diff --git a/assays/DNA_extraction/isa.assay.xlsx b/assays/DNA_extraction/isa.assay.xlsx
index 49aa9a02d76530769cba182806b7605d0add1c94..064161b044ae7250570464d452f35ee5e06dec04 100644
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diff --git a/assays/RNA_extraction/isa.assay.xlsx b/assays/RNA_extraction/isa.assay.xlsx
index 0ae210be197dfe68a89da25de512696f1642d665..b292ce19ef504cabd206de0e89250773ce12c11c 100644
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diff --git a/assays/RNA_extraction/protocols/measure_RNA_concentration.md b/assays/RNA_extraction/protocols/measure_RNA_concentration.md
new file mode 100644
index 0000000000000000000000000000000000000000..9db5ca5696731c4b64faa18cb71be37a90779389
--- /dev/null
+++ b/assays/RNA_extraction/protocols/measure_RNA_concentration.md
@@ -0,0 +1,4 @@
+## measure RNA concentration of samples
+
+- dilute small amount of RNA sample 1:5 with DEPC water
+- use 2 µl of dilution to measure the concentration with a Nanophotometer
\ No newline at end of file
diff --git a/assays/biparental_mapping/dataset/CAPS_results.xlsx b/assays/biparental_mapping/dataset/CAPS_results.xlsx
index fa8750b430e1e475061365cf7c81af0c9c4b7419..c800f3ab2476be9d2338d2bb72044d07de0e2915 100644
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diff --git a/assays/biparental_mapping/dataset/introgression_area.xlsx b/assays/biparental_mapping/dataset/introgression_area.xlsx
index 1870f406bf3f7f35518387d0178e502e3139d8b1..3c0bf67676f709957396efdafdfe08ca3eb6f7b1 100644
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diff --git a/assays/biparental_mapping/dataset/target_genes_results.md b/assays/biparental_mapping/dataset/target_genes_results.md
deleted file mode 100644
index f92cc6afe23b4b599c71be7f51a76344b7005940..0000000000000000000000000000000000000000
--- a/assays/biparental_mapping/dataset/target_genes_results.md
+++ /dev/null
@@ -1,32 +0,0 @@
-## Results: target gene identification for *eam7*
-
-**Candidates related to the circadian clock:**
-
-| MorexV3 gene ID | pident | evalue | Araport11 gene ID | Gene name | SNP positions | Changes in aa sequence |
-| ------ | ------ | ------ | ------ | ------ | ------ | ------ | 
-| HORVU.MOREX.r3.6HG0592840 | 	73.75 | 2.26E-40 | AT2G21660 | GR-RBP1 | None	| None
-| HORVU.MOREX.r3.6HG0583670	| 69.309 | 0 | AT1G12910 | LWD1	| 32 bp del (1219-1250)	| A407F, N408S, K409F, L410* | 
-| HORVU.MOREX.r3.6HG0587680	| 66.082 | 0 | AT4G08920 | CRY1	| None | None | 
-| HORVU.MOREX.r3.6HG0595250	| 38.475 | 3.92E-106 | AT5G61380 | PRR1 | A642G | T1300C | T215A, S434P | 
-| HORVU.MOREX.r3.6HG0578070	| 55.367 | 0 | AT5G51200 | EDS4 | - | - | 
-| HORVU.MOREX.r3.6HG0589220	| 34.855 | 9.66E-46	| AT3G07640 | PBAC5 | - | - | 
-| HORVU.MOREX.r3.6HG0571470	| 36.735 | 1.3	| AT3G42170 | DAY-SLEEPER | - | - | 
-| HORVU.MOREX.r3.6HG0582650	| 30.108 | 1.00E-12	| AT3G42170 | DAY-SLEEPER | - | - | 
-| HORVU.MOREX.r3.6HG0592100	| 29.042 | 1.69E-45	| AT3G42170 | DAY-SLEEPER | - | - | 
-| HORVU.MOREX.r3.6HG0571480	| 28.319 | 1.11E-13	| AT3G42170 | DAY-SLEEPER | - | - | 
-
-
-
-**Candidates associated with early flowering:**
-
-| gene name | MoresV3 gene ID |
-| - | - |
-| PSEUDO RESPONSE REGULATOR 1 (PRR1) | HORVU.MOREX.r3.6HG0595250 | 
-| CRYPTOCHROME 1a (CRY1a) | HORVU.MOREX.r3.6HG0587680) | 
-| GLYCIN-RICH RNA-BINDING-PROTEIN 1 (GR-RBP1) | HORVU.MOREX.r3.6HG0592840) | 
-| LIGHT-REGULATED WD 1 (LWD1) | HORVU.MOREX.r3.6HG0583670 | 
-
-
-**Candidates with consistent mutations across *eam7* / *EAM* genotypes:**
-
-LIGHT-REGULATED WD 1 (LWD1) (HORVU.MOREX.r3.6HG0583670)
\ No newline at end of file
diff --git a/assays/biparental_mapping/isa.assay.xlsx b/assays/biparental_mapping/isa.assay.xlsx
