YP3?YqO^NuC5Ijc%0)0<XU^-c9
z5Bz3*wkbhld_^oa;k=5;aDtC|mw;I|O0dh__D5>Wv!lT)nxl#Ry`RcQYHE_G_0ADT
z5F)bIyS!_EDE(H>Y>cWb(OPWV1a(+dVf!RYvrSo{=kNJFDsS?-4qj#z#tVu)9Y_xw
ztC2IReK_>-d40r*>j6XGGJigG6+04B-(T7|G@0(R(tCL{ZzFj5)tG%d?&H;Sp1yy)
zQ<#mmnH>&(GS)KF*ubZN3$5X+p`;@_n%>o=O;I<CpM(^Hrl0#R3=LMskk>`y24_32
z;S7UG7w)*A(oU0mJLkDQsZIEvuVdjsVTw;hsj%4lj!6-+<u*-AR@5@W>UcBHA$-}A
zKi=ELrLlVL*`8*_y)xR>C&Gn)oh!<m7tu<+V_N>Az7H2vA86X__@Q9%@Y#x4lEB6b
z*arHkiGOGKYPAiXFcp)z7TtT1M$OPHE5oi7tUs3%RhVVZYY;r8H&BTWZH^jRsOWCa
zsGonTcLprKR7V^e>YcpxX+m9Z9+RVTe&Xfpk9`B>iWEV7ui$j4Wy<mL(uN?*^4JsW
zoC6X|J`u<D3*r#GP}OzwRydcKiBPYyl)GV@htLx~;Uj6p9%aeVn{jY<JUry#T=>*G
zYf6d1?V>OXeS;ZYcCH6_1h24z9@yPYzfyIuRZ2otoyOySBIa#ekp_8gSaf1ols9R^
zwV|C%$Yl}?HnA#!kc+|IsDd9<ZJHZKObjD<-{J`Ixfk2X+eEANC0kAegB7#o@ECjw
zo7y}uwMq2xab9aDr{ppT(@6@`2_AlMzf(9eF$Bq(@N)b;Bm^lw#UyM943<}XiY*6?
zHRg;R$m=rJD&R_ZsXw4XyA+q(MO=i3ByVS|LKE4^7k?)%?oMvJ!EJj31KMFj3X|}t
z8xKktQh3yj1`~yzSR352rrbgGkcxOhkf^C`!ZpPVgxU!NigSo4pEa@c@#~1E?N3wr
z`qfz16O+^H-ZhcKpME!U6TZ|{h=*=qLO5TuTPUq#LO5Q-K`e&|K8_ai%$PszgbBq&
zc=&!T)~U85uF1~L)&WXA1zkG@Mc6`hY)z6;TJBZ8u}s$;Br@gmCDPkp>y=J(oyE1X
z%`^9A^h|#&%U5hYFr;qv>b8Pb$NF%0c6B{+%Kwudtb^*Kwp^IlZ0oPCi;-XU`YD}d
z*1&J`y7464>x}M}!F1t=hxY<+m!t~rsr9`}mR3Av@5HXH`?@RE4DS+tk1o3@_vmYP
z!Q67&FU<2rj=oioMKi@y-uz>OOYfrX%_yC-y%{OgO~0vuiO7Y^^ai@v-xnF!?n|K0
zUL|Jx$=*B9yWMTf@{b1lGP;dCI{@qlKt+rIJ}<)>_d$8ztC3$aq{9I)$%ixDwvhBp
zDfkB;>vm+ZUv?u6FiRMx=W;b~U>z(1s#LP}Nqpbh>ijsNC@?+~;GF7ONYpsPn+uDB
zK&(|I1!qhb)Q(d=vF=vmlPnj8fNrcpPRCu7c+?KwZ!xXvad3%62_WvnxrNzV50o3@
z`^|IA>bR|C-6R8nQ0G{|w$TG5xFAF(+t!Egyefx@+={{8p7D<90A*23LGtoV#mptD
zX5YJDAHjS9o}uJ7SKZ4Cp+%<6U{EfBR_LcsVClBC2&B@b@1Gd-d{@R|A|M?o8-E6q
zU1mR@>&s6#pu=%k@`QAx{%yhyU#bfJ(ZNxEqNA-?Un?oGNI{0y4qcmhR^K}NED0<2
z8cj)Sz#_fP!V6>JMkl@qdQEon&&SG*eifqTW_n0Ho+P!poW&N`d<~OVpH!IcN)WZ(
zbSm*IHP>0wE$6S)d{;cx)J!TZ+_Jp*O6F{6`>MB(lt=mN4e(k0=*58=w+?x{zZLB=
z7mG<P+9}KIkEqYHhM39`P0^3qBF)~`Z%wwm$|SswB%Ex7F3&#>7xO;dHoCChHZeW8
zpHB21I#A`Pu<oipPdQF`d3CssUhPlHNH6i95WpAOdJ*Pi4<*;GdWP2-S$Q8Q`Yh)X
z`XXAZ^WA}as$H0K=9oo)%X8Vi_=huziQuN1wSPzHhLy1W3y}u`){7Ri<Z|u-uTJYv
z5gfy2NU5JH)hVXy=3{4V^gw#n@ynAScq@H4+U|wX=V+WPX$;MAFRBZxM9xwJ1(7dJ
zH0I9G812o1l<t(6(ah?Wo@wZ_IcL5F{Hr?c81M-I<zV7WWMm1u#KNrAw>&#gX^H0v
zl&Pr}%HPr0Aa*nt5Dy{j+vTjivZ3J$s*8%@16!5%HU5%Ak3{no!i-QR0WV5T(mDM4
zbNrP)rwwK_snX_W4zn3f^ie64ZxLdaQ?Jml%Prca{fW=-T;E;zSimO0+oQ=L1||{I
ze$$O?tBm2-Jk%9v6UbYk(C84*a(lO61ZILa(90v<hxeH1$kAuR?Q%DzH9iP%>OOSz
z!wZenDs%_$|JcJqWRFXHA6N86)YMxh0_V%Ej^o^2LNtJIh$j7cP}iRaJ6a*2`X;u9
zXa|2RtDD+HpY~9a?+iI<DO@_QS1i_<`N*r!sx0!9h)D)Ve$Zady0`EBDnm<cB2&vR
z+{`j~f48Cg&$)$VE)i-d?2>#-upAd%r_P@yKH60sU)E=<*~M)YB@<WGU+-6{@<ZI4
zJ9Bdw!9G^4{fnM?tl?w5$`!VC%e3>+(vwj?mKq(1SdpX>cUA83FS5-RV{0DTtE7v_
zz5*`7Tq<5CpYzEobnDRCp1+Tc33h9nkbj|FJMkmT6T2mTaOdR2)tMZMQe^Tg5(v-+
z1!v9!QASK&kJ94$7w!euQCi~L5+>%@1pr3{06=KFH2xWitRM`{5Bi~bm@Y1(5s))r
zHX6fRwJ=sU!C~|vvHySI{_((=#DNMJ4AbU!={AJl8T%Lv1>!I}=@Kvqh$&ct*@?l}
zh-Nzv07PJwLVY{~JQ;8a!m=Ou2mjlpQPiXpp#bn)902(Ka=63hL2(H*GwdFnD=z05
zZ|^RK9oN5XNT9of2y-)xKoAQsS3<~ndo#^2$?gOQ0O&FP%65AH9ia#S@W7q53c&@P
zQ*sXqQj7?|{%=mq%fa}1oDq|e`)@-I<dGC-=5(Vmy&uc4sbbi`ezO1oGH4}<hT4d4
G3;zR@(YS{I

delta 3288
zcmZWsc|6oz7oU+Q6o%{uV}`K}Df<#aS;p4%yvdp+WEnf5Foj66{+jGU>9Lc2=OHn&
zL}aNHCSz-)j6{=nW_q4J&-=XhkMq6vo^#K+=XdWt=lpJ(?V>r(nH^$20s?_pK^C_y
zo^WJ=577`P1;goBKMaQaoS0`4V=xYwBpD2;LsCB(R?M;-G)bH0JD9dOCJ?9>xW%lA
z^UdGc5ag+3GHL>v_9^WeX2j~kDM-2oRF`wVEALA#sXCd{09v*e(<2X0Uui9O>qZTZ
zCG1!5CEj(9>bILpis@iA^c#YF113@*bN3ptu2|>``y_;lK<96#WM>PXNmXu~5Um$n
zbHpB2u=yaiHkTzuK#;RG2#K|?HeGO~ZTB6pyzjz_o275_E7WIoc@dpQ8&bMircY8^
zVAU;ahtFW$Q6H0HGfJ1%$J#G>HTiDUKX4h{&HfmpzH1p&b+`N@dmxS{YJbEwuir%O
z3wlvN<f6_*@$o^0%1xQHmf^P}Uyl>~waU+o>{L;!3v}69edNg)G@`M&YNH<~5Xhxq
z$tM}1vx8~$8+LE2zNFS0;7}9uX!Qdh)WbI0hr+usbcp=9CuN`2M=;`e_Bb!FJaFBA
z>#&HDAZ$o772+-y{2jj5`w)I=ZOb_?OtiOsCp;ui9kMW@Gf&Y_<X9*X^Vc1<kNd<g
zrYK5MFbp?KZ5AX|8HA%!n?-OWcd^tTshJTSQ@2RV<nOK6?~ZBAeAgE*lFqamX6bdE
zK7rZddc@Tc<XOA|A4GgojY(`v5Kr$>XOlw1VjP&9q_Rq*Str;cA2=I;Se1@MmN@r<
zSu>7ARyeEP9F9rrI(5PY!cmv7xAUURgWC;4`B-!?$8){Y*I9cDznYKRu$a6vcQZg@
zyDYWMr{ZwftqTnoUX_zYRA-uQ=^B;lSKZTL*-G3uoS|~bDxB00+mjhAY?v~)ixeEd
zq4GS{W1o5$)<-niOt80xPu69mnhT2X4(LfcJh7W&p_o}W1?JD*%G|*Xi+72159$5S
z9kz*b;Ac{y0{Sc}I5_&eD!|FUfu8caczxssP{?HTj1aQ7KJB9QdkWAY7xu&{{6s3!
zG9?q%J&g}ttV5lxubX}Qv?&}&D#q@h_TSY&V9QNYWtFmZXq8C!?oXpXT7F#qCQoc8
z_q5ij6s}tD=$Bnx&~S`?ANuNT;(c|kSvK1%Xvl~8RXajGuDH9bI&anOm`13z+78ME
zj!S@FZC4`Mr^9^aOE2CgUU<Cyx!rK~s(*vlfv7`1!GB=K@c5dwM8Qz`e-w2lo7N(?
zTKwaN3*@MC@3J#L_-{l9+^l)-aL00EGXELXVdaB%g5`?m#5LP{dmN*$6bNCceIENq
z!;Sfry6)W~Cmd10i!U-$6h&zcPl;&Nlj$_>@=bhLJ`{gIu<Do?A1Zj!dL2UvrlJM<
zpWhE_-D#|gI-qjDHg{hy;T^lLHnx4dc{Tzz8}kIEZb^RJbtyEuYZvG`Z54Vg($4A+
zGg8APt#4xih6b7OUnRFaTaZOoePfdBp1Y@eg*YURjpDonffJ7wmQI97tC*V%dS+#O
z%7h!QM~CT(eu&hP6t+{BRB4z8Uc6{S78OyH**K~otWY@C+~BgI7`K}K%)PjUP!d^&
zM82^iwBH?=9xR|4MkmHItS*=7!0ht7>utv{a&i!vBXPO8-*8li_=ZkITqNR>b#OG~
ziL*$Ae{BoK-3!K<s5JOR65kk)M$rkkn!(Hr9cYFGKi6nOj5HzfXO;qUL7I@XFLV+d
zm&~QcNdpTmHDtWUbpDu;<^ztzX9nuZ#K`!(v9vEjK`FJ|z0Z{YGE@Xr4bdI?7I}Jm
zL|Dss)R8p!O+@p71c~m|slQFNVGR2)qkZu4$|87>7=pwgbO{jzi8WUoi)MdYT7*@q
zmd#<$_TWRV-nyETGw<bn=Z`Wku?z{56ff_g1R`_B?|{V-VH`8zq=n*li6AC|Y-s4i
zrn*25Ip~g4m#w1^79+HQ5yGAq+Bgr_j3H+IX~dVoV`5oW0S&#M>|;G!D{yoe{oJ{I
z$hmvSxo^mM;0S?Ra)4c}DlPAH5ZW<Yby_GdwQ;uK08faT4YBSI>kOevn|2lSQ@Zh<
z`%Z1f;m6R4xIN#H_qKn2h<F5R<}v8x$h%0^a}c#R8$9ptfs1Lavxnn{(Ix(`zUakq
zmiyYTNnI1Z=5iu8KIi)4dHgqg;Y;AVL(4WP^kR9<Vt3uSgdZU_ur3(9;9}vZbgq+9
znHEZ5;PC^oVY?s<KgwR0pE@;K^PKXYx*bMkym~fz>H^VI7vO(Xk&&T_j&3p%(!Kaa
zB~MyH5(M(u<#FEQ)?j?5l<b@*W>D<0cTNWpWR|$Jm&e&f#oAf;*48V*O*Re=GTWc$
z%RjsLx($(9n5OP}ERQoD492J+1=dYJDOg$R9%feMK~@NZ0cRFL2a9*f+^Q!_drWJ`
z?JmW``JtskoWg9qG8INs=D8(y2{L@O$J9Y>)xGr#xB%W)cav`LTA&)(wA)xsP`idl
z$6t=F$Y-UbTMb-8XPWIriL9+^G(g94Z)1&@dulJ7i+v&a&NMtXiCE}uki_)D+QRSk
zo<Qm48TXgvOeXx&esT$}5;^6zo7X1RvQh{`iDK!K#jbNZ1HR_rzY*_Gu|z1NF5Ac#
z%M%9=@8c-W_6s}j^_#A^abF=gs-@PKXus&an_sq#Qm!Z7`8tFTpzy!W%XE`!S+4B8
zbQvpEyA~?1=CQaR?3#e@p7gSndpR0C=G~7PZCH({QS^~p!A;Bu4hxC~{SeAwoAnMl
zz}EWijyK9@DZLivZFPzTO;oZ9c(9d1I`Tb<R2<765A75Bz9PznR^OT9pAJi>-<dA_
zA^Mg4Wg|#Kq##-g)~R|+mv~m~$i|Z+2bm-NtK+j8Y3<f}p~+KqpF^tNELu$ti3~WN
zeHN&uw@GedU1LV_M)oIFho86-AzX5AIl`^l%Po4u*YfwAtNH1H6WvnY7MhJPv_wT#
z#T3HRyQ{1-Y|6#zF<I9*;-hSUVno)=*i&7pE#<^iQ>yveWxwyk$v`&#O{`7-+4r&j
za+QmSBPCIrSjE;XRp5%)Gm~kuE73A)%c2tRaQA+ffHQvjjOULz^8?V|+2`jqJPtuJ
z3M6YtBopI4PI3RNn7(tj9cFM^1q*(1?4Un6H=zw+HhK-!wcSd*1n7#waF%^1xH`V@
zrEiu2ycph+GUifgIXH%S(PP8cCuin<CvxQ7(y5$=Vrf5Z?fRuC4SSL2h+XjdBkSN}
zR)}La7VS(L^MPiHQit?S!^h01h8WGVKhw`f1A#!0??S)#A%0{_4^%cYNLgC@3~+vJ
zmlM4#b*bo7>v)sfO3~Z%xW3&2-<wjH5M#5`Qi4izg7F>!lAR^*V@ot=idDJt48Ta4
z5S4<bA(M!i2}cFbY-M-ZCu#u~t|3?`;{<)13saABn$Ew&nd@1P)qE^1`p-zYM%pQ!
zQy=&Ry>q+EIw$Z$E4I}O7*}vaF4+*)+BdBpurYDy(-Y7@mCDNIBraWm4VR)biErwS
z*kMx5bY->oT~85CXZbC-<uhsCgbPBMS$C3K4|_cVLVVITZRaS+`ntOG@|x*qNwi;|
z4BOJGRzV3SL#lr4F)3+pymkZjt$B%1_+WF<X}SCF17noDHg`JkQ&=zvR7;B$5Lzq=
z$0~-^zZQ%AS>C#c>oQKUSo|adUx}+R5CT8Wz|(LQ28O}UGO!!2`LA;LH-sjPez>%<
zM1^_?1k&fH#Uy&r`qg9rM})LEUFO#mt;73kz(woX9|dZU@&j!Mc7_=O0?L$3pF#ph
zCD<AIf5khtf3Bq~!2xO#5{zXI5>QPcnv*miLtI?3?!k)Z%)m^%pkF@#Ho`wxy)0;7
z;(+DfTJ(Y1zqFi&Lq&SHe`@h`_jUib5`aSz3MK)vk_d)TOWNoW;4LY_7||D>g@QnC
z{+G`M`3L;p4uBq-I2L##31fK0coMYJS)%QUX7V3R0uV-uGgRszq2OA;7Ku1)Doz*p
EFI-Z?umAu6

