From 4282035e174e0a8e511c308e594d130448f95408 Mon Sep 17 00:00:00 2001
From: Senthil-Kumar Devan <devan@hhu.de>
Date: Thu, 2 Jan 2025 09:53:59 +0100
Subject: [PATCH] S7_human MLLE added
---
.../isa.assay.xlsx | Bin 6913 -> 6912 bytes
.../isa.assay.xlsx | Bin 6923 -> 6922 bytes
.../isa.assay.xlsx | Bin 6931 -> 6930 bytes
.../isa.assay.xlsx | Bin 6943 -> 6942 bytes
.../isa.assay.xlsx | Bin 6934 -> 6933 bytes
.../isa.assay.xlsx | Bin 6917 -> 6916 bytes
.../isa.assay.xlsx | Bin 6959 -> 6958 bytes
.../isa.assay.xlsx | Bin 6923 -> 6922 bytes
.../isa.assay.xlsx | Bin 6945 -> 6944 bytes
.../isa.assay.xlsx | Bin 6954 -> 6953 bytes
.../isa.assay.xlsx | Bin 6937 -> 6936 bytes
.../isa.assay.xlsx | Bin 6943 -> 6942 bytes
.../isa.assay.xlsx | Bin 6957 -> 6956 bytes
.../isa.assay.xlsx | Bin 6952 -> 6951 bytes
.../isa.assay.xlsx | Bin 6947 -> 6946 bytes
.../isa.assay.xlsx | Bin 6946 -> 6946 bytes
.../isa.assay.xlsx | Bin 6913 -> 6912 bytes
.../isa.assay.xlsx | Bin 6930 -> 6930 bytes
.../isa.assay.xlsx | Bin 6930 -> 6929 bytes
.../isa.assay.xlsx | Bin 6935 -> 6934 bytes
.../isa.assay.xlsx | Bin 6926 -> 6925 bytes
.../isa.assay.xlsx | Bin 6956 -> 6955 bytes
.../isa.assay.xlsx | Bin 6929 -> 6929 bytes
.../isa.assay.xlsx | Bin 6932 -> 6932 bytes
.../isa.assay.xlsx | Bin 6925 -> 6925 bytes
.../isa.assay.xlsx | Bin 6951 -> 6950 bytes
.../isa.assay.xlsx | Bin 6960 -> 6959 bytes
.../isa.assay.xlsx | Bin 6961 -> 6960 bytes
.../isa.assay.xlsx | Bin 6949 -> 6948 bytes
.../isa.assay.xlsx | Bin 6964 -> 6963 bytes
.../isa.assay.xlsx | Bin 6932 -> 6933 bytes
.../isa.assay.xlsx | Bin 6926 -> 6927 bytes
.../isa.assay.xlsx | Bin 6934 -> 6934 bytes
.../isa.assay.xlsx | Bin 6949 -> 6949 bytes
isa.investigation.xlsx | Bin 7918 -> 8269 bytes
.../isa.study.xlsx | Bin 7538 -> 7538 bytes
.../isa.study.xlsx | Bin 7553 -> 7553 bytes
.../isa.study.xlsx | Bin 7536 -> 7536 bytes
.../isa.study.xlsx | Bin 7544 -> 7544 bytes
.../isa.study.xlsx | Bin 7538 -> 7538 bytes
.../isa.study.xlsx | Bin 7530 -> 7530 bytes
.../README.md | 0
.../isa.study.xlsx | Bin 0 -> 7535 bytes
.../protocols/.gitkeep | 0
.../resources/.gitkeep | 0
45 files changed, 0 insertions(+), 0 deletions(-)
create mode 100644 studies/S7_Human MLLE Domains Differentiate between Binding Partners/README.md
create mode 100644 studies/S7_Human MLLE Domains Differentiate between Binding Partners/isa.study.xlsx
create mode 100644 studies/S7_Human MLLE Domains Differentiate between Binding Partners/protocols/.gitkeep
create mode 100644 studies/S7_Human MLLE Domains Differentiate between Binding Partners/resources/.gitkeep
diff --git a/assays/S1_A1_Protein structure prediction/isa.assay.xlsx b/assays/S1_A1_Protein structure prediction/isa.assay.xlsx
index 8a278e849d8163e93db04b21f5c57a6217171de0..08c168b9bbdfb3698bfa04a8f6975c1cc7f469f8 100644
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diff --git a/assays/S1_A2_Protein Purification for structural studies/isa.assay.xlsx b/assays/S1_A2_Protein Purification for structural studies/isa.assay.xlsx
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diff --git a/assays/S1_A5_Isothermal Titration Calorimetry_ITC_using Rrm4 MLLE3/isa.assay.xlsx b/assays/S1_A5_Isothermal Titration Calorimetry_ITC_using Rrm4 MLLE3/isa.assay.xlsx