index 6671a698fc90341ca6b287870b7d59588d4bed18..d41888c738931722f4d79e248ad6d1876142b7c7 100644
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diff --git a/assays/biparental_mapping/protocols/CAPS_marker_analysis.md b/assays/biparental_mapping/protocols/CAPS_marker_analysis.md
index 0f84933595bd017380d7608e88b2dc8eab482006..cf942a5f21fd0baf48feca5f371ac0c4c0de3aec 100644
--- a/assays/biparental_mapping/protocols/CAPS_marker_analysis.md
+++ b/assays/biparental_mapping/protocols/CAPS_marker_analysis.md
@@ -28,7 +28,3 @@
 | ------ | ------ | ------ | ------ | ------ | ------ | ------ |
 | M-PPD-H1 | F | ACGTGAATGGTGGATCGGC | BstUI | 60°C | 506 |  433, 73 | 
 | | R | TATAGCTAGGTGCGTGGCG | 						
-
-**Analysis:**
-
-- based on observed recombinations in combination with flowering time data, the eam7 introgression area can be redefined
\ No newline at end of file
diff --git a/assays/biparental_mapping/protocols/redefine_introgression_area.md b/assays/biparental_mapping/protocols/redefine_introgression_area.md
new file mode 100644
index 0000000000000000000000000000000000000000..a7e569b0bb1e7a2bf31aaa8bbac7df9dc6e32157
--- /dev/null
+++ b/assays/biparental_mapping/protocols/redefine_introgression_area.md
@@ -0,0 +1,4 @@
+## redefine eam7 introgression area
+
+- based CAPS marker results
+- combine observed recombinations  with flowering time data to reduce the eam7 introgression area
\ No newline at end of file
diff --git a/assays/cDNA_synthesis/dataset/eam7_development_cDNA_volumes.xlsx b/assays/cDNA_synthesis/dataset/eam7_development_cDNA_volumes.xlsx
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diff --git a/assays/cDNA_synthesis/dataset/eam7_diurnal_cDNA_volumes.xlsx b/assays/cDNA_synthesis/dataset/eam7_diurnal_cDNA_volumes.xlsx
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diff --git a/assays/cDNA_synthesis/dataset/lwd1_diurnal_cDNA_volumes.xlsx b/assays/cDNA_synthesis/dataset/lwd1_diurnal_cDNA_volumes.xlsx
index f6e0286234b679a53be3ef39409720310b4da40f..fc120a51e8e74119cb5f5907bf9d5eefdeb3547b 100644
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diff --git a/assays/cDNA_synthesis/isa.assay.xlsx b/assays/cDNA_synthesis/isa.assay.xlsx
index aa6541150a760052a8c1b6093c9a3aa7dc856ac9..3dc46412f95f588d6c9135451b4dccb644f6cbed 100644
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diff --git a/assays/cDNA_synthesis/protocols/calculate_volumes.md b/assays/cDNA_synthesis/protocols/calculate_volumes.md
new file mode 100644
index 0000000000000000000000000000000000000000..8072be77a076d86b2b6cd3664d0bc5c21e8e7d3e
--- /dev/null
+++ b/assays/cDNA_synthesis/protocols/calculate_volumes.md
@@ -0,0 +1,5 @@
+## calculate sample volumes
+
+- from RNA concentrations: calculate the volume of RNA to use 1 µg RNA in cDNA synthesis reaction
+- max amount: 11 µl
+- fill the remaining amount with water
\ No newline at end of file
diff --git a/assays/plant_genotyping/dataset/complementation_F1_genotype_results.xlsx b/assays/plant_genotyping/dataset/complementation_F1_genotype_results.xlsx
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diff --git a/assays/plant_genotyping/isa.assay.xlsx b/assays/plant_genotyping/isa.assay.xlsx
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diff --git a/assays/plant_phenotyping/dataset/complementation_F1_phenotyping_results.xlsx b/assays/plant_phenotyping/dataset/complementation_F1_phenotyping_results.xlsx
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diff --git a/assays/plant_phenotyping/isa.assay.xlsx b/assays/plant_phenotyping/isa.assay.xlsx
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diff --git a/studies/allelism_test/isa.study.xlsx b/studies/allelism_test/isa.study.xlsx
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