diff --git a/assays/qPCR/isa.assay.xlsx b/assays/qPCR/isa.assay.xlsx
index 5f9b32da4914f6b1ad8e6c9d77bf6a96652ffee0..f68e337e5c7717add5060f0ea1ade5f720ea0c78 100644
GIT binary patch
delta 5442
zcmcIo2UL^WvW5r(p(PM{GtxnNlM+f06qFL0ND<*kG18<-5q^Xa6h*)QL7G4mLI5@N
zY6HXq(go>7P>Mtjy(ll@J?FgRefPX`*IhR&Yt7Egp800>p2<J|RG~Icvs#`!KnJFw
zp<$#^3pXdTX3!p>QXG*M{+(8|)3X0yjDdvr1$!W|eSyRQi5~(BI%ziQPW#*!ey<8a
zG&G4|oIV2|?k*hz(CwS02*Xk~U@tdV2boN+MU$Lue0n6zoQs^bU(l6Ar+mKmIX6o3
zEr+J+yLo1@#RKEOqfS5bsGXsz?p#^9^Dc*UOe|X>BxJk&m{%9(COxhn_VIG*wp(x1
z_j4i)|7!j1aDRpGQ4J_fxO3i%3|FqUOtnTr_+f@I!+Yr@0&ozE7FaO2<nSI}uP$Mt
zoTM!i9wb)UcbvEU0sZvFS0O@_4roE>N!EK01(ZH<mi;2~EZ7D?!3sz;&_V>d!7Cp5
zQuBlJ3)T1pUx&@b(>jF3mg?Bco92q*Rizzt{(BsedmU%8TlHmDOrP=y+99kO<-3H=
zj&k0dQm$dw8wA7vB5_J>v}zXh_{yZ)Fz+A%W)$G*(7ob!rPGm-OR6q==ZK@Wr;4+!
z-^B-frKhj<tR5j3V$<txD?m$iu+GAtTt$|_E@29Hl3}+!;yo!7v>82$V|Wu`${QUI
zf7<zWQMRPrq~n6Zx+~s`V~HsX4!w}F;^wSdl_P_T^}xF$$1cu(=}Ac!$Z{DlHLSFX
zui?E=N1h2T3%mAiWYS$!P6LZ*B{M=DYoA^UcA`VfkXcZU^-nKFQrGmi<B0C^{!VZn
z1B>euVlQj1-*5^|c0GPIg8Q7sC07ni<54zc_5glNP>z|7?R8Is69Z4_B9bpade)?u
zZB%j@;DEFC?P7*HMr3`is4&ljJETXA+XV6Q2;*FReCUW_%!r}W1|%usL~_Kn1!3h7
zi^bhShWeTD;-Q4I$K@W%F{&el96=F&AI?$o64ZNm-{%;!1|4z|GCmjUU>eBZa(v0c
zH^fjZEt<|p)HcsRhCo#OqTIfh0`VG%jouS^<zevtih=S3a=?qOful?D6?;5qsl8k~
zZdXpGcTl34tuv<`9=kbWk`B=RsRrziywtmcW~8CnK10o95n$v@;E)F_et9PfjNLg{
z5h^roUKTlycLbG}NgpzPY2It$!lxnqkORRvdS-i4Z_3}?f0m_wZ<;b1vTE1YRz9TA
z)@#8tjUv08&I;IT6qF=y?{tI)dE4!DpdCNonAyB|NpNrZ%kWn`>D$7l6|95EIw*pl
z#usXim`Sv)0Vm0hLVC9GZsV`5Z7FtU5%zi(x8m#VeaxR!4x4-M@SMhtl17sBIF{yJ
zUJ-M1UkAfaFAO-7{dAG@ZVl+6H+qj#<ELvXN4HN;g_LYR9B8I2pf7ug>f(pXx5B|f
zNg)f`(_t?CC7r|T?t2L5(s$$K77ThVl-I$|LM27BfVIHJc-*(mOh3sQoci2kly&vP
ziKcl%eW=5&z3j1>is9uCliya)tp%k-A%<WUB?CU3b}p+0SE4QqZF~yQA)U?gsZ&^-
zDjTe>6m+@v@g6!t>vDZhL&xd5qYs9|<=XK0@w>>gY9;YI_1ns5Sv{ZendbSgk=bJ%
z+<IHBHvo%@H|wMU3j4Q;$e@V%LE$Hec3+C5ANvMw4cH95wZaS)r!6}C8ua#<4PEvP
zBDfZU;{0ND%=xJ-l$G|Okt%&7w439RHGD^qCkLzv3X%B$9xP6lJXeH#9GwHEr!rtv
zhNT#lL8daqsf^UzY4;-J9qO+c5b(_<-(>jXcvhr3@xABA>pA7R;6dpU>h{v|=$vvH
zP{?c2cZM-ptCb%VG6uo9$t6@tzstAByEO$i&IetyAk(&Dk={i$hZ7Q|)uC?Mfmv4G
z#^gGP_Fh;;CxhC~t`51kGbs?guBo<@of&D~p<CopWS`@fsHvvi3OK+nT9+D<<y*s_
zH}n*j{lnUZOUOU0W&AJ}v9jXf!h&9J4RhP*%%E4>iOGyK=y;sx;bK`~U20B#5tEto
zhi8cJ(^nE$rPOuW7Tz)#A0sQZN+7*I9uU1hc+)KqUj4B%<BdT_6qCiq2|x<^8UxNZ
zB|_&h2lGw5phFn8{F9%c+ZbBc6THwD7$#TK4CpLEN_D3{&*Mpfhh!?FJ2K8vypJ&$
z8QUdR$>@WO?-E~SjC>xgD0Y+am**Ho@pi@)VOZwZaLWo8>k3X&jB-Ab$brUa<r{c$
zIAGNC4L@;&V{~2hc{z*$jFKxdgTn(8#t!a?QX#(gBfe)6N8Yi7+c2pibGi<xGRYyc
zy5K=f2;^PGLo7_9&odO^r<hcpH!{R|JQ3<!tm#|CaO9sNLP!|?d~+{ICWbrT>=UFO
zBb;x+3&CQbuBS2}g&029u~=k<g#y+mO`bT461U;AHLyjg0X9PY`f4aS8-ad<U=+ee
zL`|O+CECZUW?+U=>1(uTmFBH=%$b5En-Y~tF{A=CQHyjHUEn}eC&kVegcEhq(fkF*
zL?v`gW`PGW>~4a!qW7HE{iXp?5=Mp~LzE$5Nd$hP1St+p&?3r{;^zqmiEuQApCCb$
zMq@L9jpC#9&DCUUhiiy}e*?oz`@Y%xzlpIAv0h{CH1W>}z`qWItlion|M#NUM^Jxk
z?X>mJ2>%*@OQ+QtQ2aL#LRzeyI0%3Dl*YUHtF?0{mw0WFX(%omE?dKX6srwqKe7rX
zWW&>MxQ05=2LaTOi73uKn3`e7j!kxqYr{0((yiaK<Nr^N%{b=~p}*}CH90QpG><C%
z5i{^t$+3T|A#E!E5yD>s0MzXJ?;`v)0Pug8&`+oImodz>!A`yP^^UMd@Vq5O$#1lE
zSBGj<MeP_^0VBsYRs*et%=N1F1~#44%&K-mR;^0ajlM>yiX`QdNLwL*;?~Q=gxNJk
z(tNp4ac@~Xe%jDhV~ylJ<l@`8XI=FujeRDdF=JHT_u&K28lNRcl*Y`qq`$WXH^n96
zvDe*)-cvHN8Xa%usvC=%DI4D+pTx|5O>g-|^1Vd}UaQy3(bd)_QC@chI0<C+5+wKZ
z8WEdO!?W?fbtMec-u!!Oj)Su*?04YStd#wR8=vmgb@KoX4KEAMl8qlIv+M93J_>nE
zv4&_>#oLEuJ~>#;jID}0r%^2{8-LiI?&dMa7OQ(mtKvusZnb+`Oo(JYnNU6*5|K=E
zd%XS1?$K=5y-^b6)Ab9@X@Yc3<{J8^3T37PG#Pzy%iTuNH}5MGkS6Mk@7n1oSYR!Y
z%y{ZPA6;G5j5}|pswX|5CS<G3B+GoC8SP5M=S!;*?!4lwh+|A@7_E4e=X6lYHmx#t
zVs}$jKkY*jmuS`<jc1SiHXr%Lhw8S8?Bolr8)}g6sA3;<vl0q>O3(EaoOdplka4@6
z-wiGhsL{iSb6sria2>OJ9(2_|)3;R8cKK;gZ%D;Xc~1dBICX*@$ea&u^5MmD2IP$3
zDl{ZN`T^qePPSU^Qo@N@c5hu9iZJ)<Y>;vTWo}QQ*F@hiV?D%->CFP=5tb!IdWTz9
z=eHjZe_ju7T2i1JEjzFo(cO8<a^crUOjn-dP9WhRDFk=l2d{6-GR7$$rwWcsc8-r!
zM~DPI>%ws72K32g0bOU}N4m@rOQo1IVYi%+g!fXy7SmZM9Y1!}SZyYUJ;TX@s@5GQ
zwb^aRAZuq=)rWLz@-&-wv}kRvn}S<<iSzrF_Uqf)<7eB>%r4DDwYxo|FXAruRgkxf
z`MhBx%69UDb4WwrvO{{B(Pe>XZ7h(Le8<l2zG>whPTSNx2>=$|u)%p#`SJM|K73!>
z%03be=$pbv6TE!O=`{%a84mUhH{jl+^I*ZCvJjQhk~MtcJ?ToC)8==g+zgm`f@+<a
zn+w;fl{4$)TOp8CiT*}!!kkJ%AwIZYlOjaw6}};-B_bmuS99nc=dmIGlTrSJLiq}X
zmB5+Z+k!6HL4X3Acx~tTg;V$kTgCKK9N1*bCz1E|R!%h;j!rSQZgKXX8BH-|Z8CXM
z$_x9p9X*ztEkqjB#mT96O0PS5o3oogij?Sm9i<>%Db;$*>ULRsqyrQ4L+otN2!b3g
zoHV?NPROeil*?<5{JKluWEwD0_+kVxRM}P#qk>QtKM8Eb6m_)DZf^En{InMNh_}9D
z<Av&Fyt-j=iSJ5PrDp8$j0Lg+^lDl7<zz_qxlN-CF<wbj>anBCxyMY7ozqP?@xk8&
z1Yw`X1bwa7^b@`eW;r<~iqpTcVZ?iYXQNGcjuAq44Z`4mg|?r&I`Ni#8YQ_l6g4%X
z^<*L?bmzt)G%F3Ll0z_sn<<-O+y%*9Z}$7`wc<zp;-TV<-(QrMU6L<Uv_RpsKmnUE
z_qtW!!?Pmk^S0@ECpTRRpQ+l^RmNTDBGlQ6<~kH^JZESMyC6tX<>6?R5i)f12c_$n
zWHi1llVhi6BO$I=cz#$s6S!Wg9ig6$$a<SA=h<0Z;n|iG#-1`_dw5A1dO7D>gJp}e
z^prf;rGbRn8%87j3DmF7Qfh+(fU0tM7U9C{&A%<tuJ80-yFhDfc+k)3mpe1u2wkF6
z8w=Ox`8mVm_4z94>&un)Jixlbsmi#z-q$iGV55LY<Ta5Q<?0#B+lrwi2-*<?XQBI&
zlH6YNifgr#Ud2c%e0Kd6bNS=AY-PDFNB3l&?cG-9B655nS6e%*OvEezP>PjUy#8(k
zWu&&t?X$Zq3{FhDnU8k9#qb2_*v4#hR{yhg+V-<x8P&LFOcYLRp5+C%4wb!t8&P5R
z#zbmH6<L@rK=n|Jny9V!Pf_#?PXc7*6of$v$r}RjULiQl?s9X4g%$d^$sLxq-X%r!
zKy$U{uWOv8*-0bBT6$&)fX^zhMf}KQPXtHTZl~NA?V5YRzY2$fs%2ltwSAH8H-W3Y
zR^>Sr!9Aks@a6Mbt<Hm-@LmhNln!cZ>*c+e7$23R_!ucIGlS-p7shI*!Hp@G2j<jk
zvM!u7N*6XCHY83=>jQ>Sj}}rBXPkU`NBMwq%tuhI(igbW)X<>WdFd@p%R%2ySBp0n
zA9Y1$NQ=<NU6>|UU@6yGzJdOnJ7BIKQx_$!`h)x9mnDH*(EigPN%)7PTDXc9_?})`
zn_o3tXlZDssk0a;_0e(O?-$DeKmS05U;F~x<wJeEbFAL@K39Y^Zpa=UkLAo`H-ew=
zX)QjH21fU1T~wI3J(%94`hl{b!+30_Z}{!o#ZVFRk8Ow9qn>IN_up(GT%*gY<+k$i
zJm2JiVHfj%nR>3yPEnNWsB)(-VCBp4K(5ij=V<{QPpIe&hp)%^crOl9p>cy}BQIrB
zB{hb)SrC<uXx{M(xvopF(QZ&O6ZYmiZ2p{(iKld^-vu^xKNh;8WJ6l8P~veV#6_t0
z<O6Qi_PFw7d%jv3L`u{4r}GL&-UQf~^A}U}3Ps-FYdrcaN#VAFC(^;WfIl-!RmVH@
z!=PfT@RX9U)C|LS_Zqs6FMU~K6&wy?zjEa1C0W*O?WzxlCOgUTq&~Z&ootqo(%47+
z)#zfCUk`b*;lGUtFinxQHn#Dm4Wrd6(Tuz1w?kqjXCr@IZFETX7ECO1Rb`u=lX+}5
zwR2u;t29Em?=I_&r4&Frmjzb8b#PC4hyJ&_+aIY_?7;CqCS_@&y8Bo5PE={1g2mML
zsiBzsK5dc|z$J<C?XOG3jP~h@nC8#ZH7)U@BHu6ik1++c2l(D3{Qfb;rHD)Jt2c-X
zfack8imbf2FXG^R)>kS^5JF{f;}j(X4t=-uM<+o;1N+^|_XQgicTwW-zFx9~0H_^?
zE0f^e*ZKZ0#z*Zw&}={Jtio__q1?C~36_05YE*)HRR2P~6@t9necTl+Ptt;5G{27=
zaR!nCAP-)gJ{Q-KpG5Zb+R<l2sCj(gAPo)cpBxhv!QGV<_zgg_1^&Mh{bwuD<G}+7
y)QT{mx(oS}l?6BsDkZ!h&(CG^$3B86&O%CLAL^2n07yw3cS{O>@Rh{(9sdK~<Dhc@

delta 4676
zcmb7Ic{r5q_a9?_(O3qPwXqJOWXYZ_$wa0QvP7ut*@?z7q7f5g$-ZP6BYJIPr*|SH
zDzeL7c7rrShWZVCzwi6)xBT(DujjhX^PJ^#p8LA*``qW8-D~v-4s$p?!yf<ufCXS0
zZ(7aqgpQs@u{b*DA+7DD1N~x50Y#1kKY<cQ0x5c_UxLdFGTbyx>jpHU83hCYh^znr
z1c1fB1dwUz2%qfJoRQNza*wA4)y_&lf%qUq{l#o$uUyI+gy$L1h=3(f$t`N|&s7CO
zpky^conzGYobBwzs>EaZg5`VBFHS;}mzwY{9dfVV$5AVIA3k!8=&~J3h;C&u@a_S9
z#|~ghxrjzAOQw1P9&v#}f>ZHHnVABH7^V6Fq;M@{#om)i-ujEk%J>thH)5nGYi}O@
zIlSS7YfiWG1WyMSHAu(v$=5z<zw`OVySk(f<`Kn%M$xLq6(&PZSGo0sm=xUn>iZUl
zI|Q$-+I**XyP50JXLrr~Dj(t3+3zBGBB*^fIbFuG+a`1TLf5nhiWFYUKihykZtR`x
z+d(S4@zKB=_E9Pis`7MLn><dE5GG>v4V7zM{C7F!&3Gk3wJC^t?_SsDDhE}fuif+L
z;^i;Af^IgM9%S%r4?XGYizF(G2P9M>vmcCI=)UK(#UykFBHAN?0lA9!??YFJPoY{X
zTQ_oog^4Yckbs=CpxHj{DYDurj@c3sq>s+K>!?jWkyFBp@&+MrOao-GQa?lv(;&3y
zDuVfe$p~#7id|eF?KgSu+dpRDy*GDl(Xh$j$+>pj(}*q3V$N2-+eJ&z*J7J0(GQ#B
zP9(oL%PM6e8f^!3lzM`@&oaOoo_|9hz;fn~@RA!uI+m0_!Ygj5MD<2LZr3{P1VVDu
z#O+Z&l)G`cfXM5GKgW6QwRzpp+)7){T{9g-k4O26e=El{dsHw5$6D4|4&zBeDx-v0
z9V47xWvVvw)<den=mDpUyrN$49_)2N-Owf5a7Z^&F6Z{ym`*o?+E9Y^0DDu&U`-0<
z5=02xeNNi0+IF0o47VcO%^i!)kfb1cPqYhl^ql)`k6UMh-Ch$I0f5p||Jtd%$TJEd
zUY=>=*Zs3>A+NTm2Qoq=!S@#foHY`0CoZV7G*~D)5zzD!UOQ#eoywISDnH7m81L^g
zIEpx@bWJX9w0O-+%J-a{#-vg#;dhFumhJB-7;#DV(tPhUBO6I-U`^l7vhnxi^qxg3
zlGOgCtK-YnEUQF~8;(h-Wq1vCWOkn)IhB<1RrXvl)mAmM8jcUE4e?Bm6Ehv|=3giD
znN<W%ev%w>2!%uVkl17&)iGJi?V)Xj$!k8)^UbFCy>D;J*38?>)~%2{4RACvACzzP
zon(F?ypLc*o`>L-gDMJtG`>&xyh^w~F+I`dLe7i$v@3o;qY~ZPdv*wEDZI07_%r-{
z%tC>U^yGA9?VfO}SsS7_JNavg_M?f2l2Bx@R!ErE#fIC@KAL`Qt!&-TPItpxwv0&J
zGZ9Bt5yo^>K4t`5|7d*YA@$XFO5;XI=}R(5MgAJO)yU-MPJ=mCwy8tzt50Is*Y!PF
z(Ug(ZQIVi9(bhi$hn7cfA=|>Vci|BMZ57WN97&qFEemfC?ET3+q6}+jHNHQki)3#&
zc0P<85i?_K<+>|1QyHHXNzX;Tx<)X}VH@S^=QPiHEK{Hih3nqYCqxdQgy>3Gn}8-f
zwk$By*E}>K60LnlKZ+*Nr%B`)Q>DPHFjE-c<_;<=@I5jO+2)TJ(=2;9U@gj!`bvY(
zT%ba>KzaC$45g&njFHB9YMtmDNLRvkrp!9V*%Vz58!olJpj!@A=u&_U^O&!sU#_O>
zdH^)pSx<2mM<+72{%BmAOz4@?Hcj2z|4>pBT)t*6doQDBs-))XGo$LTj2^RUrmifo
z2jZD&by6g9z|$UWZ~jcWU>}?7OpoTcyk$$2>@orivQ@8R-cGgP*4jQAejj-vlGb*?
zbptVW&w?V7mg}s79=c}{gjRtK7h5Mdd!YlD@QvV>0_)51X*#FF(Ht;UuyYCM(Z7&x
z-A`P0w4msOw=feG3r*CZIo$79RP=Lw&5*Y_vrv46rc0d7C^mh}2WfT|1EQppAtYa~
zaBYM??I5eiOijvyRT_1bc)ZXE$McSrLm&G=td3P!Kf_mViE9r<=VaU{@rY$!36^@W
zP*gK*KE~ROlAT5Qny85nvIG*<3-xYu+oDtp4VJhSShV%?PoH3C%|LNEg)_z0Ag3KH
zDA#2*XP=l$=5U&^-a-i!nyE=EvzY29e2@xYu_rPXURdH`LP2L!PK!NyUtmu8>%6Pz
z|I0_i^^8i{dK?LN(}FiJTH}0fp*v1vMQBJ@1tE{L5FFAAMDXK8@EC!D2RQg3i;7O!
zoW1YtxVzv6a6l1{*3io>dS|X;Asm?GUXX?3!zZp3G~?JTKtmTe%nb%5-BAMhSGN=z
zJ^SlTR~<nAo0tE~$(TFRGn=nd#Jn3PyTTBN)-V_{4;)m-N4Xc-;#Bc5D@6+C+7_ZJ
zx*UiM9G82zSy#(UjqA87El3t5AuI=3SHOV}@P#Wle+&8{!+LWs3+AEo_61=$9rs9q
zA_au_;BF2&_%GMh1~0o8=Y^l*aXf=EE9{mALx@Ej6aJxlA#xmd44=@fOE!-f1gIF=
z7a8HU)FWEhvZO&!(Uk5%6Lhzyqbgx}!TLb31ktL!8NT1#1L}Uh()&Er@=ME3Wtp-~
zS=Xx7L4WO=?Ujh9-_uvihPDfn`E4TL!lFE)GI6aqv_!=U{|NQxTaQtEoM-VjjhLyK
zy;3EdzvDpB)gCKRU7L+djz60$e{OZW!Joj?1d;>7QG1QwSJl@?lyDBBqQTfAS;30^
zP~@kGng#@WE!kM+8+mJKVdLd$q9bN>`X}h$VIFXp%3yaur;aif8P1KP1ciB`ef|VJ
z06?W>J755|N`?<vLQ7D_Pjhxp@5nsU3Is{MXikC__$kGIu(~m$b7@F9^bOrGw`P6r
zv8kPllzz&^pwh|C6y;bFoy5e??St@OowDHSi#&eJ<1CU?hl>7hEU%5b^sDx!R0MN_
zw46_7C|*uQwKp)%+p{}-dsNL}TC#l4!=tupBl|Xo%vp{!WK?Hb$$(6Q+MwLDi$I9y
zFhJFGKd3g8RAy(4F_g_9Y_zS^X{W&NW*hjP^S@8x2s2_23)1Ch+bdt3(0d=u1H!)A
zly3rh`*Fw^!$(zPURt1{%vck}PLl>*Qpz0lL~pj3Hzh^(#yxeHW9qlX8&(ojtQq?i
zEz(La==O0Vz3uPgW5tsJnVWT;eUmj?KDYk*#Q)%I(EKYY#q0qig<CGFIhfMzirH|)
z`t1j<anc7bs?+iN2Tui9BjVRgI$ci2@@gs86QNc&u2ej!te#uV4Eg?<x~iO{Qd;X!
zYlk-UO;CS6)Mp7KYp#R4QxRjNEdhbICmTL5=*<jlBAZ~DcU&!tQ)IVwOO6}y`1JR+
zuu4{2N8P<3HI0(@ve1P}pOWM4GO${5vlB1xs?Sz$PE39DSZ|}qK45j+X2eB{s1SG1
z6WLDxJUUj$`<kA0-4x~#(@1>Oi2~(hJ{w-QOju4(cAr}Xxis*0j{8Z9ug-#<t&^g4
z@X~TrBJ#j>UX5tBsXQ$KsrCLq%2Cmb0}f}deF<RXj<@B8-i>D@uciLDWd^@Ed9zc8
zn!7q0i*~UsF33+B{pQyS|1eRzZ6I!StLDOXS!dq)?Y$Xbg;M4Mr9Ev^87^{1a_d$2
z!>^rlAFtclHa?HHdN?0;UtMz4)+|F{W(1S}8HKD&HcdoP75XL7LjGayXW~1r7<P5d
zH6AqE<cv=;!?)_2kWctX1Ft0fCcUcDf;fyIUmZrvbT@G&nh=Im#6H`d7cf_+*ZMuy
z%e_vK+fERaSvSPQM1bFT$AN#bZ~ZCVtCBfzb3yNczDaV|!AI_Zcr-u{DDB&d!~0#2
zReGvqId$6ihyDT~kUE#7w;VpJzy#AfY4ox{jKO;&`l@J$19J!6@5gEkEXi`1@8h@}
zRco1ep>#-NdU3XU<xSU~gWzOY_y@`TQy*^#;O)kV%1iy9@LZSWKi->-nQB!&W|_tI
z&^av$s;EW>&y%?1usEC^2V@?~>l{<^qdZf;H=L_2_%6@%*8B9@TN7io^Y2>Yj7hRw
z!I|+bW}Wu1xhnA840NN%`A=P9B=_^QM<lq%z7mPEt(<8)#jeT`!Q*zKYE2j+yy3NW
zwyL_<FF{1qqUz=YbP)Mlq4?y7<8W$-?X!e)RDP*(;-@>Vyb@?q2S%q8<9B?*4|Wlv
zWyw-6Pvm3*?iw2}Onm-hZ!tPk46N->{mf`Ht#6jew^VuNHCx1wx!8}RFPqRe-O$4r
zDcTb0@lXssNVp<_`w6N)LO`*vOkSDSD|E*=7FN#3ik&K;l$#vPXz*qcXHYw=2Ie^B
z>V-^X)A<gqD;t;zZ^#2wU3@+am4n;&oWVuMII5?m^Mj)JUsDqwFDG&SQPDEnCM{F{
zwD{74`8&ao`c<b1rSE&JR_`u&TYQRU#3I?t)#td=eV4UaZ~s{2+s(Z`pb-kvqMP9T
zLcF<~wo?39z%`4lRGW<?B)>}uvlAIHYg;aZgY$6v;VxJ7{vsUDf$M>DOABU0Z$8bE
zW1M>3vKo**(N|X@1_za`LoGJ%7IZ+*jRy9-@~a{&lOCP3A^OvOg6uwq-1S<Ms*%|j
zf_a|(_QE1O$a+bqHx(02tlJv3dAVcAg#2%N=Mv;s@#qg}W;&`OPmAUOkAieR^p|88
zT2IG%xV_rHHGOu#62wK3W-m{3wr=w#Z<J%f2yjU`15R2NieQ*?Tl4bB8clDL?3<p~
z%Bm}p_SV#_osUqvF7#Gxmu|J#%AfnP7<c5Ht#N%Wwt;-6RXWO`ltHd8TD|<Q<n#Bj
zcd>q6vt91=e3FeX1Z6V(l%zEcu~$}hkC`k;ITUI&^%Go{3Ma21U+(64MM)t7F2HrA
zAZNxQ58Qku+Dc|(O4LV-R5)|==_FwR%6XjugJPot_VTwgm0V@2RedeP#F)wbZ}hA!
zhl;ZZSEiAd&RM;GzK$!j=)<c$*5c9n!Uu8B?kH~?Nb6a$shUMN(}iY}3`Cn=j-2&f
z8=&8;26R^{FKrCEC-bu+le7oZ2*gkdP$k2e<+|5ul0Y&uqkrSq#VKP>5P5XfQFb+W
zq7NXpsd=%5Bk#%1^8ClJi(e&7ykEjt=a)6|N)RbhweL$86ZZQ5Toe7?F#o0?e`C&Z
zq2u3Y`>6V_)sf8jRn(74=^QP~acRXPYAUUIL?1{i9MTjyLF|C^@go*V`uq`9g{dDq
zT)2Pw0N4na+KEHf?*$jF*YNj%G1D3ayx0{O*Ad1Km>>|$ffbYyJNnd>5d<1>VC`iT
zk6?bk!2iaey{H|dUFTv)O8?0|Y-{`)oHT;w!fwhy{*GN(PFX%+4HuS^mk+BW%YNvP
zHZAo7FaQwZc`D$xtC#C3b2uFk4EVb{Vx96%MfwpF0MK~?0O0u-^e-a8i!GFe>Kx9N
zQ8UsZh}H<9rzvv$rZg*fgzX;?>gno#SaJS?f0VM&`~#y!u)=cu$U~sW>A(>*9RQ$5
zOIi*m@Xsh00RUWlZkqe~`1+r6^7Z{4>u4>19Uz+ZJndJw{xPM!Ii2_q>zh7)uK&|q
f#MJuRtO&+~W?w_I2mNMGf@1sSpiB?M54ryZAW~0z

