From f509b063192cf0b28ee82ac7423161b564c23cb2 Mon Sep 17 00:00:00 2001
From: Tom Winkler <t.winkler@uni-koeln.de>
Date: Wed, 25 Sep 2024 14:10:48 +0200
Subject: [PATCH] readme linebreaks

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+## Isoform-resolved genome annotation enables mapping of tissue-specific betalain regulation in amaranth
+<br>
+Tom S. Winkler∗ , Susanne K. Vollmer∗† , Nadine Dyballa-Rukes‡ , Sabine Metzger‡ and Markus G Stetter∗,1
+<br>
+∗ Institute for Plant Sciences and Cluster of Excellence on Plant Sciences (CEPLAS), University of Cologne, Cologne, Germany, † Heinrich Heine University,
+Duesseldorf, Germany, ‡ MS platform, Institute for Plant Sciences and Cluster of Excellence on Plant Sciences (CEPLAS), University of Cologne, Cologne,
+Germany
+<br>
 - Betalains are coloring pigments produced in some families of the order Caryophyllales, where they replace anthocyanins as coloring pigments. While the betalain pathway itself is well studied, the tissue-specific regulation of the pathway remains mostly unknown.
 - We enhance the high-quality Amaranthus hypochondriacus reference genome and produce a substantially more complete genome annotation, incorporating isoform details. We annotate betalain and anthocyanin pathway genes along with their regulators in amaranth and map the genetic control and tissue-specific regulation of the betalain pathway.
 - Our improved genome annotation allowed us to identify causal mutations that lead to a knock-out of red betacyanins in natural accessions of amaranth. We reveal the tissue-specific regulation of flower color via a previously uncharacterized MYB transcription factor, AhMYB2. Downregulation of AhMYB2 in the flower leads to reduced expression of key betalain enzyme genes and loss of red flower color.
-- 
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