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diff --git a/assays/S1_A6_X-ray structure of Rrm4-MLLE3/isa.assay.xlsx b/assays/S1_A6_X-ray structure of Rrm4-MLLE3/isa.assay.xlsx
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GIT binary patch
delta 710
zcmZoQYcb;s@MdP=Vqjq4U?^}?irUE6#>fI<OrF800A_67!^j5}I>#gnk$cai43QIK
zmW9fhvuHqsl3BJfL0Gcv3!##SIH2lZa_nS-NG{`_3sE-NT?i_fC$x@{6J)pWiZuJU
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zwdZc$c{9I1`Ixy`>8Hu8bB8qe7Qa-RwS2RM@1*m~p0ECOal;$=pW7ebTrmIrtN3U8
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Q1eibhu9Om+hB!zB0Cgt~?EnA(
delta 690
zcmZoMYc=Bw@MdP=Vqjq4VEEEGA#x*M8zT#dF?j}~0+_LR4<jE`=p2(QMD9J4GDJ>{
zSr#g1&Y}SkN@m%{1YyatFN8`S;()4u$+43SBDsuzE=1X6cOj@`p3pi*PLSO?X&R34
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z8+!}|<~Z@OYLuAB9sRP#bwlg!s0#+-r<{^fAFTS~^6k~)$$K~GoDQ_iT(a-~jJh@R
z;%5gsuY46+s1T`DaY)zTidl7V^-}Mtm%3xlE<Pf&N$qZ{T~Yh`{0BFdRX<2(?2FF4
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zpR`5V#_;{*<IBHJN_m`N!~3{U;{3Ibu|oINF2C6Pt}>wBOlOz-zqb`eFP=&NIsHZ)
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D#E3Ax
diff --git a/assays/S1_A7_Multiple sequence alignment of Rrm4-MLLE3 orthologs of representative fungi from Basidiomycota/isa.assay.xlsx b/assays/S1_A7_Multiple sequence alignment of Rrm4-MLLE3 orthologs of representative fungi from Basidiomycota/isa.assay.xlsx
index 9b42e31fd31edae9f22af9ab69c8f83937bddfe4..367943e573f06214fbee030060d5f5d4a47e49ed 100644
GIT binary patch
delta 681
zcmZ2)w$6+%z?+$ci-CcGgQ37pDQY8M8zT#dF?j}~0+_LR4<jE`=p2(QMD9J4GDJ>{
zSr#g1&Y}SkN@m%{1YyatpN2}l;ee_a=G@5!k-We^7ou!(p%7GZhR`}jPLSQgE7I)a
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y9fZ*;301sD5^C~aNppylg%ngOU&;z8#y3fsLFC^^Nim+B%r33O79<W#nhXH-<_$pr
delta 690
zcmZ2yw%&{{z?+$ci-CcGgW*f(gvgD2ZHz1+#^f1{3Sh?OJ&b%%p>s^K5V`kE$`Cm*
zW?875Ig18FD4As&6NDwpei|zIh6Aczm~$r^MDhavT!^yCg+frt8A9tAIYD;oq-i+D
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zC1J%v{YpX&kD@%b&YisdtI;0yM(1TLr?)m)t~@Z&wQO?H<bvFXN3)p4RCgSZ)|_5o
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zZ|pG?nB&C9s!?Jhcl65|*A1<^qb?YTpK?k{eX#0_%ePmHC-2>$b2`v6bIHE{GwRmN
zi=Q3nyz*6Op+clq#UWjTD`wTf)l0pnUh0lHyZDIACbhe*c17*$^B>$;R{bEEu`fFF
z!u^%1?40#|wjoQm9jZ($Yk1{t*s^w8sQ287?3TqlK0UwZA;5oi=k@&|x881>%joi;
ze9{(a8^iaLk1zi^Ddlm74e#SZiSyS!#tPk6yZmDFyUKuiGo4-T|K3&@y?7@5=kyzK
z)cD?fU9=q<NlD_i;Ha6rSlj@@xGruAVF*a*LKuz`#t=q@gbRdmK*9pT_#@#2VK_<J
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D%u+Ju
diff --git a/assays/S2_A1_Structural analysis of MLLE3 of Rrm4/isa.assay.xlsx b/assays/S2_A1_Structural analysis of MLLE3 of Rrm4/isa.assay.xlsx
index 9a8b661e1953276d3be91558fc3a5ebc26ac27dd..18c15db8ce8dba9e28d20fc46af634030b219fbf 100644
GIT binary patch
delta 710
zcmeA+>oVgD@MdP=Vqjq4U?^}?irUE6#>fI<OrF800A_67!^j5}I>#gnk$cai43QIK
zmW9fhvuHqsl3BJfL0Gcv%b}7dIH2m^bL?b;NUq_Z3sE-NR|qOuBD9W?6J)pWiZuJU
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zwdZc$c{9I1`Ixy`>8Hu8bB8qe7Qa-RwS2RM@1*m~p0ECOal;$=pW7ebTrmIrtN3U8
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z2t!`d4#G&3G=?x{NJ34&DQOOqlA5e11vSfC$_gpw`=rd|LFph(*SRi+k%6IviGhJ1
Sm_!j^>Ey>!N^E-KAQ1p{_YXM$
delta 711
zcmeA&>o(&H@MdP=Vqjq4VEEEGA#x*M8zT#dF?j}~0+_LR4<jE`=p2(QMD9J4GDJ>{
zSr#g1&Y}SkN@m%{1YyatFNaE=;DD-s&#{vYBDsctE=1X6Um>VuiO@PmPLSO?X&R34
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zNm#K^zmibHqbQH9b0=^AYP3ha(Rmrm>8(wcD-TR`Et_04xghu9(JW>$)g1?<HK!LC