diff --git a/assays/qPCR/protocols/qRT-PCR.md b/assays/qPCR/protocols/qRT-PCR.md
index 886784a..c813b45 100644
--- a/assays/qPCR/protocols/qRT-PCR.md
+++ b/assays/qPCR/protocols/qRT-PCR.md
@@ -1,2 +1,3 @@
 ## Quantitative real-time PCR (qRT-PCR)
+
 Cultures were sampled (0.5 ml) after 72 hours at the end of the growth experiment. The pellet was processed for RNA extraction using the PGTX method (dx.doi.org/10.17504/protocols.io.jm3ck8n, Pinto et al., 2009). The remaining DNA in the extracted RNA was removed by DNase digestion using the TURBO DNA-free™ (ThermoFischer) kit according to the manufacturer’s instructions. Extracted RNAs (250 ng) were used in a reverse transcriptase reaction using the RevertAid First Strand cDNA Synthesis Kit (ThermoFischer) according to the manufacturer’s instructions. The resulting cDNA was diluted 1:20. For performing qPCR, the DyNAmo ColorFlash SYBR Green qPCR Kit was used according to the manufacturer’s instructions. Primers for sqs, dxs and the housekeeping gene rpoA are shown in Table S2 (SI). Primer efficiencies were tested before performing qRT-PCR and were deemed sufficient to yield quantitative information (Figure S3; Table S3 (SI)). Changes in gene expression as fold changes compared to the control were determined using the 2−ΔΔCT method, using rpoA as a housekeeping gene and the Δshc strain subjected to the same rhamnose concentration as a control.
\ No newline at end of file
diff --git a/isa.investigation.xlsx b/isa.investigation.xlsx
index 72ab4b090510c2c8388cb0e296766191c9f1ec7a..fdaf9fdb6aac515b97f48b8714b09eddf085f085 100644
GIT binary patch
delta 693
zcmez6^xKIyz?+$ci-CcGgTb`QZzFFzBQubmJe^SyL~q{B$PW=X%OnSuc*mpymJnr@
zgGiXMXo3ZjSoSl687dqc>|mw({1ByK{JYq|GQwi>n7}eyBp@=kB{nm10<DR#`tjF1
ze)4oF`TD#=1_FD&Yb)Jv7GA*bs_2n>bfw2suB@xGv-KZLx-o69$&>f5Z8%(>Ub%hl
z+?xt{zvsu5`0EZ>t-RWEWN`<}f*oQ(x#=l;qgwb?3QkN(*coP^ENWqNJ})RwXr1n!
zsN4gKSi~!op9<xrrL<=VdCA^)Jb34X_7rvVTVg!6TcWe-CGKz5y-+A}_af5-&bFRw
zZ3|z@dZueu<Y)4k<@2yCpWw{MCEM$6XqzpV^KhM*$(hzo6CxycXxUEO`|CxDzRu~Q
z5I?Dv@9me#pPs%w?MlF^s!$n^X<YLPxOujoy_U7UWMxp*#MPBkW;kD4vipMjyANM^
zWp0=7*XSH5)aLzVy*2xZ!o%|$+gDu)vpCNeP^;Ot;p(=mmBybG()p(UyCco{XrtBl
zU(>yI-`!^1!12d#QdzV5v)WHz_C!s{k?CEYXu|jSrPe;*N5507ey*vOyE31*``yHP
z>v=r8ezN^H`pt?G*_-8LdLVJQR@M$2FYjax!L*W`8JLci(*x7z<)tStmy-mu56iiN
zX>NH-Fzqhy45oYK?ZNbUc@r?rrT{V1UBLn>E<Jg!0>q4+3f4%`{#U_F9+U{WYM!l5
bU}RvZVPat52c}2_5SkpMsKhp379;`y9~=kL

delta 692
zcmezE^vj7iz?+$ci-CcGgTc4McO!2*BQubmJe^SyL~q{B$PW=X%OnSuc*mpymJnr@
zgGiXMXo3ZjSoSl687dqc>|mw({1ByK{JYq|GQwi>n7}eyBp@=kB{nm10<DSI_hsjk
zxXII{<m>$o8wl+AEIRT1%E=;uB1>1YtWeid3}ktf_9i!b){SX<RnOjkY%^=iBK16L
z>&=gAEuv*kEB#=6y(Fwy$X`jQ;Zc;w*140ne>K{p-srrHMSDw=<;sH-UF#+nPA<xQ
zcr=SyOm)WrY0c?H#_HBClY?IU;PZN>7Pru5=f!O)FBaYnsz3Z=UT&jWV2Qi8gPMfV
zEs3_Y0+qc>A2ctuys^ksV2%@`sz!;)ydx!7lx|##)y<e`oT|CetRS>XiT&%vla3Lg
zSC`D%7IeSf$3E=*`nM|<hMZkxF~LUI=Bb!O*6jT&_g<QM>P6(bhk;3qm9yVD%kMmV
z-Mrw<CFTzs8IG?tdGY>A)<kj6`aat$Q@0(e{KjNDJ&7Ya_jRAtM0VEV9iN`x^AO<w
zdgFDx*6Z@yXBm_}SbOf~oj2qA%g2|iJU^*;<sH`GeEiaC-qOHHYMak5d*1!);)XZ!
zKes<VxnTbLNAb`0qr~-Qd6^za6t0uC14qkySwk?bEN2F$W90O}^aXk8$t&a}!R#Y)
zu3(x+-V#iE$UB4SK6!gEeL>y?OtULM%=A#OfQm~`o~HmYW0!(8Qmp?|Fp~$Rfv%co
ds}mR*7;2ap82Et+5&;A!2P-PE&65R*006G%75)GK

diff --git a/studies/Englund-2014/isa.study.xlsx b/studies/Englund-2014/isa.study.xlsx
index 94c78835b03dc869dfaba57fd0d4eccada8d1e21..ab8902acd6c55e12f49f27285dc6d1c6d000c8d1 100644
GIT binary patch
delta 773
zcmZ1<u_1ytz?+$ci-CcGgTb`QZzJyvMrI&Ac?F{)h~9jLksl&(k4X+J@t;WrETP7%
z29fY*(F6-rvrJ<FGekI7FoBis=hg?)AGzOyB_8vv<p2vz7F7ic>=r!=QQ0g3F?5y0
zE;g`Cy8Jwd42Kd#Mqg<gBPY;75mrC`n#WImrz~HecgR3s&v$L5`^~}&_+1q}a*wX`
zn97xPb#}J?gGo20?KOGw{<RH<%hM~j&z*ZyA@BG6xDtQe0jrf)dyXvbU|Fz3EGRcU
zWp7jqze>T0DG58n43tGJjLzo;<q56R-4m62U=fRWh4NFOytI_|3?VPs`;G_ioY0=4
zZhlLQ$979}R=vdi&AJx~Mebf?n!wrCbFFRROIgo!&5Ha?KC^rtmgN(i8M$P8-3@KC
z1#=#*6Eiu}x@kg$<PI&{iF<#&NYU3hT@>Ocwer3FGWpZfx2IhRSXC7&<1vkEUI91H
z*0a~L)|adds+zdEa>@+nYfE-taDVsVE3eG$68;*U1BKeWzpS^`KT&vieq;NpD`6Jr
z`2uP++csR?mbKFOlR`S*^nZ7xIUjAb`u=OW*Y3O9j2k%q_)RKnR)1Fe>C2v|2{|&o
z%M(rb9>3Ju=lke)iq+3G)pA$n^LD?RSZ_U#XV*`*|3<%AQIbVOQREDfY(@r#O-u|7
z{J_Lgk)yx4Q?(hA0{GSKz|k6@ZV0AZ)Xl*3UUfY%{Z8EkOsi_Rg6UihOEA4s!x>D!
zhtj5+_F#UwrXQF-0p)XPnS%LFS`hhn>e7?vYe|B|c56ZG{-b39=7Z#dv>|eN+SW)(
ZW|KC=Rj;+B88aud>nO1?ssnw(008siCeQ!?

delta 773
zcmdlGu|9$~z?+$ci-CcGgTc4McO&l%MrI&Ac?F{)h~9jLksl&(k4X+J@t;WrETP7%
z29fY*(F6-rvrJ<FGekI7FoBis=hg?)AGzOyB_8vv<p2vz7F7ic>=r!=QQ0g3F?5y0
zE;g`Cy8Jwd42Kd#Mqg<gBPY;75&OREd=fYLow9tr-(drRJ)cD<zF#?6Bv54ON|qJs
zT8e=zkJ8@cX3x4YZLjLt`;TpAZCRwAXKlUtajiwP%xR?`jIWo36$|+*2{k;5^4L0e
z^7gMrd(<19m$7JXX|h~-aH4D7<ig2Cxet$KF^j40I3TS#y~tSI+GTRks~>z`&(z`;
z+U&fzE#<|+yFvAbf6U8mR0}L|_jXW|FuEntmR6v$cj<%XrIt4qnF`EtVpP>AF`0Ly
z<ciXbOR>5cGmTR<H<}fMRw=Q6y?D|wBJ}E#S=)l{*ZbIqonQZU#ln!Yt1Kqi2-`dr
zlgOIAf92jwQ%}8!T=y_AiLr9_J7@Wwhp(F#yt%~uVI#xwwI(m#U#Xuc&RO4Qdu8gj
zLzUl{Os6MtMCZQllbXoRTD;@a^Lriw{9kXpj@No!e)}wg(g$nL-MsT=e1G})a+T*N
z6|cO*8k~<`TFqM;I7w~u`DM?$e_h=0M*ipa$0rxefBz`{*?yE%5m6L5LnND#fngI9
z0|P%WtyJXbmv8P?ZGxl#0d+fYv<9jhg6URuGcdhRT@OsZS2qFEY8tL!I#0tAOs~>#
z2Gbv)w3((om|vmk2c}O#`P^EjV7{{!ME<?H^yCFvl3=ktS`fScYFU8!Ah}>|h+Mw5
cHByq<tPOG18*OREjL952N^A`3K(8<W0J-8e>;M1&

diff --git a/studies/KnoopAndSteuer-2015/isa.study.xlsx b/studies/KnoopAndSteuer-2015/isa.study.xlsx
index fc93c1637f03774ff325e10c12fa2fd30ede346c..80f629eaf7080ddae6765a62d66dcb4187c21729 100644
GIT binary patch
delta 713
zcmbQ^G}nnYz?+$ci-CcGgTb`QZzFFzBQubmJe^SyL~q{B$PW=X%OnSuc*mpymJnr@
zgGiXMXo3ZjSRz@#jC~wpY+$9=`5;RF@$CW&Y~C$8j|nUjBLR_Vme|0^3A84{>c?O6
z_{la>^7VO#3<UOk*H*gUEWCi<Rna5&=t_^NTv=CVXX`(hbYt3HlPB+A+i<u%y>k29
zxi=N^e$S69@z))&T6wkS$l?x`1v|uoa??}xMz!#(6r7lnurtg+S=7Sld|ptV&^p~c
zQMm^ev4~eFKNZSLOKHy#@{+ypc<{~%?J4T!x5RjCw?t>vOWfbAd!bO|?nR~voNYbV
z+7`Z)^-R~S$j{_6%jaQPKEauhOSaeD&^B8z=ixdrlQXTGCPYZ?(6XJl_t%RQeVx-q
zA%0RT-`g*fKRtbW+LeG+RiQE-)41jpaPw?Edo62y$;zOriK{E8%y7Q8WcLO4cOSm;
z%G@sDuhBVBsLlJ!dTad?g@@-iwy(MpW^tY`pjNYO!_{qBD~&%Xr1MSxcSoA@(MGH9
zzovWbzPru1f#Z+gq_Sr9XSJWc?1`F?Bh$M)(S+~uORasrkAA0E{ajNmcV#|r_q&Pp
z*7JCF{bc)Z^qUnWvLm=`Ok86b85l~K7#R40NuVM}fAe+eQb@e|%i4kCYJ#jGm_8zF
z2B!bY>VfG(dFjcXa*|+ns+=pBUMpt_reDfAgK2$vdoW!nZvv)Q$V1G0DQ^K4m!52|
j05Kz4!5S$k%vUgz2PF)2Cjwmw1=}ZoQBY!Ylm&4CIb;gL

delta 691
zcmbR1G{=cIz?+$ci-CcGgTc4McO!2*BQubmJe^SyL~q{B$PW=X%OnSuc*mpymJnr@
zgGiXMXo3ZjSRz@#jC~wpY+$9=`5;RF@$CW&Y~C$8j|nUjBLR_Vme|0^3A83+-<O?F
z;wIZj$=CZGHW1kJS#;w2m6JsRMV78)S)s0_7|8M{?M-g>tQ*tzs-C_7*k;z2Me2Fh
z)|(&KT13m7R{FvCdP!KZkiU{p!=osVt#c=D|7x^Hz0r9Yi}sc#%asQwy4FoDoLrRq
z@MspZnCgxL(wftYjMc4OCI`Lx!RPf%EpDOB&WqbpUM##DRDbx#yxc~$z!G<F2Q>+!
zTM}()1uA=&K4@NQd1H~Oz#Jz=RgDspc}GgFDBZXetD7;?I8}3_SwU!(68qPSCmka~
zuP&LjE$Du|kA2wr^>0@!3^}{XVuFpZ%~LUntl9fl?!7ei)QiY<4+E1JD`&rRmfv~!
zx_QByOUxfOG8|uP^5XrK`ibJ4^?kNirfxe_`HjhRdJ;!;?(06OiR`S!J3c+X=OMuV
z^~URXt=HwZ&oU@|u=d=|J8#DKmya)3d45vy$~&yV`S_*PyrqGY)Ha`A_PqPo#SL%d
ze{O$#a>4xfkK&*0M~UkQE*lfqSVjhh5+())eqaiy$k8v~d{epv60ZTWcHp?0C~F9&
zkII^X>3_0%U|L_!1Wc#Nxq|6+a+YBFm7Ft}HjuXm)B1AKlY8YQ!R(dt5HnxNTfpTU
h6d-aj3f4$TVSxg~wwnsljN2xERZwDckOexC0RYQ#7;pdp

