From a471cbc359a7c397e30eeba851686ec6f5c68b20 Mon Sep 17 00:00:00 2001 From: Senthil-Kumar Devan <devan@hhu.de> Date: Sat, 11 Jan 2025 03:37:27 +0100 Subject: [PATCH] Protocols from manuscript added to all the assays --- ...ture prediction, modelling and analysis.docx | Bin 0 -> 12866 bytes ...ant protein expression and purification.docx | Bin 0 -> 14791 bytes .../Recombinant protein purification.docx | Bin 0 -> 13614 bytes .../GST Pulldown and Western blotting.docx | Bin 0 -> 13455 bytes .../Isothermal titration calorimetry (ITC).docx | Bin 0 -> 13207 bytes ...ation of MLLE3 of Rrm4 and MLLE of Pab1.docx | Bin 0 -> 14592 bytes .../protocols/Multiple Sequence alignment.docx | Bin 0 -> 12729 bytes .../protocols/Structural analysis.docx | Bin 0 -> 12445 bytes .../GST Pulldown and Western blotting.docx | Bin 0 -> 13416 bytes .../GST Pulldown and Western blotting.docx | Bin 0 -> 13416 bytes .../protocols/Structural analysis.docx | Bin 0 -> 12412 bytes .../GST Pulldown and Western blotting.docx | Bin 0 -> 13416 bytes ...hal growth and Microscopy data analysis.docx | Bin 0 -> 15218 bytes .../protocols/Microscopy data analysis.docx | Bin 0 -> 14136 bytes .../protocols/Microscopy data analysis.docx | Bin 0 -> 14136 bytes .../protocols/Microscopy data analysis.docx | Bin 0 -> 14136 bytes ...ture prediction, modelling and analysis.docx | Bin 0 -> 12866 bytes ...ant protein expression and purification.docx | Bin 0 -> 14791 bytes .../Recombinant protein purification.docx | Bin 0 -> 13614 bytes .../Isothermal titration calorimetry (ITC).docx | Bin 0 -> 13170 bytes ...ation of MLLE3 of Rrm4 and MLLE of Pab1.docx | Bin 0 -> 14576 bytes .../GST Pulldown and Western blotting.docx | Bin 0 -> 13416 bytes .../protocols/Multiple Sequence alignment.docx | Bin 0 -> 12703 bytes .../protocols/Multiple Sequence alignment.docx | Bin 0 -> 12703 bytes ...ture prediction, modelling and analysis.docx | Bin 0 -> 12866 bytes .../GST Pulldown and Western blotting.docx | Bin 0 -> 13416 bytes ...hal growth and Microscopy data analysis.docx | Bin 0 -> 15218 bytes .../protocols/Microscopy data analysis.docx | Bin 0 -> 14136 bytes .../protocols/Microscopy data analysis.docx | Bin 0 -> 14136 bytes .../protocols/Microscopy data analysis.docx | Bin 0 -> 14136 bytes .../protocols/Microscopy data analysis.docx | Bin 0 -> 14136 bytes .../protocols/Multiple Sequence alignment.docx | Bin 0 -> 12703 bytes ...ture prediction, modelling and analysis.docx | Bin 0 -> 12866 bytes .../GST Pulldown and Western blotting.docx | Bin 0 -> 13416 bytes 34 files changed, 0 insertions(+), 0 deletions(-) create mode 100644 assays/S1_A1_Protein structure prediction/protocols/Structure prediction, modelling and analysis.docx create mode 100644 assays/S1_A2_Protein Purification for structural studies/protocols/Recombinant protein expression and purification.docx create mode 100644 assays/S1_A3_Size exclusion chromatography of H-Rrm4-MLLE3/protocols/Recombinant protein purification.docx create mode 100644 assays/S1_A4_Western blot analysis of GST pull-down experiments with MLLE3 versions/protocols/GST Pulldown and Western blotting.docx create mode 100644 assays/S1_A5_Isothermal Titration Calorimetry_ITC_using Rrm4 MLLE3/protocols/Isothermal titration calorimetry (ITC).docx create mode 100644 assays/S1_A6_X-ray structure of Rrm4-MLLE3/protocols/Crystallization of MLLE3 of Rrm4 and MLLE of Pab1.docx create mode 100644 assays/S1_A7_Multiple sequence alignment of Rrm4-MLLE3 orthologs of representative fungi from Basidiomycota/protocols/Multiple Sequence alignment.docx create mode 100644 assays/S2_A1_Structural analysis of MLLE3 of Rrm4/protocols/Structural analysis.docx create mode 100644 assays/S2_A2_Western blot analysis of GST pull-down experiments with MLLE3 variants/protocols/GST Pulldown and Western blotting.docx create mode 100644 assays/S3_A1_Western blot analysis of GST pull-down experiments with GST-MLLE3 and PAM2L variants/protocols/GST Pulldown and Western blotting.docx create mode 100644 