zt6RHF4tVv0kL#IR+(Mh37q=z6Sa>(+@Q-=9jeUzV+_)X;)g+9fq}!I2tIS>cVDD1P
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z;%5gsuY46+s1T`DaY)zTidl7V^-}Mtm%3xlE<Pf&N$qZ{T~Yh`{0BFdRX<2(?2FF4
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zpR`5V#_;{*<IBHJN_m`N!~3{U;{3Ibu|oINF2C6Pt}>wBOlOz-zqb`eFP=&NIsHZ)
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SX%qpLO@1V$#HKF}5&;0UTQboA
diff --git a/assays/S2_A2_Western blot analysis of GST pull-down experiments with MLLE3 variants/isa.assay.xlsx b/assays/S2_A2_Western blot analysis of GST pull-down experiments with MLLE3 variants/isa.assay.xlsx
index b070428abd1726a6c9c31c8b909b3d06e46d0d3b..f929451a3a907d3ddfada5aec3f54c184d06356a 100644
GIT binary patch
delta 689
zcmZ2zw!n-pz?+$ci-CcGgQ37pDQY8M8zT#dF?j}~0+_LR4<jE`=p2(QMD9J4GDJ>{
zSr#g1&Y}SkN@m%{1Yyat?}bX<<AADX<=n{zkvzmd7ou!(vJh0VOK2S<C&+H$6>0Wy
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D%)<_h
delta 682
zcmZ2rw$O|(z?+$ci-CcGgW*f(gvgD2ZHz1+#^f1{3Sh?OJ&b%%p>s^K5V`kE$`Cm*
zW?875Ig18FD4As&6NDwpz85Naj{~Znm2)Q>MDh^-T!^yC$wE-cE}?adoFKb((li|7
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zlCWZ-ekGxXM^PSI=T6@K)o71;qw_MB(_5P?S00$?S~j_8azXCHqgl*isyhxyYfdjP
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diff --git a/assays/S2_A3_Western blot analysis of GST pull-down experiments with GST-MLLE3 and PAM2L variants/isa.assay.xlsx b/assays/S2_A3_Western blot analysis of GST pull-down experiments with GST-MLLE3 and PAM2L variants/isa.assay.xlsx
index 7a68c6c2bde027018ac4e75220a4bdaf3bbf3d24..6a2314db69c7847d8c29d915eb8de9d2ad8c8f5b 100644
GIT binary patch
delta 710
zcmZ2ww$h9*z?+$ci-CcGgQ37pDQY8M8zT#dF?j}~0+_LR4<jE`=p2(QMD9J4GDJ>{
zSr#g1&Y}SkN@m%{1YyatAA?Fh=YXo`<J`#xkvz>m7ou!(ju2FGvd}t4PLSQgE7I)a
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Sz$A(QM<z2#E3x^CgG2x%un*n<
delta 741
zcmZ2!w#tkzz?+$ci-CcGgW*f(gvgD2ZHz1+#^f1{3Sh?OJ&b%%p>s^K5V`kE$`Cm*
zW?875Ig18FD4As&6NDwpehe!4oCB(!k8>v*MDjHMT!^yCIYLm$$wKQGIYD;oq-i+D
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ze9{(a8^iaLk1zi^Ddlm74e#SZiSyS!#tPk6yZmDFyUKuiGo4-T|K3&@y?7@5=kyzK
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diff --git a/assays/S2_A4_Structural comparison of MLLE3 in U_maydis and R_irregularis/isa.assay.xlsx b/assays/S2_A4_Structural comparison of MLLE3 in U_maydis and R_irregularis/isa.assay.xlsx
index 408f3c480ff464ac5586edc718777bd4ecdb094b..d94615b8f150ebe1c475d29b7376563c06dc0a38 100644
GIT binary patch
delta 741
zcmbPfHp7fBz?+$ci-CcGgQ37pDQY8M8zT#dF?j}~0+_LR4<jE`=p2(QMD9J4GDJ>{
zSr#g1&Y}SkN@m%{1YyatZ-q);<AAFF%dwLUBDsryE=1YnXd$R%lh8UwPLSQgE7I)a
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z57wT$dFRdi{^VokW~HAdv(6pT;9LAsZPxP57QU0tFMGcF*ToHQ<bQ5|d~?D4_pjog
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z5;uh~ev9iu82OS?liegFA)I6h7YJjugaw50T*3*$(3P}<F!CjhA&g~`P}84Fn!}`|
mCfi6s&5D$=LP{8Oq|D?&$pqc)K<7ij=E)zWl-O*<L0kaVTo~8@
delta 712
zcmbPXHq(qRz?+$ci-CcGgW>0f36UH5+89|tjL9<?6~K(mdl>nkLg$!dA#(4Tlp%6r
z%(759a~2JVP%_IlCJ0NGeJfP*8V6MUUyhw@5XoKqb0NwmM+-qEn}pUea)Ruhv9FOk
zezK*AX8q&~m$bMXv$XwOSA_(uz86!?IQ_`BH%k@k<DWY+ObyPrw%+`>)?&8oDWxBb
zua|@c3-v1rH9U&)*gA94)gn2&2?rE|n?$1yPPy{ngwFnxJ3M!8`;fJjv0EtSLGKjr
zoiiutF7nhYt>IQJR$d=4FD5(M=*xw?6^S*+%^W6c%(@^{KY_EY$E<Ckq>N|2=8uHT
zZ`(3>S(XPlaB|7^x*OVN3g*0AC${Cx%uQ1wq<3i9PHO)3;EBSTRaqgu(JSBEFO%<{