diff --git a/studies/MeasurementsOfSqualeneProduction/isa.study.xlsx b/studies/MeasurementsOfSqualeneProduction/isa.study.xlsx
index d86086f434d5abca96dffff0ecea4baa1f542a62..522bafa87f35ef7b8daf6edee18bad3946fca6b0 100644
GIT binary patch
delta 2815
zcmZWrcU)6h6Aht<YDhq8=tz+wh!Kga0Zf9@r3gw9PzWWVV^)b$jnYF0gA`?vUKIl<
z3IZYsNRcL0inIk$q<<l-yPv!7pL2gR=gcejzB99-m88vOe4ddB1ONco0Gb5DGOh>)
zMjDcn86@_xg37>i5NHRA(GyERX?g<6D0Yz0WRmBmF|CYLi#HgV0DxElvIi54m@*Wd
zuF4y}yal<trTjw|nUIU6KC#YEd?ME4rlLkNf7t>b@XV~|9*Sbo%<)&2Y!ds?oU(E4
zU7_6$Hhs!z+y2T^%zyz!_Hn^*hyRwr=FSi`xlKbbc**~{*Mosvo@;1354*zU2YV+)
zBH1yJ*>D2_Tb7;kfU)R>f(YS$V!E<5cE(0@qI0<-YyI5voAg21$s4v#Mb%d}|0rGE
z%NhSNXffSq-rVOqZqk^3F5=ntxc$~Rrl@EaRouHfQ%1a0Qyl{is4g3KfEbXgt#5q{
z=$NO<p8l>P>-Q}e!A)s>TD|It_j^Y2CJJnBr?wTo%kK8Ct5{+0pi%<Oh`8>4_iv9|
zKDblGRDw<@uT~iOKkjRmz3H{S95n(%-b5)F46A8WtHat`HM%M>U+0Ex`XhZN^)0Cp
zHtH9>UTEf<3J5&anq3^EZb>g`-^bPT&#bptEWEw7!DZ>y)w?m+zY+{T-ninLUQ+SF
z|AG06z$0aX$m|Mn&g)^bGLew8$W^&AU(eK(3?N*cKEFMboV!3~BCI~AWY5Y!%qyOU
zLh69C(Ee}y33XQhbxrQLERP!_{qg1BWjYm0<`W@x;5Xvn9wj-GcpXeQy8C6wl$x}z
zpd7|<jPGu)I0hMg82lqr7aVd#P5QeayDW?ARrC*aun{M)iT~~tF<6?t#(@nUsmmQQ
zs~ReLE;!;W0d4_Cui?==sM&F80z5ZDY7GxY+%%=|65u4U)A>j?M20R;#2P+S%rHAb
zhX6<NsG#!zXr9den0zS19r9afg!_v360bEg|A+JOI%rCue|M@?*`G=nZi(cpLBpxm
zacI7ibH2>^P$G63kJSr4ry8%*QklZq-g8eBhPiIeKoV%Hc};@076tp;hi#mh_KDzA
zjF)AWx4GL|1|8Bct>#s=K}#EeOpBnZFtk!2rpn^Xgba<5-v?@`Y?P#2bYsr7kc{BO
zJgEYE%f}5X&=|;7X<)E)uQmICDH@rSYpp1OAcC?`-Sr#d2+-C&=`Ja`(OYbYc-@%L
zwIiWom~0f1071sk;t~iNFMc*IRxGSD2fcO#9fO=TktRTLQ4(uMzz9&cnfQOv`UBHn
zacnodLF?2$Kkv+e?k5sy3wiV!B$jg3(1=AVvF=m4(crSj3F)YORMs=M-7-b3U7ljt
zUXx|e3=+TiVb*@F<Hy${Z`>Cz2MRgGJhwA|e<yv_RK_pJ;JQC;j8$>1OvCqv^mKfN
zhJ1PzoG&Q_3i=tnVYRuU#_83aaq8U43Rbwj2Ieoo?U?B&VoOY`nSnYbU)%i7^NYb)
z31P_IjEn$4Bqsm>q1jHLyNZvCgSWGjnXk92=XD?DKo9pKOB39nDsRweN$ILB@&u`v
z&-hVRz9a(%lhTvdD$QCp^)YqvLi>wMoxx~i#+l=`;x)@10h#YdQ&&dL8+O5X<MBkz
zvSL;p4u<oA`X4>77CA0|p@!wYQff+2PqBic=RG%_l^!7n6I)4%^5)y69;r^Tjwi>M
zRXqm0;~XEsnmUrg02yyN&wTFL)e?zb5aGL)6`Fj(pfKHyBQbJYxxvFW(z9sJDt^w&
zASV#<yVwv`t9o9bM8!PSqQ&Tre7Ou!JbIDiWjQ3)jmlZwwG1}1=LJ!cNZpCm&G$*!
zot|lTE-=Zzt2e1>B^6%MRWIZ;dF8Ex3AQ-n7u3nH#>QOPxIwyvRcCNrhq~~QSdTvw
zsx{v5F4s3uNJHrEPL}U_TLv9wEoiaQ9#Df=hNV6@0l0T|ss#gfX|YP$nD!+SIXw@l
z=mA~6jaA8s6fe)z&o>5@YUB>8M!JE%jB=pkew&Zz0KR}tB`8b++esI9#-eStLiIoe
zrj+~C(97fiSTkiZ?Nq~SQa7a1Z<_UXjX5_U`J&H6pJh0oUPnb12&I2HD@3X%4aW__
z!DT?k5<ilRkCNE>i<5N`CBzm>_M`e|S!->5rAq(!K9~<%9Q(9)yeAWv)AiXcJ+<3`
z`l>0`DblRIz<OiAffRoMU$lBt4j*TZZhN6yep`30|Dmp&8ESkFW<sdHJo?GD))$4U
zqJ~2X2yaDS<9va$a|+zrYqPdTC8riDGt@&|G#sLWU*O=b%Z#G;>WR&I84YHnb-vP*
zGkYuzw!7=aqN}jtU^qUc2BXhxsXbmfS@}Ze-OLW-l;n<<-@;H<K=LQoo#@LY7hdg!
z{}>pKA{a~Xr^!4jo9Xnsy~`=pymbBR#A<ElQ~1c~8K)b!PdgH0Ix`gtkDtrzrZybw
zQ*Y~ON|UME7Mb6|qS{Tl-bzh~d<>qoVV1gQj};o>`t$6lx2v4wJKwsIlj9#Ie|HJ!
zzUUH7RU0DQ9FP9mIcAZ849G=HWY-~9+=h&7_8z3{GXMN_0Q<d}tif^6dTltKv(S6+
zVK4<qZ^|{0gUlGDl!1M}87E2|^RgqS^23OpuT*(!*A*p4L--!@=t-bGn)1<!AZ%~C
zo61=H$D}%qspWZXHr>xXLmeFpfiT0FW=Wo)ms<I~k&QWbnI1mlH}$ygRA(K^BaLrK
zu&=RDm4d>Lz4tWr1Q#Ezwf1<K%_I;g^%?AW%_+hKtS>rxwqdwMF+uLcAU`Lf(gsUB
zJX&$I(+e`v1&n16kL(N2niIubmk-3ba%<u^net+F7(k*?C^dxJA@}iOevNlw<*`<R
z&lC`Gb(^zJDoSnM7Y&8-mw$T<YfFB5t;hHY!CVBL1ft+MIIG(GuqD3vri8eH8wn{o
zeYw<5)Y6~dxI~70d2TAb^it&7JXPg3B|iSXEaFLz1^hj?@h$oA(%x!pzWS>8b?)Td
zVPW=(GOhK^WPR#Lwfb$gZNqr~5V`4Ft82B^vF;*Kc@7%flXD971`}IOT04cmi}hr3
z-Cv3$o}zF*-(cB0w)OW0(TArB@x!EpnW#|kG<{zd1=Z*%A*4x1YawMi-VqTdKNb?C
zuU`r2(Getk^51imi7*_tznlN|Oqy-}bw!i^5SIE`68@Tl?x(&k&K}Mx#^)J;5WwG)
zomG6tak)qq0H9GE0O0$nr{fp0goxzn{Tnf#x^3$Z1OOOmJg#3jdEf)9_PycmO!w%2
z${!p~+A9IkP%=eCfVf|2VrRlGi~#_UrCB}iFO_gm0Kf_7XzY!{`=~hJ@%x7VPciz3
zJUG5I^(5_C4*jB*6!<^2BhK6Tzj9GSE0DH^-W8hOm!{|WMPEub5tU@o650>`4<Bv7
A<NyEw

delta 2649
zcmZuzc{r478-K@)kVK3nG#JAm%T)H|6n)mQ)SxCiWl6?f*{5g`2QgV9<EVxvBSegS
zD{GcP8adH1geFV2B<UMdeb>?Ty??yF=YH?|_uS8QJ@56qe;N8;boox8!I0em0B{3V
z@m6JgH$h+)5;8$D+gM%;;{WlXhXck=^z%Z6T!TIRLezE;%Z0(PABCC_#l0*hmIi&{
z+YbhS1`z@dB88{Z{0C9cUGE}^@Gb*%lwaY6S0W%G4ju&LxKku~&;b!NNj<=r4LWiv
zHyPGk{m8DpGobww66w;gG4gDr`3CJvOnPF`;XXgtuSv|RqRr8{+RWGCnkIt*mdwc7
zE~$@MjSh|2v9F6~|2`v84((4ViV|g%DkPMRjr9I`ItE`F{rG&;jHTs^Qk6CtZ24W)
z4{tcSo+{}wHZ~8r@7qGQY9$rTC6#>6onxFeD=of7{>td(W7s;J{%+&s-IDTc@#)&z
z+wgfO=0qzr+uON*y>u=bbs1MPmuGZ$LorfmQ+T{ucb%s7N$JJ6*_rXr`fBfuEgaOe
zRNpoS4VAm$bL_Vql*jBmT_~A@oeKrlF?&baG`+^#)V8+jFOE7}_L)uJ9d93AU3*|a
z*R(HQTH2&Lj$5}E5LGq#wJuQx!-|88ZLI#z@)_=aw@|LW1UHy!mdtyAjpu!xe)=!l
zLMEfSWRPdJKdbBJ#cJifOwW^rt_iwRpsqMP>m`IQtRv6!J&EhanOi#wPIY?YI`LH`
zZN|eB#F~4BI^p6|v)$ps$P%OQS5tNSz5Tou0@nQeg5Iu9RX)*)ZZrvB?hX&J9+T`d
z^uQ#hksdxzjg6mdZe4;LGUhCW_br;kF;C%TvWAvX&1ndfoZ-vp<`zV$yrCt&c?p41
zIE0sldsEClng|3!(8*1q5O>qkMQ#e$Be|<2u2Puv3V`N!GdMN_%7AG*61feU2Eg7$
z0{L9n2!IJP;xAnRhQZfhZnGc?7dwgN7l^p>FJ@Z5?3oC}uq=;38p+hdAT2`p>})DF
z1+ii_#(X>SH8%pk6?^#<`q*t{N5RoF2&D6=T$zgb{|zxvNQTNSoFYf8#|Va=alb(b
zTM4ZsadRhlqTL-6uqMz8o)~Njd_`eQbYKK2m~UFPqChd-7Xd}5v_wF6hUz~<A$){7
zI;Aaw6_>C0P)vn>hO2YE0}skzRx>nZ192wp8mwp3LwoeB^omagENRupD8*}*hE0+G
z5!$iRtZHIHziruy9oA;m$>!?X>aOx<d6x8=n3oQtmWJntS{Sg2m7^Q(8=0^#xhb^E
zHl$n)35jGpN!?pwfnl2;_VSxABc>xNkQ_JI%T$tzif^W7sam(=zu3{n_RLd#dtTLL
zH|tNq{NkT9oH$evw?=JD^DhbdG>pHTL(RD)S2%H=xlE6ns93Gr+9@7bCEgn{*&G0X
z=LG;LOH#u8)IxmRgFVmLhT?<I`+J9|hT;5jGe-R%pagC#d{$JRm#E>gFS1WdkRusc
zaBx1ws5xgr&~4VySdD;2`3h%o6rz5&d&7ROn3Q(nSc4t(8>bA9_mOGl<Qv1LU>AYP
z9Gx6x>c*@z8Fdgfwa2R$^e{y4`{8tq45MrErDFP<@4?P@Gf%kd{DY5lYkN9%zolza
zSnu>a=R2be;PL(WDkf8+s^yxF!gMzIZpd=0VRouF-xf1*p*KpYGwSjC^Oa}xt(`UU
zYE~0pXIhAIK}DLNBZ2~jYr<}1PP;bM2e=K&A<kW8@2>ZzlPiw8m_V<`404=P?HHTS
z`B0e9;b2_R)Fmi4Y;y-csQ~g_iUXmfq5a~g50tBWaSR+d*e@q&<GYRu&tD=fr#skH
zP|>YlFMeYn-R~Kj`>GH>igoRctkn$wx{ld(bcgsn$1*>VYyS|bx^p2FY%w3Zb&b)p
z;5id{Myyzctht-v5W5l1$+=sUF$3S-E@M-a##@2FB(;L;huZL%>**QO!I|+FmSKb1
zi&2qCi1uld*oNLsfbK}*bi!D*<0yO7tm;kC!o)l4R~#IDq{m~{(uQur_t?>vdZg9%
z7e-wcvs!`F>-UWTqJ{fyDIdUY+*Q5WPC2B=1=r$%wR^nO4vVn<b?ud$;jN=zlZ6&$
zbWxus5MA)24)`|(H{T^p-`lIcuIJ%;i@(Fzv687>uvyzZ16sBA7aXNT%5JH@zPeAT
zt>w|fJ(0;yDjP=<?$zWKC-xQ9S5vdrbdcR5(QO;V{yZg$RvSHV`N2i6wu<7!B#ZaU
zXul^uU=1z1W6yQy30ZM>_8Fs|<(}dT^H#kSdOIF%yAY^hO|6X{y;P!bjTV+Q;?E-&
z=5|!wsYP**sji@CF|NHNz`!{qj`$t?YpMa;<B-tLi(rqz&%8Ce*oz85A_sd8+6({4
zL<yIIc(&(V!%Fp}3qeCv3UA$t5~y1iPF)}qpeLauGUO3bN#-PE!s{dMLN-04Uan`H
zp`TrGAL*~BSI&smc9iUfuY;HmPlX8Dzy+^NIG8=lB~+~*u0viuUH~~*5vxOPPBo4p
z1QCL9|Ge-8i^x%%Bos4)k0AB_L%@7k-)r$+-X&kZnpSykCjTu4-?~o3U6nr>YKlH4
zFLwBi*bT2hL_O(U97%_MUqj%Y5lBuURGs)dbO=r#a8~iTd&E<*Of%3v0?xHc>ommL
zzj~Nmi5bUR9zE4pGWRIouII7#ZG9pADG@Q>oJMl}Kzi5AnJ538^Z<qD%paGkZhfs4
z_;CQdSO&BgtIsS9`KF5U;FAr8(kolS*ElpXJ-8il%w+LYF3u3@()5^_0RJkT>8ixM
zJlX@m7xm0*`G{GcXBmSL=1T|*|5gPa#;h)pbTUo8ysuz7af4R+QR+(-qw}x4g$dX9
zjlb@PZCA?c#cus@9p>VHu&*US{16)(#5LLYSzMKkumci=;}ZMXYgY+lHWo_g{O(ld
zCA6isFY|XLV~N?%$B|$xDf??nZ6r(SSSlCl<B9WR86pq|6!@Q)!lw0VAphJ20MDfX
zK<F2rjn;$)NjSR^r`{EpODxF*v+DSE)bJ9%OG^G~gr~6d^jyH%6Ttz2+s<oeqls@5
zuGc{TAkVT}0y{Pt{5Q=#FmPLde`m9QTo#+bI>x>o>>DD#ni8l7MA_%vt*>tE%qk9L
T74z>X79z|afbYuPzy0yQy>pYh

