diff --git a/README.md b/README.md new file mode 100644 index 0000000000000000000000000000000000000000..fe46a0d4eb2df0f29d0230244a98e4885a224cf3 --- /dev/null +++ b/README.md @@ -0,0 +1,3 @@ +# Identification of nuclear pore proteins at plasmodesmata + +Here we used bioinformatics, proteomics and fluorescence imaging to identify proteins with similarities to phase separating FG-NUPs at PD. We identified 20 NUPs in PD fractions, and validated dual localization to NPC and PD for 7 NUPs. Structured illumination microscopy detected the transmembrane anchor NUP CPR5 at both orifices of PD. cpr5 mutants showed reduced intercellular transport of SHR from stele to endodermis. The identification of FG-NUPs at PD is consistent with the recruitment of NUPs in the green lineage to form a PD pore gating complex consistent with liquid phase separation domains as diffusion barriers at PD. \ No newline at end of file