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diff --git a/assays/S2_A5_Western blot analyis of Rrm4-MLLE3 from U_maydis and R_irregularis/isa.assay.xlsx b/assays/S2_A5_Western blot analyis of Rrm4-MLLE3 from U_maydis and R_irregularis/isa.assay.xlsx
index 0051730fa60e7d6a9be7b9ca1d8c5265e6596cba..f872043c2485e72167ddd4109d9e2bb35e23be67 100644
GIT binary patch
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delta 671
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diff --git a/assays/S3_A1_Hyphal growth of strains expressing Rrm4-Kat with MLLE3 variants in AB33 background/isa.assay.xlsx b/assays/S3_A1_Hyphal growth of strains expressing Rrm4-Kat with MLLE3 variants in AB33 background/isa.assay.xlsx
index 62dccf75d31724278f65cef9a69417890830b45a..c1332b99d0d8e9acbf05654d08ff57a9422144fe 100644
GIT binary patch
delta 720
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delta 741
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diff --git a/assays/S3_A2_Quantification of hyphal growth of AB33 derivatives expressing Rrm4-MLLE variants/isa.assay.xlsx b/assays/S3_A2_Quantification of hyphal growth of AB33 derivatives expressing Rrm4-MLLE variants/isa.assay.xlsx
index 8e3f11b5b166e3dc657e329a8b08fbc3516ffd8a..f5899b4bb99ea9cf239ac91f5702cff249e8a287 100644
GIT binary patch
delta 710
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delta 712
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diff --git a/assays/S3_A3_Micrographs and Kymograph measurement of Rrm4-Kat_MLLE3 variants movement in hyphae/isa.assay.xlsx b/assays/S3_A3_Micrographs and Kymograph measurement of Rrm4-Kat_MLLE3 variants movement in hyphae/isa.assay.xlsx
index e475f84572e4d74da6c70307b5b05e46375ef130..4383ca10fd15f041327f7c060f87e6269bf31803 100644
GIT binary patch
delta 690
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delta 691
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diff --git a/assays/S3_A4_Quantification of processive Rrm4-Kat signals - velocity and distance travelled/isa.assay.xlsx b/assays/S3_A4_Quantification of processive Rrm4-Kat signals - velocity and distance travelled/isa.assay.xlsx
index c10e9276cdcb22d05c82d6c730a2724520a2423e..b87240e1cad14d51fd34212fac6df0b9d4b630b7 100644
GIT binary patch
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diff --git a/assays/S4_A1_Protein structure prediction/isa.assay.xlsx b/assays/S4_A1_Protein structure prediction/isa.assay.xlsx
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delta 664
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index 573bf7b375fb7ba71e28e828d7ea1471c8d4a588..c132b48061730a84bfce96fe3cbde15275c527bf 100644
GIT binary patch
delta 675
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delta 675
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diff --git a/assays/S4_A3_Size exclusion chromotography of H-Pab1-MLLE/isa.assay.xlsx b/assays/S4_A3_Size exclusion chromotography of H-Pab1-MLLE/isa.assay.xlsx
index d7097e1ccd3844d717cac23dadc43e6ce21000a7..77103cc46970beacec4f8bf163d96ee6ccefca06 100644
GIT binary patch
delta 671
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delta 672
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diff --git a/assays/S4_A4_Isothermal Titration calorimetry-ITC with H-Pab1-MLLE/isa.assay.xlsx b/assays/S4_A4_Isothermal Titration calorimetry-ITC with H-Pab1-MLLE/isa.assay.xlsx