assays/S3_A2_Structural comparison of MLLE3 in U_maydis and R_irregularis/protocols/Structural analysis.docx create mode 100644 assays/S3_A3_Western blot analyis of Rrm4-MLLE3 from U_maydis and R_irregularis/protocols/GST Pulldown and Western blotting.docx create mode 100644 assays/S4_A1_Hyphal growth of strains expressing Rrm4-Kat with MLLE3 variants in AB33 background/protocols/Haphal growth and Microscopy data analysis.docx create mode 100644 assays/S4_A2_Quantification of hyphal growth of AB33 derivatives expressing Rrm4-MLLE variants/protocols/Microscopy data analysis.docx create mode 100644 assays/S4_A3_Micrographs and Kymograph measurement of Rrm4-Kat_MLLE3 variants movement in hyphae/protocols/Microscopy data analysis.docx create mode 100644 assays/S4_A4_Quantification of processive Rrm4-Kat signals - velocity and distance travelled/protocols/Microscopy data analysis.docx create mode 100644 assays/S5_A1_Protein structure prediction/protocols/Structure prediction, modelling and analysis.docx create mode 100644 assays/S5_A2_Purification of H-Pab1-MLLE for structural studies/protocols/Recombinant protein expression and purification.docx create mode 100644 assays/S5_A3_Size exclusion chromotography of H-Pab1-MLLE/protocols/Recombinant protein purification.docx create mode 100644 assays/S5_A4_Isothermal Titration calorimetry-ITC with H-Pab1-MLLE/protocols/Isothermal titration calorimetry (ITC).docx create mode 100644 assays/S5_A5_X-ray structure analysis of H-Pab1-MLLE/protocols/Crystallization of MLLE3 of Rrm4 and MLLE of Pab1.docx create mode 100644 assays/S5_A6_Western blot analysis of GST pull-down experiments using G-Pab1-MLLE and PAM2 variants/protocols/GST Pulldown and Western blotting.docx create mode 100644 assays/S5_A7_Multiple sequence alignment of Pab1-MLLE orthologs/protocols/Multiple Sequence alignment.docx create mode 100644 assays/S6_A1_Multiple Sequence alignment of vps8 and Taf7 orthologs/protocols/Multiple Sequence alignment.docx create mode 100644 assays/S6_A2_Protein structure prediction using Alphafold2/protocols/Structure prediction, modelling and analysis.docx create mode 100644 assays/S6_A3_Western blot analysis of GST pull-down experiments using predicted PAM2L variants/protocols/GST Pulldown and Western blotting.docx create mode 100644 assays/S6_A4_Hyphal growth of strains expressing Rrm4-Kat and Vps8-Gfp variants in AB33 background/protocols/Haphal growth and Microscopy data analysis.docx create mode 100644 assays/S6_A5_Quantification of hyphal growth of AB33 derivatives expressing Rrm4-Kat and Vps8-Gfp variants/protocols/Microscopy data analysis.docx create mode 100644 assays/S6_A6_Micrographs and Kymograph measurement of Rrm4-Kat movement in Vps8-Gfp variant hypha/protocols/Microscopy data analysis.docx create mode 100644 assays/S6_A7_Quantification of processive Rrm4-Kat signals_velocity and distance travelled in vps8-gfp variant hypha/protocols/Microscopy data analysis.docx create mode 100644 assays/S6_A8_Quantification of Rrm4-Kat signal accumulated at the tip/protocols/Microscopy data analysis.docx create mode 100644 assays/S7_A1_Multiple sequence alignment of Mkrn1 orthologs/protocols/Multiple Sequence alignment.docx create mode 100644 assays/S7_A2_Protein structure prediction of MKRN1 using Alphafold2/protocols/Structure prediction, modelling and analysis.docx create mode 100644 assays/S7_A3_Western blot analysis of GST pull-down experiments using human PAM2L variants/protocols/GST Pulldown and Western blotting.docx diff --git a/assays/S1_A1_Protein structure prediction/protocols/Structure prediction, modelling and analysis.docx b/assays/S1_A1_Protein structure prediction/protocols/Structure prediction, modelling and analysis.docx new file mode 100644 index 0000000000000000000000000000000000000000..69bbbcb6ccc8dec03a59ee6b65c48ad47c8be76c GIT binary patch literal 12866 zcmeHtWqTdR((M*oWHGbF%*<?A%*@QpWHB>X%*@QpY_VjqEM~A6ubiB`Nt`_Q51ca} 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