diff --git a/studies/PlasmidAndStrainConstruction/isa.study.xlsx b/studies/PlasmidAndStrainConstruction/isa.study.xlsx
index 9a001cb1ff6211afcf05b8b93467f7c64e102756..add116d522806561a03f88b2e6b9d513cab1c34d 100644
GIT binary patch
delta 8705
zcmZ`;bzIa>^CwQaOB!jAmIDL?q`N_omXbU|x(=j4B#!Rx?(Pz#8w8X_x=ZADoZsj9
zKF{~}``sV!+1Z_$o!gz)?tFF*(%{e2;4xL?5dmm$aBwJaydFwbm_zW0PzqUur+%b0
zzu~d}bl@OT!Unhy>0kreh!TGWG62k2P)Y5^YVA5q032M@QwT093FHVs4>rat@r`zP
zk#>Kv$0<1Bw`JkME=BtCOE|m;^4diUl`SMSf~s_nm$_wls@ExQY3Z<1_Tjh7gG&;F
z`1rB`UpaTm`4^1cmV=awoU_&794_im_~lC3Nb2(vR<hz8%M1H$kEuSn1FsVCZ|A`_
zJ8ctpC-SzClUE$oZ<g4-mB89JhF|QRZCPqQ%oOqHyJ4N=Pf%llUoQH%$y%2fhFaG>
z`21XbQ+{C5>u+o0Mk+p)TlOXcJMHW?E41L=Usk`(G?GlDuc7`FWbfP<?(l$pzWsr{
z=0&*d(#1+Yccb1#Z;A(`{e4NKWV-p%#r2OnhbZv1shyR#Rd>eW2?SgfY!Y%MlNTx&
z*zd9x&Y!{%&ub~XeAUIX-tLfFaz8bSq1kGXqEWO*?IN&qu-Gy{XW&kB<XFLR6<szT
zakS~G*C(o#FxDPP719#a=)JPFx8JJ&Uh`MD>f9@=(`##Y@{KC%7419B+3N!n)S)WC
zAbyQW=v*W{^PKF*SMFdzWz|!HLG^|+G&uwK)37CX^r1R^-`2kU#qPz^%c}U;Dh^Qt
zcfpF>jW~NO8c6ac9X<aiQyDr;%GiM@=AoC&jvtkuMSmnfrQkAM<Bp+2V&*bE<i=w_
z;^8vA<&I%Q60LfI*Yr$Mj1R-FN5+vjw+Bb?Q$Vn&5V<E^)VV#lFqqckr7U)^$II+s
z$ocV?b<~L-S&!=t=760abVB4me}qsfP4;9_e*XVhgBSyFCS~-Pp)Z3b;N!Ceyz%(X
zm13ECKrKBE%12ZA*SZLP&n!5=kOmQ+mdUB-FAAQ>ru&`(pft9@4a|c#gg<=4uTZ>M
zd;3l;t|qBI<;{DJwGQPHFP*jwXmggTKy&|1Omm>`vKWn!Vic@le3dcH2G}RUYkA0h
zU*>!N8afhl>lg4J4Qe|;%rrLLJ~EnRK+Jh*oJwoA&*_BEndr%19gtP;5K6G@ByARD
z;7&B15Z+JK5XyhBl9M@^&{0)7A+(>&I6`5$(xO67vZbTXnF<SDpEJc!KDi(Wp_J4G
z`gx$)kObvQD-tRFe`4t$a|?Vu!kW@CN;NKTjoPiimCI3JU_Pb)n&#P9N%s0f*Tp*c
zBwnNuNAIrM8R%j6%Zz1oVX^7BI$CJ^w^?_Qa%zKv@4C(@!$BIh!4ggf`PIXoan{1c
z<>~Zuv$w2nBp=55k#(1uFdPb+N{RcXN^GyUeplVulh3^!7}+yEGy^O+b9vuU{l{^F
z3_TTytzJq%&{2U1z#51sDhXIIzD&po8Sz&3=NX6EbGwX#&iX}U#PYRW)*lLjPa+)j
z`@pYO^u0G&Go2#HJ9op5oWD0*1Un-CW<J-UrS(N8Ji;9i3(54bHB0O&q%hMtenTU>
z8p`RxmeTkIi$*?%>|LJ2FBzs^p2XwzQoB5bU#x<qL+1P?s;NA<gYZYd#aG`;&y}a#
z@;W~U%qMnz7Z&5MDQ-L>cWWZqnIGHLE5;WL({i(p4TfVIMY%FQzexHJjZQOTX0iha
zF6XXT3agkjj&o2=sJdkL@H#G?C`(29h14>(=p-~5LX_GS;O}r7zVg#gjZpdbXYY^H
z{n-=Q3l+{P)8%0tMB9d?VEUov^GcKH>)4=ILp{V(G~OnLFNTRW-cnd;X}r#Q?V-y7
zQM1`oW4aA-Mlydu{L1b-cO&xJ;fG6X+VAJy@AZuQLA39`B#F2%l;id{X0zME;qJ>`
z0Fe){e<s%u!6}Q8H?8t0(IVOn8n!ACQg!7dAX#$vf#K<cE-ao4k13zJ`_z1OT$@}H
z%~_EFpiPd*;*&~PALIHYBi+sKF^wS#z3lAa@r<HGROf6WZV!23n3%uzyFGMfO_@LR
zOuZD0_^%Cyd%Q0o4CoxNYe5_R2zCodQeEvzL2rTCKeqq~0~u^+w<tr<w|b?n?PK@#
z`vXd$oMq)wsm6gz-PmW6&f<fre(}lug4HfdwZlO28M`F@%afCP`T*{;E0N?y_o(Iy
zjTZa9kzQw0-D2CB!>5NLtDsf-@~M>UWuiK(&2I0QwmYAjfnTb-NB5#~>)QVHhK<N3
z%}LuAo1(mu;2f~Pf{s~%lR9zBv}eUpEo*&`qT+!fBV^Dztk^k&!u;0t)ig*e&arIB
zgjV;=CfiJ(n5;uYL;qoIHnziLj^OsL%2TU2zlP{aQ$MMoYuY*4G5$z5FZ^z?{Sq6O
zU^D!xva!;xSgpk1;A=$P9m)A=nmWft>6Bx8**;ln{vp_+Nw<-zcVFqcydf3)=_(d=
zht+!)*S;!VaM6Imn>+uiPhxYb(&}1etq|<$`pNFJ@wUif%FCeKnu95w%e=I?Zp@xJ
z=~8rc)@>aj0hiNmwZkxcX)gRJ7Ct3VewLzsI{R;<ihA8PeGyg@t}Dv;4;8<d%R^pf
ztx3};6*YnxvX%RkB`^xz<a?vS$Y`WAzJ?I1b1@o=^^Hj=6kTuXDa_*>hFn{FrJJ3g
znF^o{o_~vuaCT-#B1dV0jCd(Z@SZ74m~wZ})1=%WEtn7TGScK+B!zsMeM<8}$93CS
zpb4v&>PfGN>js!w7-5a}84T!f?l2dgEnzHxxBluBo4lR#1LXJuwm<I^YQZDmJ$nWN
zI-G|=v3io~5kvsp>(>Z?fZT|3L{w>b)G>;;<C-D90Vpz$fP&f^R3rK*Ck~*Kcr6B%
zQ>;J?m4Xi)CGQKs^d_XH!KJ}_1Tp+7<q6EwktjP#YC2r77#=kp@bFv!;zj^T)UN(g
zZrn>Jr2qp98kaq!8}mWFNL&apS12w%DPQX-9Z4S@b^LzI$a7Hzyk5FT2w*VoS$ejL
zakGVL9P^9;)mUtuVJ;~*Co#7-M#w&nhJo2Q<`Km3P%p<}GpGO62RsCmrAa9C*Y%=u
zZPo=0KGhEK=n5<*$I#>_AqszMm+6dD_MzBOKx5ObaOkFTyo=0NYSv9uK^#j4x)um{
zI8na77OX3jSui;RxIY~`*O;%@t=batrUDQ@ju>=WaTql`t^8J_&5R7V6RI73Vsnk~
z#tU9h7*og_oU<A3z+-sbd%nhm!RrlQ((bEo*jYVheA0|v#%+;?K7akB^cRAQ4^eW1
z&(Z#PHOuAcnAlNCy{lCdS>e2$$L)=;)Ad3j==#fLuBX{2D}y)4Z*B5~%l6M)<dPBs
zulDa6fCHnd&DFKRCYymv%(hOdB%U?P56W+|3|wcr-(u!lMoFCj>)Nr^Qi@w?&Rx{g
zf4eV69_yR67lBL4_%Wo*drmL(u3|e=Kc{pMEuJeCeLkr4uHV~vTc_VBu!^PS*}>ir
zK1X}A`S7p92bQct262v29#hZLFyINK6PE$3tNxP{XJB=#U~og<0~a8`_Bo8nAbLIN
zjC?89+$Kc{@A!0g3=hyU@$Qw~!ae=NKFEdl<iuJthEPjqP#{Zmpdetb=&MAV%udF@
zmo8sCTkW(ewb@r$c6w9m6BXBz#qag)K`1EG0$G7viW}|%Y;Ju{(!8xmG4h&Ri1|8T
zw`SE;vr83CkE|mqcS3xgWhRNAjHEBdB!>oG=)Y;@CByBLH-F}(A0lNpQ+&?oNT@zG
zy!9+j6A@22n_z1sOie9s!bw%WFI`UNj%TOZsl+yd<1|htZu$iuMbsV2x%H^H-HzWR
z(<s2SvRpv*mGX`(&WQNW2;&x4W0O>7aLh?6n>=>{M}i(J8lv)ajs&|Rvz1SeRx2P@
zh3an9)Y6-GoXL~yLz-9<-s0XtIWc#SR8<TI0FA1Xme1z?lPCd3JO7SrHzgpgoG+sj
zWN%rimE(isS)#h1M|DgfO4Y*+5XTrmp)_{;Z1l7T^`j652hOYRW4tcmAawvTnAm{&
zW$$q_CbAMPXps{oO%KH79MjY@{bh?%oiU9hUr87{Q2=#BRV+jKQ1oFxndw&r1KQFR
zg#eF$?Ns@c@%!sS@c~-_`(n?}nd;wAXPp<%j57{5g_oIUodxdDD4Y#8NvWJcZC%q%
zmoA2#u6GFS1I<baBbU3v`%`Hq;N|uyDFbVE9-A(^B%Kf)NX&M<`)zFD2u7_nEm_M)
z_iMU{=$YB)Mr)3B^;pbb@_@QMOFO@}%olKq0KmNamw1aZW(4?1SpE<C2uuSJG8TN~
zF2U0G_9)HA@}$u|h`^UWB2m1Eo0>QyPb&r$-W3${xaN3L_`L-)ap!+xU@6j@on1b~
zBMfEDvPxc9UfFixbjdi}`Ol;X8m{K`ITY0p19Un_B|$$dfQ>kR!$Euq8Nf@9DKZ3-
ztJ^G0D<&3)g>-p%Eb$a5x#ll;#)#|ap1)QfuU_}MueIObsol{3p*RxMr^<1YJ@V^5
zGM|^yO++JGKXHGE7jq@vSiP<#@aCu?#WmUzquPQ`l1-<bGvnH*-S9ULnBe~E-B=Tl
zAd`Y<%U}p({#LwcTaimI^fS2O`9fGbbFR*%p!JT2flYsS@}i@SU}bW))yVtq(g*yY
zc~D7Ag@n6>8%qYYPz8EXKh>osU+Z}Csj|J|1X#rBNN&Oj&B1Uc&WkiFe<HS~MW5w%
zt^JMN9r9V&X`m4M=&_>ar7@1Kd!Bs<k`Q>TicmMKHr4L=1=i;l&^g$vg;S*R?Wo?A
z&gcNduAjQ&vOmZ!T%7HJD6*k-@gUD}BPHnNV6&C`5S3e5cA({y$y_#NWCUcCSD8gP
z)~bUj|EOcdSaZ;r|EMn~%O#z8Sl{7%(0qU_Ro}vpzdgD6Rr)W{v@$GAtNTifg>N3(
zqh+UB*U<sIm=((6TT)=4{sb_8modhJ^d=~OQN=o00N9pSBtIpX>;b%2P|wImRYXkA
z2Vz>@2IhX28nq~nKAQsGwvoh7-v9iTwDFC)#%fDAJ^%L7U`n2+j3wqac~%)XQ@fIy
zU*)oU3;YDMZJ?XJy!^bP;VGDb%P0CR)?R;^Z_PX;Wy*bdxEZ`G+pJ%>B>4z|P`Cp|
z)KN{<g*&y#G@v`vf<87DJ(8eC{<OK4(xsH#CI4n27!*QV%2Uu!!G_By5cck6Ca6~t
zhwlPPMsWBF&TbQ&?;uWhDh-j3fbD#za%D+s{k;y#%0O9|Wheo|O!GCC3MS?X`ZgoN
zpb*-UwX(j_M;>(b^+F!!TVn`GL4p#P*FD4SJ+kfMJAx9A5CDag-1>U-J)9e?=p&q4
zsc!&>sYin0@Ik=NX~7lv#TDQ!J@^RYP=HL&2I)ZA0555%MKIK|)W0mR54W$&wwvq-
zN<Bgl6jE{(9uO#LSGi6p#8*R7o`Fao2{lNm(a(E<ucm;IofoLI#=W`N*ZhGrLw3%1
zSs)^*Ufmim!@Z!0-JqogM462rqQrcwAT047Cr#bySn8^qfe3_g_kLWY=QqhEc&rkP
zSEF(@mI+3>=iaBvf=Pc95rav8Z~Xz*x#_pR>o>aZw}0rjhaa#<ls1t*`cBOHgV^Q=
zaruvD0)9KOKNzsGxkE;o1>ABznM^Id4BC5%boVj{oj-_-KZu2&RM3NYz=&nQh;6{0
z19<{fq5wnd15TQ#lhOp(Z)Nl?<CsCS@jwT`eYq8K&eoD@^R3Ich{!gHq5MQd#WdrF
zfedqU!c6*8vK1<=pFX<O8^hfmTfciYv$!P;i?FAzoowE@WG8s5$~spG{8lf_G;p5j
zK2Mzw_a6@>yz;xMe$D~#7Z{9uXe{ioTaxp^f6ydrqRJqT7@ivdst=%UoD?n0WheNn
zhKUPO3iDf?*I3nX-nERl)nD8>)wy|BH~#wX^9-U)dJN0`BY5PDr4iuZil4w<fL_Zz
z0msF5DXnwj1RdQG#2-z|F4ii>0^sxH^CZPuN-y^XluV*cX_nY3l{?fE;sxxD?9y-c
zMb^P<U)T*7gZ6WI(VA0(a(wX?P?<CvzU&?iZ1$z%nYe46A_*i-X<6==ov?W#-J4o5
zvx)kRZq(M-E0b_%$FuR#?wAGVA}l+GgR@pRr>wuoyB6AN69Cj_9cL!|#fm$!;WhID
z^nB;*t80*P*~mauUg{+)<TE-agiY~#1-4-7%mY>9GEy_cG$#5o8Lbp7pdp{zL4tjE
zpX$;RstsLwAaUV7%H|5%z1wyGJw{wusfL?>+n&Vm^8&4R&0$O|FB)8Tt-Qu_!Lfv^
zyqAoxR%Ppo*y@?`0rmB&X}_plt3_j{I>(k@uRE5H*Lvy8(2kd<_MhzHql4U|E!`L_
zyh0QYZ`vc?C3`ut6H9W<vR-;t*mLJ&^tTujncHZYDztW4V<QQ-@(2HLJDdts#?M&s
zaC)I)aO<=+bwn9qoUwA_^mA&4ADq^)8lUxn@h<zJisMv{BGKMkiE-Tz{CmPr96hoh
zF&N}6V6ilrvz`Usb`mC;-|q5jU{Q7@#ojl04>lg-J5Aq<_=#a@x~Z3<nvD%^)79Ns
zMl<XrEe*URp1JPNU6D4Cdk*J`F)w<RP`i}w`(_@K@44fme|<7bcre$)Q*9hzxWT3q
z9zDcVARKSHugN0r8bGYDrh$U!Wg1r<c`O}Q?{YL4STN9B(RnC6h&VTk1HUwyH&!iC
zQ2e#XAP&Umx%#=w@+;8;+<&KjofLm!PFnouq}0D-&WexS&DJI^)=qhe6Q_Um2>QvX
zoEC7doK1(qL=ne}YOCOBOI}bV;~0HFG+(eflShwbVSMCxB`DJFNiNvp1|qA5EHdpl
zk}4s{nKEW-EHe~z9BREsm;1D-|AlPFRLL+m>uF!YKI(Z6WSoo~+@nxI&#|0c|4tR>
ztM;&_G&Wk%?@ve?ad?iX#!Ew^loGWzjeVDjWgZ_itoz<?=#*16+$Z_gONS!QFx{<5
zFk4DCuQ+Aii2Iv}1am!=wtd<Pv5Olw%B;qZ^|U>||B5P4{G9M@k^RR%!Iki?`7<=Q
zv|1d6RxH(q!oYT9cZlhryv1pvNDDbs8`~U#8^uFYf2IPzjFzDOO}!k;o9bApOnv?|
zC1qXKrcKHGAEB8i)Rc~6R|CZPUy%1c$^!e+``Rz@!nw>iR|wBIO<HJ7)(8#UIgfu_
z-~?@>XRv!GU!V8qoXEIuPBkfacmR`c&u0s`Gs=UVPQbiu;@e7>k`E?^z;7Vl#X~EZ
zb+?U-1|TJW?fH(=#(0FX^g#XT&dq!Wwf?7ryQg}0J)_c>Rb3hLXA!?fFQlA<fYpxW
zBg_-Q9V_0@*m}C+i(E;xXri%B0r8+pQ&)qZH|fM`7Rg(_1k`p<*(*ybd5*vNVCKNJ
z^#J$LTyvo$wO<vFvBo_%lf6CsO(?c+7hOBrJKuy-wM$B$lF8Xa%BEwdw^tPN_xO$j
zbvzQC^&fUc<99UT_-FPeHES9iF_gw^PM-dEY;jT_V?KUXAkE3b$v%ODyM(aOP=b}#
zUlO#h7F2rl8DQATHK+hS$yrd>jK5KwpRlMcRxsAF#uqdZ3~3(_o)ex*&-E2JQJ&nz
z%w2U=8qFBvKkVC{W0mBPkQrJq8xTBn#(Br3%%p4RLYcE$P=ghNRs$$VjUFD29~|8-
zS!K`FK#@pl-M5Jy8f(!fv6Bhf<N}YOB5ovwW3adp?3I6g(iQp*C%d|K>F6S88AE+m
zl#3&=c^^Zn2kSZUy($j)DuVCTo}RvphjUhW_s+@IlBAZtzSA(rO1p++wWO$6V)j^U
zh(Nnc)mMub=CXx=*5Pf1=c>JEzkqvTg>s=J&D1Z5fDOYzed<zXB;ro~agyNSY&SW}
zPw{m0+IYwga_S$=UrrgJa?)4tIhM=Q3$uqVt<Pz+TiG%Bhk_X1*$c8fTn`)JjwEEw
zI5e9xEpA;7w&JTuNCfpeD7g3~5-vc}pN4A>qT}M%rYejeaZpwqA%e-DoF(;5>pMA+
zd^~+Xj>-I<pX9-foh-X9X4?pUeWg)sUY+y#(lV>NILg*N7%<1MOt8K?-=Nh^Fn}gz
zR6LY{a;dgJOTHGtFuT$J5@TSM)!<WJukJbAb_EWd|H_ZbxvxUKP6<fCPd%$~L-{@x
zc(w76l5+gogkK9@0%_P+?v9sh@MGyYS&#M5v$o`wXj+$~Q<T|OrAmJQgMI9*@jtRq
zo=xk0*$g;k&FSS4eQn)Ohzl=oLz}-+ptb0Uk?Mm!D(jzfiS`ics1iK!BqeN3Jl7%K
zhm$Iye)iYswRJ-Su#!mobvd=*<V3r|zG0}0eyg*dSNdk<JFc0bAt9IWU$gTa8;Q{O
zAdbuJ8kGF716Hxv?-y6ZU>DioF~Ql`Fy2~Zv=14ok`7j6<$`Mf-tp-#+BThr4T{=!
zVt3asWdXhOBkn%=%zdBFD%aWE<-R39?-y;F+1S7NRfvd4RN1PsbC+VDl-;pM07l%V
z2{M6aA=vL+T_wwxDoyhHZ0>`TcDEu6cDike*1MWvQ{yvLOazsggC$;y9CdBi@>y8>
zi)VwniOV^aV@rO5o>{sth3U?pZ*A@xaSCv9N=3V8xxDRto32xxsLU`N+%+`zrY)Vf
zy%*{Ir=C6r@GzTzPN(Z)IGSuPV-ke;(AI&XRD`iYXJjBHRy=ZqFF=(^hOOBZVr>g*
z)mJ?e%N_U?T5v9F1g<JO%s-wlGkvqNYwu+4&~$EU#%V4>vsjt`Vh;4|?v~swPbFpl
z8K<R+MGs3LqQBSyaE@T{SndZEQeXonnyp)&y@iU~T;_O?7Me0oAgc4vn(jD(GT{wu
zT}6$b`}TRDT*3yGQ4GOjwXC@kf9q6h=cbBrKP|L6lXSbj3^02jR;yZJo8snZ0P%MZ
z#6Xe~Kw14ex+0qDCinV-#E20=yu>ftm;N^PTbS77rsmPFTBpE-catI~t+)bV!{`W_
zf!Q1qkbuIVot+$gf4=i4JrugM@rpXC{WZ1<b(^`G@)Q?BWs-X8K9~!)$nWAaNfv}G
zB;mCHtVT<{%-|s-eq-yLhmy3OlF7V$1wXSy)g+$xRz4J|J*po+3)`eHC&(;EdAVlT
zSR#8NF}C^dSB6X<pd`{*pIqh;mY$c%&+kQG>G6N1x#b^q713+!#CwN234Rz-w3!#~
zW}`g`8qigtkNz4t(S0>>tU#5`{U8u>T+$BW(>M?QHl%-sv`B80>s#Wkb3rwY+|kp%
z#j%gg@>c)5V#-H~<oT>3ism|TS0W~v!Y6+G=AuKPrhY>U#(qQ0@BA`<=te!iBHFh$
z)$VMUB5h&GYrg$=4*BODIhBzfmP0!FavlZ2!@-dwLb|vJYc?3;U{%H%FXlJ|n1C;{
zzfJ}8!nZ+(2>@B!|MX9cWcNiv`%h3|{e&Fp2(UV3J(o2C>f>pikoHDI5Yoy;S|b6J
zgN;F=dH>Wh8+n_NV8YHqf3zS(um6k)y<UTdX~)sNa4>{0iBW+;-JCeBS1dHE{`i^L
zlGHM`eMK^HXjU^R)*Rns=HuId8%KMuP$V{|mqthT-Kdnd2WYT;It7YmKK15=05Thi
z)NJ3Iw&?_5)7cNk8a2J)q$Pa$Vhp4P!YgNM)v@i&20V46-NXZ#n+99p$x*C|c6}RU
ziDl$lB*GA?)wKc>uhy`QI}j{SAVi@CeVPr*+NF?v&+KMriN$M&0Vs$PhexA`kmeGy
z#<lrTP6YfKSRJKJ()e5`y6twyl!JBHQA3He=tv}=YB-_6d|IX0Lz7%49xdG-9iwh!
z)~dp(NX;X<#631qd^WdbT>9|%0+W2n3EPXc(}4x^R<O=`<Jpg~s^H@3H!sJqRJ@sk
zDrf4ginvdoy~j%U{f!KDtxDkPHbJgsxt`k><(E>7i$CL*_vv}7PLvIKM8P{C*81-A
zcEz<jQ-S+ZPs-^G%<#i#uwXhy^9|C&i@PWPbraWAh_C!9GDk@Y!^#X3l3XzQM2Z(i
zg{9bG)J_Trqxn*jFnTD(54*zuU6h6ZrTL#dhQVV&>L)b7MiJrQh@oZgzkl$k5LGfl
zt{0Cfq>4N|0s-7(SsWIg+J8&I!4dqM!GX4@(IF0UM37x+3|O34dL;H%K~Cfd5!4?C
z$RM0DM6h}PE{yzhUP+9{c_E%MxG>ivWylb^aA3Lvf9XEHZ^l7myAk=Hy0y44-BsKt
z1b@2>dmM$mGC_{zh!DU8Fk_VjXb=Gz445;I?@gJ|Doq;sKMgt(!VDJ4{&A*FmJC6L
z6sCV6`{$4R{gwAmT|qLaF6sYrgm)vo?9mbUMu@%K3#!LW_&aO=r;QRwmmDK(9ronN
z5E!XpQ|nNpLD=LmV5<L4%AlL~_f9-+2`NNdo))I+BTvR3#|Q`KX2aq1&e+E61IIrX
z=kH_YpH|u+lk&8%nId?&K<3a@_eS}rj5CBl;m=G03S{t@kT-vEUQq53lK2<b4&^E!
zi+{KnMKX8_2)W`PH9ILX_%MipA~DQecj#CZBu<eA#x*OFJp&2Bod4kD4t4(jh)2ky
z0c;4a(jNn?N@Vc75E&(^|2V4bl?V~Y#2{Q^_>g2J44CC2s8|uCPl*O8MDlUL{s%rL
B&=3Fs