index 828bf8f07d19713a7949522a034cd5e8244895dc..c1203e04242ff88fc348b7742ecd4ad69f23aa1c 100644
GIT binary patch
delta 733
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delta 712
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diff --git a/assays/S4_A5_X-ray structure analysis of H-Pab1-MLLE/isa.assay.xlsx b/assays/S4_A5_X-ray structure analysis of H-Pab1-MLLE/isa.assay.xlsx
index 6993908838d30dfc664f1dde1f54a7f34582286f..0ef34386996eb717231a65071b301c7fd0b1c851 100644
GIT binary patch
delta 690
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delta 691
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diff --git a/assays/S4_A6_Western blot analysis of GST pull-down experiments using G-Pab1-MLLE and PAM2 variants/isa.assay.xlsx b/assays/S4_A6_Western blot analysis of GST pull-down experiments using G-Pab1-MLLE and PAM2 variants/isa.assay.xlsx
index d3f44ea8e583a269fabcc4f12f5b6ef1d6342fad..95bb0bd81f563309da0bebb50ec54b1a8eeedba9 100644
GIT binary patch
delta 711
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delta 712
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diff --git a/assays/S4_A7_Multiple sequence alignment of Pab1-MLLE orthologs/isa.assay.xlsx b/assays/S4_A7_Multiple sequence alignment of Pab1-MLLE orthologs/isa.assay.xlsx
index a56dbc5406887c4b622165473c4b052737090391..2f8e7c4bbe171e4d357bd5fcae3a03be4e14c928 100644
GIT binary patch
delta 676
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delta 676
zcmbPeHqnePz?+$ci-CcGgW>J236UH5+89|tjL9<?6~K(mdl>nkLg$!dA#(4Tlp%6r
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diff --git a/assays/S5_A1_Multiple Sequence alignment of vps8 and Taf7 orthologs/isa.assay.xlsx b/assays/S5_A1_Multiple Sequence alignment of vps8 and Taf7 orthologs/isa.assay.xlsx
index fb5cebce2ee3f5a530a40c31e08492515c7cdecb..689fabc9492024afc4fed41e3c64bc38ecfa5d2b 100644
GIT binary patch
delta 675
zcmbPYHpPrDz?+$ci-CcGgQ37pDQY8M8zT#dF?j}~0+_LR4<jE`=p2(QMD9J4GDJ>{
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pAPfyjI|u`$p+yp^VWA|{hDVa-Fll25BSgvy5%bfepwbtmoB`E83%>vW
delta 675
zcmbPYHpPrDz?+$ci-CcGgF#~7gvgD2ZHz1+#^f1{3Sh?OJ&b%%p>s^K5V`kE$`Cm*
zW?875Ig18FD4As&6NDwpz7Z;Ui36(sC&x}Uh~zf@xe#TO!-b%dbwcYHIY4$_KeF)6
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diff --git a/assays/S5_A2_Protein structure prediction using Alphafold2/isa.assay.xlsx b/assays/S5_A2_Protein structure prediction using Alphafold2/isa.assay.xlsx
index 381533fe6e118c1b7daa948da8447419cc00f002..058ddca0ae1779f25d35aa6e253cd3244c49fc4f 100644
GIT binary patch
delta 675
zcmeA*>owyG@MdP=Vqjq4U?^}?irUE6#>fI<OrF800A_67!^j5}I>#gnk$cai43QIK
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delta 675
zcmeA*>owyG@MdP=Vqjq4U|`)hA#x*M8zT#dF?j}~0+_LR4<jE`=p2(QMD9J4GDJ>{
zSr#g1&Y}SkN@m%{1YyatuYyXR=76gI#IchNBDtP_E=1Yn03oPkxzIXB4v^i($`=JD
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zE3Y=WEH>nHDAZkYOaDaKX0GQd1t+E?><rtWAZoGcj9gHj&^p~cQMm^ev4~eFKNZRo
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diff --git a/assays/S5_A3_Western blot analysis of GST pull-down experiments using predicted PAM2L variants/isa.assay.xlsx b/assays/S5_A3_Western blot analysis of GST pull-down experiments using predicted PAM2L variants/isa.assay.xlsx
index f16a5b2b5691754dcc802cc7793837e02e2748cf..e4cda2b9025348c6abc4eb86ab938acbb324e746 100644
GIT binary patch
delta 733
zcmZ2(w#<w#z?+$ci-CcGgQ37pDQY8M8zT#dF?j}~0+_LR4<jE`=p2(QMD9J4GDJ>{
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delta 722
zcmZ2xw%m*_z?+$ci-CcGgCStwgvgD2ZHz1+#^f1{3Sh?OJ&b%%p>s^K5V`kE$`Cm*
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diff --git a/assays/S5_A4_Hyphal growth of strains expressing Rrm4-Kat and Vps8-Gfp variants in AB33 background/isa.assay.xlsx b/assays/S5_A4_Hyphal growth of strains expressing Rrm4-Kat and Vps8-Gfp variants in AB33 background/isa.assay.xlsx
index fa2a6ce0609b4ee4cb75c1e0999ca911af0bb82b..27e84bab5b09b2bb51b4ac60fa6bc845ea1ac662 100644
GIT binary patch
delta 682
zcmdmBw%&{{z?+$ci-CcGgQ37pDQY8M8zT#dF?j}~0+_LR4<jE`=p2(QMD9J4GDJ>{
zSr#g1&Y}SkN@m%{1YyatpMgrg<$$Ue;oQjvk-W%17ou!(kq}gJrqDV@PLSQgE7I)a
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delta 683
zcmZ2)w!w@qz?+$ci-CcGgW>Pq36UH5+89|tjL9<?6~K(mdl>nkLg$!dA#(4Tlp%6r
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diff --git a/assays/S5_A5_Quantification of hyphal growth of AB33 derivatives expressing Rrm4-Kat and Vps8-Gfp variants/isa.assay.xlsx b/assays/S5_A5_Quantification of hyphal growth of AB33 derivatives expressing Rrm4-Kat and Vps8-Gfp variants/isa.assay.xlsx
index c48cbf3ea126f5f284b9debd8bb442eba3206e36..3355102b7a4be741209693e4c6ee28d6e055b46d 100644
GIT binary patch
delta 720
zcmdmJw!w@qz?+$ci-CcGgQ37pDQY8M8zT#dF?j}~0+_LR4<jE`=p2(QMD9J4GDJ>{
zSr#g1&Y}SkN@m%{1YyatpM^@k<AACc<=n{zk-Wq|7ou!(u@F>pme4vzPLSQgE7I)a
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delta 712
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diff --git a/assays/S5_A6_Micrographs and Kymograph measurement of Rrm4-Kat movement in Vps8-Gfp variant hypha/isa.assay.xlsx b/assays/S5_A6_Micrographs and Kymograph measurement of Rrm4-Kat movement in Vps8-Gfp variant hypha/isa.assay.xlsx
index 37f7dc09218ba18dc2f1148856c60b6f10615113..f4279a9eea6548cb0efb122424334354c10cd6b8 100644
GIT binary patch
delta 711
zcmZ2#w#1Atz?+$ci-CcGgQ37pDQY8M8zT#dF?j}~0+_LR4<jE`=p2(QMD9J4GDJ>{
zSr#g1&Y}SkN@m%{1YyatAB0Li;()5><lM;ykvzsf7ou!(x)4;dPiP$@C&+H$6>0Wy
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delta 691
zcmZ2tw$zL-z?+$ci-CcGgW>(Y36UH5+89|tjL9<?6~K(mdl>nkLg$!dA#(4Tlp%6r
z%(759a~2JVP%_IlCJ0NG{UB8G5eHN~C+AK!h~zQ;xe#TO(}kdteM0LPIYD+8ztoY7
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DKxjA@
diff --git a/assays/S5_A7_Quantification of processive Rrm4-Kat signals_velocity and distance travelled in vps8-gfp variant hypha/isa.assay.xlsx b/assays/S5_A7_Quantification of processive Rrm4-Kat signals_velocity and distance travelled in vps8-gfp variant hypha/isa.assay.xlsx
index b68bf2fd0b7ed50fe9ba96f330eed15a322b67ee..5167d6beab12f465919311c493a505d2b532ed66 100644
GIT binary patch
delta 706
zcmdmDw%Lp?z?+$ci-CcGgQ37pDQY8M8zT#dF?j}~0+_LR4<jE`=p2(QMD8Pput<DS
zYEH2}s_xBV%(76m<}4Zz?a3_Lm>?`!_6tzSj~vPnAqmc%Y!KE}{<#oklgosll5>UD
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Nv=UpmI55pJ000%`5bpp0
delta 707
zcmdmNw#AGuz?+$ci-CcGgF#{cgvgD2ZHz1+#^f1{3Sh?OJ&b%%p>s^K5V?;W!XoiS
zsX4{^sJb_cG0Q^LnzLv?v?sG{V}h_`*)KpPKXNETgd{k3vO!o^`R78EO)e9HO3oEp
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L*doM%iIxEXL9iS5