delta 8781
zcmZu$1z42d(x*e0ZkFzp4(aYL>28pg##N9mVWqnTB%~#!OOOUh=?3YBZ&~iW|L^+T
z_j&d=bLPyMc~9&+=bSmsfZfl4MN?CRM|cJU1A_vi9H#sgZ2%S?Lcz1Jl#jIf9v0(C
zfC*0qt>A#CfmZ0kOFdO&AuysrG<5~koy8ClU|`(9h5%ylAp$LEg+>RKdeu_kW_Q}m
zGk29+cHEs~?7O^i)bdMAwxzqR**(i!TcfstUq&f5h0gO+=QrB-7xg#wCqlrWgZjod
zEqd#!)<2fYmRQI$9z@8ZQ1t*?z1nY4%ye<PXGoNadIkBCMRYuey#%_H+t_;Afh`%W
z6SatJgC$!v`zM>A55W%!fcm*#J&uO%drIV)lFfE+!aB(@JPA$48aH082<*3!ht@~$
zh7cZ^8UQm3M}&4$yEg+4o8Q{5+C7+R@Ui_G?@>L<c-;(KcroAI@PK@M@^V_*s4M@>
z&0&=&-A4Gtx_)4(y1TdJN938?^`ATLK2iTV9>D;|&a8tY5cunjWZ1OadWvAk)cHo_
z%M{*39iNngo8Pl`OWb4K=XMr7bi>n3uXfzRqS1X@P7gRDxqhx_lbv1(R3SDUwH(Kk
z@^5Y2{<=7Vcbz7zSKW2fOP?Cd4F_@T#P^DmfmmaMggpDx?AzLj+X7g`Unau%tnBEn
zoLR^Z2+4n>2RUytDrCa>?06bW_m_$pzY%nnNtq++OEVf`{W9cC?w~?+L$Wqme`2p-
zjCLr#R%lHtFON!1ge@P0yw0(PZ<UUl@*77kpF&zf7VzzeNFF=r6QSE77d9Od569ZM
z4UH-w(433LO(x=l6Cqq^+#0)FD5WPMDn^hm|G6B+HfUK5L-y1qo(%oWMGAv{d%1rV
zb+l97*ZUY(;{S{P()zm?D|U(!PX>F2A{9%qjina*-MCxM7h!@LQ#kP4H>r84f0v*+
zKSB(X#sF>>8wCOO^^kG&hq|t_NRXC(M$sgOU9C!KT0YZY&9$F?i!WB2YN=4!Tcy&O
z0-7^;*qirK#5ojDrmI}Em>gvWgU0ht{!Z-sTZ%Xt1_;yfKbY)~kSbM8)NbZ{EQQ$$
z0S05UHXMi`<+e)lR4$$j^^8F(mIkyPrxq*mPx-0H5Ko5qSWUI9{#XkwYK4(WkL6`&
zJ{!%G^TnOer1Zsot%tBvj42$EFH5UPJu{0Y9~<b)^wdf<cuSo|_}ODMp1dmJnbx%L
zvr7DzTP;^5cZ=s1Q>hEMxHdzg6(B#A2V_2_hi=9D-x4khgH!EWWk;K3-ail0pR)nG
z-49IYNJ4-30Fn92@GFknuYT8}9SyoZw7tNe9Wwo?TBbiW88yvuVd-Bv6x~7Sm3oq@
zCe)IFwlpv52}B=P*s1Z+D;JK<ZeU5Oc!2+}uZV7TdN*JP5f%n!7#?f{AOdru;(_vO
z&6-f~ahWS&yQj=-q!VA~B-+Y(jO}grGAJgN340*JU(4^DuxT(I8t;9tn?;5%U)g3^
zRuV*vb~Wm56J0P_aKl$?ltKUP(S0HCr|DYq8~g)_Z&@7H_uz<&Fbhg4wU#>0AEpyA
zoUGo=aruW*ge{56^OneQwEY^ob|fHC>}L;TNHt~ZzG(JUv&&d3XB2UJp^H(=Qq?=c
z{LFVJ+{TQR)Rer|><zJM!(W)l1dxrLkOa;Z1(J5UVpi}LiPtH`BDp&5c(1R2eCtDu
z+o|I42$Y;onSR~<%I@nx!{<R=KXPFa->EGf75KNo3-qrW$?T+_51V$h^WW)#oX^CH
zBj`cBA|03(qqd`a(*g|kueu2$PuQlgt&DtUIPCouB+1szqU_>Yzp|xRJwN_}Udzms
ztwzyOmgK`&_l6NSpi2P0`T^FO;QQ_z=-o=kK7-($^!0GVcccZGVKkfjnUn?@!qtez
z8d#}H`pI#U8qv=V!}>5nsIF^o?Z^3}0nL=4BLQuHgji$Z{2|;2)K7#{dBvAPgPT{!
zbc5lF&dAZe)L0C1eDun;m}TwsmuAF!78Q9y7^lBsFsAp^eE~}CYvz|!1O8^I5jUZ9
zI+3F5G{dT2?-Bn!{V<O~1pMMT8#Gp!K0kzp1|J2tW;sY`n1qA|N|2FrnjB&9;l(S8
z1E7$<1<|WF3xu;@wDvt~rxAL1nb>U!>4)yGNx^jMq=K^RFSwA=Loeh>vh-RWMtP^;
zlO$OiC#?CN&#f3SmNW|HpNlRzEp^xNe9kS6kns?z&AK#gGkN&xi+g<IvSz3^n+?>s
z`K;CEk)9)TTu106^%EpmwioR9yddfLH=t!rnrCr>H>OGVgNngK#@$}!r?yqf^P9#s
z1NBV(#bO(r{xpg0%g(O{p#=4Hx1>#VAD2|`nlx%!>KZE2^o64f>n0NiZ%0t|=J~E`
zLF{b|Ce6Lw!2t$I8UXVOr<#SI*-3}#{NZ^SQ>7(S&Mujav{xXJTG7gN(i2CU7Gkzm
zQpvXoI^7rD#p<B&-l*x&ys;>_Ic)mL3DUMzjOI}dd$z4b+0iIJi!rOSnsv$I&4gL;
zKi6Teb0W?ZB4ia+GwlWfTsQg>f3&!*uJoXJ>>T?aAqUhh5}#h1k+SLxclxe>673$+
z0^l&crSalqata4+X&m8T2{SEXj~1=Ogu&u*QH5yz2q#oO;=;0EdP|wh@u8`h@PRlh
zPp=uy)dtqJD5gi3Pji&({YSy*6z6c;AGbJI(J4#Vqsdq3zpVRs>2t+*xv<dmO~PzP
z8mZ0QNW=J^hw-^8{b<9)fIY%|0_?s^v|p5SfL|LRGPo5=3Nko}vBv55m(}ksHDy=v
z_(b4Vs41X8^YJP!*pbUJ?FJ<*_T424iagK|8T$tuwi0P{b{Y&UD(1&Wz{Kt&9ESSG
z_?IA_w-ucx9g!wofS7CP1BzVOJ18hg*RhL8dG+y0w)%vHeFy`|g@uhY><Pr%;>U;S
z5`!0{!sI_BLt#X!r%Z4yjdDpyLW!!2MncKf@Ie6VjSo)NB{q4@%VCa9O$P<;IF4r0
z<DrkvWd9a8d1T0QM#@XDL?b(4chQI|LBW=4HRs9TzXWoI=O7tcvq&FWS8=5w9f`H)
zEK)7MCA4t>+RB_VES<i{Wn8uynv?mG+Bg{6$|5qhhiGD4213+@t*Bw*VgNXEOw6En
zwk*{`61xEXO|2G~E(!`H*wK+?;Jb}l-wo{XJ_LkF;h>?+cKe^E^?c^tbQHRWId6td
z+ifbBxpa@BM?lV>{CO+ZtL;>+4!Y$DS*`)R0Z64HK}JhqR&@ck8REO??HxZ&S8Xbf
zfjL8Chf2dNH!I&CSk`h5kV=<t;v((~>9c;y_GTq)^=5e}Hxej>pIg0IlkQ&kDafiP
zkZ55^w^?fYCUBPcv9?e+lc~s)Ek9nm>~zTYK{O}Wdd^_Fc)uw;>qA_c?Go|}Z6jkW
zq?Z1l4?<_Mm#sQWU2Sg)VphX<8~lZ*gz42b$2Tg1wSu%GH2IuVJz2kfDV<34;W6I7
zZ8T&vR$ZI^EAW7aG5?@HZbkv@;PwPK7?=j+$M^%{e&PMvF(F}2W0f5ca(KZg)LQg%
z<b=lToyL|Mlac57ERD)4WjI%zfoaxT?WDv$cGB|~V>WkjmeC{`%{sJt?ghbLEQme)
z6}&SBlqLp~@871Ap)rnzOcF6$4Ov|G@CeJlm15Hn-VJn@6w99CV2!ft$t)TVe5K@N
z+37$5`lf})Wm-~D1nkzc4k{UY9?*8Etu*0L%C56C`qAfwhDh9Y$x7|72nJ(L`0ZT@
zZr>uEf~C09WM5+*+2Sw6AHA^)*qwDg#WRuqOsv(~EB;Vr67)jRYj*0A#w1)zp4ELE
z_S=P&=(NzW3>gEhI$d_4@^tu$kCJN85mml1Ht1KiX4<M@T-2tcc51Nyw-s|e!iHQj
zS~n{N^%G$025olo^^DgG#og-gnCg1eX~r7n!j{E*0vu~yY{n~z>?2r1w@%(^!l<BS
zg7<If_r%AxH~uiDBPAjEWdLsb4Cv#MT05(G_hQ+FWaD5%a1bN`Y?wklE)k{#or(y4
zgdk(enO>KW-!Pq7DCiu`G9z{!%0Q$X%|X^e6%MatfysG`olji76UCdbnnl^tY3QQm
z^Fdd?Fw`$iByn>eUJ461jF)qnZ!(<D<bZie1r}PwM(hr7cLi2`eB>^6J{|ye1;BSW
z!2<Pe(UKW$i>5ob=jUo2UZL2ny^X`4hCmqGA|zu*rVFiHGR6*UJdXX&Df$um;P_2X
zZ=_G3_t9&XWO&b?pD%;CWpo5f-$f5j_6QWxB#rF>oJ(&a)3hb?vDrVJFNfJtC#WkC
zq98q(pk}9YQxz__Opu--FQa%YCva2U!P&ZW0I@DB-Q3N{*2&{iI-Il}4qjc*!LwBR
zsBI__DQkQyDQjA%wP&eHF441A^&{_XpAl{B7yWnigdV}bQMgZQSUKtgOEx5GW{^Pl
zP?hqCpoA17_cVTJ@MNFo)7_Y}Xd3T{2212r&t<gG>DHydnSV&<zB^+E)15I3+6-iL
zzYm@EO~)YLI0SLmo_)763HLOsE)9QuREL{ZvcS3rYFlWIbS!-(-Na}=dK`S$<#%&;
zTyd56ap^{Qb71UUoym+}L1W75>3SxgGzdg1u()H%Y^ll6@=37hkcN%7Q(Adni5~pj
zE~2D13zh4N9`JQRht?$gc;t_cup~{z^Mc;P3+?H)k<?>V7iG#e@<y)$TY>0?iX8=E
zG_^VVfnN*dcvTG*XLI-M&AI+&7?E85nh6@G=B4G_2h-V`hc7+NWx<Ij$^}d9uG1ja
z{`%)P@M-HmYBSdT`LC=Ak4tNK{S8R$&+5IK*C(ASYN(g$y2K~72Q}}%JCL&Op$dDl
z?kvx+Z#$mUtOOKaIGEks@3QIyGbOq+lCid&C>b0?<jL|1F8<!@=%1XJ)=cUJi*8k)
z<rr6xCoWqa2(fIcTruBz6C-h;Rj7g_H$u3LM!9ph=~Ic<fbqUPY7VKKsf%MC3gd#Q
zjof!inz4nb$^of`+-SDf!TFj&>7x@An?-h~eq1DFH<MQ$pH3K4CfP5JxOwU?QjP6x
zjYcO%uEX<NbIvxnqoWk3X}D_^;zwrY1bsDE_x)w&5nMGp-Y74HrBOPmY-WIrr}ksU
z_9YfxKw$#H71=r7CYKxK&q+5LeFnPXbSXa)uCAf&<^!vRMTP~kiG9jP5QjiOYEO@I
zLv5&spIkli8)~P(hT=yO((p24y6MXtdBI$0V?h2Re1?GP_zX-1q$mq1LM;b?{%!i+
zYN4HB0d|6v;t|9kpgb1ty7cCqKXRWJOu(aMyGQb9nXh3_kYru(L#yQ4BWyuHUVy{X
zjFf7L@|aWt(l-hx;z#n>MKrdX7@4b>>_ZeNT*qWP$E!r;Oko|9QZ8YEPNN%8R|>Hp
zglJ{MV{xnM(EHON;dM;hBjiAUj*+YFU2mUPlz;CC-wIt=S`UO+hoz1CtPZyRvNT-g
zeBUGQUpU_|<Kfg*=s}#NSH!{PX|KG(b;!-r4fNt2lJtNZWt7h958VRfx<{ZdZW+(?
zbwryz0IqFjK%$-ZMCYpJ_{sM~r$4hnA$QbI+BdRK+B3lW-UMery)$6S8F1kYAaDWj
zxo}%sBlnu3_L@HLbwNWOMU^T7@VR1Uh<m7vwgat5fYUu3hP@m!y&Q&p9P@n~hW(@7
z_K9wQIyb<S8{onXGegW{z=a2Slt>D+iA$QipYDFVSHSFft4QgkJ!inPgg$mw4}W!=
zZsT1h#n(KR_0ccqldZ9ipRr?uQ2FUyoy6y);FBMBp{0^GsCwHN<9|FH&AcR-^t2RA
zzQjJ@3VeQLR9o3%x7RJsAI)>|UQs)NAkdh6trui?x>WzVpf&uVBzhJ@H6~<TaCfzM
z6=COcV$Xq6+c{xn1U*zWM&C{6HGW<59Kc4fO?5hQnm%&y0rtPXXu4SMn^?ecxU^sp
zaS!Tac#felM3Dol0BJ$W?rH3pA%}N(#0wU%J>=|Sbm6N#T>DCe%0)KPD0!%rQ8a?e
zpnz$&J&Jfq-|++LmM@FaX-4;Uz^bHKhAlT@6*vV;`fRNQ-l8_LDFQ`>sCA=$;FhI|
zNq$aJchVlwDY&?x1_4n3JU%-sV)Y|TziwVBJBc*@na3b&h%abRse+bmA*aqv9rK6Y
zptfx6v*P<GB&`H&H$?O4fnhS~8pnq2W92emcMXSbn>GFNEYG{(cXhJivXcxqD^iSh
z(v817v#%_Irtfij4AX0j{;0HSO9Z_iP*FRm9l7vQ(d|$x?o$Zn<8M%@`Qqk_SC|%7
zMdj`{UEbrTte^)vGO_@DKgrOVn>CNL{`7sAw*<VjX3QJrMtu1VXlpo(mzv1NY=<zL
zF#c=rHXN_MxsO{2hg+nJ?&5Z&hh15OpFk;>Xo>~hufm0^5YTgDj%Dd+VyV>Ju}hgw
zFValZ;nMhLd!R@$Yw_A6zxmu&=wka-tjt%{Lw|vjZEHDDl5@S)*8H#5Ezn+MvxY34
zA%-1E^zBJ(42k}g$J$7ltW92BnXmxq4PXA?cAp4FO!I<w<B7K=Iq)`Icxm9!&{^9?
zj+%LMHV`}Dc6VV`;!x)jj;vkZR#iRPS!qX-yC5H~vgjS@8<0ZNE~;(tf=eD%k+5y)
zw<>SK6A-MSc=e99$|^%R_=-wFjbJlZdj;N<JzSF#@Fz}tK;*l#_Uvp6H9;o%ZVsFu
zA?1akfh5A7KoXf{xQcd)W((tj(|H|f&`C1u{a;ItcP+CFy5tT?pOzdr4O}7%ZY86I
zoImF%a3Q-uX3Pt;x>f&~Dx+HEYMI%5``sFcK-VbyAVeCw^Ib2A)QN`4iG{25%|C9#
zk(5nu?SM6_vnaIgBr$MN4VERiZs1iD)xpx2GCdl4V>0rYtMGi6jhFHJ32%9MHu2xT
z<9=CQwyz-pDD_bsl6zwaSNzGTI9SaY6t>M>RA4Z{OY<y{(XRO8W&X#VpSGV%u%p;;
z=jse+!C@O{wIi*?(l*2PtT$1Hif1QvP39&0V&<&GW*92Cd5Hz3(ORkHK*Af^C`Lht
zrr#O<%*i@3+MWn*716C(FDX%B3#gb8m0UbX?Tpti>6Bh!(MfOECzbcgMk^SPf?ivI
zKHtF;q|J6<DYI)B%%SwR9g#Z2tn>eI_bPFHIc=*?hCk0<$=nO>w~9opt?8?orDhlT
zAbGHLMA*rFWopD8K{vuBIJGFokq_u<GRL>Hd}aBerDIMcolc~Ax6?)FWV@rtJ!|pC
zBfI(3R_N?$#gY399Br4VZi1Z0v0V<#O-@D6rSJ9&gZ7<nxXCbXPZE3JL-9pO`8^It
z`+v_Ql96KE?T%lKw1V0bME5*Q$+z#qNf-VcYB_)4{=A&v{yHR1<nHWXu4Fi%9Zi?n
zLEA6JzQMwfJdZ;rLF1g{Bltkosh(6r|GQm75mj%-n2x5I8OPcK1B}5?F3!uCJQ|h4
zY6e&%Z-O#Yau|4dZ@dne7kadN;A>U|gC@VVjzKG7Pt#b{KI+LSio&|F0zbWcP4x}k
z3WZn7ivyGmLe<?S|NW68Q+{^_U2(>gJ<wZ^Z`s!@vWPG+D_{;PGLX{>KW^(%QDwu9
zF#vO5M58v!_StJs12LL~QQH~`I@k8uuHhLK?L~_$hb%i)xUyt^&kmRIkV8TG&7Yej
z?sw~~;iJr0@ot{uZnF#cR4i*)R%vNd?(BCSza%uw@RyUh+{S0IeqD23@9QfBi+$=(
zo6;#hEg6qnPNdPT^8qOkQm`4)=(gw0cvv!_#H=M^CUj*O*9&gZBv;`-^XZvTE)~6<
zmmta$<y<*vb44O38?DXHbKp4++H7*3Cgo{7STiAM)zYhxG?q%vW&0Gy*&6m$$(GwX
zt^%QXa9xQhF8JB)mnl3oJh1&%OrP4w1k0|??uP-PkS%oPphS>#U5s5=A`P7`_H$PS
zi$H7sQBzcQ+A0h8a!FdJ%`T%G)<ox7;IV0LQ~2S+&tuVpF$08?0%wnOC&Fi*#V<Jz
z5pXf%vRw(|11PNZs-{lNF;9HxBmxt`cD3!1n{%>1Ns$-*t=Zp@8>NR*JUoO;^);0i
zEe^H#j`3?6ychvdCzND57Ux-{R#XmHYA!Oi^T<zkdkc6DC9rqr1Y&Awud5=s7n5MA
z9LeC6x?AkstU4pH^=Pb+`UajPp~j0HR?Zj<33q#>Aw?3%R>7jyNA>zwm-5s|2`>yQ
zAkwFymdUS|Ey?hm^QCuI;k=l)8tsX&Q3M*WY_`v5h^B({1Aj+^3YC}7`V+ql`D&Ji
zpUtxzff6fS=&Eth&%7^;mu?I{>=T{0L3I`GrolIgxErw|neXZJmOU$}koR`@(xEMH
zq7q+MtejGCY^<bYrVTr;%6qk;K}g;#&AcQoL3R)6iuEg~|EmJ&n}F$zpK!?(h1DqP
zfzzVqGeB05$f2GlQ|d@2!w+v6yzZ}d9}mKDW_T@_Exsax_Ib@(P)S!;8L%-e1UJ`%
zdvFbgJ2UIoIKDbC5z?>gfVnnL^3a*sV+&FwmM}VeBJN*k&a<XRV#XkTQLH?C3vx~-
z{%VONkoL{kWnEyiWx4w>VXdmdGp>pf*x}*8Lw$P%(k2igSa_=mWWlz=>2WdA(=3nh
zdzXJT#N=o?-aZ)l7UXSi$|Sv!GHZiHZ|B%&E|9{Kb<NDD_oiv~65Al19X%=e^rL}C
z-MhmY0;~8iRZd#U`Oywe-M2A|HK`c&9HC@sPN;cmAN4)R>FQ_a`3+^qmAYQHZg3bq
zXYuS72H}zk2LBlNMhIX-d$F1Mg(>P~Oc?K%Vx`)-p06U$jTt8B1W}aiaZ~?Dn6*jd
zc%~{oQ})jJ;~v~`LmW)ktj7OY?NTjo<O9JoHtt}o+8wTrV1Y7`H4IH<+?^jTIZmJP
z>eZ$I27e55##w`a>Gp4YzKjGCJgc?HJm|{e4aNsGt9@=!E|~hD^?e=b8J7;KzGJ7H
zhO}kCiQ_DXLz))_JD6<<S?^(tD4oBrL|WrP`~h(<cJbRPU{o*J1oQI%ZUAj6jnt&9
z4f#HCb4~@}!8kF8^H>CD=AJ|eD}A*7PUWU8>q_FWLEn@pN;S$*-@Q2Vvj!?t*g3iw
zb+|zg)|}RL+pJ*ofKkaHu5JiXf_y;XM*Sil3GLQaP+>|{_$M^^i;Mmc&+kQ`Md5z*
zAh}=Yv5Zw%q2!-U3!Du*RJ^=b2Gm(|vsOJGs3)0OutF&AE-L0j@a96>ENJGBU64y?
z;_ZN}h6HFY&L{=kom*hqws$?1r9pjVBt;blL$ETO4XM4-58}dq<__)dJMJsvyAfOM
zHQ6O`xVU*FFRZuPVSKQ7DA;=eaw2g6H4y{Ij~0N*?GLZ9w)idpjS0W9;(gD7T(QhQ
zw?0qz&AIfn(46D|eJwO6Ssloj00)&2vn)O_H!oVBm}U-#Cx(gJ9?F0@;BmpFyqHk^
zR^CP=DB~xb`BY0H_LT3G6kCCX?p<3?zpWXAUr3OHR65x)n@{lK4vWFK>bM2P2%qVh
zDAf^GtoL3!q|PL^&<-uF3Z>TM(mM$XR<8!|8;}fAUBd3>>$qd9QenSa(U+^u0N0;!
zHq*bCEJR?g34B@H9w+@4><V^!z1(dNk5Ak19mtsE#zikE1=iTPL|53LGtLqEHd<%7
zm9wA$>b%T+{hm(ULsn6Yj*xSfFvQx0rlsI_P{GTYTprAH30PVN5AMt^j|r-oF(X#n
z6fP^que>hWzEsF(qy6H#+LQUIbs9?`B~hK975kraw1!IfKMLUpt>Y8gr?nNgj3o?g
z>6I_5o5T8~9Y~UY>zw9u*&BoZ^A)DIjC<>F0u)Dp3W^b)NT}=ZIfvs(GDk6Zy&FRu
zhm7dnaJ;!Fhlz1Evunb%>oqq7L-j{cz6mWe`C@x@+*kgXM!~6*0d;j-AhSR{p04_5
z;b!FZXyqRHRsCvzcGlsF$wu3M2iIxNlgKJaK8YD}AA$i%R(m_Lc~uWe_CKYdlcYr+
zCk;F!%>ktV8D1!rmU#iCx5_|poD30^FO!jm(leQtf2FMjWnWS}9!{XiD`@Tt28Iyg
z>!0Te1#AYu0~gC;K~1#C0^x|BgO}y;!GB}{P|*WKr1&TTf+L<k1JB3-peFy503rC>
zq%Z(tk{DM_5f%;?=09n8UGeddbg-!cK3o$f)Yz~bKGe`Z_nLnjD#wDp8<G6eyRpgx
z;e2qRZLQ>=+WvE&^mkiFJZRfWc`TI20e~LYAkJYWz`x}=$^Ua;gWRW<K=w2LJtjP0
z4h4E>-whOiaMh$xmxrX!z!?fpeTQzm|7X)eGN{`{g(tVr4b)?wsVSjGj47c52=)J;
zy%fYb?mrU(;qbvGique@|1W+V$)^VsLSn%=ichoOq6mbo2mex}ewr;sAe=KJIF1n?
z<F5$-iz@+PA$P}0Po_tQa=T+8eK<n>+x-?e>t8ypqh0bs5S<;Qzjcbi%m30z%Fq!N
z{GU1mU~1*3mx3%-k`KJlCGKHs_1cQ<?^k=L41_HOrz=xI`_K+4*@738NuVW2V}4XI
z7#K@u3pF=q7x%v#>#lsGH>!s$?q`rc(&Nzl^RR<eRmh<O3H`!BbXFm6iuI2Igu??z
Xt5854RjL4CbHP7UsF2=EKdSs6k&@qx