diff --git a/assays/S5_A8_Quantification of Rrm4-Kat signal accumulated at the tip/isa.assay.xlsx b/assays/S5_A8_Quantification of Rrm4-Kat signal accumulated at the tip/isa.assay.xlsx
index c52c473808e6081832a61f870aeb147a76f07f26..178b981310fe08777493a209cda7f36b215a747b 100644
GIT binary patch
delta 720
zcmbPYHr0$Tz?+$ci-CcGgQ3t(DQY8M8zT#dF?j}~0+_LR4<jE`=p2(QMD9J4GDJ>{
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delta 721
zcmbPgHpPrDz?+$ci-CcGgF%X6V&q1?Hbxc@WAY3}1u$dt9!5T>&^abqh}?T7Wr&;@
zvn*83oJ9j7l+3b?3Br<P-w2hw!~s?RlVc|vL~<MdT!^yC;X+W!I-zxpoFKdB<sIvc
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diff --git a/assays/S6_A1_Multiple sequence alignment of Mkrn1 orthologs/isa.assay.xlsx b/assays/S6_A1_Multiple sequence alignment of Mkrn1 orthologs/isa.assay.xlsx
index 07ebadda9ef908ca30b9e27371fa1339adba5c3c..28ecbb79c44f0ab92871629a27f8cd60ee23b90e 100644
GIT binary patch
delta 691
zcmeA(>o?;I@MdP=Vqjq4U?_A`irUE6#>fI<OrF800A_67!^j5}I>#gnk$cai43QIK
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A5C8xG
delta 682
zcmeA->oemE@MdP=Vqjq4V8~;e7`c(JjgbY!m^_0~0nFIEhmj8|bdE_DBKMw286qdf
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diff --git a/assays/S6_A2_Protein structure prediction of MKRN1 using Alphafold2/isa.assay.xlsx b/assays/S6_A2_Protein structure prediction of MKRN1 using Alphafold2/isa.assay.xlsx
index 7bbf26cccc77f4e1f68ad1c4a7e8835c84661045..7667d3b69d2472cf32ee0af3fd1ef43fcb90a88e 100644
GIT binary patch
delta 676
zcmbPcHqDGLz?+$ci-CcGgQ3t(DQY8M8zT#dF?j}~0+_LR4<jE`=p2(QMD9J4GDJ>{
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delta 676
zcmbPcHqDGLz?+$ci-CcGgJCAy#K?_&ZHz1+#^f1{3Sh?OJ&b%%p>s^K5V`kE$`Cm*
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diff --git a/assays/S6_A3_Western blot analysis of GST pull-down experiments using human PAM2L variants/isa.assay.xlsx b/assays/S6_A3_Western blot analysis of GST pull-down experiments using human PAM2L variants/isa.assay.xlsx
index 4c3bf863e0715b9ed6439828493559e83a84db36..14504298fed617d91d7231e38acbfda93e988083 100644
GIT binary patch
delta 675
zcmZ2#w$zL-z?+$ci-CcGgQ3t(DQY8M8zT#dF?j}~0+_LR4<jE`=p2(QMD9J4GDJ>{
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delta 675
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diff --git a/isa.investigation.xlsx b/isa.investigation.xlsx
index 08e0de048779fa4ed994e5540ce9549d2355d5f2..a73142e19683cb1a681c7c7d6ec1aaefa1f954a7 100644
GIT binary patch
delta 3252
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U$x41XEplUe_ykY*LVpMU7kI+vZ~y=R
delta 2915
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zI(yj*D*raA<e1s2%M2h;3>XCBpqtdwqe7V91b9pMH2u1|gpqWyC47o5RNzW<aT%^g
z7uoQ$bTJ9n{C{qg644a>b;<wliGS_*yA?8K+z=7}XGs`1i!I~12tPfhion3_Y#Cc3
zV)R%D0TYWlPIpvvRFL=IR%&C;0OkSx!rtHS?=l<)hw*_xUZI{gsL-&8zfS(o2s#*N
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diff --git a/studies/S1_MLLE3 of Rrm4 Constitutes a Different Type of Seven-Helix MLLE Domain/isa.study.xlsx b/studies/S1_MLLE3 of Rrm4 Constitutes a Different Type of Seven-Helix MLLE Domain/isa.study.xlsx
index cfbd505167521ef7228516b2ca19cbc9fc31457b..d721875f6333e2c6ebac11c45d8b21c764ffdd31 100644
GIT binary patch
delta 675
zcmexl^~s7az?+$ci-CcGgQ3t(DQY8M8zT#dF?j}~0+_LR4<jE`=p2(QMD9J4GDJ>{
zSr#g1&Y}SkN@n@R3}Gd5oM3{e*X4$)58>X)29XpLnhTZOBm$MZDYBlC17!D};+2(?
zCx~g+YlwC^O}Nz+JW)&Z$}02gaR*d4>Q-l-xPQHJLc^(*+vm=``O$8Uo}a7SpN7()
z)s~&^f}9S8x=U`IJ(;$bCtaoB#FT`cVFv1=7Mo7I3(6B(r@JRA_rM|+@e1XqLV3?p
z`ZI*QWbZp4ymLZ(iu(3jVm!86tg|HSH^^Qn6tTU)G@+iet>;?X!k4n1>6#V!nSEyY
zJS@v6I5Tp|_PQI&ZsFKgV9qV|%qh}i4bPn^^G?Rq7HtxrmTIY`-h1V{{N?_ur=yLt
zG(z`k@u_&T`tM+EyOkzg8n7!wbMJ|(HeP2GvoFQIP%i)Ti>)tr7rUL<gB?@Z{?3j1
zr1kK8VZ*8`VHW2T;}-r3;z?Yddo_splR`RQ_`f^RoR2n2RsHo|dN=R3qytNxy65hL
z#-HsftK#%M&H9dAHt0H>v8ONXq=}!}_xYvg!@o8sUbOv`e|)o}`TeW=&(txZM)zhZ
zi4JH4E|au{MAmaj0|-M}$`rx~k<x`Qs%4}m&zF*faP~;KKo~6277&Jmv=fBUCT#~{
ifHXXkhHCgP4Yk2R#vCSX3}I}Nu|mZB7nroZtTO<pw*CG9
delta 675
zcmexl^~s7az?+$ci-CcGgW*f(gvgD2ZHz1+#^f1{3Sh?OJ&b%%p>s^K5V`kE$`Cm*
zW?875Ig18FD4FFKGlZ4Mae@h=UY8rHK7@NG8$?o2Xf9N8lL%DurpS6m4v^hCX&R1`
zCx~g+FWA!MG~rfP@I<Ytt3vbF?QQT*ivD(K!v6K26$GXR=UZEEeq3u2E7NWBgYor}
zuwtQpC835#Q65|8PTv02XpefM^D>sxTbnFb9+>D_Ho0hWLGHt&S<GUpI}S)|PA@Q4
zw|1Ev@ahL2*E6@cg*H1cZcBKv@NUrIAM<h>`xa-oaXZwjNf<>*w=FAInY;AC-ldi|
z_81DxapGguC^3;c`elvlhSuFt7YxKtIVGh&SoOu_+pEQs_ioTR9cY=kWZ(Z8b!+Cu
z&kl56`6{$fAyTX2kgmZMv+CgLrQTC7b;q1td_-oG+TB*WqW1Oq4{j{0evr)A7oB<G
z{z_GL&iX#vkfqxWRVJ1-yz(||S-UONd+tPb%i<lMp5OBj;J>=_`u>nxZ@0~5ba_xd
zX^XUt;rq$Qmw%m<@;JkW_i>@b`D-6zh3>0eezEyoWk9`|&Mx<VZ!3&mJd^%&`i(eh
zbZ?fD=zvDxGD%xVWIdNOfH0(`Od*UADP0JoT1IN}d?`r?XOEN%gux<h0bw{uJ3$z2
m(smFANW&v(sD}U2P#YX%%wf{T5XL4MD@4qHfl2GjIs*VPTrd*=
diff --git a/studies/S2_MLLE3 of Rrm4 Recognizes PAM2-Like Sequences with a Defined Binding Pocket/isa.study.xlsx b/studies/S2_MLLE3 of Rrm4 Recognizes PAM2-Like Sequences with a Defined Binding Pocket/isa.study.xlsx
index 00edfdf8d29f55d5eb6741298844863649d635c7..128d5a29cc23330f1d0114ab2904681744ef4bf2 100644
GIT binary patch
delta 675
zcmZp)ZnWkL@MdP=Vqjq4U?_A`irUE6#>fI<OrF800A_67!^j5}I>#gnk$cai43QIK
zmW9fhvuHqsl39K+Ls*F%*O?&dZMdQ8leu@YK_nG~=0YV8ia;e_h^%Mi0NK5#cxC0}
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diff --git a/studies/S5_Deciphering the Binding Code for MLLE of Pab1 and MLLE3 of Rrm4/isa.study.xlsx b/studies/S5_Deciphering the Binding Code for MLLE of Pab1 and MLLE3 of Rrm4/isa.study.xlsx
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diff --git a/studies/S7_Human MLLE Domains Differentiate between Binding Partners/README.md b/studies/S7_Human MLLE Domains Differentiate between Binding Partners/README.md
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diff --git a/studies/S7_Human MLLE Domains Differentiate between Binding Partners/protocols/.gitkeep b/studies/S7_Human MLLE Domains Differentiate between Binding Partners/protocols/.gitkeep
new file mode 100644
index 0000000..e69de29
diff --git a/studies/S7_Human MLLE Domains Differentiate between Binding Partners/resources/.gitkeep b/studies/S7_Human MLLE Domains Differentiate between Binding Partners/resources/.gitkeep
new file mode 100644
index 0000000..e69de29
--
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