diff --git a/studies/Synechocystis/isa.study.xlsx b/studies/Synechocystis/isa.study.xlsx
index 75f8466ac578f82348fadfe265e50865a6cad79e..0eaab6e34adc7b597404a948dd8b83c7d2127528 100644
GIT binary patch
delta 6745
zcmcIpbyQqSlOHTN1b2tvu0aFA2@(b;kig(B!6v{!Ao$>J3Blb01P$&I+}#3%Avhrf
zc7XT3@8$br&+eYHcjla`>gulgb#>joee3=->$AYtP(eb*0001J03oniC3Z3b5}d{r
zAkf{?>OlnD`-UY%>N~{^BIBLn5z?c3g*q}TKD?)%fIZo)Dl!0YK?(qn0^%NWlS2|x
z<{jom9tItpvm!4F<EzJ-&v2!FmM57(30vd>m-fbUYT=`Vxu^PE<|aUSwZs*->HP|q
zuY>8gDX6P1FRE>`t7}1^OSeJTn8=uq`I#z2ujj^l-bb%<^jp90%i6r@y$k)Q!=53>
zVrCE|LZQ@X1N+jMiY9|1QHf7S0kW8|o<a8dAYpE%>~)JZZl8#r5iFm^&AxqHK&7E-
zXPqQC_cswPa9TCDE>G00!GrsePF?QtB2Cl~PfLT_WciF+?r&#uNv%AJrY_L95X_4Y
znq6ja?fVVNNn?03CzZlctb0&+*xh2wW-AYD6mvX>C@i<Q#t?>j%$1x$A&`K90tFp7
zNCHDxm4KR1@y<YFVcbjmPt$H*Hj6K}cETNS6t=e&yJ8;K*Y2FsT$UJem#zzVpS_yf
znVlHly!I;Y>5rNg)!8LCHEeLHuG(TfVi>vNz}+;bo{e3+Faq}^9K3e>31hxNxv@Ig
zKYnDyv^~UDc=f)n;nH~p(zATL-Wp}}`_VqN&6PWcbSRVG`{XYCgPz!U=h#;Dr86L*
z6w1|v{g;TfB!n;DYhS97%~M`%R#(28TXQc#$vwba(Oo!WXYoZDlx8f{SN_QOE)lCT
z#~-y1q!`AhR)w`f5Ryx)FB3@`dl4avAHc%Pcut1?=z+DV;w3-6Is^-`%cYZ#SzpG1
z6cL9Zrh`@#%Op5v#Uz?Kk`tW~ERqw<aN>k7K{?ie2NnsXrshyblSr4v#nqt;q*nVF
z{1hxAgUdYHK_@|(1sAG3IO!z3TYLj|>9uHNYS1P}{Mp7d7T>WYT0h>=rmcB9g7knb
zQ2<l(N$;oVV?X~e$Ph#t11*$fR{Yfm`ga;R@qUO?NW5t`Mg{bOsyv!c^f))ft!0Rm
z$lH_<OgLkzbLw%mc@NY+(91nV)AV>n6>GDU@g!sD=4rvO#!}F(9h+3J4KL(*0h?Ja
zUd}GdD>tnfEw(W_hMB@IDg966E=Y1Rg8c-anH;Ond7<g$5<)Zukgd1rUQucGexy?r
z!$n|+%CJEh_r)1Ym@sBtl*Wdiw%cSyA2BLfTA+uHSZwY{YQ>}{<^)s+ZkQjZ<7hMH
z=Q5%MzOZni=Fx~biO-RM!UaXJGJX=Dh$(1CX-!jxi=RV6>4kEyc~CBMs0w=hV2o&~
z;tRH3^T>@)5PIiA+N8%W^cpz?{%<!n(a^$P(`!VRQZ_2mmwI80#W9?)%xx0pFe`j}
z&ItaSYB?#q`<ktI!lI}ic~3_WvzQr1<D|jFu3&s82Jv{*-<H<6s#5Z$Wy}mxHfNh>
zUYFkod3=t5*H-ELi?(|O1I@Kbi6fBNInwhvMPu)qDVTt4w@^#Kc*bv0>Ik=5yY!n%
z$aVRlOe0n509db=e!y$hXJoD+uYoS&I;&-2@aJ?f#rcr8;~7k3(NcYAFZX9IYTxO5
z;<OvUAN!Twm3~^{0et)V47}ZS002)rZVyKnTURS{^Vf0I+^7&fE>C;Agmfd<IUV>$
z^oyMoM!}JWyUq)vw4r^dNE?mV%s@N;41rfhE%o}cKL;JWoUjapAx4dqx##*=@Kr2a
zpPjn{FYvpA-9Fh81_+aM$$U1HFFu7;KED#Mz5yF?P{wvS)Xc~>Ry@BVrVjhE_}k@|
zVAzeQ_&XC#MI^{~9OxP__Pe8UZpRVp0vC?sN1x9seNPD;Nt7=6d^xDjoImSP;o1x5
z4upr>SU2h&ge@~Hblxz_pZusW4muw_@}hvn9!Re_RV$7SNQsx82h)t!4%`qpG=|)O
zmu?y&YJUlIZl79Yc#A#YB(5DugROIgk-QhSo`s-pb{#<!zOQ2v_%<4MkJ5n^mvUCG
z8#N4Fo3*%eV_*)td!ODWm65Fd$a?;|4N8HMV7dc4yO`cz*Tz|IXY<w*cZ`i1ovvHG
zJY-dJ)Xdcj$&4EUlbm&MuRfB4uA#J?zxnjI#iMB=ZL;pykBVm$Q!F}atT2+kHJDIj
z3-Q<#>W)2RiQCx0%n8`i|Jd_zt18y`>}WH}=yH0;F!<y&sc~;$ek`eRe(XqU2HEr7
z4-Y@{z;ggQnjxSVZ608YCI%?SYeCUdm>FunL}{mP1+0qsO=L+v+5HNjb^9g(r>Jn5
z4o=bFG6S57U<P2?j3Tq1ek0Jd8KY5z6siDoCi2KMcgHDN1$WhRCRn#00?S_z@VX7O
zt<xY+aCt-}Uv3(N6q=MllSQ{gLki7doTj@ed-QpE_0*=YIkC=#8c9<ad4#M}pV6DB
z<i;}uUJv__<VGPG?_C2{qHXmz#+l|LDria>4i?t$PD2%TxE2_4)4s|mpMQWt;vJ+>
zzY#6^*YP>(Zta_xO<5%xKhMAPjCc4BU==))&?FDSt@@C~VHFs&lPcBU3nKG+8?&<o
zkx`DhiT29pJ9s8Z?mDPqc_Z5&2hG;l>T{sq>g%><IX2sKb^=pV;>ga<5LQ+emQh%K
z9IWcfVyU)U-eEtm75_@goIPj+8P8rlu@j+;JVFmpEg!DhAqvb<6Rw_^A&ewXGcHs%
z)GhjYmO!3@qX7b@)Uh9*@$k(Hs6bT@S>_2@Z~t1v0`VwNc&nB?^*}E{#GsH|zfi)z
zfDH)A+1Q0;zp@LPxr0$MyW`~~@^C6I1gh$`C_(_a<4zOK1*xqf;!Ny|(uyoQR-Lre
z&ME8+BnR@$(Ue9M`QZ*%3o5PkwddH1W#-KV`KUg0=iLX4-->?8ys(m$dh=$TVe@7K
zBy9)O|EfVO(B5kYB=h26P={l?#krNy-^BmZYLJ(Eo)F&ul`XKdJ1+zRRW%<{8wu#}
zuMm>6vn$%`PPu2wo5~NLfYPySfs0xa6ga`zE=6!ej|cLI(3F~OEZ`O>1%*lrlnsfr
ztr|bd=OInZXl?EHH%Zt%_-BAHP1E|{2338)leb9wYw>3D6le4J4&Z?L6hM$jFSra<
zMKDaG7rI5jX6t^tYJoMZrXZk^@bEq3v*`mxC0{qwOWV!coplnSOc=MWus-ET)1hND
zxBDASk+PvS98J;x0u3bQ4><o<G(f}Fyqan|gMpxuF@}jjO%PDT#?AnkP-|24)m;_(
z47H%LaBx1s>&+9W>TPmGRjI~QsaDd~LJB#oSTM;=%xViG#1mtfNmJ~@;_cav)y$Vt
zyal$BlkCIb-7D^*0bj2wi~Q}j)hBwl!J2eie|FF4E=_xW;8hE%DRd~x#18IwF0rUl
zv2&^~)EpFjl~BMTDD*D7J8!yZY^sLslTYbC!t(*rou>~^P=&iF=so-&r8CCN9Q=;D
zT_64G@#7UI+7eYfinQGZ=STO<Uw2o>oR+ZmNKnUWL1rq3Q0aT~anZmWiqXG=qnl8>
zTl5v;ZuH+o=l>-*KAXUTm9?hwy_Zikt|62d6?kmaLh?+5%1nc5OoN(ob|pow9&Rvd
zQwE*Z?vmFt-k~&=Kgp%0x?CpRu-%LpFou06+j>MV0^e4fqF005V1>gH<G2IqF4dOk
z6r=QYc}xykDhr==reWf7YgSq%4x#f0=X;md1|`m+6r13(F9)kgxcMoSbEhZM{1Cy&
z?!3!>W}UW_aLo!yjm?n~fZ_2P%%9is1BL^h&=&RtkK04T<NgJsjK<)ZRN?Saufqyn
zZc~tP$w0F1l;DILl;tyTIhN#98#CcTGD#(G`JlvPz2&7z3eW*$+&R_M>N*&{kV;Z7
zSYEQ|^{8vKU?cffD0`pB)YAm%E%iD*J(uuaSry=ayfyjz^cgg}vasc7N5^R?RvS?K
zK=9fdvqG?ZsTyMgUzR;u<>CGl*!XKWq+N6NJ4m`P!%-8sr|u^3rt<XPfQ%c*?f~gJ
z8t*IsGv4IUBtG60+Bz+HNjJh<Zix{7S+Lv^MFm1~V5Q|UxHsE=G@(8o3o;&|Pu#xz
zMJ@TmDK&-i7+hN^erRoHQ|^sVoL(1A)M_9zbS3WhqOZMUstL@>9*s$0-wt=ot+EZ<
zU66p!)<rlRhvJxCXlrs$zo9Iv%vQDy>UA2Hh$ES`0`I7zvYolR!2i2qkhKmDLmPtW
z73n20V9;6WC9!AF;Hi*(i=jI)-#0Z8?mn?re0ur(hkx++;70Ovb^T_jItch?6Ii{{
zv{?$!A+@=xCwpaU-28>8cQZ_fHi>=Ce_?!wwsvb$<%OsRZlz%P!urP!xZk+&UB0c!
z#up7`cqqbfY%gx}hvIk_0_DnhQ{*~w(!rO%(A|_-!?p2v>y*PCuMQq6_nkE=s4^Vi
zyiq1Rf8b%#|8evJvfP16t;Qb*$C;SKED2TJuTh^FHax+2wU}igX%bg#>^YOF%l!t$
z1uvVbHzO0r6b|r5uIu@28f9>c+6@-hwG?oHjGNDM_aNlYo#5PMZh-o28ZBLq)#r<z
zKa=8c?YD=!LwK4AcY{yrY->D1p3Jp$n>^Fi=v#$%$&+c$GxG1;IkgM)S{t94xFD$2
z+|orq5ASiR2%(v7d}=}<N$F<DPP}&T#n1D~1Ajm2MmfMYGL~`f+7oh0$faX)b;LG#
z_LPuG$~eBIhbp-5xaDEjp4NH~O{5*+`SbM7aJN`$wdEUT<+d%~FAjtQNvAH&28|{8
z&R+tZtBkk&o?cp99OXuY3oMJK$c~?~d5K=<tsQQT&^UP4!w>eTOu^wIj|me;k6{<?
zTZ=N@)y9Hh&K_=8dt)R!BjY4ekk`ksmwz9e0k<#uaZ?1`cklCPga>!8@0C1`te6h~
zfP6{-fDjPJ%|i?+)mznE7kYTTod0!W`V_SjhslZ836vf<K-p=H4|a7OuYYcbXKQ09
zAA9iQ&58CUqK}^>kV#CVr;3sSgFo8y+;HEQeZS26aFrFK%|n*#(V_W>xDXi7MSbYp
z)ck$1JYQj3qE#fqhcuSd=!~xuOjG9D@G1fc0Xl2Wy&?`FJN-3?sewGptE9ofh#M#$
z9bW!=-V$Bzt0jVrIL0re4$?D*kag-GisZ)wOS4Z(V!JPR<<t&4#l;ScjCj1=+RAnI
zejO%-OMYqiHh|g~EPl$*bNqbp5J_Gu#*+64am_peq=Rb=qW%aTCFPA;3&hmiCDPe>
z)c!2?L3gw*q=aKkHAJF9mhLT<Ad8xFNGqj$STZ`Ve90FQRT_Rz4yM^dU~eX2Tr3w)
zW{HKc>(3GWVPad4`Z4*iI$k}?(9AGPlnQwP#M<pF`XeuLdz<9);8I0p3FO2$>*kK|
zUwiW@pmIyti**}m=6I!;_Xp9q7V8~FAP;xFJ~gi=5SGtf5i~juGa}|SM8V>d-zBum
zG3!N7=pyrLvzO6<-<+kT7ljspUmX)-Ws<B2XR>&{PxfDb3~jf-vRF~0{2c#LQ7hO0
z!qB-I)Z0OZNAvFEjJAN8Jw+ul_~S<CTGzwhkzifPA-~}EhgVNLDV#I}(^l+THb5B1
zRa!X(MG&_DQ{+eLV|K$(stz7d1DiIDhM2EM!eb?C&u3;$6d2ZtNoI#NQXUq2j>A7T
zlB&-ar>B^eQthkih;um}(al=a)Z>-Xi?4~uyjtauMs5c5q+;vZ9ze3Xn=^g*u{s1)
zvyaEX7J-wAQ^a%|RRKDa`Ng5d$yAoEV)U(e8W2%zI?UGHfm8eijX={MEc#c0g65@q
zdh?JEgw@xJ$IkWh8Hr6Oo9%PNp8}v6Be~7vI3P#TEU$GVrrveJxypk`6$?EvvG6sP
z>jn?}d1)pPs(=Tl?M|6dPxIs{yRyikqTWl*O&&99z^=-ErgHvN79vIezU0P=*2zb&
zFOZ4T1xx61Sj@5C6ryGu6-h%4<65$(wcbe^+D{QE$0^>0TDyQuBBxOM1A@rru^!7T
zF-bAO5>6&5Pk`BBrAQdQtej(RuPMUS)9>Itq4G<SEf$Mp%S6;2`I2?eQJ|06kg3!u
z4*tuqLhU8_soq#7w+$?{k<#bajTO_dUPv^`Zc^3-Sh$)byswuBd)!4*t;~|a)l-xd
z_G+t@6l+8boV!e@<1mFUHHK+h=UG{nTmGAy{V}6*r?yP`Mv#8CT4R@Wfz_AYR}*t0
z0<j`6Z_XfgBc_L+!ZsbVJ_`tTzOYi|wa<1B?z*4=MVb_(@nUv`eztiBB@g%eCJOmp
zt**i8Z(hIu%O%x%%FDBrt}G+u>?Dy<b|}#Ws#dS<bm=|3#<;n%rzV}ZdS28&pi}7o
zC7t1iHm6)zZW#B<;z$koB#Z3{`ShapWAmTC^inW)QD07u?0%p3D?T(%Nmqg0=%(Y2
zpK6lKALXG=fIrZcN$T}kpc<U*cr!rWs|Id0ml~nDMK(`XKbls?u0!f6Xa2e0CLjkS
zCu@++PSz6VuKQIh){F;q0SnK+cDdk0_k8mpRZ}D7YlEDd2wtvqu|0JvEmP0ALSLjW
zjeC;-QLS4Ox~7Y_@JVgyWEam|=?hyPhyHLK>}<w~PrHz7GyijF=o?0zyvRKW#W?bT
z%vG}KOWsV3$f)GcZ~F&8+IqizKQ=LjOoXZ!Tgur+@~OM!E{2mI|1NX^QL?Dq{GP5Y
z=W?XPEs7eBXZBZ2;sgJ*Qo)NoXeQNpX}Q!$1*-Sh3@7R!P1p9{D#XWBjTfffW}BYL
zMqW*JK12<{z?uPJup)Nh4AIa+qB^hl#07)<!@3WxPe=Dh`TU+gOXgD~G1PcwR>iIL
z?)`M?5Gyiy$W5mJDKlEANRpDDDM$CXu6<S9YG^D8lkd*kZn44G%I@YDIl-zY6-r2U
zMZu~RuY|!fsz~3nsn4FHrv20lh{eYak=U)`U?PuJsE_P=k>hV~!uPe+g)!zqqS;B@
zgT!zFp3HCGqVZ8CEF)h2#{Ba+QbW#kR}Wq!-$%N8pbSyp7l==&8y?(gDw#47?=+e$
z_ZlyjS_Jgll5qk9pYzK&5jGl#Lp#sIrgL`s<p6>YxN>xg_FaXF2^cn$X|~)eu``Ly
z0viW=;%Ks)6Z6Bv-#uy6wtMJteOpBfCnGwuLy$jwCf2mKG;1~p#AS5qjek|I!^1!%
z!Z+fe>40Cx*<@hf`VpDLlVKCz!NM%q3SXIOS-NeZmpz_Yc#arL;*+5bgmk%@^Q$xA
z;wWM?dQikvP}UBWk|nFBqcx6@BNlRg^iu>3DyRalge{)kY8kP>;Jd15J+jYi5;4t}
z-^{o<23)k%$O{jo@@NK<>MSNSion{GiisGRPMBCVLsK^8uM0K7F~wf-$xo+p8ow&Q
zew<=c&cDX>=4f?h$G#M+vE86u9jOd1n$Qs$!O`$x4XT)|wJGF3qP4_Hx?Z3_U#k>7
zzf4kYT&(5yL%ULobq`?P@;N$bGKjXLgyx$F;H>YkwWzNBG86q>@`ifiJ$5)O1|pV;
z)$sGd4c{-6zgO(8#9#e|J?Xx3ug@uYw=Suiymxe%Q|OMOa&g^Je_o0>AQ#yk@5m*0
zN9(vA<NR6ekGtj)p}lST&r%$`8u!<Ahz9>0Kon=ojdy1Q!cBolOc=MsO^mCdf`CW}
z_}Ax$xHh;-@m9rqXY$WO$=~K~sVEWrh(dqY>7UKFmhP{IaN<D`=gdQT=QDzb0`WaX
zTp<trod};AB#P#)T=?3`+}@n~KY-}P4hu3zz>h<nv;Y9XUncKK?LUXz4d%TqG5)6k
z6fr+zcSHaH32p@Y4+E}`?);LuzV@;+cl~qh{n-qT4v~;GE|ZtU_%^Ts#mnGu1OPx9
z2>`gA*1s<?Rsg`v5v1Yb=;X?6;^g$FvAgBIzscaE*WqCB{yh}Vov_78vk?IQ6S<3i
rGNCPeKoxud?jHl*a{Q~nYU=1{d+!YeK0yG02>v5O0RYIkZl(VM?<Qg@

delta 6529
zcmb7I1z1#D*B(j<VQ7%<?(UFALO{AMASGQ=!hjM2k|QE0AxMX$G>CM^3?U#bGDF7z
zg1|ov_kQ2?`=3AVnR#Zdz1LoAz2{wf_St9mJN$fv|KL6bCN2N~zy@f)(5}LNgNA{W
z;371}Ygsdd2E6H5K&L|)uFzRf1~v?~8-p$;CoyuQiHqb%=R24HKm`Q=KnVaZ@l%0P
zXDmJ5s*~PYI=>)$aeiwZ(o=0&hfp<lHZEzhL}V;=sAAp1w=0BwToiOJ6Nak68efn~
z9OFeD3Urn&hVIU;xz5kbgo3M^Wwf=dzlK2Q#b6-ookbqVqa*uve)GAv+Gme?j<$~z
z5qW-#J$Zt1IA|9Q8i@<QQXcBkJQ!$Te}td_m^#~3abyFbt@iRPnAf$2&%XT8IMP%N
zgZzj{J<q&jKCNy4<dc+N!O1A&NNql_P@e9s%~OrdlEs)!&691BmSR`&h!@cXZoeR;
z8ElqyX8{}K-1M`1HSNNtM*LqPJ^cHY29naVvx|`p+3aVV9(>hIcp7tvHXKm<lJ_Ku
zBV79|p?t?L%V7?2w0sU@k#BtD0Y8AAjUMmwLueA@=9yF3j@RZ2#6fRsoRyrx>-%lM
zPnpNsj!m=j+e0Rin{^tgO?0-#XWq?Ejs<ayvm%>iUZtJ)8Ey5P97tDu(J)RMZNsC-
zZtkfJSy<oPYO!=QJjK(SmH`nQoVo<ktW~)zJPZc9{5r0}{BDB27W1{LYqK}y)h3H#
zR!e3fM<DK6@myd=N}*y_TV{QZ#T-_j`A`LK8LtPui-zP0Yah4!53*M+=*J8bP#$*9
zej64gCg;5znW$Qh)en8x*$PZpoWxSL>Z`&jEVnoXKb+jfA$gubIdKVkxfY}Nz%^W%
zPd#}IUuj7oh2|Dapo@Tc+2#STHwrU_jsW4Q3}lBbKLDy7d8W|O;p@Jj)0ybZ)59L`
z)CiJ*b`r_H`w*=pOY^@r(Z`w9gD|1YgtE^*s42*zzl}{k!Y)!{03kc`tm9v<`+LiE
z#FcPWguW=1s@Pe9y9OOPT3Gf>o;Spb#51ImkFOECP^n~4DM7sDh!RU@F4$uz9<+4r
z$ZNEOt*{;(k+STg$ENi`43fI=IINg-bv20j-v`9V$g*m*L|hMe^+8+~r+d(L%2v;i
zQI=QZV=(c6!67Isp>&2jn}wFJ>EWUHP(y5OAxnIhP!PBBtU-!}=7zq_wuU$7`}>h~
z?EU!>d}LEuENR3|5Bq$~k}bG4^qFPL)%nPLi<3JnlT~f8zB^++V;Z(2tIbc2Zf1%P
z#D$N~#NxVXV8O><(5X!1<=T@eCo;kG9we$Baiq{;A)G+}YCEOS;Ujp~gM=y*BwyV=
z)P)gf%d?di7v^|Q&L3vLj@s)xkE|QM1E+%LT3u<i8^w33$$~z8nre4_G}?GY1)?I}
z%<y~$(L7|MEjz4meR}FWbJZDjubDbyFu<hm9)AFl_h`@0f+ju6P8}apU0nH(?!PF`
z1?s+@uh!y9yIG|L@jE72rp?x0Vf?n-n5e%<lvqWsKFtPyE*fNDCLCfANz%{CeM<iX
zm(PSwj7fl2W`?;8blZq6kqbns2FYO?cYEPH7G1XGc5aA+kZt1`Vt2S{kB04>V?ivg
z<J`N7&^>LRYgSGqE}L!JpQ8JVoTaOAoL>w6+is8Lw$n`nzp?e|+Q$n!%7RFq&rcS4
z<O*Or)emR+={tvQujCd$k#jHSd;1-d9r(e~6QOAlag)nq4wh2fX`A`OOta+eY7JVK
zx-U;J<;<e$_Ya&&+#$P)DW0wBHG_-ts?8UPPH(?o;nbV5fMmB9cvpw{@b+2F)L`{W
zW41OmEn9M~tB>~WGgB}8A6W8$y5w2}mc_?~Vovr$&gAe;79(dt8PxfzoN>M(b+OgB
zR!vswU(OxIvC`a0p|Sa!rJdIGKx0WQ+|s?!{aPLQ9_!sN8_R;jav#j92<7uPov4pH
ze|ToTcc^-~dqMsYxJ%22@J4Kl&GXkpiN@7Ulh()idWEERS>u^*KHsui;I)$LTdFqe
zmoy0l84dCU|2*gg@ttpOm4_Uk{XCOt;F7hrPJMmVK^^9Z4Z<){48W_5t;DK~s>H8M
zsKnT#S*HDr7hxHOAJJ+Tpr?9@#^6^3Op+1-sMDU&GWcx(!=UdO72spoNSzreDH;5n
zyzfv$-|GU3m9o+FqYIEy7&%B1Y0O6I1nxgUx9a*jWEXSjBpYDVP?p>NArA_~8p&-R
zzj9$NFlr>Qef+vvNo(8NvI{COtu(}Y9`+`9N^MA+nqj@7g9Q`Ke;e2}U&m;>GmE|N
zGOd};3*tK5VzJLsREHl83zk<4?{kFU)~mymoEY;*bK+mgJtNRR!`ykaP%$)z5!AB-
zQXV)^9ynGWI8z?Dd_{(DufqIND|=k+ZXge{u7FVHMZ~L-(AR;5Lc3ZE)ILM^k90rC
zG)v%-WqqUWLMjAgS(dUu9biOfOi?Aj7Yo<cptPkpflBuVY1Mdf+d*3oM!c60*Gq(x
zge)~dblyQwO_&ZhJFFI+u^1xW3*7*bCQxM>J<KnU<*K#RV}>XWNTmig3wZ#G#yRz;
z{`D;`bK>BpvUxOB{8Hw1GCO6uU+gPCu0tLBh4dEj^*3pLvCs`t$Byf)oVIxerZo_Z
zWlyFu9U|&Xc#{{$jl#X_A~QzG-U)vwZa5m%xm?s1x&X?7z%``G@2OwXUkHjyMdqm%
z8X7v6mf*S>PxkpHRU<PXnd)?S&`KXhmAPWtw0v6~7J5a?T%%*JqGURbeXXojy_D(b
zD>L{|W{~dBbvUxtD%jhCY^oN9m0v?(5|c_5m6jzWVE+QY=B0u<`bKFx0NpTDrsHRT
zaFw7*fV+Ilfy^QiDXKT+ytRAmi>nr|<5DtVq)j$kQJf58u+JQ5u}rUz9{wW}T~w;O
z29@>YkW}hT?T|`xuh0P|5?1mx_~IdH@JSENVYN;&RVMl;DHT`W*qM!oQ(H$067R4}
z4M1J0g-z}>xTOY2<!s=b3MkUkUnw=IJz2BtDN*u~($`F0qtFjq<79F8Pk#K6{8Zq&
zP5;JErB3)YJ*bMQI%E#SMpfq$T`PTdcLSd#n-;2@BInS<_00ZYyM#bwGhPSH97zo5
z8WESvlOP5foruZn+99V;BuWYS9uj|>YW0yxCcFUt)l-6Ia{5!4&ZzDL?59^B)wg@s
z)8~5jWR+@~|0o$dZlp>l(4Q(EnoA7~R*3(9;sO09pnrg;ZW>7H8|0Ou!_UC-4f8KJ
zRz;fT6i7Ic|1UV8|AU`@0!O@!V^Tt+5FfkW`ju3HYN01|qxL<Qo9M&$+fn}$7|=f{
z);|J6r-Jnz(pG96mGesgw^ERcPE3<^NQZSupLNKHb;xY8v02I=SOpT~w#_q=8g^$L
z^3GpccllLa`JT^Jxx=(l>eS?R_5;r+JT|Y(Mr0=&9naj;4cy6jZS2g}jOx1LU1F%e
z!e=ubAJPoRB6z)+Ep#tL_>3C6w*4;<h!feTOUoj{Q_WeIK?ObIGth+qSF(2vY*@jV
zqM@ExGbI#hgfD|I3_U?{m3kgIQN>C#MaJtp@OjxTqt>wUp#54se%m~&JMK_!JZktC
zRnqw)<6HEbOC-4N(75ZNS@3z`koqCcdgQoLt0hUeiu+{Te2MYYj!fQ)laV*{x-qT0
znv!R=X4HCic1|a^=b4dCgMj}FP#4*|PwpVH&m)SN^xkNn;FHwG;qy^WSl-mRw0+$f
z1U7kAtxxiOP6*8r@L_H#H&kMNYuJ~lrb;3#arh*jiPUMtGin5!mM1f~#Ao#An^57r
zYHOAX&zdA0QD#e24@dCW!B%L8H4}nl&rPz<oGrYeo2LB-7NEt>+jKg@;5?AksMTwB
zxp?i1_+Fb1=TcL&Eq3V7aLPYQty(k5`i5hS7{u9UBjSS)QLjh7O*RI<C=WusCeIXu
ztGGf-De8P}lq_dnT!XOZrG0v@139qm^}oxNXEi!Oen5i=n)>v@91%ob@4KJiz^c}o
z^^NzsT#|4QqRb<(qJ4K616Y{eulLb0dXOZ$r{J<DuV$%Mv;y$tF8tTtol3)x3v0M*
zuT{8{%*nSE__lnpks1B?GMl4kN{l^x$DNT}K~%1@8>L-OAEaWNMj-coNwqbo{{D}D
zSL>r=2VNkO4Q{Kh@*vs!R-mQ;wHjoRMzhiiL#fh`NR3)$rWa54!lNNWYemyFyWeAU
z?F>Mhf^*K?)@WO@&|y2V#-qq+Bn`914B|qw;TAhELNWMcsrB`IMgqOeg&?zD#a)wv
zFYqTjtO9?sL-*!4c0fXuD0(_j^nCe?o=kxodJtuizp*1ebj{94;#W;Id94O>nTY2q
z2ZU}Xk$wT7z3srNq^DOzU7hWa0RK~C@}v9j3ij7~OM5-5aKUND>Giv-5*PcqN3uH-
zTG>w`C1QjU=|e%%)u!{^8W}vfBGT_#uXNvqBewY-lb1TiKh6sco$6bWi`Jmx_4zCp
zEd2E6V^zsPihOVYRry43=O`DQ)#b14o-}TC>reyl2K9*$o4fLEKo9y>b9KHv!<sj~
z#?kG3t(SqvD?fJKt*-F?+7AP+U%yR|@8QS`%tgw9df7H4-9^1y3qpK!Vz2;!JJbLG
zDFA#WKn}_``KG@rM%uP(;N)G`IwL{AIz~AosDqw`u0v8NEiFx}TBTA}>~>e9U`_Un
zD<oV_A-lMmwy28d3NWOQdl+)ypMboc9)Fj_?I6j$13rD4160EZvrRmeSjYs5?W`Qa
z00IPd^ieFTKc36lKIf;9e<#=zp3}4Sl+ZIv3nUsJh!)F0or2l@<v_s+v+-2ZpXxrx
zGdVoM6}_T(wY(T|MH*n3+Qge|pw1B(P2KL-8>UjqarVOJal%pjBd6W7--g;Uoqw%p
z4c;PnE`vDve5^OLkD>aode?3Zt7}d;!BqBZw~R8P;I1uQHx7kj@$E8*TZAdOh`@6T
z!9kGFx2PEmZc?Vc2N<5=N|-x;u%xF8*mc#4FF3vFuyObb%vL()(N2%V8(Mcchx45~
zmT%>6mQ88u?(^N+k<*J_!2(z)Gyf4p$0gH#KhI5jZPVE$MIRVG`BaZTps}%~iWgFs
zDIE!AdM9B1YU_~qAY9fZdW5E#_ECWh1L-{IkDj>>{1}6%a>=z~rjth&*-IreZh}^C
zUQ3aXkF7Fc`Z=H8%F#(B&Pfy}E+5ACX%%bdY!SHoJlK<4%tBL-r9|oZLXayxOj}qa
zKyRhV*1DI4r8%T@47av@WELlA&>||yvAY$gg2zcfSa_S<tAUj%+9M|Mp4ZfxD6jYw
zXsQ;&%^`%hyNSAYUg+MTW}8k@FQ<szVtQ(U&9`;a70akg(a4`M23u|J(BAyI$BJ~1
zmj=9O2OIUs6f`CF)lJ&fY9NLlj3owJ_#cdUQ)1jW5t`1j4%W$UQ%hd7GlX&ny&;DZ
z>k~=yRn{qX3GPo+a+DDrcv0OwAPiu#0Z}n_lEzeaN7#Kl+V9>N(n(P3Nl1|o1W1rG
z)2QI&=9(BhssvmzRxdPkG>2i(_>c+@okZP+8OikauH8NFtF)6xm|<8S6hoS{<BPo<
zzwSV(=(DLHzx<t>MtoU9kFwcTHp|`k(hgzj^sp#D+4kDPv$X&j$+4q-CmG3YP_bqv
zsj6H#W2g{W&+>A&kB`A1n1`4(SDZ|`ae1#q$$ti)?5J5xb(_Y`@!j|N#+6zlLv$je
z{Znd=roCI)cu;f*U!^(ESuv&09VJ7EKHx{LKaiSeP~mj03}=9~(p5YpJC;)1j*iar
zg^dz|!;_mhcRk%(`D0yb031;ZT4njZbdHw9+qrAl=TZV4vpyj@<x697E{G-HgY}vz
zPYzO9toi^Ab%K7WuIbwIG_&fMqRV;(l1?i`ZIDnwH!!~iio#2`s()R@`2;suZQ4#Z
z6ywz4l7^T1i^Vx4R<_{(xV`$7bnKVw=K8(N%0w=g6eB6m;I7jP#mfd^koLkWvnaU*
zbpy?T!QPN*EswQV%Je~Rt)9tO1L&>83s{SMoi17)TfflHoAjg2;9y<$Fz?T5nu|<p
z`cm=bEwUY5Q14RCmoXmt-K@h)-->2ZK=WR=-o>sp&)!aYgPLveW<$$_-yUaIBIj{_
zzX8$esFsCd&7j?+$wjCLs3bwzyEoO+v3s0mTh>(5a_(t>?%NL{G$~uht@%kihZMCd
zrLXmN%404Mt9;{V?t5SU3@+?XQSJ2d+fb&$=_1zLev|lwlyT{OlFiS|uRSo>U{B*H
z*QC=^eO7pH3cpD5g8jRJ{a!j&?B17g@(K^_Khqhg6LD0F(JRo!T!2nEC)p=R)H+w;
zW5YiT0eNo(iW~VR^nIPbn(B#$`jO#q-@%Q&8X~3P#*UdO)d;iYF`M#d{W`v;Zbs36
zrS<F{twX;SBfogDvyZ6Tf`WOGbKI@j)Ql&S3e8543PX{(UR)ywy`-7E$Em_`&(`!R
zVr|{^$DRn><#uY+P`uB0d_;l8E6(X8qZi3sqs|g97`jjY+gc8epk_s#l$KF%W1v>^
zcl0+$r=9dow@{Wawk&j%g^}~dqR#mV4d?nf(00_gW(B^@O%KxP6d-IlBum~c29xTM
z<`-iYv2!u%VXioAxw&M_yl!P3UR;&QsLf?}mzJ(s4UsUX8Du&|+x%eUL#)e09JXSn
zUY7~3M+mjBhbt9ea@RhSEbd5F2?cwBz1^0(A7hZSHhiY$O!F3ImsSSr!%qn`*V(Mz
z%QTLEdbIKWn?9)XG|MfVP0v^Dz5*Mi&@5$?gC|RC{?hY&$(dYH!gu%3SUG$}vbubs
zOfwUfyiV!D_MBB>o`yk8w-Mw0iYA7WA2L4aFM_n>jYdCi7rlQtTq2PqLn8B?obvJ8
z_Ttuw)PW7tie)`pw7|DJO7xAL)8d|66Bv6{fZlSEja}&DWC|Qmf-E%k)0e<wbkQ_h
zY;(8G1ghlQSUwF0KNi#pfryz+YpzZIxnTg)p0q|Ye%6~4*eWDQ<A6oey^{lH6(*IH
zub0ABGg|N??rgkri~eW*YJX1l?uzw#`(Fh^oqg9N@}%7yX>;<)p~~`@PY@-u_{30h
znvV}9^@OOw%=~vzx;(!MN=EZb68wG)4j$o`V7Tu3{gCVC5r6YriH$rbCj(0h5TRn|
z3Q(i>lYlD($bk>;qoI=m{&g-7PDYx}uT6rekiTyT{vL9h6uCWMLJj(R_jRP3ix4S_
zsKAPXl&G8*g4F0^RNz2CCR7u7YoO0`06>5%zps<Mn?3)305M4!5oLdQ3jpY1002n-
z40$7d{M`-ZEXWt&=K7xju%yGRo}dE&7|0;_zXkZfipqP}$2ZW`-sg8;)b<FBM2D`z
z0d^On09_ONymT=r4h;ZM!~g)UZ|mQeD+d7Z$iwb|w}+<>zm2Eo@4-;zzWI+Ky;qT7
zi2m)0)L6Ox=56QUZU5ihRkTgKP2Z5ZApNV6{=nb-tGQ7(;_u<@V(a1Ia^sDKyk7u-
P4Eec>+{tP3Ubp@WP)qc{

-- 
GitLab